| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Buydens-Branchey, M Branchey, P Fergeson, J Hudson, C McKerni. The meta-chlorophenylpiperazine challenge test in cocaine addicts: hormonal and psychological responses. Biological psychiatry. vol 41. issue 11. 1997-07-22. PMID:9146818. |
we report on the neuroendocrine and psychological responsivity of 31 cocaine addicts and 14 controls to the serotonergic agonist, meta-chlorophenylpiperazine (m-cpp) (0.5 mg/kg p.o.). |
1997-07-22 |
2023-08-12 |
human |
| R D Levitan, A S Kaplan, R T Joffe, A J Levitt, G M Brow. Hormonal and subjective responses to intravenous meta-chlorophenylpiperazine in bulimia nervosa. Archives of general psychiatry. vol 54. issue 6. 1997-06-27. PMID:9193192. |
our goal was to further examine central serotonergic function in bulimic patients using neuroendocrine and subjective responses to the postsynaptic serotonin receptor agonist meta-chlorophenylpiperazine (mcpp). |
1997-06-27 |
2023-08-12 |
Not clear |
| P J Schwartz, D L Murphy, T A Wehr, D Garcia-Borreguero, D A Oren, D E Moul, N Ozaki, A J Snelbaker, N E Rosentha. Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects. Diurnal responses and nocturnal regulatory mechanisms. Archives of general psychiatry. vol 54. issue 4. 1997-04-25. PMID:9107154. |
previously, we found that the serotonergic agent meta-chlorophenylpiperazine (m-cpp) produced increases in activation and euphoria in depressed patients with sad, but not in patients with sad following light treatment or in the summer, nor in healthy control subjects in any condition. |
1997-04-25 |
2023-08-12 |
human |
| L Buydens-Branchey, M Branchey, P Fergeson, J Hudson, C McKerni. Craving for cocaine in addicted users. Role of serotonergic mechanisms. The American journal on addictions. vol 6. issue 1. 1997-04-04. PMID:9097873. |
the authors evaluated whether the acute increase in serotonergic neurotransmission after the administration of a challenging dose of the 5-ht partial agonist meta-chlorophenylpiperazine (m-cpp) had an effect on spontaneous cocaine craving. |
1997-04-04 |
2023-08-12 |
Not clear |
| S Wetzler, G M Asnis, J M DeLecuona, O Kalu. Serotonin function in panic disorder: intravenous administration of meta-chlorophenylpiperazine. Psychiatry research. vol 64. issue 2. 1997-02-21. PMID:8912948. |
differences between intravenous and oral administration of mcpp are discussed, and the present findings are related to the serotonergic hypothesis of panic disorder. |
1997-02-21 |
2023-08-12 |
human |
| T J Zethof, J A Van der Heyden, J T Tolboom, B Olivie. Stress-induced hyperthermia as a putative anxiety model. European journal of pharmacology. vol 294. issue 1. 1997-02-12. PMID:8788424. |
antidepressants (desipramine, fluvoxamine, nomifensine, tianeptine, amitriptyline, clomipramine, imipramine), serotonergic ligands (ondansetron, ketanserin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), fenfluramine, metachlorophenylpiperazine (mcpp), eltoprazine) and various other drugs (phenobarbital, pentetrazol, haloperidol, apomorphine, amphetamine, (+)-n-[1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-3( r)-yl]- n'-(3-methylphenyl)urea (msd 365260), dizocilpine and acetyl salicylic acid) had no anxiolytic activity. |
1997-02-12 |
2023-08-12 |
mouse |
| J Benjamin, B D Greenberg, D L Murph. Daily administration of m-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects. Psychopharmacology. vol 127. issue 2. 1997-01-07. PMID:8888380. |
the serotonergic agent meta-chlorophenylpiperazine (m-cpp) increases temperature and plasma acth and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-ht2c receptors. |
1997-01-07 |
2023-08-12 |
human |
| P J Schwartz, T A Wehr, N E Rosenthal, J J Bartko, D A Oren, C Luetke, D L Murph. Serotonin and thermoregulation. Physiologic and pharmacologic aspects of control revealed by intravenous m-CPP in normal human subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 2. 1996-04-25. PMID:8597522. |
meta-chlorophenylpiperazine (m-cpp), a probe of central serotonergic function, elevates core temperature in rodents, nonhuman primates, and humans via serotonin receptor-mediated mechanisms. |
1996-04-25 |
2023-08-12 |
human |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
these effects have been attributed to the interaction of mcpp with serotonergic receptors. |
1995-10-03 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
the present study was designed to characterize those interactions of mcpp with central serotonergic receptors which mediate mcpp-induced stimulus control. |
1995-10-03 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
