| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T K Lundgren, Moritz Luebke, Anna Stenqvist, Patrik Ernfor. Differential membrane compartmentalization of Ret by PTB-adaptor engagement. The FEBS journal. vol 275. issue 9. 2008-07-09. PMID:18355321. |
glial cell line-derived neurotrophic factor family ligands act through the receptor tyrosine kinase ret, which plays important roles during embryonic development for cell differentiation, survival, and migration. |
2008-07-09 |
2023-08-12 |
Not clear |
| Toshihiro Uesaka, Mayumi Nagashimada, Shigenobu Yonemura, Hideki Enomot. Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. The Journal of clinical investigation. vol 118. issue 5. 2008-07-01. PMID:18414682. |
it has recently been shown that glial cell line-derived neurotrophic factor (gdnf) family receptor alpha1 (gfralpha1), which binds to gdnf and activates ret, is essential for the survival of enteric neurons. |
2008-07-01 |
2023-08-12 |
mouse |
| Amaya Izal-Azcárate, Silvia Belzunegui, Waldy San Sebastián, Pablo Garrido-Gil, Marianne Vázquez-Claverie, Berta López, Irene Marcilla, M A Rosario Luqui. Immunohistochemical characterization of the rat carotid body. Respiratory physiology & neurobiology. vol 161. issue 1. 2008-06-24. PMID:18280799. |
in addition to tyrosine hydroxylase (th), type i cells expressed numerous growth factors such as glial cell line-derived neurotrophic factor (gdnf), basic fibroblast growth factor (bfgf), brain-derived neurotrophic factor (bdnf), ciliary neurotrophic factor (cntf), insulin-like growth factor-i (igf-i), epidermal growth factor (egf) and transforming growth factor-alpha (tgf-alpha), as well as the receptors p75, ret, epidermal growth factor receptor (egfr) and platelet-derived growth factor receptor-alpha (pdgfr-alpha). |
2008-06-24 |
2023-08-12 |
rat |
| Jelena Mijatovic, Outi Patrikainen, Leonid Yavich, Mikko Airavaara, Liisa Ahtee, Mart Saarma, T Petteri Pieppone. Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18248620. |
the ret receptor tyrosine kinase is the common signaling receptor for the glial cell line-derived neurotrophic factor (gdnf) family ligands. |
2008-06-12 |
2023-08-12 |
mouse |
| Milam A Brantley, Sanjay Jain, Emily E Barr, Eugene M Johnson, Jeffrey Milbrand. Neurturin-mediated ret activation is required for retinal function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 16. 2008-05-05. PMID:18417692. |
the glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) [gdnf, nrtn (neurturin), artn (artemin), and pspn (persephin)] interact with gdnf family receptors (gfralphas) and activate intracellular signaling through the ret receptor tyrosine kinase. |
2008-05-05 |
2023-08-12 |
mouse |
| Thomas W Gould, Shigenobu Yonemura, Ronald W Oppenheim, Shiho Ohmori, Hideki Enomot. The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 9. 2008-04-08. PMID:18305247. |
glial cell line-derived neurotrophic factor (gdnf) regulates multiple aspects of spinal motoneuron (mn) development, including gene expression, target selection, survival, and synapse elimination, and mice lacking either gdnf or its receptors gdnf family receptor alpha1 (gfralpha1) and ret exhibit a 25% reduction of lumbar mns at postnatal day 0 (p0). |
2008-04-08 |
2023-08-12 |
mouse |
| Elly S W Ngan, Cathy K Y Shum, Hiu-Ching Poon, Mai-Har Sham, Maria-Mercè Garcia-Barcelo, Vincent C H Lui, Paul K H Ta. Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells. Biochimica et biophysica acta. vol 1783. issue 3. 2008-04-02. PMID:18006159. |
glial cell line-derived neurotrophic factor (gdnf)/ret receptor tyrosine kinase (ret) signaling is indispensable for their survival, migration and differentiation. |
2008-04-02 |
2023-08-12 |
mouse |
| Pia Runeberg-Roos, Mart Saarm. Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases. Annals of medicine. vol 39. issue 8. 2008-03-31. PMID:17934909. |
ret (rearranged during transfection) is a transmembrane receptor tyrosine kinase that is activated by a complex consisting of a soluble glial cell line-derived neurotrophic factor (gdnf) family ligand (gfl) and a glycosyl phosphatidylinositol-anchored co-receptor, gdnf family receptors alpha (gfralpha). |
2008-03-31 |
2023-08-12 |
Not clear |
| Christel Baudet, Ester Pozas, Igor Adameyko, Elisabet Andersson, Johan Ericson, Patrik Ernfor. Retrograde signaling onto Ret during motor nerve terminal maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 4. 2008-02-14. PMID:18216204. |
ret is localized specifically to the presynaptic membrane with its ligands, gdnf (glial cell line-derived neurotrophic factor)/ntn (neurturin), expressed in skeletal muscle tissue. |
2008-02-14 |
2023-08-12 |
Not clear |
| Marina Quartu, Maria Pina Serra, Marianna Boi, Maria Teresa Ferretti, Maria Letizia Lai, Marina Del Fiacc. Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age. Brain research. vol 1173. 2008-01-09. PMID:17825269. |
