| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sean Jmaeff, Yulia Sidorova, Hayley Lippiatt, Pablo F Barcelona, Hinyu Nedev, Lucia M Saragovi, Mark A Hancock, Mart Saarma, H Uri Saragov. Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFR Molecular pharmacology. vol 98. issue 1. 2020-07-30. PMID:32362584. |
small-molecule ligands that bind the ret receptor activate neuroprotective signals independent of but modulated by coreceptor gfr glial cell line-derived neurotrophic factor (gdnf) binds the gfr |
2020-07-30 |
2023-08-13 |
Not clear |
| C R Donnelly, A A Shah, E B Suh, B A Pierchal. Ret Signaling Is Required for Tooth Pulp Innervation during Organogenesis. Journal of dental research. vol 98. issue 6. 2020-07-14. PMID:30958726. |
in this study, we analyzed the expression and function of glial cell line-derived neurotrophic factor (gdnf) and its receptor tyrosine kinase, ret, in the regulation of innervation of the mouse tooth pulp by dental pulpal afferent (dpa) neurons of the trigeminal ganglion (tg). |
2020-07-14 |
2023-08-13 |
mouse |
| Zhenghu Chen, Yanling Zhao, Yang Yu, Jonathan C Pang, Sarah E Woodfield, Ling Tao, Shan Guan, Huiyuan Zhang, Shayahati Bieerkehazhi, Yan Shi, Roma Patel, Sanjeev A Vasudevan, Joanna S Yi, Jodi A Muscal, Guo-Tong Xu, Jianhua Yan. Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth Oncotarget. vol 8. issue 61. 2020-03-09. PMID:29262623. |
herein we report that ret is required for nb cell proliferation and that the small molecule inhibitor regorafenib (bay 73-4506) blocks glial cell derived neurotrophic factor (gdnf)-induced ret signaling in nb cells and inhibits nb growth both |
2020-03-09 |
2023-08-13 |
human |
| John P Russell, Ehsan Mohammadi, Casey O Ligon, Anthony C Johnson, Michael D Gershon, Meenakshi Rao, Yuhong Shen, Chi-Chung Chan, Hilary S Eidam, Michael P DeMartino, Mui Cheung, Allen I Oliff, Sanjay Kumar, Beverley Greenwood-Van Meervel. Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity. The Journal of pharmacology and experimental therapeutics. vol 368. issue 2. 2019-11-04. PMID:30413627. |
here, we aimed to investigate the therapeutic potential of inhibiting the receptor of glial cell line-derived neurotrophic factor, rearranged during transfection (ret), in experimental models of inflammation and stress-induced visceral hypersensitivity resembling ibs sequelae. |
2019-11-04 |
2023-08-13 |
Not clear |
| L Lauriina Porokuokka, Heikki T Virtanen, Jere Lindén, Yulia Sidorova, Tatiana Danilova, Maria Lindahl, Mart Saarma, Jaan-Olle Andresso. Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice. Cellular and molecular gastroenterology and hepatology. vol 7. issue 3. 2019-06-04. PMID:30594740. |
ret, the receptor for the glial cell line-derived neurotrophic factor (gdnf) family ligands, is the most frequently mutated gene in congenital aganglionic megacolon or hirschsprung's disease (hscr). |
2019-06-04 |
2023-08-13 |
mouse |
| Muhammad Usman Janjua, Xiao-Dan Long, Zhao-Hui Mo, Chang-Sheng Dong, Ping Ji. Association of medullary sponge kidney and hyperparathyroidism with RET G691S/S904S polymorphism: a case report. Journal of medical case reports. vol 12. issue 1. 2019-04-09. PMID:29983117. |
given the key role of the interaction of glial cell line-derived neurotrophic factor gene, gdnf, and the "rearranged during transfection" proto-oncogene, ret, in kidney and urinary tract development, variations in these genes are proposed to be candidates for medullary sponge kidney. |
2019-04-09 |
2023-08-13 |
Not clear |
| Xi-Bin Hu, Shu-Hua Fu, Q I Luo, Jian-Zhong He, Yan-Fei Qiu, Wei Lai, Min Zhon. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541958. |
this study aims to elucidate the role of mir-216a in yttrium aluminium garnet (yag) laser-induced retinal injury by targeting glial cell line-derived neurotrophic factor (gdnf) via gdnf/gdnf family neurotrophic factor receptor α1 (gfrα1)/rearranged during transfection (ret) signalling pathway. |
2019-01-29 |
2023-08-13 |
rat |
| Kamal Hezam, Jiahao Jiang, Fumou Sun, Xinrong Zhang, Juan Zhan. Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the neurosciences. vol 29. issue 1. 2018-10-30. PMID:28937965. |
artemin (artn) is a member of glial cell line-derived neurotrophic factor (gdnf) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored gdnf family receptors a (gfra1, gfra3) and ret receptor tyrosine kinase. |
2018-10-30 |
2023-08-13 |
Not clear |
| Zhijiang Chen, Christopher R Donnelly, Bertha Dominguez, Yoshinobu Harada, Weichun Lin, Alan S Halim, Tasha G Bengoechea, Brian A Pierchala, Kuo-Fen Le. p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell reports. vol 21. issue 3. 2018-06-13. PMID:29045838. |
here, we show that the p75 neurotrophin receptor interacts with ret and its gfrα co-receptor upon stimulation with glial cell line-derived neurotrophic factor (gdnf). |
2018-06-13 |
2023-08-13 |
mouse |
| Li Li, Haijing Song, Peipei Mu, Ming Xu, Chaoxia Liu, Ying Wang, Yingsong Qin, Shen Sun, Jin Gao, Ting Wang, Dianshuai Ga. The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells. International journal of molecular sciences. vol 18. issue 9. 2018-05-14. PMID:28880247. |
the actin cytoskeleton is involved in glial cell line-derived neurotrophic factor (gdnf)-induced ret translocation into lipid rafts in dopaminergic neuronal cells. |
