| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D W Robertson, W Bloomquist, D T Wong, M L Cohe. mCPP but not TFMPP is an antagonist at cardiac 5HT3 receptors. Life sciences. vol 50. issue 8. 1992-03-12. PMID:1736030. |
the prototypic arylpiperazines, meta-chlorophenylpiperazine (mcpp), meta-trifluoromethylphenylpiperazine (tfmpp) and quipazine are widely studied serotonergic ligands with nonselective effects at 5ht1 and 5ht2 receptor subtypes. |
1992-03-12 |
2023-08-11 |
rat |
| E Klein, J Zohar, M F Geraci, D L Murphy, T W Uhd. Anxiogenic effects of m-CPP in patients with panic disorder: comparison to caffeine's anxiogenic effects. Biological psychiatry. vol 30. issue 10. 1992-02-06. PMID:1756202. |
the behavioral and neuroendocrine effects of meta-chlorophenylpiperazine (m-cpp), a serotonergic agonist, were compared with the effects of caffeine, an adenosine antagonist, in panic disorder patients. |
1992-02-06 |
2023-08-11 |
Not clear |
| U Freo, D M Larson, T Tolliver, S I Rapoport, T T Soncran. Parachloroamphetamine selectively alters regional cerebral metabolic responses to the serotonergic agonist metachlorophenylpiperazine in rats. Brain research. vol 544. issue 1. 1991-08-29. PMID:1713115. |
selective abolition by pca of the metabolic response to mcpp confirms that mcpp, at the dose studied, reduces rcmrglc in the forebrain via a presynaptic mechanism and that postsynaptic serotonergic function is not altered by pca. |
1991-08-29 |
2023-08-11 |
rat |
| N J Leidenheimer, M D Schechte. Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142. Pharmacology, biochemistry, and behavior. vol 38. issue 3. 1991-08-13. PMID:1648746. |
consistent with the serotonergic properties of thbc, administration of the 5ht1b agonists tfmpp and mcpp to thbc-trained rats resulted in thbc-appropriate responding. |
1991-08-13 |
2023-08-11 |
rat |
| N J Leidenheimer, M D Schechte. Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142. Pharmacology, biochemistry, and behavior. vol 38. issue 3. 1991-08-13. PMID:1648746. |
this generalization was not based upon the serotonergic properties of thbc and norharmane since administration of the serotonin agonist mcpp to fg 7142-trained rats failed to produce fg 7142-appropriate responding. |
1991-08-13 |
2023-08-11 |
rat |
| E Hollander, C DeCaria, R Gully, A Nitescu, R F Suckow, J M Gorman, D F Klein, M R Liebowit. Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine in obsessive-compulsive disorder. Psychiatry research. vol 36. issue 1. 1991-05-23. PMID:2017519. |
to investigate the effect of fluoxetine on serotonergic sensitivity in obsessive-compulsive disorder (ocd), the partial serotonin agonist metachlorophenylpiperazine (mcpp) was compared to placebo under double-blind conditions in six patients with ocd before and during treatment with fluoxetine. |
1991-05-23 |
2023-08-11 |
Not clear |
| L Zhang, D C Dye. Receptor mechanisms for 5-hydroxytryptamine (5-HT) in isolated ovine umbilical vein. European journal of pharmacology. vol 184. issue 2-3. 1991-04-26. PMID:1981873. |
the order of potency of serotonergic agonists in this tissue was: dom greater than 5-ht greater than alpha-methyl-5-ht greater than 1(3-chlorophenyl) piperazine (mcpp) greater than m-trifluoromethyl-phenylpiperazine (tfmpp) greater than 8-hydroxy-dipropylaminotetralin (8-oh-dpat) = 2-methyl-5-ht. |
1991-04-26 |
2023-08-11 |
Not clear |
| U Halbreic. Gonadal hormones and antihormones, serotonin and mood. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274628. |
the cortisol and prolactin responses to tryptophan were blunted during the late luteal phase compared with the midfollicular phase, and the cortisol, but not prolactin, responses to the serotonergic agonist 1-(m-chlorophenyl) piperazine, (mcpp) was also blunted during that period. |
1991-02-26 |
2023-08-11 |
Not clear |
| W Janusz, Z Kleinro. The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms. Neuroscience research. vol 7. issue 2. 1990-03-08. PMID:2533336. |
other agents specifically affecting serotonergic receptors, the agonists 1-(3-chlorophenyl)piperazine (mcpp) and 5-methoxytryptamine (5-mt) and the antagonists spiperone, metergoline, methysergide, cyproheptadine and metoclopramide, did not influence pilocarpine-induced seizures. |
1990-03-08 |
2023-08-11 |
rat |
