| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Van Der Kooy, H C Fibiger, A G Phillip. An analysis of dorsal and median raphe self-stimulation: effects of parachlorophenylalanine. Pharmacology, biochemistry, and behavior. vol 8. issue 4. 1978-09-25. PMID:149989. |
intragastric administration of 400 mg/kg of parachlorophenylalanine (pcpa) depressed icss rates in the group with dorsal raphe electrode placements over a similar time course to the depletion of brain serotonin which results from treatment with pcpa. |
1978-09-25 |
2023-08-11 |
rat |
| W P Bullard, P B Guthrie, P V Russo, A J Mandel. Regional and subcellular distribution and some factors in the regulation of reduced pterins in rat brain. The Journal of pharmacology and experimental therapeutics. vol 206. issue 1. 1978-09-01. PMID:660556. |
in vitro measures of ph4, toh, and synaptosomal dopamine (da) and serotonin synthesis in the striate cortex of untreated animals and animals subjected to neurotoxin or electrolytic lesions of the dorsal raphe or substantia nigra exhibit significant covariation of ph4 with synaptosomal da but not serotonin synthesis and a significant partial correlation of ph4 with da synthesis. |
1978-09-01 |
2023-08-11 |
rat |
| D W Gallage. Benzodiazepines: potentiation of a GABA inhibitory response in the dorsal raphe nucleus. European journal of pharmacology. vol 49. issue 2. 1978-08-14. PMID:26577. |
based on evidence that the dorsal raphe nucleus (dr) has specific and independent receptors for 5ht, gaba and glycine (gallager and aghajanian, 1976; wang and aghajanian, 1977), alterations in the firing rate of dr neurons following the administration of benzodiazepines (bz) were evaluated to determine whether they were the result of a direct interaction with 5ht receptors or due to interactions of these drugs with gaba and/or glycine. |
1978-08-14 |
2023-08-11 |
rat |
| R J Bodnar, R F Ackermann, D D Kelly, M Glusma. Elevations in nociceptive thresholds following locus coeruleus lesions. Brain research bulletin. vol 3. issue 2. 1978-07-15. PMID:647413. |
serotonin depletion or lesions of the midbrain dorsal raphe nuclei attenuate both morphine-produced and stimulation-produced analgesia. |
1978-07-15 |
2023-08-11 |
Not clear |
| M Palkovits, M Brownstein, J S Kizer, J M Saavedra, I J Kopi. Effect of stress on serotonin concentration and tryptophan hydroxylase activity of brain nuclei. Neuroendocrinology. vol 22. issue 4. 1977-11-25. PMID:1032978. |
two h after formalin injection, 5-ht levels were increased in the dorsal raphe (rdn). |
1977-11-25 |
2023-08-11 |
rat |
| M Palkovits, J M Saavedra, D M Jacoboqitz, J S Kizer, L Záborszky, M J Brownstei. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain research. vol 130. issue 1. 1977-09-22. PMID:884514. |
concentrations of serotonin and tryptophan hydroxylase activity in individual hypothalamic and limbic nuclei, as well as cortical regions, were measured by radioenzymatic microassays after dorsal raphe nucleus lesions and various surgical transections of the brain stem. |
1977-09-22 |
2023-08-11 |
Not clear |
| M Palkovits, J M Saavedra, D M Jacoboqitz, J S Kizer, L Záborszky, M J Brownstei. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain research. vol 130. issue 1. 1977-09-22. PMID:884514. |
fourteen days after lesioning of the dorsal raphe nucleus there were 43-65% decreases in 5-ht concentrations of certain hypothalamic and limbic nuclei. |
1977-09-22 |
2023-08-11 |
Not clear |
| M Palkovits, J M Saavedra, D M Jacoboqitz, J S Kizer, L Záborszky, M J Brownstei. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain research. vol 130. issue 1. 1977-09-22. PMID:884514. |
there was no change in the 5-ht concentration of the spinal cord following dorsal raphe nucleus lesions. |
1977-09-22 |
2023-08-11 |
Not clear |
