| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark J Millan, Mauricette Brocco, Alain Gobert, Anne Dekeyn. Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Psychopharmacology. vol 177. issue 4. 2005-05-03. PMID:15289999. |
anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-ht2c receptor blockade. |
2005-05-03 |
2023-08-12 |
Not clear |
| Jordi Serrats, Guadalupe Mengod, Roser Corté. Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei. Journal of chemical neuroanatomy. vol 29. issue 2. 2005-05-03. PMID:15652696. |
we have used double in situ hybridization to examine the cellular localization of 5-ht2c receptor mrna in relation to serotonergic and gabaergic neurons in the anterior raphe nuclei of the rat. |
2005-05-03 |
2023-08-12 |
rat |
| Jordi Serrats, Guadalupe Mengod, Roser Corté. Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei. Journal of chemical neuroanatomy. vol 29. issue 2. 2005-05-03. PMID:15652696. |
in the dorsal and median raphe nuclei 5-ht2c receptor mrna was not detected in serotonergic cells identified as those expressing serotonin (5-ht) transporter mrna. |
2005-05-03 |
2023-08-12 |
rat |
| Methvin Isaa. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Current topics in medicinal chemistry. vol 5. issue 1. 2005-04-06. PMID:15638778. |
serotonergic 5-ht2c receptors as a potential therapeutic target for the design antiepileptic drugs. |
2005-04-06 |
2023-08-12 |
Not clear |
| Methvin Isaa. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Current topics in medicinal chemistry. vol 5. issue 1. 2005-04-06. PMID:15638778. |
more specifically, the recent finding that the 5-ht2b/2c receptor agonist, 1-(m-chlorophenyl)-piperazine (mcpp) is anticonvulsant has kindled an interest into the investigation of the serotonergic 5-ht2c receptor subtype as a potential target for the treatment of epilepsy. |
2005-04-06 |
2023-08-12 |
Not clear |
| Kenny J Simansky, Kuldip D Dave, Beth R Inemer, Danielle M Nicklous, J Michael Padron, Vincent J Aloyo, Anthony G Roman. A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits. Physiology & behavior. vol 82. issue 1. 2004-10-25. PMID:15234597. |
serotonergic 5-ht2c and 5-ht1b receptors mediate inhibitory controls of eating. |
2004-10-25 |
2023-08-12 |
rabbit |
| A Pereira, A McLaren, W R Bell, D Copolov, B Dea. Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow. The pharmacogenomics journal. vol 3. issue 4. 2004-04-12. PMID:12931136. |
expression of mrna encoding dopaminergic d2, d3, d4; serotonergic 5ht2a, 5ht2c, 5ht3, 5ht6, 5ht7; adrenergic alpha1a, alpha2; histaminergic h1 and muscarinic m1, m2, m3, m4, m5 receptors was analyzed by reverse transcription-polymerase chain reaction methods. |
2004-04-12 |
2023-08-12 |
human |
| M D Waldinge. Lifelong premature ejaculation: from authority-based to evidence-based medicine. BJU international. vol 93. issue 2. 2004-02-12. PMID:14690484. |
based on psychopharmacological studies there is evidence that premature ejaculation is related to a diminished serotonergic neurotransmission, and 5-ht2c or 5-ht1a receptor disturbances. |
2004-02-12 |
2023-08-12 |
Not clear |
| Nina K Popova, Tamara G Amstislavskay. 5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female. Neuroendocrinology. vol 76. issue 1. 2002-12-20. PMID:12097814. |
the role of 5-ht2a and 5-ht2c subtypes of serotonergic receptors in the control of sexual behavior and plasma testosterone regulation was studied in male cba mice exposed to a sexually receptive female separated by a transparent partition. |
2002-12-20 |
2023-08-12 |
mouse |
| Beatriz A Rocha, Evan H Goulding, Laura E O'Dell, Andy N Mead, Nicole G Coufal, Loren H Parsons, Laurence H Tecot. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427861. |
a line of mutant mice devoid of 5-ht2c receptors was used to examine the contribution of this receptor subtype to the serotonergic modulation of cocaine responses. |
