| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramez Ghanbari, Mostafa El Mansari, Mohammed Shahid, Pierre Blie. Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19116183. |
this study electrophysiologically characterized the in vivo effects of asenapine at dorsal raphe nucleus (drn) and hippocampus serotonin-1a (5-ht(1a)), ventral tegmental area d(2), locus coeruleus 5-ht(2a,) and alpha(2)-adrenergic receptors in anesthetized rats. |
2009-05-20 |
2023-08-12 |
rat |
| Francis Rodriguez Bambico, Nhu-Tram Nguyen, Gabriella Gobb. Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19147333. |
these were associated with a decrease in the spontaneous firing activity (35.4%) as well as in the number of spontaneously active 5-ht neurons, and a desensitization of somatodendritic 5-ht1a autoreceptors in the dorsal raphe. |
2009-05-20 |
2023-08-12 |
rat |
| Stella Manta, Jianming Dong, Guy Debonnel, Pierre Blie. Optimization of vagus nerve stimulation parameters using the firing activity of serotonin neurons in the rat dorsal raphe. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19150228. |
optimization of vagus nerve stimulation parameters using the firing activity of serotonin neurons in the rat dorsal raphe. |
2009-05-20 |
2023-08-12 |
rat |
| Fokko J Bosker, Joost H A Folgering, Anatoliy V Gladkevich, Anne Schmidt, Marieke C G van der Hart, Jeffrey Sprouse, Johan A den Boer, Ben H C Westerink, Thomas I F H Cremer. Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors. Journal of neurochemistry. vol 108. issue 5. 2009-04-22. PMID:19166502. |
systemic administration of sb 258741 significantly reduced the effect of combined selective serotonin reuptake inhibitor and way 100.635 administration on extracellular 5-ht in the ventral hippocampus as well as 5-ht neuronal firing in the dorsal raphe nucleus. |
2009-04-22 |
2023-08-12 |
Not clear |
| Tyler Fortune, Diana I Luri. Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex. The Journal of comparative neurology. vol 513. issue 5. 2009-04-17. PMID:19226511. |
the soc receives a serotonergic innervation from the dorsal raphe, and serotonin has been implicated in auditory temporal processing within the brainstem and inferior colliculus. |
2009-04-17 |
2023-08-12 |
mouse |
| J L Lukkes, C H Summers, J L Scholl, K J Renner, G L Forste. Early life social isolation alters corticotropin-releasing factor responses in adult rats. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19010398. |
we tested the hypothesis that the stress of early life isolation enhances responses to crf in adulthood by determining the effect of crf infusions into the dorsal raphe nucleus (drn) on 5-ht release in the nucleus accumbens (nac) of adult rats using in vivo microdialysis. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
estrogen has been previously shown to have no effect on the inhibitory 5-ht 1a autoreceptor (5-ht(1a)) in the rat dorsal raphe nuclei (drn); however the regulation of the inhibitory 5-ht 1b autoreceptor (5-ht(1b)) in the midbrain raphe by estrogen has not yet been investigated. |
2009-04-15 |
2023-08-12 |
rat |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
interestingly, using in situ hybridization experiments indicated that trkb receptor mrna was expressed in the hippocampus and dorsal raphe nucleus in adult mice suggesting that the neurochemical and behavioral effects of intra-hippocampal bdnf injection can mobilize both pre- and post-synaptic elements of the brain 5-ht neurotransmission. |
2009-04-14 |
2023-08-12 |
mouse |
| Sabah Kelaï, Thibault Renoir, Laurent Chouchana, Françoise Saurini, Naïma Hanoun, Michel Hamon, Laurence Lanfume. Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. Journal of neurochemistry. vol 107. issue 6. 2009-04-09. PMID:19094059. |
alcoholism is a complex disorder involving, among others, the serotoninergic (5-ht) system, mainly regulated by 5-ht(1a) autoreceptors in the dorsal raphe nucleus. |
2009-04-09 |
2023-08-12 |
mouse |
| Sabah Kelaï, Thibault Renoir, Laurent Chouchana, Françoise Saurini, Naïma Hanoun, Michel Hamon, Laurence Lanfume. Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. Journal of neurochemistry. vol 107. issue 6. 2009-04-09. PMID:19094059. |
furthermore, ethanol intake produced both an increased potency (+45%) of ipsapirone to inhibit the firing of 5-ht neurons, and a raise (+35%) in 5-ht(1a) autoreceptor-mediated stimulation of [(35)s]gtp-gamma-s binding in the dorsal raphe nucleus. |
2009-04-09 |
2023-08-12 |
mouse |
