| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A E Frampton, J C H Andrews, A Parfitt, I A Jagroop, D P Mikhailidis, J A Henr. Does meta-chlorophenylpiperazine (mCPP) activate human platelets? Platelets. vol 17. issue 1. 2006-03-29. PMID:16308184. |
mcpp (meta-chlorophenylpiperazine), an agonist at serotonin (5-hydroxytryptamine, 5-ht) 5-ht2 receptors, has been used as a probe of serotonergic function. |
2006-03-29 |
2023-08-12 |
human |
| Frederico G Graeff, Cybele Garcia-Leal, Cristina M Del-Ben, Francisco S Guimarãe. Does the panic attack activate the hypothalamic-pituitary-adrenal axis? Anais da Academia Brasileira de Ciencias. vol 77. issue 3. 2005-10-20. PMID:16127553. |
pharmacological agents that increased anxiety in both normal subjects and panic patients raised stress hormone levels; among them are the alpha2-adrenergic antagonist yohimbine, the serotonergic agents 1-(m-chlorophenyl) piperazine (mcpp) and fenfluramine, as well as the psychostimulant agent caffeine. |
2005-10-20 |
2023-08-12 |
human |
| Methvin Isaa. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Current topics in medicinal chemistry. vol 5. issue 1. 2005-04-06. PMID:15638778. |
more specifically, the recent finding that the 5-ht2b/2c receptor agonist, 1-(m-chlorophenyl)-piperazine (mcpp) is anticonvulsant has kindled an interest into the investigation of the serotonergic 5-ht2c receptor subtype as a potential target for the treatment of epilepsy. |
2005-04-06 |
2023-08-12 |
Not clear |
| H J Gijsman, A F Cohen, J M A van Gerve. The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system. Journal of psychopharmacology (Oxford, England). vol 18. issue 1. 2004-08-30. PMID:15107176. |
to exemplify the possible usefulness of this approach, we apply it to meta-chlorophenylpiperazine, one of the most commonly used drugs in serotonergic challenge tests. |
2004-08-30 |
2023-08-12 |
Not clear |
| Neera Ghaziuddin, Kathy Welch, John Grede. Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496949. |
central serotonergic effects of m-chlorophenylpiperazine (mcpp) among normal control adolescents. |
2003-03-17 |
2023-08-12 |
Not clear |
| Neera Ghaziuddin, Kathy Welch, John Grede. Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496949. |
a placebo-controlled design was used to measure three neuroendocrine hormones (prolactin, cortisol and growth hormone) following a challenge with the central serotonergic agonist m-chlorophenylpiperazine (mcpp). |
2003-03-17 |
2023-08-12 |
Not clear |
| Neera Ghaziuddin, Kathy Welch, John Grede. Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496949. |
we conclude that mcpp is useful in the study of serotonergic neuroendocrine hormones in adolescents, is well tolerated, and the levels of prolactin, cortisol and growth hormone are influenced by gender. |
2003-03-17 |
2023-08-12 |
Not clear |
| S Erzegovesi, L Martucci, M Henin, L Bellod. Low versus standard dose mCPP challenge in obsessive-compulsive patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 1. 2001-01-18. PMID:11106873. |
in several reports, the acute oral administration of the partial serotonergic agonist meta-chlorophenylpiperazine (mcpp) in dose of 0. |
2001-01-18 |
2023-08-12 |
human |
| T Terao, J Nakamura, R Yoshimura, O Ohmori, N Takahashi, H Kojima, S Soeda, T Shinkai, H Nakano, T Okun. Relationship between serum cholesterol levels and meta-chlorophenylpiperazine-induced cortisol responses in healthy men and women. Psychiatry research. vol 96. issue 2. 2001-01-11. PMID:11063789. |
we investigated the effect of cholesterol on serotonergic receptor function in 20 healthy male and 10 healthy female subjects using cortisol responses to meta-chlorophenylpiperazine (m-cpp) neuroendocrine challenge tests. |
2001-01-11 |
2023-08-12 |
human |
| T Terao, J Nakamura, R Yoshimura, O Ohmori, N Takahashi, T Shinka. Prediction of lithium response using. m-chlorophenylpiperazine challenge test: A preliminary finding. International clinical psychopharmacology. vol 15. issue 1. 2000-09-25. PMID:10836285. |
as a preliminary study, we investigated the relationship between several responses to meta-chlorophenylpiperazine (a serotonergic agonist) reflecting the serotonergic receptor function and the clinical lithium response of 10 patients. |
2000-09-25 |
2023-08-12 |
human |
| M Leone, A Attanasio, D Croci, G Filippini, D D'Amico, L Grazzi, A Nespolo, G Busson. The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study. Neurology. vol 55. issue 1. 2000-08-07. PMID:10891925. |
