| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Melillo, M V Barone, G Lupoli, A M Cirafici, F Carlomagno, R Visconti, B Matoskova, P P Di Fiore, G Vecchio, A Fusco, M Santor. Ret-mediated mitogenesis requires Src kinase activity. Cancer research. vol 59. issue 5. 1999-03-22. PMID:10070972. |
to test the involvement of c-src in ret-mediated signaling, we measured the levels of c-src activity in nih3t3 cells coexpressing ret and the accessory gfr alpha-1 receptor or an epidermal growth factor receptor/ret chimeric receptor when the cells were stimulated by glial cell line-derived neurotrophic factor or epidermal growth factor, respectively. |
1999-03-22 |
2023-08-12 |
human |
| M Takahashi, N Asai, T Iwashita, H Murakami, S It. Mechanisms of development of multiple endocrine neoplasia type 2 and Hirschsprung's disease by ret mutations. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 154. 1999-03-05. PMID:10027003. |
the ret proto-oncogene encodes a receptor tyrosine kinase whose ligands belong to the glial cell line-derived neurotrophic factor (gdnf) protein family. |
1999-03-05 |
2023-08-12 |
Not clear |
| D H van Weering, J L Bo. Signal transduction by the receptor tyrosine kinase Ret. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 154. 1999-03-05. PMID:10027007. |
ret is the receptor for glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn). |
1999-03-05 |
2023-08-12 |
Not clear |
| A Chalazonitis, T P Rothman, J Chen, M D Gersho. Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1 in vitro and in vivo. Developmental biology. vol 204. issue 2. 1999-02-03. PMID:9882478. |
no enteric neurons or glia develop in the gut below the rostral foregut in mice lacking glial cell line-derived neurotrophic factor (gdnf) or ret. |
1999-02-03 |
2023-08-12 |
mouse |
| R H Baloh, M G Tansey, P A Lampe, T J Fahrner, H Enomoto, K S Simburger, M L Leitner, T Araki, E M Johnson, J Milbrand. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron. vol 21. issue 6. 1999-01-26. PMID:9883723. |
the glial cell line-derived neurotrophic factor (gdnf) ligands (gdnf, neurturin [ntn], and persephin [psp]) signal through a multicomponent receptor system composed of a high-affinity binding component (gfralpha1-gfralpha4) and a common signaling component (ret). |
1999-01-26 |
2023-08-12 |
Not clear |
| M Angrist, S Bolk, K Bentley, S Nallasamy, M K Halushka, A Chakravart. Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. Oncogene. vol 17. issue 23. 1999-01-25. PMID:9881709. |
mice that carry null alleles for ret or for its ligand, glial cell line-derived neurotrophic factor (gdnf), both exhibit complete intestinal aganglionosis and renal defects. |
1999-01-25 |
2023-08-12 |
mouse |
| M Yamamoto, N Mitsuma, Y Ito, N Hattori, M Nagamatsu, M Li, T Mitsuma, G Sobu. Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies. Brain research. vol 809. issue 2. 1999-01-20. PMID:9853108. |
the steady-state mrna levels of glial cell line-derived neurotrophic factor (gdnf), gdnfr-alpha and ret were examined in various human peripheral neuropathies to determine the relationship with myelinated fiber pathology, and t cell and macrophage invasions in the diseased nerves. |
1999-01-20 |
2023-08-12 |
human |
| K Wartiovaara, M Salo, K Sainio, R Rintala, H Sariol. Distribution of glial cell line-derived neurotrophic factor mRNA in human colon suggests roles for muscularis mucosae in innervation. Journal of pediatric surgery. vol 33. issue 10. 1999-01-14. PMID:9802801. |
glial cell line-derived neurotrophic factor (gdnf) is a ligand for the receptor complex of gdnf family receptor alphas (gfralphas) and ret receptor tyrosine kinase, the product of a known hirschsprung's disease gene. |
1999-01-14 |
2023-08-12 |
human |
| M Inoue, K Hosoda, K Imura, S Kamata, M Fukuzawa, K Nakao, A Okad. Mutational analysis of the endothelin-B receptor gene in Japanese Hirschsprung's disease. Journal of pediatric surgery. vol 33. issue 8. 1998-11-25. PMID:9721987. |
recent studies have shown that mutations in endothelin-b receptor (ednrb), endothelin-3, ret, glial cell line-derived neurotrophic factor (gdnf) genes are responsible for the occurrence of congenital aganglionosis. |
1998-11-25 |
2023-08-12 |
Not clear |
| P Puri, K Ohshiro, T Weste. Hirschsprung's disease: a search for etiology. Seminars in pediatric surgery. vol 7. issue 3. 1998-11-03. PMID:9718651. |
recent expansion of molecular genetics identified multiple susceptibility genes of hd, including the ret gene, the glial cell line-derived neurotrophic factor gene, the endothelin-b receptor gene, and endothelin-3 gene. |
1998-11-03 |
2023-08-12 |