2018-05-14 |
2023-08-13 |
Not clear |
| Li Li, Haijing Song, Peipei Mu, Ming Xu, Chaoxia Liu, Ying Wang, Yingsong Qin, Shen Sun, Jin Gao, Ting Wang, Dianshuai Ga. The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells. International journal of molecular sciences. vol 18. issue 9. 2018-05-14. PMID:28880247. |
glial cell line-derived neurotrophic factor (gdnf), a potential therapeutic factor for parkinson's disease (pd), exerts its biological effects through the ret receptor tyrosine kinase. |
2018-05-14 |
2023-08-13 |
Not clear |
| Paolo Ria, Antonia Fabris, Alessandra Dalla Gassa, Gianluigi Zaza, Antonio Lupo, Giovanni Gambar. New non-renal congenital disorders associated with medullary sponge kidney (MSK) support the pathogenic role of GDNF and point to the diagnosis of MSK in recurrent stone formers. Urolithiasis. vol 45. issue 4. 2018-04-19. PMID:27573101. |
it has been suggested that the rearranged during transfection (ret) proto-oncogene and the glial cell line-derived neurotrophic factor (gdnf) gene are defective in patients with msk, and both ret and gdnf are known to have a role in the development of the central nervous system, heart, and craniofacial skeleton. |
2018-04-19 |
2023-08-13 |
Not clear |
| Logan Myers, Hiran Perera, Michael G Alvarado, Thomas Kid. The Development (Cambridge, England). vol 145. issue 3. 2018-04-09. PMID:29361562. |
the the ret receptor tyrosine kinase is crucial for the development of the enteric nervous system (ens), acting as a receptor for glial cell line-derived neurotrophic factor (gdnf) via gfr co-receptors. |
2018-04-09 |
2023-08-13 |
Not clear |
| Hongfeng Ruan, Huan Luo, Jirong Wang, Xing Ji, Zhongmiao Zhang, Junsong Wu, Xianning Zhang, Ximei W. Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth. Biochimica et biophysica acta. vol 1860. issue 9. 2017-10-26. PMID:27316313. |
rearranged during transfection (ret) proto-oncogene encodes a receptor tyrosine kinase for glial cell line-derived neurotrophic factor (gdnf) signaling, and high ret expression is closely related to the tumorigenesis and malignancy of neuroblastoma(nb). |
2017-10-26 |
2023-08-13 |
Not clear |
| Hyun-Jung Park, Eric C Bolto. RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development. Development (Cambridge, England). vol 144. issue 12. 2017-09-21. PMID:28506996. |
glial cell line-derived neurotrophic factor (gdnf) binds gdnf family receptor α1 (gfrα1) and signals through activation of ret tyrosine kinase. |
2017-09-21 |
2023-08-13 |
mouse |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
glial cell line-derived neurotrophic factor (gdnf) is a ligand that activates, through co-receptor gdnf family receptor alpha-1 (gfrα1) and receptor tyrosine kinase "ret", several signaling pathways crucial in the development and sustainment of multiple neuronal populations. |
2017-09-18 |
2023-08-13 |
mouse |
| Nicole A Gabreski, Janki K Vaghasia, Silvia S Novakova, Neil Q McDonald, Brian A Pierchal. Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction. The Journal of biological chemistry. vol 291. issue 31. 2017-05-08. PMID:27226544. |
rearranged during transfection (ret), a receptor tyrosine kinase that is activated by the glial cell line-derived neurotrophic factor family ligands (gfls), plays a crucial role in the development and function of the nervous system and additionally is required for kidney development and spermatogenesis. |
2017-05-08 |
2023-08-13 |
mouse |
| Tao Xu, Neng-Gui Xu, Zhong-Hua Yang, Yan-Zhen Wan, Qing-Long Wu, Kang-Bai Huan. Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats are associated with increased expression of GDNF-RET and protein kinase B. Chinese journal of integrative medicine. vol 22. issue 6. 2017-02-22. PMID:26033318. |
to explore the neuroprotective effects of electroacupuncture (ea) on hypoxic-ischemic encephalopathy (hie) and to further investigate the role of glial cell line-derived neurotrophic factor (gdnf) family receptor member ret (rearranged during transfection) and its key downstream phosphatidylinositol 3 kinase (pi-3k)/protein kinase b (akt) pathway in the process. |
2017-02-22 |
2023-08-13 |
rat |
| Mathieu J F Crupi, Piriya Yoganathan, Leslie N Bone, Eric Lian, Andrew Fetz, Costin N Antonescu, Lois M Mulliga. Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2. Traffic (Copenhagen, Denmark). vol 16. issue 11. 2016-08-15. PMID:26304132. |
ret isoforms are internalized from the cell surface into endosomal compartments in response to glial cell line-derived neurotropic factor (gdnf) ligand stimulation but the specific mechanisms of ret trafficking remain to be elucidated. |
2016-08-15 |
2023-08-13 |
human |
| Yongping Wang, Arjun Stokes, Zhijian Duan, Jordan Hui, Ying Xu, YiPing Chen, Hong-Wu Chen, Kit Lam, Chengji J Zho. LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia. Journal of the American Society of Nephrology : JASN. vol 27. issue 2. 2016-06-07. PMID:26047795. |
the expression of ret proto-oncogene (ret), a critical receptor for the growth factor glial cell line-derived neurotrophic factor (gdnf), which is required for early nephrogenesis, was dramatically diminished in the mutant renal primordia. |
2016-06-07 |
2023-08-13 |
mouse |