| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Chiariello, R Visconti, F Carlomagno, R M Melillo, C Bucci, V de Franciscis, G M Fox, S Jing, O A Coso, J S Gutkind, A Fusco, M Santor. Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene. vol 16. issue 19. 1998-07-01. PMID:9627110. |
the ret proto-oncogene encodes a functional receptor tyrosine kinase (ret) for the glial cell line derived neurotrophic factor (gdnf). |
1998-07-01 |
2023-08-12 |
human |
| R M Duberley, I P Johnson, J E Martin, P Anan. RET-like immunostaining of spinal motoneurons in amyotrophic lateral sclerosis. Brain research. vol 789. issue 2. 1998-06-19. PMID:9573403. |
the receptor tyrosine kinase ret is part of a functional receptor for glial cell derived neurotrophic factor (gdnf) and neurturin (ntn) which are potent neurotrophic factors for motoneurons. |
1998-06-19 |
2023-08-12 |
Not clear |
| K Wartiovaara, M Salo, H Sariol. Hirschsprung's disease genes and the development of the enteric nervous system. Annals of medicine. vol 30. issue 1. 1998-06-11. PMID:9556091. |
in addition, mutations have been found in the gene encoding the glial cell line-derived neurotrophic factor, the ligand for ret, but these may only have a modifier effect. |
1998-06-11 |
2023-08-12 |
mouse |
| C Bidaud, R Salomon, P Edery, G Van Camp, A Pelet, M Bonduelle, C Nihoul-Fékété, P J Willems, A Munnich, S Lyonne. [Mutations of the endothelin-3 gene in isolated and syndromic forms of Hirschsprung disease]. Gastroenterologie clinique et biologique. vol 21. issue 8-9. 1998-06-10. PMID:9587491. |
three susceptibility genes have been identified in hirschsprung's disease, namely the ret proto-oncogene, the glial cell line-derived neurotrophic factor and the endothelin b receptor. |
1998-06-10 |
2023-08-12 |
Not clear |
| M Angrist, S Jing, S Bolk, K Bentley, S Nallasamy, M Halushka, G M Fox, A Chakravart. Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. Genomics. vol 48. issue 3. 1998-06-08. PMID:9545641. |
knockout mice for ret and for its ligand, glial cell line-derived neurotrophic factor (gdnf), exhibit both complete intestinal aganglionosis and renal defects. |
1998-06-08 |
2023-08-12 |
mouse |
| L M Mulligan, T Timmer, S M Ivanchuk, B G Campling, L C Young, P H Rabbitts, V Sundaresan, R M Hofstra, C En. Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma. Genes, chromosomes & cancer. vol 21. issue 4. 1998-05-20. PMID:9559344. |
ret activation may be mediated by a ligand complex comprising glial cell line-derived neurotrophic factor (gdnf) and gdnf family receptor alpha-1 (gfr alpha-1). |
1998-05-20 |
2023-08-12 |
Not clear |
| T Azuma, A Okad. [Management of anorectal malformations and Hirschsprung's disease]. Nihon Geka Gakkai zasshi. vol 98. issue 12. 1998-05-15. PMID:9526745. |
recently, gene mutations associated with hirschsprung's disease have been widely investigated and gene mutations of ret, glial cell line-derived neutrophic factor (gdnf), endothelin receptor b (ednrb) and endothelin-3 (edn3) have been identified in patients with hirschsprung's disease. |
1998-05-15 |
2023-08-12 |
Not clear |
| G Martucciello, H Thompson, C Mazzola, A Morando, M Bertagnon, F Negri, A Brizzolara, L Rocchetti, C Gambini, V Jasonn. GDNF deficit in Hirschsprung's disease. Journal of pediatric surgery. vol 33. issue 1. 1998-03-20. PMID:9473110. |
in 1996, the glial cell line-derived neurotrophic factor (gdnf) was identified as one of the ligands of the ret transmembrane receptor. |
1998-03-20 |
2023-08-12 |
Not clear |
| A Puliti, R Cinti, M Seri, I Ceccherini, G Rome. Assignment of mouse Gfra1, the homologue of a new human HSCR candidate gene, to the telomeric region of mouse chromosome 19. Cytogenetics and cell genetics. vol 78. issue 3-4. 1998-03-04. PMID:9465906. |
glial cell line-derived neurotrophic factor (gdnf) and its alpha receptor (gfra1) interact with the ret receptor triggering its tyrosine kinase activity. |
1998-03-04 |
2023-08-12 |
mouse |
| S Jing, Y Yu, M Fang, Z Hu, P L Holst, T Boone, J Delaney, H Schultz, R Zhou, G M Fo. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. The Journal of biological chemistry. vol 272. issue 52. 1998-01-23. PMID:9407096. |
