| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Gestblom, D A Sweetser, B Doggett, R P Kapu. Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595945. |
constitutive loss of ret, its co-receptor gfralpha-1, or the ligand glial cell line-derived neurotrophic factor results in renal agenesis. |
1999-12-28 |
2023-08-12 |
mouse |
| O Geneste, C Bidaud, G De Vita, R M Hofstra, S Tartare-Deckert, C H Buys, G M Lenoir, M Santoro, M Billau. Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site. Human molecular genetics. vol 8. issue 11. 1999-12-16. PMID:10484767. |
the ret gene codes for a transmembrane tyrosine kinase which is a subunit of a multimeric complex that acts as a receptor for four structurally related molecules: the glial cell line-derived neurotrophic factor (gdnf), neurturin, artemin and persephin. |
1999-12-16 |
2023-08-12 |
Not clear |
| C A Schiltz, J Benjamin, M L Epstei. Expression of the GDNF receptors ret and GFRalpha1 in the developing avian enteric nervous system. The Journal of comparative neurology. vol 414. issue 2. 1999-11-26. PMID:10516591. |
the formation of the enteric nervous system (ens) from neural crest-derived cell precursors requires the growth factor glial cell line-derived neurotrophic factor (gdnf) and the receptors ret and gdnf family receptor alpha 1 (gfralpha1). |
1999-11-26 |
2023-08-12 |
chicken |
| J M Li, D E Brackmann, W E Hitselberger, F H Linthicum, D J Li. Coexpression of neurotrophic growth factors and their receptors in human facial motor neurons. The Annals of otology, rhinology, and laryngology. vol 108. issue 9. 1999-11-16. PMID:10527284. |
in the normal subjects, positive immunoreactivity of the growth factor neurotrophin-4 and acidic fibroblast growth factor (afgf) was observed in facial motor neurons, as was positive immunoreactivity against ret, the receptor shared by glial cell line-derived neurotrophic factor and neurturin. |
1999-11-16 |
2023-08-12 |
human |
| K Kami, Y Morikawa, Y Kawai, E Senb. Leukemia inhibitory factor, glial cell line-derived neurotrophic factor, and their receptor expressions following muscle crush injury. Muscle & nerve. vol 22. issue 11. 1999-11-12. PMID:10514237. |
using in situ hybridization histochemistry, we characterized the spatiotemporal gene expression patterns of leukemia inhibitory factor (lif) and glial cell line-derived neurotrophic factor (gdnf), and their receptor components (lifr, gfr-alpha1, ret) induced in muscle cells, intramuscular nerves, and motoneurons in the regeneration processes of both muscle cells and nerves following muscle contusion. |
1999-11-12 |
2023-08-12 |
Not clear |
| M D Gersho. Lessons from genetically engineered animal models. II. Disorders of enteric neuronal development: insights from transgenic mice. The American journal of physiology. vol 277. issue 2. 1999-09-23. PMID:10444438. |
the second, associated with mutations in genes encoding glial cell line-derived neurotrophic factor (gdnf), its preferred receptor gfralpha1, or their signaling component, ret, appears to deprive a gdnf-dependent common progenitor of adequate support and/or mitogenic drive. |
1999-09-23 |
2023-08-12 |
mouse |
| H Murakami, T Iwashita, N Asai, Y Shimono, Y Iwata, K Kawai, M Takahash. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation. Biochemical and biophysical research communications. vol 262. issue 1. 1999-09-23. PMID:10448070. |
we compared the intracellular signalling pathways through ret tyrosine kinase activated by glial cell line-derived neurotrophic factor (gdnf), multiple endocrine neoplasia (men) 2a, or men 2b mutation. |
1999-09-23 |
2023-08-12 |
Not clear |
| J Widenfalk, H R Widmer, C Spenge. GDNF, RET and GFRalpha-1-3 mRNA expression in the developing human spinal cord and ganglia. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380959. |
using in situ hybridization, the expression of glial cell line-derived neurotrophic factor (gdnf), neurturin (ntn), persephin (psp), gfralpha-1, gfralpha-2, gfralpha-3 and ret mrna in human fetal spinal cord was studied. |
1999-09-16 |
2023-08-12 |
human |
| H Kitagawa, C Sasaki, W R Zhang, K Sakai, Y Shiro, H Warita, Y Mitsumoto, T Mori, K Ab. Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. Brain research. vol 834. issue 1-2. 1999-09-10. PMID:10407114. |
in an attempt to elucidate whether glial cell line-derived neurotrophic factor (gdnf) receptors are induced after ischemic brain injury, possible expression of immunoreactive gdnf receptor-alpha1 (gfralpha-1) and c-ret (ret) was examined at 3, 8, or 24 h after permanent middle cerebral artery occlusion (mcao) in rats. |
1999-09-10 |
2023-08-12 |
rat |
| K Yoshimoto, C Tanaka, M Moritani, E Shimizu, T Yamaoka, S Yamada, T Sano, M Itakur. Infrequent detectable somatic mutations of the RET and glial cell line-derived neurotrophic factor (GDNF) genes in human pituitary adenomas. Endocrine journal. vol 46. issue 1. 1999-09-02. PMID:10426588. |
infrequent detectable somatic mutations of the ret and glial cell line-derived neurotrophic factor (gdnf) genes in human pituitary adenomas. |
