| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Narita, A Tanemura, R Murali, R A Scolyer, S Huang, T Arigami, S Yanagita, K K Chong, J F Thompson, D L Morton, D S Hoo. Functional RET G691S polymorphism in cutaneous malignant melanoma. Oncogene. vol 28. issue 34. 2009-09-08. PMID:19561646. |
ret proto-oncogene encodes a receptor tyrosine kinase whose ligand is glial cell line-derived neurotrophic factor (gdnf), and its polymorphism at g691s juxtamembrane region (retp) is a germline polymorphism. |
2009-09-08 |
2023-08-12 |
Not clear |
| Li Foong Yoong, Guoqiang Wan, Heng-Phon To. GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms. Molecular and cellular neurosciences. vol 41. issue 4. 2009-09-07. PMID:19463953. |
glial cell line-derived neurotrophic factor (gdnf) transduces signal and promotes neurite outgrowths in diverse neurons through the interactions of gdnf family receptor alpha 1 (gfralpha1) and other co-receptors including ret receptor tyrosine kinase and ncam. |
2009-09-07 |
2023-08-12 |
human |
| Jing Li, Cynthia Klein, Chenguang Liang, Rami Rauch, Kazuhiro Kawamura, Aaron J W Hsue. Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. FEBS letters. vol 583. issue 15. 2009-08-24. PMID:19580811. |
analyzing the expression of polypeptide ligand-receptor pairs using dna microarray datasets, we identified transcripts for artemin, a member of the gdnf (glial cell line-derived neurotrophic factor) family, its receptor gfra3 (gdnf family receptor-alpha 3) and coreceptor ret. |
2009-08-24 |
2023-08-12 |
mouse |
| Liang Li, Yujin Su, Chunli Zhao, Qunyuan X. Role of Nurr1 and Ret in inducing rat embryonic neural precursors to dopaminergic neurons. Neurological research. vol 31. issue 5. 2009-08-10. PMID:19133164. |
ret is a member of the receptor tyrosine kinase (rtk) superfamily and a critical signal transducing subunit of receptors for glial cell line-derived neurotrophic factor (gdnf). |
2009-08-10 |
2023-08-12 |
rat |
| Manuela Vargiolu, Daniela Fusco, Ivana Kurelac, Dietmar Dirnberger, Ralf Baumeister, Isabella Morra, Antonio Melcarne, Roberto Rimondini, Giovanni Romeo, Elena Bonor. The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. The Journal of clinical endocrinology and metabolism. vol 94. issue 7. 2009-08-06. PMID:19366855. |
ret transduces a positive signal leading to survival, differentiation, or migration in the presence of its ligand glial cell line-derived neurotrophic factor, whereas in its absence a proapoptotic fragment that initiates a negative signaling for apoptosis is generated. |
2009-08-06 |
2023-08-12 |
Not clear |
| Hitoyasu Futami, Ryuichi Saka. RET protein promotes non-adherent growth of NB-39-nu neuroblastoma cell line. Cancer science. vol 100. issue 6. 2009-07-08. PMID:19320641. |
by the addition of glial cell line-derived neurotrophic factor (gdnf), both the expression and phosphorylation of ret and the phosphorylation of erk1/2 and akt were further increased, whereas cell proliferation was not stimulated under normal culture conditions. |
2009-07-08 |
2023-08-12 |
Not clear |
| Vimal Parkash, Adrian Goldma. Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling. Acta crystallographica. Section F, Structural biology and crystallization communications. vol 65. issue Pt 6. 2009-06-24. PMID:19478429. |
glial cell line-derived neurotrophic factor (gdnf) activates the receptor tyrosine kinase ret by binding to the gdnf-family receptor alpha1 (gfralpha1) and forming the gdnf(2)-gfralpha1(2)-ret(2) heterohexamer complex. |
2009-06-24 |
2023-08-12 |
Not clear |
| Yoshiki Murakumo, Mayumi Jijiwa, Naoya Asai, Masatoshi Ichihara, Masahide Takahash. RET and neuroendocrine tumors. Pituitary. vol 9. issue 3. 2009-06-11. PMID:17036197. |
the ret proto-oncogene encodes a receptor tyrosine kinase that is a main component of the signaling pathway activated by the glial cell line-derived neurotrophic factor family ligands. |
2009-06-11 |
2023-08-12 |
human |
| S Qiao, T Iwashita, M Ichihara, Y Murakumo, A Yamaguchi, M Isogai, K Sakata, M Takahash. Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis. Clinical neuropathology. vol 28. issue 2. 2009-04-30. PMID:19353842. |
because it is well-known that glial cell line-derived neurotrophic factor (gdnf) and its receptor components, gdnf family receptor-alpha 1 (gfr-alpha 1) and ret receptor tyrosine kinase, play a crucial role in the development of ens, their expression was analyzed by immunohistochemistry. |
2009-04-30 |
2023-08-12 |
Not clear |
| Alessio Pini Prato, Marco Musso, Isabella Ceccherini, Girolamo Mattioli, Camilla Giunta, Gian Marco Ghiggeri, Vincenzo Jasonn. Hirschsprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): a novel syndromic association. Medicine. vol 88. issue 2. 2009-03-31. PMID:19282698. |
therefore, we designed a prospective study aimed at determining the prevalence of cakut in hscr patients and at identifying ret, glial cell line-derived neurotrophic factor (gdnf), and gdnf family receptor alpha1 (gfralpha1) mutations or haplotypes associated with this subset of hscr patients. |
2009-03-31 |
2023-08-12 |
Not clear |