the receptor for glial cell line-derived neurotrophic factor (gdnf) consists of gfralpha-1 and ret. |
1998-01-23 |
2023-08-12 |
Not clear |
| C Bidaud, R Salomon, G Van Camp, A Pelet, T Attié, C Eng, M Bonduelle, J Amiel, C Nihoul-Fékété, P J Willems, A Munnich, S Lyonne. Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease. European journal of human genetics : EJHG. vol 5. issue 4. 1998-01-21. PMID:9359047. |
four susceptibility genes have recently been identified in hscr, namely the ret proto-oncogene, the glial cell line-derived neurotrophic factor (gdnf), the endothelin b receptor (ednrb) and the endothelin-3 genes (edn3). |
1998-01-21 |
2023-08-12 |
Not clear |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. |
1997-10-23 |
2023-08-12 |
mouse |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
not only were there remarkable similarities in the distribution of glial cell line-derived neurotrophic factor and the proto-oncogene ret in the developing rat and mouse brain, but also in the phenotype of glial cell line-derived neurotrophic factor knockout mice and mice with ret mutations. |
1997-10-23 |
2023-08-12 |
mouse |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
mice with either mutation exhibited pronounced renal and enteric abnormalities, implicating the receptor tyrosine kinase protein product of the ret proto-oncogene as the glial cell line-derived neurotrophic factor signalling protein. |
1997-10-23 |
2023-08-12 |
mouse |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
more conclusive evidence showing that activation of gdnfr-alpha by glial cell line-derived neurotrophic factor induces phosphorylation of ret has confirmed ret as a signalling protein for glial cell line-derived neurotrophic factor. |
1997-10-23 |
2023-08-12 |
mouse |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
preliminary results showing that 6-hydroxydopamine lesions of the substantia nigra markedly reduced ret messenger rna expression, established its localization to presumably glial cell line-derived neurotrophic factor-responsive dopamine neurons in the nigrostriatal pathway. |
1997-10-23 |
2023-08-12 |
mouse |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
in contrast, it is not clear whether other glial cell line-derived neurotrophic factor-responsive neurons in the cns, such as the basal forebrain cholinergic neurons and striatal neurons, also express ret, nor is it evident whether levels of the protein are regulated by disruption of the respective pathways. |
1997-10-23 |
2023-08-12 |
mouse |
| C A Nosrat, A Tomac, B J Hoffer, L Olso. Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Experimental brain research. vol 115. issue 3. 1997-10-02. PMID:9262196. |
cellular and developmental patterns of expression of ret and glial cell line-derived neurotrophic factor receptor alpha mrnas. |
1997-10-02 |
2023-08-12 |
Not clear |
| C A Nosrat, A Tomac, B J Hoffer, L Olso. Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Experimental brain research. vol 115. issue 3. 1997-10-02. PMID:9262196. |
glial cell line-derived neurotrophic factor (gdnf) has recently been shown to signal by binding to gdnf receptor-alpha (gdnfr-alpha), after which the gdnf-gdnfr-alpha associates with and activates the tyrosine kinase receptor ret. |
1997-10-02 |
2023-08-12 |
Not clear |
| D J Marsh, Z Zheng, A Arnold, S D Andrew, D Learoyd, A Frilling, P Komminoth, H P Neumann, B A Ponder, B J Rollins, G I Shapiro, B G Robinson, L M Mulligan, C En. Mutation analysis of glial cell line-derived neurotrophic factor, a ligand for an RET/coreceptor complex, in multiple endocrine neoplasia type 2 and sporadic neuroendocrine tumors. The Journal of clinical endocrinology and metabolism. vol 82. issue 9. 1997-10-02. PMID:9284737. |
glial cell line-derived neurotrophic factor (gdnf) and its receptor molecule gdnfr-alpha, have recently been identified as members of the ret ligand binding complex. |
1997-10-02 |
2023-08-12 |
Not clear |