| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Tao Liu, Yuan Han, Yue-Peng Liu, Angela A Song, Beth Barnes, Xue-Jun Son. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 22. 2010-06-21. PMID:20519536. |
the increased mmp-9 activity is mainly distributed in the superficial dorsal horn and colocalized primarily with neurons and small numbers of astrocytes and microglia. |
2010-06-21 |
2023-08-12 |
mouse |
| Margarita Calvo, Ning Zhu, Christoforos Tsantoulas, Zhenzhong Ma, John Grist, Jeffrey A Loeb, David L H Bennet. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392965. |
primary afferents express nrg1, and after spinal nerve ligation (snl) we observed both an increase in nrg1 within the dorsal horn as well as activation of erbb2 specifically within microglia. |
2010-05-14 |
2023-08-12 |
Not clear |
| Yu-Wen Chang, Andrew Tan, Carl Saab, Stephen Waxma. Unilateral focal burn injury is followed by long-lasting bilateral allodynia and neuronal hyperexcitability in spinal cord dorsal horn. The journal of pain. vol 11. issue 2. 2010-04-29. PMID:19744891. |
in our burn injury model, rapid and prolonged activation of phospho-p38-expressing microglia occurs bilaterally in the spinal cord dorsal horn. |
2010-04-29 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Ernst Brodi. Spinal astrocytes in pain processing: non-neuronal cells as therapeutic targets. Molecular interventions. vol 10. issue 1. 2010-04-07. PMID:20124561. |
recent research, however, indicates that activation of microglia and astrocytes in the dorsal horn of the spinal cord is of central importance for the development of chronic pain states. |
2010-04-07 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Ernst Brodi. Spinal astrocytes in pain processing: non-neuronal cells as therapeutic targets. Molecular interventions. vol 10. issue 1. 2010-04-07. PMID:20124561. |
understanding the intercellular communication among astrocytes, microglia, and neurons in the dorsal horn during acute and chronic pain may be instrumental for the development of new analgesic drugs. |
2010-04-07 |
2023-08-12 |
Not clear |
| J J Cragg, A L Scott, M S Rame. Depletion of spinal 5-HT accelerates mechanosensory recovery in the deafferented rat spinal cord. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079735. |
intriguingly, we found that the density of activated microglia, the amount of bdnf protein, and density of npy-positive processes were all significantly reduced in 5,7-dht-treated rats, suggesting that serotonergic input to the deafferented dorsal horn is required for all of these consequences of spinal deafferentation. |
2010-03-26 |
2023-08-12 |
rat |
| Joanna Mika, Maria Osikowicz, Ewelina Rojewska, Michal Korostynski, Agnieszka Wawrzczak-Bargiela, Ryszard Przewlocki, Barbara Przewlock. Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain. European journal of pharmacology. vol 623. issue 1-3. 2010-02-22. PMID:19766105. |
to better understand the potential role of two types of glial cells, microglia and astrocytes, in the pathogenesis of neuropathic pain, we examined markers associated with them by quantitative rt-pcr, western blot and immunohistochemical analyses in the dorsal horn of the lumbar spinal cord 7days after chronic constriction injury (cci) to the sciatic nerve in mice. |
2010-02-22 |
2023-08-12 |
mouse |
| L Luongo, E Palazzo, S Tambaro, C Giordano, L Gatta, M A Scafuro, F Sca Rossi, P Lazzari, L Pani, V de Novellis, M Malcangio, S Maion. 1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. Neurobiology of disease. vol 37. issue 1. 2010-02-22. PMID:19804829. |
in the dorsal horn (l4-l6) of neuropathic mice microglia activation (quantification of the length of microglial processes) and astrocytosis were associated with cb2 receptor over-expression on both cell types. |
2010-02-22 |
2023-08-12 |
mouse |
| Sarah M Rothman, Benjamin B Guarino, Beth A Winkelstei. Spinal microglial proliferation is evident in a rat model of painful disc herniation both in the presence of behavioral hypersensitivity and following minocycline treatment sufficient to attenuate allodynia. Journal of neuroscience research. vol 87. issue 12. 2010-01-12. PMID:19382225. |
approximately 70% of brdu-positive cells labeled positively for iba1; dividing microglia were significantly increased (p < 0.004) in the ipsilateral dorsal horn at day 1 following injury compared with sham. |
2010-01-12 |
2023-08-12 |
rat |
| Marucia Chacur, Daniela Lambertz, Ulrich Hoheisel, Siegfried Mens. Role of spinal microglia in myositis-induced central sensitisation: an immunohistochemical and behavioural study in rats. European journal of pain (London, England). vol 13. issue 9. 2009-12-15. PMID:19095475. |