mouse |
| S W Moore, A G Johnso. Hirschsprung's disease: genetic and functional associations of Down's and Waardenburg syndromes. Seminars in pediatric surgery. vol 7. issue 3. 1998-11-03. PMID:9718653. |
hd mutations have been mapped to a number of genes, i.e., ret proto-oncogene, at 10q11.2; the recessive ednrb gene, located at 13q22; its ligand endothelin 3 (edn3); and the glial cell line-derived neurotrophic factor (gdnf) in humans. |
1998-11-03 |
2023-08-12 |
human |
| P R Towers, A S Woolf, P Hardma. Glial cell line-derived neurotrophic factor stimulates ureteric bud outgrowth and enhances survival of ureteric bud cells in vitro. Experimental nephrology. vol 6. issue 4. 1998-10-30. PMID:9690097. |
studies using null mutant mice have indicated that the ret receptor and its ligand, glial cell line-derived neurotrophic factor (gdnf), are crucial for initiation of development of the metanephric kidney. |
1998-10-30 |
2023-08-12 |
mouse |
| P J Svensson, M Anvret, M L Molander, A Nordenskjöl. Phenotypic variation in a family with mutations in two Hirschsprung-related genes (RET and endothelin receptor B). Human genetics. vol 103. issue 2. 1998-10-23. PMID:9760196. |
four different genes have been implicated in the pathogenesis of hirschsprung disease: the ret tyrosine kinase receptor gene; one of its ligands, the glial cell line-derived neurotrophic factor (gdnf) gene; the endothelin receptor b (ednrb) gene; and its ligand, endothelin-3 (edn3). |
1998-10-23 |
2023-08-12 |
Not clear |
| B Doray, R Salomon, J Amiel, A Pelet, R Touraine, M Billaud, T Attié, B Bachy, A Munnich, S Lyonne. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Human molecular genetics. vol 7. issue 9. 1998-10-16. PMID:9700200. |
considering that ret and glial cell line-derived neurotrophic factor (gdnf) mutations have been reported in the disease, we regarded the other ret ligand, neurturin (ntn), as an attractive candidate gene, especially as it shares large homologies with gdnf. |
1998-10-16 |
2023-08-12 |
Not clear |
| H Enomoto, T Araki, A Jackman, R O Heuckeroth, W D Snider, E M Johnson, J Milbrand. GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron. vol 21. issue 2. 1998-09-17. PMID:9728913. |
glial cell line-derived neurotrophic factor (gdnf) signals through a receptor complex composed of the ret tyrosine kinase and a glycosylphosphatidylinositol- (gpi-) anchored cell surface coreceptor, either gdnf family receptor alpha1 (gfr alpha1) or gfr alpha2. |
1998-09-17 |
2023-08-12 |
mouse |
| V Pachnis, P Durbec, S Taraviras, M Grigoriou, D Nataraja. III. Role Of the RET signal transduction pathway in development of the mammalian enteric nervous system. The American journal of physiology. vol 275. issue 2. 1998-09-16. PMID:9688643. |
natural and induced mutagenesis in mammals has shown that the tyrosine kinase receptor ret and its functional ligand glial cell line-derived neurotrophic factor (gdnf) play key roles in the development of the ens in humans and mice. |
1998-09-16 |
2023-08-12 |
mouse |
| F Carlomagno, R M Melillo, R Visconti, G Salvatore, G De Vita, G Lupoli, Y Yu, S Jing, G Vecchio, A Fusco, M Santor. Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease. Endocrinology. vol 139. issue 8. 1998-08-13. PMID:9681515. |
glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and hirschsprung's disease. |
1998-08-13 |
2023-08-12 |
human |
| F Carlomagno, R M Melillo, R Visconti, G Salvatore, G De Vita, G Lupoli, Y Yu, S Jing, G Vecchio, A Fusco, M Santor. Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease. Endocrinology. vol 139. issue 8. 1998-08-13. PMID:9681515. |
recently, it has been shown that glial cell line-derived neurotrophic factor (gdnf), by binding to the accessory molecule gdnfr-alpha, acts as a functional ligand of ret and stimulates its tyrosine kinase and biological activity. |
1998-08-13 |
2023-08-12 |
human |
| M Santoro, R M Melillo, F Carlomagno, R Visconti, G De Vita, G Salvatore, G Lupoli, A Fusco, G Vecchi. Molecular biology of the MEN2 gene. Journal of internal medicine. vol 243. issue 6. 1998-08-13. PMID:9681850. |
the ret gene encodes a tyrosine kinase receptor for molecules belonging to the glial cell line-derived neurotrophic factor (gdnf) family. |
1998-08-13 |
2023-08-12 |
human |
| D G Walker, T G Beach, R Xu, J Lile, K D Beck, E G McGeer, P L McGee. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593897. |
the proto-oncogene ret, a membrane-associated receptor protein tyrosine kinase, has recently been shown to be a component of the glial cell line-derived neurotrophic factor (gdnf) receptor complex. |
1998-07-20 |
2023-08-12 |
human |