| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefania Echeverry, Xiang Qun Shi, Ji Zhan. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain. vol 135. issue 1-2. 2008-03-25. PMID:17560721. |
there was a close temporal correlation between microglial proliferation in the spinal cord dorsal horn and the abnormal pain responses, suggesting a contribution of the new microglia to the genesis of the neuropathic pain symptoms. |
2008-03-25 |
2023-08-12 |
rat |
| Ting Lin, Kai Li, Fei-Yu Zhang, Zhen-Kang Zhang, Alan R Light, Kai-Yuan F. Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models. Journal of neuroimmunology. vol 192. issue 1-2. 2008-03-14. PMID:17919739. |
both qualitative and quantitative analyses showed signs of microglia activation on the ipsilateral side of the lumbar dorsal horn on day 3, day 7 and day 14 after formalin injection. |
2008-03-14 |
2023-08-12 |
Not clear |
| A Florence Keller, Simon Beggs, Michael W Salter, Yves De Koninc. Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Molecular pain. vol 3. 2008-01-02. PMID:17900333. |
disinhibition of neurons in the superficial spinal dorsal horn, via microglia - neuron signaling leading to disruption of chloride homeostasis, is a potential cellular substrate for neuropathic pain. |
2008-01-02 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Kazuhide Inou. [Neuropathic pain and ATP receptors in spinal microglia]. Brain and nerve = Shinkei kenkyu no shinpo. vol 59. issue 9. 2007-10-19. PMID:17886477. |
within the spinal dorsal horn, peripheral nerve injury leads to a progressive series of changes in microglia including morphological hypertrophy of the cell body and proliferation that are considered indicative of activation. |
2007-10-19 |
2023-08-12 |
Not clear |
| Peng Zhao, Stephen G Waxman, Bryan C Hain. Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699671. |
we have previously shown that activated microglia, through an erk (extracellular signal-regulated kinase)-regulated pge(2) (prostaglandin e(2)) signaling mechanism, maintain neuronal hyperexcitability in the lumbar dorsal horn. |
2007-09-14 |
2023-08-12 |
Not clear |
| Simon Beggs, Michael W Salte. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain, behavior, and immunity. vol 21. issue 5. 2007-08-31. PMID:17267172. |
design-based stereological techniques were combined with iba-1 immunohistochemistry to estimate the total number of microglia in the spinal dorsal horn in naïve and peripheral nerve-injured adult rats. |
2007-08-31 |
2023-08-12 |
rat |
| Simon Beggs, Michael W Salte. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain, behavior, and immunity. vol 21. issue 5. 2007-08-31. PMID:17267172. |
following sni there was a marked increase in the number of spinal microglia: the total number of microglia (mean+/-sd) in the dorsal horn sciatic territory of the naïve rat was estimated to be 28,591+/-2715. |
2007-08-31 |
2023-08-12 |
rat |
| Anna K Clark, Ping K Yip, John Grist, Clive Gentry, Amelia A Staniland, Fabien Marchand, Maliheh Dehvari, Glen Wotherspoon, Janet Winter, Jakir Ullah, Stuart Bevan, Marzia Malcangi. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 25. 2007-08-15. PMID:17551020. |
after injury, cats was exclusively expressed by activated microglia in the ipsilateral dorsal horn, where expression peaked at day 7, remaining high on day 14. |
2007-08-15 |
2023-08-12 |
mouse |
| Andrew Moss, Simon Beggs, David Vega-Avelaira, Michael Costigan, Gareth J Hathway, Michael W Salter, Maria Fitzgeral. Spinal microglia and neuropathic pain in young rats. Pain. vol 128. issue 3. 2007-04-03. PMID:17110040. |
dorsal horn iba-1+ve microglia could be activated, however, by intraspinal injections of lipopolysaccharide (lps) or n-methyl-d-aspartate (nmda) at p10, although the increase in the levels of mrna for all microglial markers was less than in the adult rat. |
2007-04-03 |
2023-08-12 |
rat |
| Peng Zhao, Stephen G Waxman, Bryan C Hain. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329433. |
four weeks after injury when lumbar dorsal horn multireceptive neurons became hyperresponsive and when behavioral nociceptive thresholds to mechanical and thermal stimuli were decreased, we tested the hypothesis that prostaglandin e2 (pge2) contributes to signaling between microglia and neurons. |
2007-03-19 |
2023-08-12 |
mouse |
| Peng Zhao, Stephen G Waxman, Bryan C Hain. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329433. |