in a rat model of chronic muscle inflammation (injection of complete freund s adjuvant into the gastrocnemius-soleus muscle) alterations of microglia were visualized with quantitative ox-42 immunohistochemistry in the dorsal horn of the segments l4 and l5 12 days after induction of inflammation. |
2009-12-15 |
2023-08-12 |
rat |
| Young S Gwak, Geda C Unabia, Claire E Hulsebosc. Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. Experimental neurology. vol 220. issue 1. 2009-11-13. PMID:19699199. |
after t13 spinal hemisection, significantly increased phosphorylated (activated form) p-38alpha mapk expression was present in both superficial and deep dorsal horn neurons as well as in microglia, but not in astrocytes, in the lumbar spinal cord compared to sham controls (p<0.05). |
2009-11-13 |
2023-08-12 |
rat |
| Young S Gwak, Geda C Unabia, Claire E Hulsebosc. Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. Experimental neurology. vol 220. issue 1. 2009-11-13. PMID:19699199. |
intrathecal application of ppf significantly attenuated the expression of phosphorylated p-38alpha mapk in superficial dorsal horn neurons (10 mm) and in microglia (1 and 10 mm) in the lumbar spinal cord compared to the hemisection group (p<0.05). |
2009-11-13 |
2023-08-12 |
rat |
| Rachel Wodarski, Anna K Clark, John Grist, Fabien Marchand, Marzia Malcangi. Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats. European journal of pain (London, England). vol 13. issue 8. 2009-10-23. PMID:18977160. |
quantification of cell markers iba-1 for microglia and gfap for astrocytes revealed extensive activation of microglia in the dorsal horn of diabetic rats, whereas a reduction in the number of astrocytes could be observed. |
2009-10-23 |
2023-08-12 |
rat |
| Junya Masuda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia. Molecular pain. vol 5. 2009-10-22. PMID:19426564. |
emerging lines of evidence indicate that spinal microglia play a crucial role in neuronal excitability and the pathogenesis of neuropathic pain, but the mechanisms underlying neuron-microglia communications in the dorsal horn remain to be fully elucidated. |
2009-10-22 |
2023-08-12 |
rat |
| Junya Masuda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia. Molecular pain. vol 5. 2009-10-22. PMID:19426564. |
moreover, in rats with an injury to the fifth lumbar spinal nerve (an animal model of neuropathic pain), the immunofluorescence for p-pdgfr beta was markedly enhanced exclusively in microglia in the ipsilateral dorsal horn. |
2009-10-22 |
2023-08-12 |
rat |
| Jessica K Alexander, A Courtney DeVries, Kristina A Kigerl, Jason M Dahlman, Phillip G Popovic. Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation. Brain, behavior, and immunity. vol 23. issue 6. 2009-09-23. PMID:19361551. |
activation of dorsal horn microglia was accelerated by stress; however, this effect was transient and was not associated with the onset or maintenance of a pro-inflammatory phenotype. |
2009-09-23 |
2023-08-12 |
mouse |
| Y S Gwak, C E Hulsebosc. Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19332108. |
in immunohistochemical studies, astrocytes and microglia in rats with spinal hemisection showed significantly increased gfap and ox-42 expression in both superficial and deep dorsal horns in the lumbar spinal dorsal horn compared to sham controls (* p<0.05) that was prevented in a dose-related manner by ppf. |
2009-08-24 |
2023-08-12 |
rat |
| Ronald Deumens, Robby J P Jaken, Liesbeth Knaepen, Inge van der Meulen, Elbert A J Jooste. Inverse relation between intensity of GFAP expression in the substantia gelatinosa and degree of chronic mechanical allodynia. Neuroscience letters. vol 452. issue 2. 2009-06-29. PMID:19383423. |
here, the persistent responses of astroglia and microglia to peripheral nerve injury within central pain networks in the upper dorsal horn laminae were studied. |
2009-06-29 |
2023-08-12 |
Not clear |
| Anna K Clark, Ping K Yip, Marzia Malcangi. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474321. |
indeed, the acute activation of dorsal horn microglia by lipopolysaccharide results in increased cats activity in the superfusates, followed by increased sfkn contents. |
2009-06-23 |
2023-08-12 |
rat |
| Anna K Clark, Ping K Yip, Marzia Malcangi. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474321. |
finally, because we found that both fkn immunoreactivity and mrna are confined to dorsal horn neurons, we suggest that under neuropathic conditions, noxious stimulation of primary afferent fibers induces release of cats from microglia, which liberates fkn from dorsal horn neurons, thereby contributing to the amplification and maintenance of chronic pain. |
2009-06-23 |
2023-08-12 |
rat |