2002-11-18 |
2023-08-12 |
mouse |
| Beatriz A Rocha, Evan H Goulding, Laura E O'Dell, Andy N Mead, Nicole G Coufal, Loren H Parsons, Laurence H Tecot. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427861. |
these findings strongly implicate 5-ht2c receptors in the serotonergic suppression of da-mediated behavioral responses to cocaine and as a potential therapeutic target for cocaine abuse. |
2002-11-18 |
2023-08-12 |
mouse |
| Steven J Garlo. And now, transcriptomics. Neuron. vol 34. issue 3. 2002-05-21. PMID:11988161. |
the authors speculate on a possible serotonergic mechanism controlling 5-ht2c pre-mrna editing. |
2002-05-21 |
2023-08-12 |
mouse |
| A Khullar, P Chue, P Tibb. Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS. Journal of psychiatry & neuroscience : JPN. vol 26. issue 1. 2001-03-15. PMID:11212595. |
mechanisms, including 5-ht2a and 5-ht2c antagonism, serotonergic regulation of dopamine systems and putative dopaminergic subtypes of ocs and ocd, are discussed. |
2001-03-15 |
2023-08-12 |
Not clear |
| P Imbrici, S J Tucker, M C D'Adamo, M Pessi. Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels. Pflugers Archiv : European journal of physiology. vol 441. issue 2-3. 2001-03-08. PMID:11211111. |
we therefore propose that the serotonergic regulation of human kv1.1 and kv1.2 channel activity by the 5-ht2c receptor involves the dual coordination of both rptpalpha and specific tyrosine kinases coupled to this receptor. |
2001-03-08 |
2023-08-12 |
human |
| E Richelson, T Soude. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life sciences. vol 68. issue 1. 2001-01-11. PMID:11132243. |
org 5222 was the most potent drug at dopamine d2 and 5-ht2c receptors, while ziprasidone was the most potent compound at three serotonergic receptors (5-ht1a, 5-ht1d, and 5-ht2a). |
2001-01-11 |
2023-08-12 |
human |
| P G Clifto. Meal patterning in rodents: psychopharmacological and neuroanatomical studies. Neuroscience and biobehavioral reviews. vol 24. issue 2. 2000-04-11. PMID:10714384. |
studies of serotonergic mechanisms in the control of meal size and feeding rate suggest important roles for the 5ht1b and 5-ht2c receptor. |
2000-04-11 |
2023-08-12 |
Not clear |
| D A Clemett, T Punhani, M S Duxon, T P Blackburn, K C Fon. Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology. vol 39. issue 1. 2000-02-18. PMID:10665825. |
immunopositive neurones were also found in the dorsal raphé, suggesting that 5-ht2c receptors may be on some serotonergic neurones. |
2000-02-18 |
2023-08-12 |
human |
| A Frisch, D Postilnick, R Rockah, E Michaelovsky, S Postilnick, E Birman, N Laor, B Rauchverger, A Kreinin, M Poyurovsky, M Schneidman, I Modai, R Weizma. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Molecular psychiatry. vol 4. issue 4. 1999-10-18. PMID:10483058. |
in the present study, 102 unipolar mdd patients and 172 healthy controls were genotyped for polymorphisms in four serotonergic and three dopaminergic candidate genes [tryptophan hydroxylase (tph), serotonin receptor 2a (htr2a), serotonin receptor 2c (htr2c), serotonin transporter promoter region (5-httlpr), dopamine receptor d4 (drd4), dopamine transporter (dat1) and catechol-o-methyl transferase (comt)]. |
1999-10-18 |
2023-08-12 |
Not clear |
| K Herrick-Davis, E Grinde, C M Niswende. Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501219. |
serotonin 5-ht2c receptor rna editing alters receptor basal activity: implications for serotonergic signal transduction. |
1999-10-14 |
2023-08-12 |
human |
| K Herrick-Davis, E Grinde, C M Niswende. Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501219. |
these results demonstrate that rna editing decreases 5-ht2c receptor basal activity, agonist affinity, and potency, indicating that rna editing may play a role in regulating serotonergic signal transduction and response to drug therapy. |
1999-10-14 |
2023-08-12 |
human |