occurrence and localization of receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and the gdnf family receptor (gfr) alpha-1 to -3, were examined by immunohistochemistry in the normal human brainstem at fetal, neonatal, and adult age. |
2008-01-09 |
2023-08-12 |
human |
| Yuko Suzuki, Itaru Mizoguchi, Nobuhiko Uchid. Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization. Archives of histology and cytology. vol 70. issue 2. 2007-12-07. PMID:17827669. |
results showed mrnas of the ciliary neurotrophic factor (cntf), its receptor (cntfr), glial cell line-derived neurotrophic factor (gdnf), gdnf family receptors alpha-1 (gfralpha-1), gfralpha-2, and ret tyrosine kinase receptor (ret), neurotrophin (nt)3, nt4/5, tyrosine kinase (trk) c, nerve growth factor (ngf), and trka were expressed in the isolated taste buds. |
2007-12-07 |
2023-08-12 |
mouse |
| Masashi Murakami, Masatoshi Ichihara, Sayaka Sobue, Ryosuke Kikuchi, Hiromi Ito, Ami Kimura, Takashi Iwasaki, Akira Takagi, Tetsuhito Kojima, Masahide Takahashi, Motoshi Suzuki, Yoshiko Banno, Yoshinori Nozawa, Takashi Murat. RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17555548. |
ret, the receptor of glial cell line-derived neurotrophic factor (gdnf) family ligands, is important for the development of kidney and peripheral neurons. |
2007-11-06 |
2023-08-12 |
human |
| Yoko Hirata, Kazutoshi Kiuch. Rapid down-regulation of Ret following exposure of dopaminergic neurons to neurotoxins. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17555550. |
treatment of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine caused decreases in levels of ret, a tyrosine kinase receptor for glial cell line-derived neurotrophic factor (gdnf) in the striatum, under the condition in which tyrosine hydroxylase was moderately decreased and the gdnf family receptor alpha1, another receptor of gdnf that is the ligand-binding subunit, were unaffected. |
2007-11-06 |
2023-08-12 |
mouse |
| Jason A Gustin, Mao Yang, Eugene M Johnson, Jeffrey Milbrand. Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth. Journal of neurochemistry. vol 102. issue 4. 2007-10-04. PMID:17663753. |
glial cell derived neurotrophic factor (gdnf)-dependent receptor tyrosine kinase ret activity is required for proper development of the nervous system and genitourinary tract. |
2007-10-04 |
2023-08-12 |
Not clear |
| Maki Ishida, Masatoshi Ichihara, Shinji Mii, Mayumi Jijiwa, Naoya Asai, Atsushi Enomoto, Takuya Kato, Ai Majima, Jiang Ping, Yoshiki Murakumo, Masahide Takahash. Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase. Cancer science. vol 98. issue 6. 2007-08-01. PMID:17388787. |
in the present study, we investigated the role of spry proteins in intracellular signaling via the ret receptor tyrosine kinase activated by glial cell line-derived neurotrophic factor (gdnf). |
2007-08-01 |
2023-08-12 |
human |
| Jian Zhong, Xiaoyan Li, Cara McNamee, Adele P Chen, Manuela Baccarini, William D Snide. Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nature neuroscience. vol 10. issue 5. 2007-07-12. PMID:17396120. |
conditional elimination of b-raf in dorsal root ganglion (drg) neurons did not interfere with survival, but instead caused marked reduction in expression of the glial cell line-derived neurotrophic factor receptor ret at postnatal stages, associated with a profound reduction in levels of transcription factor cbf-beta. |
2007-07-12 |
2023-08-12 |
mouse |
| J Yang, P Runeberg-Roos, V-M Leppänen, M Saarm. The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin. Oncogene. vol 26. issue 26. 2007-07-09. PMID:17213820. |
glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) all signal through the transmembrane receptor tyrosine kinase ret. |
2007-07-09 |
2023-08-12 |
mouse |
| Jelena Mijatovic, Mikko Airavaara, Anu Planken, Petri Auvinen, Atso Raasmaja, T Petteri Piepponen, Frank Costantini, Liisa Ahtee, Mart Saarm. Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 18. 2007-06-06. PMID:17475787. |
ret is the common signaling receptor for glial cell line-derived neurotrophic factor (gdnf) and other ligands of the gdnf family that have potent effects on brain dopaminergic neurons. |
2007-06-06 |
2023-08-12 |
mouse |
| Brian A Pierchala, Cynthia C Tsui, Jeffrey Milbrandt, Eugene M Johnso. NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17241133. |
likewise, ngf inhibited the degradation of ret induced by glial cell line-derived neurotrophic factor-dependent activation, a process that requires ubiquitination and proteasomal degradation. |
2007-04-02 |
2023-08-12 |
Not clear |
| Brian A Pierchala, Cynthia C Tsui, Jeffrey Milbrandt, Eugene M Johnso. NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17241133. |
an accretion of monoubiquitinated, but not polyubiquitinated, ret occurred in ngf-treated neurons, in contrast to glial cell line-derived neurotrophic factor that promoted the robust polyubiquitination of ret. |
2007-04-02 |
2023-08-12 |
Not clear |