| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoqiang Wan, Lihan Zhou, Qing 'En Lim, Yung Hou Wong, Heng-Phon To. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms. Cellular signalling. vol 23. issue 11. 2011-12-30. PMID:21723942. |
glial cell line-derived neurotrophic factor (gdnf) and its family member neurturin (ntn) transduce signal through a multi-component receptor complex consisting of gdnf family receptor alpha 2 (gfrα2) and ret receptor tyrosine kinase. |
2011-12-30 |
2023-08-12 |
mouse |
| M E Fratto, M Imperatori, B Vincenzi, F Tomao, D Santini, G Tonin. New perspectives: role of Sunitinib in breast cancer. La Clinica terapeutica. vol 162. issue 3. 2011-11-28. PMID:21717054. |
it is able to inhibit kit receptor, colony stimulating factor type 1 receptor (csf-1r), glial cell line neutrophic factor receptor (ret), fms-like tyrosine kinase receptor-3 (flt-3 or cd135), signal transducer and activator of transcription 3 (stat3) and akt (protein kinase b) in tumour cells. |
2011-11-28 |
2023-08-12 |
human |
| M E Fratto, M Imperatori, B Vincenzi, F Tomao, D Santini, G Tonin. New perspectives: role of sunitinib in breast cancer. La Clinica terapeutica. vol 161. issue 5. 2011-08-03. PMID:20949248. |
it is able to inhibit kit receptor, colony stimulating factor type 1 receptor (csf- 1r), glial cell line neutrophic factor receptor (ret), fms-like tyrosine kinase receptor-3 (flt-3 or cd135), signal transducer and activator of transcription 3 (stat3) and akt (protein kinase b) in tumour cells. |
2011-08-03 |
2023-08-12 |
human |
| Shoji Saito, Yoshiki Murakumo, Toyonori Tsuzuki, Atsushi Dambara, Takuya Kato, Atsushi Enomoto, Naoya Asai, Shoichi Maruyama, Seiichi Matsuo, Masahide Takahash. Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney. Human pathology. vol 42. issue 6. 2011-07-12. PMID:21292309. |
we have previously identified a novel zinc finger protein, glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (gzf1), whose expression was induced in the human neuroblastoma cell line tgw expressing ret by gdnf stimulation and was also detected in mouse metanephric kidney. |
2011-07-12 |
2023-08-12 |
mouse |
| Jorge R Cabrera, Jimena Bouzas-Rodriguez, Servane Tauszig-Delamasure, Patrick Mehle. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21357690. |
ret is a tyrosine kinase receptor involved in numerous cellular mechanisms including proliferation, neuronal navigation, migration, and differentiation upon binding with glial cell derived neurotrophic factor family ligands. |
2011-06-28 |
2023-08-12 |
Not clear |
| Jorge Ayllon, Benoit Beuselinck, Alexandre Morel, Eduardo Barrascout, Jacques Medioni, Florian Scotte, Stéphane Oudar. Long-term response and postsurgical complete remissions after treatment with sunitinib malate, an oral multitargeted receptor tyrosine kinase inhibitor, in patients with metastatic renal cell carcinoma. Cancer investigation. vol 29. issue 4. 2011-05-27. PMID:21469976. |
sunitinib is an oral multitargeted inhibitor of vascular endothelial growth factor receptors (vegfrs-1, -2, and -3), platelet-derived growth factor receptors (pdgfrs-α and -β), stem-cell factor receptor (kit), fms-like tyrosine kinase 3 (flt3), colony-stimulating factor 1 receptor (csf-1r), and glial cell line-derived neurotrophic factor receptor (rearranged during transfection; ret). |
2011-05-27 |
2023-08-12 |
Not clear |
| Han Liu, Qingyong Ma, Junhui L. High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells. Molecular and cellular biochemistry. vol 347. issue 1-2. 2011-03-28. PMID:20960036. |
we investigated the cell proliferation, glial cell line-derived neurotrophic factor (gdnf) and its tyrosine kinase receptor ret expression in bxpc-3 and mia paca-2 cells when exposed to different concentrations of glucose. |
2011-03-28 |
2023-08-12 |
Not clear |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
many of the cellular effects of glial cell line-derived neurotrophic factor are initiated by binding to gndf family receptor alpha-1 (gfrα1), and mediated by diverse intracellular signaling pathways, most notably through the ret tyrosine kinase. |
2011-03-22 |
2023-08-12 |
mouse |
| H Takenobu, O Shimozato, T Nakamura, H Ochiai, Y Yamaguchi, M Ohira, A Nakagawara, T Kamij. CD133 suppresses neuroblastoma cell differentiation via signal pathway modification. Oncogene. vol 30. issue 1. 2011-02-28. PMID:20818439. |
ret transcription was suppressed by cd133 in nb cells and glial cell line-derived neurotrophic factor treatment failed to induce ret in cd133-expressing cells; ret overexpression rescued cd133-related inhibition of neurite elongation. |
2011-02-28 |
2023-08-12 |
Not clear |
| Yongguang Yang, Chunsheng Ha. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway. BMC cell biology. vol 11. 2011-02-15. PMID:20955573. |