selective targeting of dorsal horn microglia with the mac-1-sap immunotoxin, a chemical conjugate of mouse monoclonal antibody to cd11b and the ribosome-inactivating protein saporin, resulted in reduced microglia staining, reduction in pge2 levels, and reversed pain-related behaviors [corrected]. |
2007-03-19 |
2023-08-12 |
mouse |
| Anna K Clark, Clive Gentry, Elizabeth J Bradbury, Stephen B McMahon, Marzia Malcangi. Role of spinal microglia in rat models of peripheral nerve injury and inflammation. European journal of pain (London, England). vol 11. issue 2. 2007-02-28. PMID:16545974. |
we observed significant ipsilateral dorsal horn microglia activation 2 weeks after injury and bilateral activation 50 days following nerve injury as well as 24 h following intraplantar zymosan but not intraplantar complete freund's adjuvant (cfa). |
2007-02-28 |
2023-08-12 |
rat |
| Weiya Ma, Remi Quirio. The ERK/MAPK pathway, as a target for the treatment of neuropathic pain. Expert opinion on therapeutic targets. vol 9. issue 4. 2007-01-25. PMID:16083338. |
following nerve injury, phosphorylation of extracellular signal-regulated protein kinase (erk), an important member of this family, is sequentially increased in neurons, microglia and astrocytes of the dorsal horn and gracile nucleus, and in injured large drg neurons. |
2007-01-25 |
2023-08-12 |
Not clear |
| Anna K Clark, Fulvio D'Aquisto, Clive Gentry, Fabien Marchand, Stephen B McMahon, Marzia Malcangi. Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16942597. |
extensive microglial cell activation in the dorsal horn, as determined by immunoreactivity for phosphorylated p38 mapk, was found to correlate with the occurrence of il-1beta secretion. |
2006-12-20 |
2023-08-12 |
rat |
| J Rodriguez Parkitna, M Korostynski, D Kaminska-Chowaniec, I Obara, J Mika, B Przewlocka, R Przewlock. Comparison of gene expression profiles in neuropathic and inflammatory pain. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 57. issue 3. 2006-11-06. PMID:17033093. |
our data point at the importance of immune response- and microglia activation-related genes in the development of chronic neuropathic pain, and suggest that expression of cgrp gene in the dorsal horn of the spinal cord could be involved in persistence of its symptoms. |
2006-11-06 |
2023-08-12 |
rat |
| Hirokazu Katsura, Koichi Obata, Toshiyuki Mizushima, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Masafumi Sakagami, Koichi Noguch. Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928856. |
nerve injury induced a striking increase in sfk phosphorylation in the ipsilateral dorsal horn, and sfks were activated in hyperactive microglia but not in neurons or astrocytes. |
2006-09-28 |
2023-08-12 |
Not clear |
| Ming Qin, Jing-Jie Wang, Rong Cao, Hui Zhang, Li Duan, Bei Gao, Ying-Fei Xiong, Liang-Wei Chen, Zhi-Ren Ra. The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat. Neuroscience research. vol 55. issue 4. 2006-09-08. PMID:16759728. |
it was demonstrated that fos/neun immunoreactive (-ir) neurons, glial fibrillary acidic protein (gfap)-ir astrocytes and ox42-ir microglia were distributed in dorsal horn of lumbar spinal cord, predominantly in the superficial layer. |
2006-09-08 |
2023-08-12 |
rat |
| Minoru Narita, Takuya Yoshida, Mayumi Nakajima, Michiko Narita, Mayumi Miyatake, Tomoe Takagi, Yoshinori Yajima, Tsutomu Suzuk. Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16606373. |
furthermore, 5-bromo-2'-deoxyuridine (brdu)-positive cells on the ipsilateral dorsal horn of the spinal cord were significantly increased at 7 days after nerve ligation and were highly co-localized with another microglia marker, ionized calcium-binding adaptor molecule 1 (iba1), but neither with gfap nor a specific neural nuclei marker, neun, in the spinal dorsal horn of nerve-ligated mice. |
2006-07-21 |
2023-08-12 |
mouse |
| Makoto Tsuda, Kazuhide Inou. [Role of molecules expressed in spiral microglia in neuropathic pain]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 26. issue 1. 2006-06-15. PMID:16637597. |
we expect that understanding the key roles of these molecules in spinal microglia may lead to new strategies for the management of neuropathic pain, strategies not previously anticipated by a neuron-centric view of pain plasticity in the dorsal horn. |
2006-06-15 |
2023-08-12 |
Not clear |
| Jill A Lindia, Erin McGowan, Nina Jochnowitz, Catherine Abbadi. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. The journal of pain. vol 6. issue 7. 2005-09-08. PMID:15993821. |
however, after spinal nerve injury, cx3cr1-li was upregulated in microglia throughout the dorsal horn. |
2005-09-08 |
2023-08-12 |
rat |