| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James H Fox, Melissa N Boucher, Khalil S Abedrabbo, Brendan D Hare, Bethany A Grimmig, William A Falls, Sayamwong E Hammac. Exercise reduces the anxiogenic effects of meta-chlorophenylpiperazine: The role of 5-HT2C receptors in the bed nucleus of the stria terminalis. Frontiers in synaptic neuroscience. vol 14. 2023-01-30. PMID:36713088. |
two weeks of voluntary exercise in group-housed mice produces a reduction in anxiety-like behaviors across a number of different measures, including a reduction in the anxiety levels typically produced by the anxiogenic serotonergic drug m-chlorophenylpiperazine (mcpp), an agonist at 5-ht2c/2b receptors. |
2023-01-30 |
2023-08-14 |
mouse |
| Y. Buczek, D.M. Tomkins, G.A. Higgins, E.M. Seller. Dissociation of serotonergic regulation of anxiety and ethanol self-administration: a study with mCPP. Behavioural pharmacology. vol 5. issue 4 And 5. 2019-11-20. PMID:11224299. |
dissociation of serotonergic regulation of anxiety and ethanol self-administration: a study with mcpp. |
2019-11-20 |
2023-08-12 |
rat |
| M Suhaib Azim, Nidhi B Agarwal, Divya Vohor. Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. Epilepsy & behavior : E&B. vol 72. 2018-03-19. PMID:28578215. |
in order to explore whether effects are mediated by melatonergic or serotonergic mechanisms, 1-(m-chlorophenyl) piperazine (mcpp), selective 5ht2c receptor agonist and luzindole, melatonergic receptor antagonist, were taken as pharmacological tools. |
2018-03-19 |
2023-08-13 |
mouse |
| M Suhaib Azim, Nidhi B Agarwal, Divya Vohor. Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. Epilepsy & behavior : E&B. vol 72. 2018-03-19. PMID:28578215. |
luzindole reversed the protective effects of agomelatine while mcpp failed to show such a reversal, indicating melatonergic (and not serotonergic) mechanisms in the observed effects. |
2018-03-19 |
2023-08-13 |
mouse |
| J Zohar, Y Sasso. Obsessive compulsive disorder: Opportunities within and beyond the serotonergic domain. Acta neuropsychiatrica. vol 9. issue 2. 2016-03-14. PMID:26972134. |
added to this was the evidence from the behavioral or physiological responses observed following serotonergic challenge with the serotonin agonists meta-chlorophenylpiperazine, a compound with high affinity for 5-ht1a-, 5-ht1d- and 5-ht2c-receptors. |
2016-03-14 |
2023-08-13 |
Not clear |
| Jill S Carmody, Nadia N Ahmad, Sriram Machineni, Scott Lajoie, Lee M Kapla. Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice. Endocrinology. vol 156. issue 9. 2015-11-17. PMID:26066076. |
consistent with this hypothesis, wild-type rygb-treated mice lost additional weight after the administration of the serotonergic drugs fenfluramine and meta-chlorophenylpiperazine but not the nonserotonergic agent topiramate. |
2015-11-17 |
2023-08-13 |
mouse |
| Mark C Tucci, Anna Dvorkin-Gheva, Renee Sharma, Leena Taji, Paul Cheon, John Peel, Ashley Kirk, Henry Szechtma. Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD). Psychopharmacology. vol 231. issue 18. 2015-09-10. PMID:24682503. |
acute administration of serotonergic agonist, meta-chlorophenylpiperazine (mcpp), attenuates performance of compulsive checking in an animal model of obsessive-compulsive disorder (ocd). |
2015-09-10 |
2023-08-12 |
rat |
| Mirella Nardo, Plinio C Casarotto, Felipe V Gomes, Francisco S Guimarãe. Cannabidiol reverses the mCPP-induced increase in marble-burying behavior. Fundamental & clinical pharmacology. vol 28. issue 5. 2015-05-14. PMID:24118015. |
meta-chloro-phenyl-piperazine (mcpp) is a nonspecific serotonergic agonist (acting mainly at 5ht1a, 5ht2c and 5ht1d receptors) reported to increase symptoms in ocd patients and block the anticompulsive-like effect of serotonin reuptake inhibitors (sris) in animal models. |
2015-05-14 |
2023-08-12 |
Not clear |
| I M Szeto, M E Payne, A Jahan-Mihan, J Duan, G H Anderso. Multivitamin supplementation during pregnancy alters body weight and macronutrient selection in Wistar rat offspring. Journal of developmental origins of health and disease. vol 1. issue 6. 2014-08-22. PMID:25142010. |
intake regulation by the serotonergic system was determined by measuring food choice daily for 7 weeks, and following tryptophan (trp) or mcpp (a serotonin receptor agonist) injections at 4 and 6 weeks post-weaning. |
2014-08-22 |
2023-08-13 |
rat |
| Andrew E Arrant, Elizabeth Coburn, Jacob Jacobsen, Cynthia M Kuh. Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats. Neuropharmacology. vol 73. 2014-08-13. PMID:23774134. |
we investigated serotonergic modulation of anxiety-like behavior in adolescent (pn28-32) and adult (pn67-73) male rats using the ssri fluoxetine, the 5-ht(1a) agonist 8-oh dpat, and the 5-ht₂ agonist mcpp. |
