| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang-Hao Guo, Katrin Trautmann, Hermann J Schluesene. Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain. Journal of neuroimmunology. vol 163. issue 1-2. 2005-07-07. PMID:15885314. |
after formalin administration, an increase of p2x4r+ microglia were observed in the spinal cord dorsal horn on the side ipsilateral to the injection, reaching maximal levels by day 7, and then decreasing to normal levels by day 14. |
2005-07-07 |
2023-08-12 |
rat |
| Zhi-Ye Zhuang, Peter Gerner, Clifford J Woolf, Ru-Rong J. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain. vol 114. issue 1-2. 2005-05-16. PMID:15733640. |
on day 10, perk is expressed both in astrocytes and microglia, but by day 21 predominantly in astrocytes in the dorsal horn. |
2005-05-16 |
2023-08-12 |
Not clear |
| Zhi-Ye Zhuang, Peter Gerner, Clifford J Woolf, Ru-Rong J. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain. vol 114. issue 1-2. 2005-05-16. PMID:15733640. |
the sequential activation of erk in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain. |
2005-05-16 |
2023-08-12 |
Not clear |
| Thomas Beiter, Matthias R Artelt, Katrin Trautmann, Hermann J Schluesene. Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710454. |
a significant increase in ed1(+) microglia predominantly located in the dorsal horn grey matter of lumbar and thoracic spinal cord levels was observed on day 12. |
2005-04-28 |
2023-08-12 |
rat |
| Makoto Tsuda, Kazuhide Inoue, Michael W Salte. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends in neurosciences. vol 28. issue 2. 2005-04-25. PMID:15667933. |
it is important to establish how these molecules are activated in spinal microglia following nerve injury and how they cause signaling to neurons in the dorsal horn pain transmission network. |
2005-04-25 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Bethany Fitzsimmons, Sara Azizi, Henry C Powell, Xiao-Ying Hua, Tony L Yaks. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. Journal of neurochemistry. vol 92. issue 6. 2005-04-22. PMID:15748168. |
here we demonstrate that the isoforms are distinctly expressed in spinal dorsal horn: p38alpha in neurons and p38beta in microglia. |
2005-04-22 |
2023-08-12 |
rat |
| Ru-Rong Ji, Gary Strichart. Cell signaling and the genesis of neuropathic pain. Science's STKE : signal transduction knowledge environment. vol 2004. issue 252. 2004-11-16. PMID:15454629. |
in particular, peripheral nerve lesions result in activation of mapks (p38, extracellular signal-regulated kinase, and c-jun n-terminal kinase) in microglia or astrocytes in the spinal cord, or both, leading to the production of inflammatory mediators that sensitize dorsal horn neurons. |
2004-11-16 |
2023-08-12 |
Not clear |
| Kazuhide Inoue, Makoto Tsuda, Schuichi Koizum. Chronic pain and microglia: the role of ATP. Novartis Foundation symposium. vol 261. 2004-11-10. PMID:15469044. |
in the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38mapk (phospho-p38mapk) was increased. |
2004-11-10 |
2023-08-12 |
rat |
| Marucia Chacur, José Maria Gutiérrez, Erin D Milligan, Julie Wieseler-Frank, Luiz R G Britto, Steven F Maier, Linda R Watkins, Yara Cur. Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators. Pain. vol 111. issue 1-2. 2004-11-09. PMID:15327810. |
in support, immunohistochemical analysis revealed activation of dorsal horn astrocytes and microglia after intraplantar injection of either spla2. |
2004-11-09 |
2023-08-12 |
rat |
| Kazuhide Inoue, Makoto Tsuda, Schuichi Koizum. ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. Journal of pharmacological sciences. vol 94. issue 2. 2004-10-20. PMID:14978347. |
in the rats, activated microglia were detected in the injured side of the dorsal horn and the level of the dually-phosphorylated active form of p38mapk (phospho-p38mapk) in these microglia was increased. |
2004-10-20 |
2023-08-12 |
rat |
| Bryan C Hains, Carl Y Saab, Joshua P Klein, Matthew J Craner, Stephen G Waxma. Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 20. 2004-09-10. PMID:15152043. |
in situ hybridization, quantitative reverse transcription-pcr, and immunocytochemical analysis revealed upregulation of na(v)1.3 in dorsal horn nociceptive neurons but not in astrocytes or microglia, and unit recordings demonstrated hyperresponsiveness of dorsal horn sensory neurons. |