a series of serotonergic antagonists (mesulergine, pizotyline, ketanserin, spiperone, risperidone, ritanserin, metergoline, pirenpirone, and ly53857) was tested for the ability to block the mcpp stimulus. |
1995-10-03 |
2023-08-12 |
Not clear |
| U Halbreich, N Rojansky, S Palter, H Tworek, P Hissin, K Wan. Estrogen augments serotonergic activity in postmenopausal women. Biological psychiatry. vol 37. issue 7. 1995-07-27. PMID:7786956. |
to investigate the influence of estrogen replacement on serotonergic activity in postmenopausal women, the serotonin agonist meta-chlorophenylpiperazine (m-cpp) (0.5 mg/kg) was given orally to 18 normal postmenopausal women, 11 of whom were also tested following 30 days' treatment with estrogen transdermal patches (estraderm 0.1 mg). |
1995-07-27 |
2023-08-12 |
Not clear |
| J H Krystal, E Webb, N Cooney, H R Kranzler, D S Charne. Specificity of ethanollike effects elicited by serotonergic and noradrenergic mechanisms. Archives of general psychiatry. vol 51. issue 11. 1994-11-16. PMID:7944878. |
this study evaluated the specificity of the ethanollike effects of the serotonergic receptor partial agonist m-chlorophenylpiperazine hydrochloride (mcpp) relative to the alpha 2-adrenergic receptor antagonist yohimbine hydrochloride and the placebo in recently detoxified alcoholics. |
1994-11-16 |
2023-08-12 |
Not clear |
| A Anand, D S Charney, P L Delgado, C J McDougle, G R Heninger, L H Pric. Neuroendocrine and behavioral responses to intravenous m-chlorophenylpiperazine (mCPP) in depressed patients and healthy comparison subjects. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943451. |
this double-blind study was undertaken to compare central serotonergic function in depressed patients and healthy comparison subjects by examining neuroendocrine and mood responses to intravenous infusion of the serotonin agonist m-chlorophenylpiperazine (mcpp). |
1994-11-15 |
2023-08-12 |
human |
| S J Cooper, D J Barbe. Evidence for serotonergic involvement in saccharin preference in a two-choice test in rehydrating rats. Pharmacology, biochemistry, and behavior. vol 47. issue 3. 1994-07-11. PMID:8208772. |
several direct acting serotonergic receptor agonists (putatively agonists at the 5-ht2c receptor), mk212, mcpp, and tfmpp, respectively, blocked the saccharin taste preference normally exhibited in this test. |
1994-07-11 |
2023-08-12 |
rat |
| L A Rosenblum, J D Coplan, S Friedman, T Bassoff, J M Gorman, M W Andrew. Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates. Biological psychiatry. vol 35. issue 4. 1994-06-17. PMID:8186327. |
when the offspring were young adults, these early manipulations were related to differences in behavioral response to acute administration of two putative anxiety-provoking agents: the noradrenergic probe, yohimbine, and the serotonergic probe, mcpp. |
1994-06-17 |
2023-08-12 |
Not clear |
| S J Cooper, R Ciccociopp. Effects of selective 5-HT1 receptor agonists in water-deprived rats on salt intake in two-choice tests. Pharmacology, biochemistry, and behavior. vol 45. issue 3. 1993-08-19. PMID:8332610. |
one interpretation of these results is to assume that the 5-ht1a agonists act at inhibitory autoreceptors to diminish central serotonergic activity, while mcpp and tfmpp act postsynaptically to enhance serotonergic activity. |
1993-08-19 |
2023-08-12 |
rat |
| J C Winter, R A Rabi. Discriminative stimulus properties of m-chlorophenylpiperazine. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516361. |
in addition, because of mcpp's relative selectivity for the 5-hydroxytryptamine c(5-ht1c) receptor subjects trained with mcpp may prove valuable in assessing the respective functional contributions of 5-ht1c sites to the actions of a variety of serotonergic agents. |
1993-07-19 |
2023-08-12 |
human |
| T A Pigott, J L Hill, T A Grady, F L'Heureux, S Bernstein, C S Rubenstein, D L Murph. A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biological psychiatry. vol 33. issue 1. 1993-02-18. PMID:8420593. |
in prior studies form three centers, an exacerbation of obsessive-compulsive disorder (ocd) symptoms was reported in some (55%-83%) patients with ocd receiving the serotonergic agonist m-chlorophenylpiperazine (m-cpp) orally, whereas intravenously administered mcpp produced anxiety but no ocd symptom exacerbation. |
1993-02-18 |
2023-08-12 |
Not clear |
| R S Kahn, L J Siever, S Gabriel, F Amin, R G Stern, K DuMont, S Apter, M Davidso. Serotonin function in schizophrenia: effects of meta-chlorophenylpiperazine in schizophrenic patients and healthy subjects. Psychiatry research. vol 43. issue 1. 1992-12-09. PMID:1332094. |
the 5ht agonist meta-chlorophenylpiperazine (mcpp) was used as a probe of serotonergic function. |
1992-12-09 |
2023-08-11 |
human |