glial cell line-derived neurotrophic factor (gdnf), a distantly related member of the transforming growth factor-β superfamily, and its receptor subunits gdnf family receptor alpha 1 (gfrα1), ret tyrosine kinase, and neural cell adhesion molecule (ncam) have been reported to be expressed in the testis and involved in the regulation of proliferation of immature sertoli cells (iscs). |
2011-02-15 |
2023-08-12 |
mouse |
| Yoko Hirata, Norihiro Shimokawa, Kentaro Oh-hashi, Zu-Xi Yu, Kazutoshi Kiuch. Acidification of the Golgi apparatus is indispensable for maturation but not for cell surface delivery of Ret. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20796177. |
we examined the effect of concanamycin a and bafilomycin a1, inhibitors of the vacuolar proton-atpase, on maturation and expression of ret, a tyrosine kinase receptor for glial cell line-derived neurotrophic factor. |
2010-12-02 |
2023-08-12 |
Not clear |
| Maurice Perrinjaquet, Marçal Vilar, Carlos F Ibáñe. Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20682772. |
in the receptor tyrosine kinase ret, a receptor for gdnf (glial cell line-derived neurotrophic factor), the functions of the majority of tyrosine residues that become phosphorylated are still unknown. |
2010-11-04 |
2023-08-12 |
Not clear |
| Stefanie S Schalm, Bryan A Ballif, Sean M Buchanan, Greg R Phillips, Tom Maniati. Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 31. 2010-09-08. PMID:20616001. |
in addition, the ret ligand glial cell line-derived neurotrophic factor induces phosphorylation of pcdhgamma in motor neurons and phosphorylation of pcdhalpha and pcdhgamma in sympathetic neurons. |
2010-09-08 |
2023-08-12 |
Not clear |
| Hongtao Wang, Inna Hughes, William Planer, Alexander Parsadanian, John R Grider, Bhupinder P S Vohra, Cynthia Keller-Peck, Robert O Heuckerot. The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 4. 2010-07-08. PMID:20107080. |
although these roles are well established, we now provide evidence that increasing levels of the ret ligand glial cell line-derived neurotrophic factor (gdnf) in mice causes alterations in ens structure and function that are critically dependent on the time and location of increased gdnf availability. |
2010-07-08 |
2023-08-12 |
mouse |
| Ai Kurotsuchi, Yoshiki Murakumo, Mayumi Jijiwa, Kei Kurokawa, Yasutomo Itoh, Yoshinori Kodama, Takuya Kato, Atsushi Enomoto, Naoya Asai, Hiroko Terasaki, Masahide Takahash. Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells. Cancer science. vol 101. issue 5. 2010-07-01. PMID:20210798. |
ret activation by glial cell line-derived neurotrophic factor (gdnf) is essential for the development of the enteric nervous system and the kidney. |
2010-07-01 |
2023-08-12 |
mouse |
| Rossana Foti, Silvia Zucchelli, Marta Biagioli, Paola Roncaglia, Sandra Vilotti, Raffaella Calligaris, Helena Krmac, Javier Enrique Girardini, Giannino Del Sal, Stefano Gustincic. Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. The Journal of biological chemistry. vol 285. issue 24. 2010-06-29. PMID:20395301. |
parkinson disease-associated dj-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor ret in human neuroblastoma cells. |
2010-06-29 |
2023-08-12 |
human |
| Rossana Foti, Silvia Zucchelli, Marta Biagioli, Paola Roncaglia, Sandra Vilotti, Raffaella Calligaris, Helena Krmac, Javier Enrique Girardini, Giannino Del Sal, Stefano Gustincic. Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. The Journal of biological chemistry. vol 285. issue 24. 2010-06-29. PMID:20395301. |
here we show that dj-1 plays an essential role in the expression of rearranged during transfection (ret), a receptor for the glial cell line-derived neurotrophic factor, a neuroprotective molecule for dopaminergic neurons, the main target of degeneration in pd. |
2010-06-29 |
2023-08-12 |
human |
| Jacob Farhi, Asangla Ao, Benjamin Fisch, Xiao Yun Zhang, Roni Garor, Ronit Abi. Glial cell line-derived neurotrophic factor (GDNF) and its receptors in human ovaries from fetuses, girls, and women. Fertility and sterility. vol 93. issue 8. 2010-06-08. PMID:19896648. |
to investigate the expression of glial cell line-derived neurotrophic factor (gdnf) and its receptors, gdnf alpha 1 (gfr-alpha1) and tyrosine kinase receptor for rearranged during transfection (ret), in human ovaries at the protein and mrna levels. |
2010-06-08 |
2023-08-12 |
human |
| Cynthia C Tsui, Brian A Pierchal. The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392937. |
the differential axonal degradation of ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. |
2010-05-14 |
2023-08-12 |
Not clear |
| Benson C Lu, Cristina Cebrian, Xuan Chi, Satu Kuure, Richard Kuo, Carlton M Bates, Silvia Arber, John Hassell, Lesley MacNeil, Masato Hoshi, Sanjay Jain, Naoya Asai, Masahide Takahashi, Kai M Schmidt-Ott, Jonathan Barasch, Vivette D'Agati, Frank Costantin. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nature genetics. vol 41. issue 12. 2010-01-05. PMID:19898483. |
glial cell line-derived neurotrophic factor signaling through the ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. |
2010-01-05 |
2023-08-12 |
mouse |