| J W Boja, M D Schechte. Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation. Pharmacology, biochemistry, and behavior. vol 31. issue 2. 1989-06-06. PMID:3244707. |
the serotonergic agonists mcpp, doi, 5-meodmt and lsd generalized to 1.4 mg/kg nf, whereas neither tfmpp nor 8-ohdpat generalized to nf. |
1989-06-06 |
2023-08-11 |
rat |
| E Wallis, D H Overstreet, A D Crocke. Selective breeding for increased cholinergic function: increased serotonergic sensitivity. Pharmacology, biochemistry, and behavior. vol 31. issue 2. 1989-06-06. PMID:3244712. |
the effects of the serotonergic antagonist cyproheptadine and the agonist 1(m-chlorophenyl) piperazine (mcpp) on core body temperature, locomotor activity and operant responding for a water reward were determined in two lines of sprague-dawley rats selectively bred for differences in sensitivity to the anticholinesterase, diisopropyl fluorophosphate (dfp). |
1989-06-06 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
conversely, using identical ejection parameters, ipsapirone and ly 165163 (previously reported) and 8-oh-dpat were as effective as 5-ht in inhibiting markedly the baseline activity of serotonergic dorsal raphe neurons; mcpp and tfmpp (previously reported) were only weakly active. |
1988-10-24 |
2023-08-11 |
rat |
| J Zohar, T R Insel, R C Zohar-Kadouch, J L Hill, D L Murph. Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment. Archives of general psychiatry. vol 45. issue 2. 1988-02-24. PMID:3276283. |
to investigate whether clomipramine treatment in ocd affects brain serotonergic responsiveness, metachlorophenylpiperazine (mcpp), a selective serotonin agonist, and placebo were given under double-blind conditions to nine patients with ocd before and after treatment with clomipramine. |
1988-02-24 |
2023-08-11 |
Not clear |
| J Zohar, T R Insel, R C Zohar-Kadouch, J L Hill, D L Murph. Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment. Archives of general psychiatry. vol 45. issue 2. 1988-02-24. PMID:3276283. |
these findings are consistent with the development of adaptive subsensitivity to the serotonergic agonist mcpp during clomipramine treatment. |
1988-02-24 |
2023-08-11 |
Not clear |
| M L Cohen, K D Kurz, R W Fulle. Effect of meta-chlorophenylpiperazine (mCPP), a central serotonin agonist and vascular serotonin receptor antagonist, on blood pressure in SHR. Clinical and experimental hypertension. Part A, Theory and practice. vol 9. issue 10. 1988-01-21. PMID:3677442. |
although mcpp could be demonstrated to activate central serotonergic receptors and block peripheral vascular 5ht2 receptors, mcpp (10 and 30 mg/kg, i.p.) |
1988-01-21 |
2023-08-11 |
rat |
| J Zohar, E A Mueller, T R Insel, R C Zohar-Kadouch, D L Murph. Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls. Archives of general psychiatry. vol 44. issue 11. 1987-11-30. PMID:3675134. |
to examine the "serotonin hypothesis" of obsessive-compulsive disorder (ocd), we studied the behavioral and neuroendocrine effects of metachlorophenylpiperazine (mcpp), a serotonergic agonist, in patients with ocd and healthy controls. |
1987-11-30 |
2023-08-11 |
Not clear |
| J A Aloi, T R Insel, E A Mueller, D L Murph. Neuroendocrine and behavioral effects of m-chlorophenylpiperazine administration in rhesus monkeys. Life sciences. vol 34. issue 14. 1984-05-17. PMID:6708733. |
these data suggest that mcpp has prominent neuroendocrine and behavioral effects which are mediated, in part, by serotonergic mechanisms. |
1984-05-17 |
2023-08-12 |
monkey |
| P Preziosi, F Cerrito, M Vacc. Effects of naloxone on the secretion of prolactin and corticosterone induced by 5-hydroxytryptophan and a serotonergic agonist, mCPP. Life sciences. vol 32. issue 21. 1983-07-08. PMID:6602260. |
effects of naloxone on the secretion of prolactin and corticosterone induced by 5-hydroxytryptophan and a serotonergic agonist, mcpp. |
1983-07-08 |
2023-08-12 |
rat |
| R Samanin, S Caccia, C Bendotti, F Borsini, E Borroni, R Invernizzi, R Pataccini, T Mennin. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology. vol 68. issue 1. 1980-09-28. PMID:6771803. |
4-(3-indolyl-2-ethyl) piperidine (lm 5008), 2-(1-piperazinyl) quinoline (quipazine), and metachlorophenylpiperazine (mcpp) were studied for their ability to affect serotonergic mechanisms in vitro. |
1980-09-28 |
2023-08-12 |
rat |