| Christophe Lanteri, Sandra Jimena Hernández Vallejo, Lucas Salomon, Emilie Lucie Doucet, Gérard Godeheu, Yvette Torrens, Vanessa Houades, Jean-Pol Tassi. Inhibition of monoamine oxidases desensitizes 5-HT1A autoreceptors and allows nicotine to induce a neurochemical and behavioral sensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 4. 2009-04-08. PMID:19176807. |
complementary experiments with 8-ohdpat (8-hydroxy-dipropylamino-tetralin), a 5-ht(1a) receptor agonist, and analysis of 5-ht(1a) receptors expression in the dorsal raphe nucleus after a tranylcypromine injection indicate that maois contained in tobacco desensitize 5-ht(1a) autoreceptors to trigger the strong addictive properties of tobacco. |
2009-04-08 |
2023-08-12 |
mouse |
| Chanki Kim, Daejong Jeon, Young-Hoon Kim, C Justin Lee, Hyun Kim, Hee-Sup Shi. Deletion of N-type Ca(2+) channel Ca(v)2.2 results in hyperaggressive behaviors in mice. The Journal of biological chemistry. vol 284. issue 5. 2009-04-07. PMID:19004821. |
the dorsal raphe nucleus (drn), which contains serotonin neurons, is known to be involved in aggression in animals. |
2009-04-07 |
2023-08-12 |
mouse |
| Nasser Haddjeri, Pierre Blie. Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions. European journal of pharmacology. vol 600. issue 1-3. 2009-03-27. PMID:18930727. |
attenuated the responsiveness of dorsal raphe 5-ht(1a) autoreceptors, lesioning noradrenaline neurons with the neurotoxin n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4) prevented the enhancing action of a 2-day treatment with cp-96,345 on 5-ht neuronal firing, suggesting that tachykinin nk1 receptor antagonists influence 5-ht system via noradrenaline neurons independently of their firing rate. |
2009-03-27 |
2023-08-12 |
rat |
| Qiao Jun Zhang, Xin Liu, Jian Liu, Shuang Wang, Umar Ali, Zhong Heng Wu, Tao Wan. Subthalamic neurons show increased firing to 5-HT2C receptor activation in 6-hydroxydopamine-lesioned rats. Brain research. vol 1256. 2009-03-16. PMID:19133244. |
the subthalamic nucleus is innervated by 5-ht afferents from the dorsal raphe nucleus and expresses high density of 5-ht(2c) receptors. |
2009-03-16 |
2023-08-12 |
rat |
| Polina Petkova-Kirova, Angelina Rakovska, Galina Zaekova, Chiara Ballini, Laura Della Corte, Radomir Radomirov, Anikó Vágvölgy. Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders. Neurochemistry international. vol 53. issue 6-8. 2009-03-09. PMID:18835308. |
these effects are possibly mediated by interactions of neurotensin with neurons releasing da or 5-ht, projecting to the pfc from the ventrotegmental area (vta) and from the dorsal raphe nuclei (drn), respectively. |
2009-03-09 |
2023-08-12 |
rat |
| Marilyn J Duncan, Verda A Davi. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16150426. |
we have previously shown that pretreatment with a 5-ht(7) receptor antagonist, sb-269970-a, attenuated phase shifts induced by microinjections of serotonergic agonists in the hamster dorsal raphe (duncan, m.j., grear, k.e., hoskins, m.a. |
2009-01-26 |
2023-08-12 |
Not clear |
| Marilyn J Duncan, Verda A Davi. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16150426. |
although sb-269970-a is highly selective for the 5-ht(7) receptors, it has moderate affinity for the 5-ht(5a) receptors, which are present in the hamster dorsal raphe. |
2009-01-26 |
2023-08-12 |
Not clear |
| Marilyn J Duncan, Verda A Davi. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16150426. |
to further test whether the 5-ht(7) receptors mediate the phase shifting effect of serotonergic agonists in the dorsal raphe, we investigated the role of camp because this second messenger is increased by activation of the 5-ht(7) receptors but inhibited by activation of the 5-ht(5a) or 5-ht(1a) receptors. |
2009-01-26 |
2023-08-12 |
Not clear |
| Marilyn J Duncan, Verda A Davi. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16150426. |
the results showed that local administration of rp-camps (1 microm), a camp antagonist, significantly reduced the phase shift induced by the 5-ht(1a/5a/7) agonist, (r)-(+)8-hydroxy-2-(di-n-propylamino)tetralin (10 microm), microinjected into the dorsal raphe 6 h before lights off. |
2009-01-26 |
2023-08-12 |
Not clear |
| Marilyn J Duncan, Verda A Davi. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16150426. |
in the last experiment, microinjection of the dorsal raphe with way-100,635 (50 nm) before the 5-ht(1a/5a/7) agonist, 5-carboxyamidotryptamine (100 nm), did not significantly affect the phase shift. |
2009-01-26 |
2023-08-12 |
Not clear |