1999-09-02 |
2023-08-12 |
human |
| K Yoshimoto, C Tanaka, M Moritani, E Shimizu, T Yamaoka, S Yamada, T Sano, M Itakur. Infrequent detectable somatic mutations of the RET and glial cell line-derived neurotrophic factor (GDNF) genes in human pituitary adenomas. Endocrine journal. vol 46. issue 1. 1999-09-02. PMID:10426588. |
ret is activated by a ligand complex comprising glial cell line-derived neurotrophic factor (gdnf) and gdnf receptor-alpha (gdnfr-alpha). |
1999-09-02 |
2023-08-12 |
human |
| K Yoshimoto, C Tanaka, M Moritani, E Shimizu, T Yamaoka, S Yamada, T Sano, M Itakur. Infrequent detectable somatic mutations of the RET and glial cell line-derived neurotrophic factor (GDNF) genes in human pituitary adenomas. Endocrine journal. vol 46. issue 1. 1999-09-02. PMID:10426588. |
mutations of the ret proto-oncogene and the glial cell line-derived neurotrophic factor (gdnf) gene were examined in human pituitary tumors. |
1999-09-02 |
2023-08-12 |
human |
| M Trupp, R Scott, S R Whittemore, C F Ibáñe. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. The Journal of biological chemistry. vol 274. issue 30. 1999-08-26. PMID:10409632. |
glial cell line-derived neurotrophic factor (gdnf) has been shown to signal through a multicomponent receptor complex consisting of the ret receptor tyrosine kinase and a member of the gfralpha family of glycosylphosphatidylinositol-anchored receptors. |
1999-08-26 |
2023-08-12 |
Not clear |
| S Taraviras, C V Marcos-Gutierrez, P Durbec, H Jani, M Grigoriou, M Sukumaran, L C Wang, M Hynes, G Raisman, V Pachni. Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development (Cambridge, England). vol 126. issue 12. 1999-07-22. PMID:10331988. |
ret is a member of the receptor tyrosine kinase (rtk) superfamily, which can transduce signalling by glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn) in cultured cells. |
1999-07-22 |
2023-08-12 |
mouse |
| S M Myers, R Salomon, A Goessling, A Pelet, C Eng, A von Deimling, S Lyonnet, L M Mulliga. Investigation of germline GFR alpha-1 mutations in Hirschsprung disease. Journal of medical genetics. vol 36. issue 3. 1999-06-11. PMID:10204848. |
inactivating mutations of the ret proto-oncogene and of one of its soluble ligand molecules, glial cell line derived neurotrophic factor (gdnf), have been found in a subset of patients with hirschsprung disease (hscr). |
1999-06-11 |
2023-08-12 |
Not clear |
| S Nakayama, K Iida, T Tsuzuki, T Iwashita, H Murakami, N Asai, Y Iwata, M Ichihara, S Ito, K Kawai, M Asai, K Kurokawa, M Takahash. Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells. British journal of haematology. vol 105. issue 1. 1999-06-10. PMID:10233362. |
glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn) mediate their actions through a unique multicomponent receptor system composed of ret receptor tyrosine kinase and glycosyl-phosphatidylinositol-linked cell surface proteins (designated gfralpha-1 and gfralpha-2). |
1999-06-10 |
2023-08-12 |
mouse |
| V Gattei, M Degan, F M Rossi, A De Iuliis, F T Mazzocco, E Cesa, D Aldinucci, V Zagonel, A Pint. The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation. British journal of haematology. vol 105. issue 1. 1999-06-10. PMID:10233387. |
the ret gene product represents the signal-transducing molecule of a surface receptor complex for the glial cell line-derived neurotrophic factor (gdnf), which includes gdnfr-alpha as a ligand-binding component. |
1999-06-10 |
2023-08-12 |
Not clear |
| H Murakami, T Iwashita, N Asai, Y Iwata, S Narumiya, M Takahash. Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase. Oncogene. vol 18. issue 11. 1999-05-27. PMID:10208419. |
glial cell line-derived neurotrophic factor (gdnf) signals through a unique receptor system that includes ret receptor tyrosine kinase and a glycosyl-phosphatidylinositol-linked cell surface protein. |
1999-05-27 |
2023-08-12 |
Not clear |
| N Belluardo, G Mudò, G Caniglia, M Corsaro, Q Cheng, F Frasca, A Belfiore, D F Condorell. Expression of neurotrophins, GDNF, and their receptors in rat thyroid tissue. Cell and tissue research. vol 295. issue 3. 1999-04-13. PMID:10022966. |
levels of mrna for neurotrophins (brain-derived neurotrophic factor, bdnf; neurotrophin 3, nt-3; neurotrophin 4, nt-4) and their receptors (trka, trkb, trkc) and for glial cell line-derived neurotrophic factor (gdnf) and its receptors (ret, gdnfr-alpha) were measured in rat thyroid tissue by ribonuclease protection assays. |
1999-04-13 |
2023-08-12 |
rat |
| J Rossi, K Luukko, D Poteryaev, A Laurikainen, Y F Sun, T Laakso, S Eerikäinen, R Tuominen, M Lakso, H Rauvala, U Arumäe, M Pasternack, M Saarma, M S Airaksine. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor. Neuron. vol 22. issue 2. 1999-03-30. PMID:10069331. |
glial cell line-derived neurotrophic factor (gdnf) and a related protein, neurturin (ntn), require a gpi-linked coreceptor, either gfr alpha1 or gfr alpha2, for signaling via the transmembrane ret tyrosine kinase. |
1999-03-30 |
2023-08-12 |
mouse |