| C Lucini, L Maruccio, B Facello, N Cocchia, G Tortora, L Castald. Cellular localization of GDNF and its GFRalpha1/RET receptor complex in the developing pancreas of cat. Journal of anatomy. vol 213. issue 5. 2009-02-20. PMID:19014364. |
glial cell line-derived neurotrophic factor (gdnf) acts through ret receptor tyrosine kinase and its co-receptor gfralpha1. |
2009-02-20 |
2023-08-12 |
cat |
| Vimal Parkash, Veli-Matti Leppänen, Heidi Virtanen, Jaana M Jurvansuu, Maxim M Bespalov, Yulia A Sidorova, Pia Runeberg-Roos, Mart Saarma, Adrian Goldma. The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding. The Journal of biological chemistry. vol 283. issue 50. 2009-02-19. PMID:18845535. |
the structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into ret signaling and heparin binding. |
2009-02-19 |
2023-08-12 |
Not clear |
| Vimal Parkash, Veli-Matti Leppänen, Heidi Virtanen, Jaana M Jurvansuu, Maxim M Bespalov, Yulia A Sidorova, Pia Runeberg-Roos, Mart Saarma, Adrian Goldma. The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding. The Journal of biological chemistry. vol 283. issue 50. 2009-02-19. PMID:18845535. |
glial cell line-derived neurotrophic factor (gdnf), a neuronal survival factor, binds its co-receptor gdnf family receptor alpha1 (gfr alpha 1) in a 2:2 ratio and signals through the receptor tyrosine kinase ret. |
2009-02-19 |
2023-08-12 |
Not clear |
| Jun-Ping Cao, Hong-Jun Wang, Jing-Kao Yu, Hua Yang, Cheng-Hua Xiao, Dian-Shuai Ga. Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons. Neuroscience research. vol 61. issue 4. 2008-11-26. PMID:18524405. |
glial cell line-derived neurotrophic factor (gdnf) exerts its biological effects via a multi-component receptor system including the ligand binding receptor--gdnf family receptor-alpha1 (gfralpha1) and the signaling receptor--ret tyrosine kinase. |
2008-11-26 |
2023-08-12 |
Not clear |
| Christina Wolf, Andrée Rothermel, Andrea A Robitzk. Neurturin, a member of the glial cell line-derived neurotrophic factor family, affects the development of acetylcholinesterase-positive cells in a three-dimensional model system of retinogenesis. Journal of neurochemistry. vol 107. issue 1. 2008-11-03. PMID:18673446. |
the glial cell line-derived neurotrophic factor (gdnf) family consists of the four ligands gdnf, neurturin (nrtn), artemin and persephin, which bind to the four co-receptors gdnf family receptor alpha1-4 and control through the activation of the receptor tyrosin kinase ret several developmental processes. |
2008-11-03 |
2023-08-12 |
chicken |
| Shi-Ming He, Zhen-Wei Zhao, Lei Zhao, Xue-Lian Wang, Dong Jia, Fang Hou, Guo-Dong Ga. Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats. Acta neurobiologiae experimentalis. vol 68. issue 3. 2008-10-24. PMID:18668157. |
nigrostriatal neurons expressing ret protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (gdnf) were investigated in rats using retrograde neural tracing with horseradish peroxidase (hrp) combined with immunohistochemistry. |
2008-10-24 |
2023-08-12 |
rat |
| T Hasegawa, A Enomoto, T Kato, K Kawai, R Miyamoto, M Jijiwa, M Ichihara, M Ishida, N Asai, Y Murakumo, K Ohara, Y Niwa, H Goto, M Takahash. Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice. Oncogene. vol 27. issue 43. 2008-10-07. PMID:18542059. |
the expression of mkp-2 was not only induced by ret-men2a or ret-men2b mutant proteins but also by the activation of endogenous ret by its ligand, glial cell line-derived neurotrophic factor (gdnf). |
2008-10-07 |
2023-08-12 |
mouse |
| H Qi, D-Q Li, F Bian, E Y Chuang, D B Jones, S C Pflugfelde. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. The British journal of ophthalmology. vol 92. issue 9. 2008-10-01. PMID:18723744. |
to evaluate the expression pattern of glial cell line-derived neurotrophic factor (gdnf) with its receptors gdnf family receptor alpha-1 (gfr alpha-1) and ret in the human corneal and limbal tissues, as well as in the primary human limbal epithelial cultures (phlec). |
2008-10-01 |
2023-08-12 |
human |
| Atsushi Sakai, Minoru Asada, Naoki Seno, Hidenori Suzuk. Involvement of neural cell adhesion molecule signaling in glial cell line-derived neurotrophic factor-induced analgesia in a rat model of neuropathic pain. Pain. vol 137. issue 2. 2008-09-18. PMID:17967506. |
glial cell line-derived neurotrophic factor (gdnf) has a variety of functions affecting the survival and development of specified neural cell populations, mediated via transmission of intracellular signals through binding to its high-affinity receptor, gfr*1, and subsequent activation of a tyrosine receptor kinase, ret, neural cell adhesion molecule (ncam), or other signaling molecules. |
2008-09-18 |
2023-08-12 |
rat |
| Carla Lucini, L Maruccio, R Antonucci, L Castald. Immunoreactivity to glial cell line-derived neurotrophic factor and its receptors in the trout pancreas: a further endocrine-exocrine relationship? European journal of histochemistry : EJH. vol 52. issue 1. 2008-07-31. PMID:18502725. |
gdnf exerts its roles by binding to glial cell line-derived neurotrophic factor receptor (gfr) a1, which forms a heterotetramic complex with rearranged during transfection (ret) proto-oncogene product, a tyrosine kinase receptor. |
2008-07-31 |
2023-08-12 |
Not clear |