2004-09-10 |
2023-08-12 |
rat |
| Marucia Chacur, Erin D Milligan, Evan M Sloan, Julie Wieseler-Frank, Ruth M Barrientos, David Martin, Stephen Poole, Brono Lomonte, Jose Maria Gutiérrez, Steven F Maier, Yara Cury, Linda R Watkin. Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain. vol 108. issue 1-2. 2004-06-03. PMID:15109522. |
these demonstrated that both spla2s produce activation of dorsal horn astrocytes and microglia that is more prominent ipsilateral to the site of injection. |
2004-06-03 |
2023-08-12 |
rat |
| Makoto Tsuda, Akito Mizokoshi, Yukari Shigemoto-Mogami, Schuichi Koizumi, Kazuhide Inou. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. vol 45. issue 1. 2004-02-10. PMID:14648549. |
interestingly, the phospho-p38mapk immunofluorescence in the dorsal horn was found exclusively in microglia, but not in neurons or astrocytes. |
2004-02-10 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Akito Mizokoshi, Yukari Shigemoto-Mogami, Schuichi Koizumi, Kazuhide Inou. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. vol 45. issue 1. 2004-02-10. PMID:14648549. |
taken together, our results demonstrate that nerve injury-induced pain hypersensitivity depends on activation of the p38mapk signaling pathway in hyperactive microglia in the dorsal horn following peripheral nerve injury. |
2004-02-10 |
2023-08-12 |
Not clear |
| Kazuhide Inoue, Schuichi Koizumi, Makoto Tsuda, Yukari Shigemoto-Mogam. Signaling of ATP receptors in glia-neuron interaction and pain. Life sciences. vol 74. issue 2-3. 2004-01-05. PMID:14607246. |
in the rats displaying a marked allodynia, the level of phospho-p38 was increased in the microglia of injury side in the dorsal horn. |
2004-01-05 |
2023-08-12 |
rat |
| Kazuhide Inoue, Schuichi Koizumi, Makoto Tsuda, Yukari Shigemoto-Mogam. Signaling of ATP receptors in glia-neuron interaction and pain. Life sciences. vol 74. issue 2-3. 2004-01-05. PMID:14607246. |
these results demonstrate that neuropathic pain hypersensitivity depends upon the activation of p38 signaling pathway in microglia in the dorsal horn following peripheral nerve injury. |
2004-01-05 |
2023-08-12 |
rat |
| H Nomura, A Furuta, S O Suzuki, T Iwak. Dorsal horn lesion resulting from spinal root avulsion leads to the accumulation of stress-responsive proteins. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11222996. |
phosphorylation of p38 was detected in microglia in the dorsal horn following both avulsion and axotomy. |
2001-06-21 |
2023-08-12 |
Not clear |
| Y P Wu, E A Lin. Transsynaptic changes of neurons and associated microglial reaction in the spinal cord of rats following middle cerebral artery occlusion. Neuroscience letters. vol 256. issue 1. 1999-02-10. PMID:9832212. |
three and five days after mca occlusion, some neurons in the dorsal horn of lumbar spinal cord underwent degeneration and they appeared to be engulfed by reactive microglia; on the other hand, the ventral horn neurons remained ultrastructurally intact. |
1999-02-10 |
2023-08-12 |
rat |
| N P Eriksson, J K Persson, H Aldskogius, M Svensso. A quantitative analysis of the glial cell reaction in primary sensory termination areas following sciatic nerve injury and treatment with nerve growth factor in the adult rat. Experimental brain research. vol 114. issue 3. 1997-08-06. PMID:9187276. |
our results show that the astroglial cell response in the nucleus gracilis and the spinal cord dorsal horn is rapid in comparison with previously described central degenerative changes following peripheral nerve lesions (transganglionic degeneration), that the astroglial cell reaction develops concomitantly with the microglial cell reaction previously described and that the "signal" from the axotomized neurons which induces these reactions can not be prevented by exogenous ngf applied to the peripheral nerve. |
1997-08-06 |
2023-08-12 |
rat |
| W A Eckert, J G Valtschanoff, C A Otey, A Rustioni, R J Weinber. Tyrosine phosphorylation in rat spinal cord after sciatic nerve transection. Neuroreport. vol 5. issue 10. 1994-11-10. PMID:7522614. |
immunostaining was ain astroglial cells and their processes in the dorsal horn; stained microglia were also seen. |
1994-11-10 |
2023-08-12 |
rat |