2014-08-13 |
2023-08-12 |
rat |
| Mark C Tucci, Anna Dvorkin-Gheva, Dawn Graham, Sean Amodeo, Paul Cheon, Ashley Kirk, John Peel, Leena Taji, Henry Szechtma. Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD). Psychopharmacology. vol 227. issue 2. 2013-10-28. PMID:23354534. |
effects of the serotonergic agonist mcpp on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (ocd). |
2013-10-28 |
2023-08-12 |
rat |
| Mark C Tucci, Anna Dvorkin-Gheva, Dawn Graham, Sean Amodeo, Paul Cheon, Ashley Kirk, John Peel, Leena Taji, Henry Szechtma. Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD). Psychopharmacology. vol 227. issue 2. 2013-10-28. PMID:23354534. |
the serotonergic agonist, meta-chlorophenylpiperazine (mcpp), produces inconsistent effects on obsessive-compulsive disorder (ocd) symptoms, perhaps because clinical studies have not utilized a homogenous ocd subgroup of patients. |
2013-10-28 |
2023-08-12 |
rat |
| Saima Khaliq, Saida Haider, Sadia Saleem, Zahida Memon, Darakhshan J Halee. Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 22. issue 2. 2012-06-21. PMID:22313641. |
influence of serotonergic 5-ht2c receptor antagonist mesulergine in the reversal of memory deficits induced by mcpp. |
2012-06-21 |
2023-08-12 |
Not clear |
| John C Umhau, Melanie L Schwandt, Julie Usala, Christopher Geyer, Erick Singley, David T George, Markus Heili. Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 6. 2012-02-09. PMID:21289601. |
we evaluated two pharmacological challenges, the α(2)-adrenergic antagonist yohimbine, which reinstates alcohol seeking in rats, and the serotonergic compound meta-chlorophenylpiperazine (mcpp), previously reported to increase alcohol craving in alcoholics. |
2012-02-09 |
2023-08-12 |
human |
| Carl L Faingold, Marcus Randall, Yashanad Mhaskar, Victor V Uteshe. Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice. Brain research. vol 1418. 2012-01-30. PMID:21920504. |
this study examined the effects of a 5-ht(2b/2c) agonist (m-chlorophenylpiperazine, mcpp) to test the generality of serotonergic effects on dba mice. |
2012-01-30 |
2023-08-12 |
mouse |
| Minoru Miyazato, Yasuhiro Kaiho, Izumi Kamo, Takeya Kitta, Michael B Chancellor, Kimio Sugaya, Yoichi Arai, William C de Groat, Naoki Yoshimur. Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats. American journal of physiology. Renal physiology. vol 297. issue 4. 2009-10-27. PMID:19640898. |
to clarify the role of spinal serotonergic mechanisms in preventing stress urinary incontinence (sui) during sneezing, we investigated the effect of intrathecal (it) application of 8-oh-dpat (a 5-ht(1a) agonist), mcpp (a 5-ht(2b/2c) agonist), and fluoxetine (a serotonin reuptake inhibitor) using a rat model that can examine the neurally evoked continence reflex during sneezing. |
2009-10-27 |
2023-08-12 |
rat |
| Ramamoorthy Rajkumar, Dilip Kumar Pandey, Radhakrishnan Mahesh, Raghuraman Radh. 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay. European journal of pharmacology. vol 608. issue 1-3. 2009-06-24. PMID:19269287. |
1-(m-chlorophenyl)piperazine (mcpp) has a fairly complex neuropsychopharmacological profile owing to its affinity to multiple serotonergic receptors. |
2009-06-24 |
2023-08-12 |
mouse |
| Ramamoorthy Rajkumar, Dilip Kumar Pandey, Radhakrishnan Mahesh, Raghuraman Radh. 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay. European journal of pharmacology. vol 608. issue 1-3. 2009-06-24. PMID:19269287. |
finally, the mcpp induced depression-like behaviour in rodents is envisaged as a modified antidepressant assay to identify novel serotonergic antidepressants. |
2009-06-24 |
2023-08-12 |
mouse |
| Jean-Luc Puel, Matthieu J Guitto. Salicylate-induced tinnitus: molecular mechanisms and modulation by anxiety. Progress in brain research. vol 166. 2008-01-10. PMID:17956778. |
interestingly, application of nmda antagonists onto the round window membrane abolished tinnitus, even in animals receiving a treatment with the anxiogenic serotonergic agent meta-chlorophenylpiperazine (mcpp). |
2008-01-10 |
2023-08-12 |
Not clear |
| Chris-Ellyn Johanson, Marlyne Kilbey, Kristin Gatchalian, Manuel Tance. Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo. Drug and alcohol dependence. vol 81. issue 1. 2006-04-13. PMID:15975736. |
to parallel animal studies, the participants in the present study were trained to discriminate among a prototypic dopaminergic agonist, d-amphetamine, a prototypic serotonergic agonist, meta-chlorophenylpiperazine (mcpp) and placebo and then were tested with two doses of mdma. |
2006-04-13 |
2023-08-12 |
human |