| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuangba He, Chun-Hao Chen, Natalya Chernichenko, Shizhi He, Richard L Bakst, Fernando Barajas, Sylvie Deborde, Peter J Allen, Efsevia Vakiani, Zhenkun Yu, Richard J Won. GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 19. 2014-07-10. PMID:24778213. |
perineural invasion (pni) may be mediated by nerve secretion of glial cell line-derived neurotrophic factor (gdnf) attracting cancer cell migration through activation of cell surface ret proto-oncogene (ret) receptors. |
2014-07-10 |
2023-08-13 |
mouse |
| Gina N Calco, Olivia R Stephens, Laura M Donahue, Cynthia C Tsui, Brian A Pierchal. CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains. The Journal of biological chemistry. vol 289. issue 11. 2014-05-14. PMID:24425877. |
ret is the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor (gdnf) family of neuronal growth factors. |
2014-05-14 |
2023-08-12 |
Not clear |
| Pontus Klein, Anne Kathrin Müller-Rischart, Elisa Motori, Cornelia Schönbauer, Frank Schnorrer, Konstanze F Winklhofer, Rüdiger Klei. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. The EMBO journal. vol 33. issue 4. 2014-04-16. PMID:24473149. |
glial cell line-derived neurotrophic factor (gdnf) and its signaling receptor ret are neuroprotective in toxin-based animal models of pd. |
2014-04-16 |
2023-08-12 |
human |
| T Keefe Davis, Masato Hoshi, Sanjay Jai. Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development. Mechanisms of development. vol 130. issue 9-10. 2014-02-24. PMID:23542432. |
glial cell line-derived neurotrophic factor (gdnf) binds a coreceptor gdnf family receptor α1 (gfrα1) and forms a signaling complex with the receptor tyrosine kinase ret. |
2014-02-24 |
2023-08-12 |
Not clear |
| Xinquan Wan. Structural studies of GDNF family ligands with their receptors-Insights into ligand recognition and activation of receptor tyrosine kinase RET. Biochimica et biophysica acta. vol 1834. issue 10. 2013-11-07. PMID:23085183. |
ret is the receptor for glial cell line-derived neurotrophic factor family of ligands (gfls). |
2013-11-07 |
2023-08-12 |
Not clear |
| Francesca Boscia, Carla Lucia Esposito, Antonella Casamassa, Vittorio de Franciscis, Lucio Annunziato, Laura Cerchi. The isolectin IB4 binds RET receptor tyrosine kinase in microglia. Journal of neurochemistry. vol 126. issue 4. 2013-10-23. PMID:23413818. |
ret receptor tyrosine kinase is the signaling component of the receptor complex for the family ligands of the glial cell line-derived neurotrophic factor (gdnf). |
2013-10-23 |
2023-08-12 |
rat |
| Jonathan I Lake, Robert O Heuckerot. Enteric nervous system development: migration, differentiation, and disease. American journal of physiology. Gastrointestinal and liver physiology. vol 305. issue 1. 2013-09-09. PMID:23639815. |
molecules controlling this process, including glial cell line-derived neurotrophic factor and its receptor ret, endothelin (et)-3 and its receptor endothelin receptor type b, and transcription factors such as sox10 and phox2b, are required for ens development in humans. |
2013-09-09 |
2023-08-12 |
Not clear |
| Tianwen Huang, Jia Hu, Bing Wang, Yanzhen Nie, Junlan Geng, Leping Chen. Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 26. 2013-09-05. PMID:23804090. |
furthermore, we found that, at e18.5 these putative cholinergic neurons expressed glial cell line-derived neurotrophic factor family coreceptor ret but not tyrosine hydroxylase (ret(+)/th(-)). |
2013-09-05 |
2023-08-12 |
mouse |
| Ting Wang, Xiaotang Jing, Jennifer J DeBerry, Erica S Schwartz, Derek C Molliver, Kathryn M Albers, Brian M Davi. Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 5. 2013-04-02. PMID:23365243. |
neurturin (nrtn) is a member of the glial cell line-derived neurotrophic factor family of ligands that exerts its actions via ret tyrosine kinase and gfrα2. |
2013-04-02 |
2023-08-12 |
mouse |
| Sandrine Biau, Shiying Jin, Chen-Ming Fa. Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biology open. vol 2. issue 2. 2013-02-25. PMID:23429478. |
because gas1 has been shown to inhibit ret signaling elicited by glial cell line-derived neurotrophic factor (gdnf), we explored whether gas1 mutant enteric neurons displayed any alteration of ret signaling levels. |
2013-02-25 |
2023-08-12 |
Not clear |
| Rajshekhar Chatterjee, Enrique Ramos, Mary Hoffman, Jessica VanWinkle, Daniel R Martin, Thomas K Davis, Masato Hoshi, Stanley P Hmiel, Anne Beck, Keith Hruska, Doug Coplen, Helen Liapis, Robi Mitra, Todd Druley, Paul Austin, Sanjay Jai. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Human genetics. vol 131. issue 11. 2013-01-08. PMID:22729463. |