in a double-blind study versus placebo, the serotonergic agent m-chlorophenylpiperazine (mcpp) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mcpp (0.5 mg/kg) to induce typical migraine attacks. |
2000-08-07 |
2023-08-12 |
human |
| T Rinne, H G Westenberg, J A den Boer, W van den Brin. Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. Biological psychiatry. vol 47. issue 6. 2000-05-16. PMID:10715361. |
serotonergic blunting to meta-chlorophenylpiperazine (m-cpp) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. |
2000-05-16 |
2023-08-12 |
Not clear |
| E Mundo, S R Bareggi, R Pirola, L Bellod. Effect of acute intravenous clomipramine and antiobsessional response to proserotonergic drugs: is gender a predictive variable? Biological psychiatry. vol 45. issue 3. 1999-05-07. PMID:10023504. |
previous studies on serotonergic responsivity in obsessive-compulsive disorder (ocd) showed about 50% of patients experiencing an acute worsening of oc symptoms when administered meta-chlorophenylpiperazine or i.v. |
1999-05-07 |
2023-08-12 |
Not clear |
| A Broocks, T Meyer, A George, U Hillmer-Vogel, D Meyer, B Bandelow, G Hajak, U Bartmann, C H Gleiter, E Rüthe. Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 2. 1999-03-29. PMID:9885795. |
to study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-cpp, 0.4 mg/kg), ipsapirone (0.3 mg/kg) and placebo in 12 marathon runners and 12 healthy controls not practicing regular exercise. |
1999-03-29 |
2023-08-12 |
Not clear |
| N Takeshita, I Yamaguch. Antinociceptive effects of morphine were different between experimental and genetic diabetes. Pharmacology, biochemistry, and behavior. vol 60. issue 4. 1998-11-12. PMID:9700973. |
the serotonergic agonist, meta-chlorophenylpiperazine (0.32-3.2 mg/kg, po), dose dependently attenuated the biphasic nociceptive responses to formalin in both phases of diabetic mice; however, fr64822, a dopaminergic compound (0.1-10 mg/kg, po), had little effect. |
1998-11-12 |
2023-08-12 |
mouse |
| T Klaassen, K L Ho Pian, H G Westenberg, J A den Boer, H M van Praa. Serotonin syndrome after challenge with the 5-HT agonist meta-chlorophenylpiperazine. Psychiatry research. vol 79. issue 3. 1998-11-02. PMID:9704867. |
meta-chlorophenylpiperazine (mcpp) is a non-selective 5-ht-receptor agonist/antagonist that is used extensively in psychiatry to assess central serotonergic function. |
1998-11-02 |
2023-08-12 |
human |
| J Gommans, T H Hijzen, R A Maes, B Olivie. Discriminative stimulus properties of mCPP: evidence for a 5-HT2C receptor mode of action. Psychopharmacology. vol 137. issue 3. 1998-10-28. PMID:9683007. |
previous drug discrimination studies with the serotonergic drug m-chlorophenylpiperazine (mcpp) showed conflicting results, with some authors concluding that the cue was mediated by 5-ht2c receptors, but others that it was definitively not. |
1998-10-28 |
2023-08-12 |
rat |
| H J Gijsman, J M Van Gerven, M C Tieleman, R C Schoemaker, M S Pieters, M D Ferrari, A F Cohen, G M Van Kempe. Pharmacokinetic and pharmacodynamic profile of oral and intravenous meta-chlorophenylpiperazine in healthy volunteers. Journal of clinical psychopharmacology. vol 18. issue 4. 1998-10-28. PMID:9690694. |
meta-chlorophenylpiperazine (mcpp) is a compound that is frequently used in challenge tests of the serotonergic system. |
1998-10-28 |
2023-08-12 |
human |
| S M Southwick, J H Krystal, J D Bremner, C A Morgan, A L Nicolaou, L M Nagy, D R Johnson, G R Heninger, D S Charne. Noradrenergic and serotonergic function in posttraumatic stress disorder. Archives of general psychiatry. vol 54. issue 8. 1997-09-16. PMID:9283511. |
in the present study, yohimbine was used as a probe of noradrenergic activity, and meta-chlorophenylpiperazine (m-cpp) as a probe of serotonergic activity. |
1997-09-16 |
2023-08-12 |
Not clear |
| L Buydens-Branchey, M Branchey, P Fergeson, J Hudson, C McKerni. Hormonal, psychological, and alcohol craving changes after m-chlorophenylpiperazine administration in alcoholics. Alcoholism, clinical and experimental research. vol 21. issue 2. 1997-07-22. PMID:9113256. |
to assess the serotonergic function of alcoholics, their neuroendocrine and psychological responsivities to the serotonergic partial agonist meta-chlorophenylpiperazine (m-cpp) was compared with the responsitivity of healthy subjects. |
1997-07-22 |
2023-08-12 |
human |