| S S Mosko, D Haubrich, B L Jacob. Serotonergic afferents to the dorsal raphe nucleus: evdience from HRP and synaptosomal uptake studies. Brain research. vol 119. issue 2. 1977-02-26. PMID:830388. |
afferent connections of the serotonin (5-ht)-containing dorsal raphe nucleus were investigated in the rat utilizing the horseradish peroxidase (hrp) retrograde cell labeling technique. |
1977-02-26 |
2023-08-11 |
rat |
| S S Mosko, D Haubrich, B L Jacob. Serotonergic afferents to the dorsal raphe nucleus: evdience from HRP and synaptosomal uptake studies. Brain research. vol 119. issue 2. 1977-02-26. PMID:830388. |
a serotonergic innervation of the dorsal raphe was also demonstrated by the presence of high affinity uptake of [3h]5-ht (km=0.17 mum) into synaptosomal suspensions of the dorsal raphe nucleus. |
1977-02-26 |
2023-08-11 |
rat |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10173. |
the activity of serotonergic (5ht) neurons in the dorsal raphe nucleus was inhibited by the i.v. |
1977-01-03 |
2023-08-11 |
Not clear |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10174. |
as reported in the preceding study, the ability of certain antipsychotic and adrenolytic agents to inhibit the spontaneous firing of serotonergic 5ht neurons in the dorsal raphe nucleus appeared to be related to adrenergic blocking efficacy. |
1977-01-03 |
2023-08-11 |
Not clear |
| M Smialowsk. Histofluorescence studies on the effect of 1,3-dimethyl-5-adamantanamine (D-145) on serotonin neurons in midbrain raphe nuclei. Polish journal of pharmacology and pharmacy. vol 28. issue 3. 1976-10-02. PMID:951305. |
spiroperidol, 2 mg/kg ip, given 5 min before d-145, prevented the depression of serotonin fluorescence in the dorsal raphe nucleus (ndr), but not in the other groups of serotonin midbrain neurons. |
1976-10-02 |
2023-08-11 |
rat |
| S A Lorens, H C Guldberg, K Hole, C Köhler, B Srebr. Activity, avoidance learning and regional 5-hydroxytryptamine following intra-brain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphe lesions in the rat. Brain research. vol 108. issue 1. 1976-08-23. PMID:1276894. |
variation in the pattern of regional 5-ht changes after 5,7-dht treatment was observed but appeared to be related to the adequacy of the dorsal raphe (b7) injection. |
1976-08-23 |
2023-08-11 |
rat |
| b' K Masek, O Kadlecov\\xc3\\xa1, P Petrovick\\xc3\\xb. The effect of some bacterial products on temperature and sleep in rat. Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie. vol 149. issue 2-4. 1975-12-30. PMID:126560.' |
small electrolytic lesions of the dorsal raphe nuclei which are the largest collection of neural cells containing 5-ht completely eliminated the pyrogenic potency of mucopeptide. |
1975-12-30 |
2023-08-11 |
rat |
| T H Svensson, B S Bunney, G K Aghajania. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain research. vol 92. issue 2. 1975-12-29. PMID:1174954. |
intravenous clonidine also inhibited the firing of the great majority of (5-ht) neurons in the midbrain dorsal raphe nucleus. |
1975-12-29 |
2023-08-11 |
Not clear |
| M Smialowsk. The effect of apomorphine on serotonin neurons in dorsal raphe nucleus and catecholamine nerve terminals in paraventricular hypothalamic nucleus. Histofluorescence studies. Polish journal of pharmacology and pharmacy. vol 27. issue 4. 1975-12-11. PMID:126447. |
the effect of apomorphine on serotonin neurons in dorsal raphe nucleus and catecholamine nerve terminals in paraventricular hypothalamic nucleus. |
1975-12-11 |
2023-08-11 |
rat |
| B Srebro, S A Loren. Behavioral effects of selective midbrain raphe lesions in the rat. Brain research. vol 89. issue 2. 1975-11-05. PMID:1148851. |
these reductions differed significantly from each other, and with previously reported data indicate that the dorsal raphe nucleus in the principal origin of forebrain 5-ht. |
1975-11-05 |
2023-08-11 |
rat |