signaling by the glial cell line-derived neurotrophic factor (gdnf)-ret receptor tyrosine kinase and spry1, a ret repressor, is essential for early urinary tract development. |
2013-01-08 |
2023-08-12 |
mouse |
| Amisha Patel, Nicola Harker, Lara Moreira-Santos, Manuela Ferreira, Kieran Alden, Jon Timmis, Katie Foster, Anna Garefalaki, Panayotis Pachnis, Paul Andrews, Hideki Enomoto, Jeffrey Milbrandt, Vassilis Pachnis, Mark C Coles, Dimitris Kioussis, Henrique Veiga-Fernande. Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems. Science signaling. vol 5. issue 235. 2012-12-06. PMID:22855506. |
ret signaling occurs through glial cell line-derived neurotrophic factor (gdnf) family receptor α co-receptors present in the same cell (signaling in cis). |
2012-12-06 |
2023-08-12 |
Not clear |
| D A Skvortzov, M P Rubzova, M E Zvereva, F L Kiselev, O A Donzov. The regulation of telomerase in oncogenesis. Acta naturae. vol 1. issue 1. 2012-08-23. PMID:22649586. |
before that, using a pcr (polymerase chain reaction) coupled with reverse transcription, it was shown that, in this very lineage of the embryonic sc, the expression of the receptors' genes is being fulfilled for the neurotropfic ret and gfrα1 glia factor. |
2012-08-23 |
2023-08-12 |
mouse |
| E L Arsenieva, I V Kuzmin, E S Manuilova, E V Novosadova, E V Murkin, G V Pavlova, V Z Tarantul, I A Grivenniko. The Production and Characteristics of a Mouse's Embryonic Stem Cell Lineage, Transfected by the Glia Neurotrophic Factor and Gene Fused with the Green Fluorescent Protein Gene. Acta naturae. vol 1. issue 1. 2012-08-23. PMID:22649595. |
before that, using a pcr (polymerase chain reaction) coupled with reverse transcription, it was shown that, in this very lineage of the embryonic sc, the expression of the receptors' genes is being fulfilled for the neurotropfic ret and gfrα1 glia factor. |
2012-08-23 |
2023-08-12 |
mouse |
| A Ejdesjö, P Wentzel, U J Eriksso. Influence of maternal metabolism and parental genetics on fetal maldevelopment in diabetic rat pregnancy. American journal of physiology. Endocrinology and metabolism. vol 302. issue 10. 2012-07-17. PMID:22374754. |
glial cell line-derived neurotrophic factor and ret proto-oncogene gene expression was decreased in both md-wlwl and md-lwlw fetuses, whereas increased bone morphogenetic protein 4 and decreased sonic hedgehog homolog expression was found only in md-lwlw fetuses. |
2012-07-17 |
2023-08-12 |
rat |
| T Kalle Lundgren, Katsutoshi Nakahata, Nicolas Fritz, Paola Rebellato, Songbai Zhang, Per Uhlé. RET PLCγ phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355350. |
upon glial cell line-derived neurotrophic factor (gdnf) stimulation, ret can trigger multiple intracellular signaling pathways that in concert activate various downstream effectors. |
2012-06-18 |
2023-08-12 |
Not clear |
| Carla Lucini, Livia D'Angelo, Marco Patruno, Francesco Mascarello, Paolo de Girolamo, Luciana Castald. GDNF family ligand RET receptor in the brain of adult zebrafish. Neuroscience letters. vol 502. issue 3. 2012-06-11. PMID:21839141. |
ret is a tyrosine kinase receptor, and transduces signaling by family of glial cell line-derived neurotrophic factor ligands (gfls). |
2012-06-11 |
2023-08-12 |
zebrafish |
| T Kaplinovsky, A M Cunningha. Differential expression of RET receptor isoforms in the olfactory system. Neuroscience. vol 175. 2012-06-01. PMID:21118713. |
the glial cell line-derived neurotrophic factor (gdnf) family supports neurons by activating the tyrosine kinase receptor ret. |
2012-06-01 |
2023-08-12 |
rat |
| Valentina Di Liberto, Giuseppa Mudò, Natale Belluard. mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21619889. |
in the present study we aimed to verify if the enhancement of glial cell line-derived neurotrophic factor (gdnf) production in mouse striatum following treatment with ly379268 may also induce in the nigrostriatal system a time-related activation of ret receptor and its specific intracellular signaling. |
2012-05-25 |
2023-08-12 |
mouse |
| Jelena Mijatovic, Marjo Piltonen, Paolo Alberton, Pekka T Männistö, Mart Saarma, T Petteri Pieppone. Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals. Neurobiology of aging. vol 32. issue 8. 2012-05-14. PMID:19767128. |
ret is the canonical signaling receptor for glial cell line-derived neurotrophic factor (gdnf), which has been shown to have neuroprotective effects when administered prior to neurotoxic challenge. |
2012-05-14 |
2023-08-12 |
mouse |