| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ouissame Mnie-Filali, Céline Faure, Mostafa El Mansari, Laura Lambás-Señas, Anne Bérod, Luc Zimmer, Connie Sánchez, Nasser Haddjer. R-citalopram prevents the neuronal adaptive changes induced by escitalopram. Neuroreport. vol 18. issue 15. 2007-11-20. PMID:17885600. |
in the dorsal raphe nucleus, a 2-week treatment with escitalopram (10 mg/kg/day, subcutaneous) did not modify the firing activity of 5-ht neurons, whereas a cotreatment with r-citalopram (20 mg/kg/day, subcutaneous) decreased it. |
2007-11-20 |
2023-08-12 |
rat |
| Francis Rodriguez Bambico, Noam Katz, Guy Debonnel, Gabriella Gobb. Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 43. 2007-11-08. PMID:17959812. |
then, using in vivo electrophysiology, we showed that low doses of win55,212-2 dose dependently enhanced dorsal raphe nucleus 5-ht neuronal activity through a cb1r-dependent mechanism. |
2007-11-08 |
2023-08-12 |
rat |
| Harvey Wong, Randy C Dockens, Lori Pajor, Suresh Yeola, James E Grace, Arlene D Stark, Rebecca A Taub, Frank D Yocca, Robert C Zaczek, Yu-Wen L. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 35. issue 8. 2007-11-02. PMID:17494642. |
after intravenous infusions to steady-state levels in plasma, 6-oh-buspirone and buspirone increased 5-hydroxytryptamine (ht)(1a) receptor occupancy in a concentration-dependent manner with ec(50) values of 1.0 +/- 0.3 and 0.38 +/- 0.06 microm in the dorsal raphe and 4.0 +/- 0.6 and 1.5 +/- 0.3 microm in the hippocampus, respectively. |
2007-11-02 |
2023-08-12 |
rat |
| Harvey Wong, Randy C Dockens, Lori Pajor, Suresh Yeola, James E Grace, Arlene D Stark, Rebecca A Taub, Frank D Yocca, Robert C Zaczek, Yu-Wen L. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 35. issue 8. 2007-11-02. PMID:17494642. |
both compounds appeared to be approximately 4-fold more potent in occupying presynaptic 5-ht(1a) receptors in the dorsal raphe than the postsynaptic receptors in the hippocampus. |
2007-11-02 |
2023-08-12 |
rat |
| Lynn G Kirby, Yu-Zhen Pan, Emily Freeman-Daniels, Shobha Rani, John D Nunan, Adaure Akanwa, Sheryl G Bec. Cellular effects of swim stress in the dorsal raphe nucleus. Psychoneuroendocrinology. vol 32. issue 6. 2007-10-18. PMID:17602840. |
swim stress regulates forebrain 5-hydroxytryptamine (5-ht) release in a complex manner and its effects are initiated in the serotonergic dorsal raphe nucleus (drn). |
2007-10-18 |
2023-08-12 |
rat |
| Andrea Godino, Laurival Antonio De Luca, José Antunes-Rodrigues, Laura Viva. Oxytocinergic and serotonergic systems involvement in sodium intake regulation: satiety or hypertonicity markers? American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 3. 2007-10-17. PMID:17567719. |
to discriminate whether the differential activations of the 5-ht and ot neurons in this model are a consequence of the sodium satiation process or are the result of stimulation caused by the entry to the body of a hypertonic sodium solution during sodium access, we analyzed the number of fos-5-ht- and fos-ot-immunoreactive neurons in the dorsal raphe nucleus and the paraventricular nucleus of the hypothalamus-supraoptic nucleus, respectively, after isotonic vs. hypertonic nacl intake induced by pd. |
2007-10-17 |
2023-08-12 |
rat |
| R Tao, Z Ma, M M Thakkar, R W McCarley, S B Auerbac. Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux. Neuroscience. vol 147. issue 1. 2007-10-16. PMID:17499930. |
this may involve interactions within the circuitry controlling 5-ht neurons in the dorsal raphe nucleus (drn) that project to the nucleus accumbens (nacc). |
2007-10-16 |
2023-08-12 |
rat |
| Duk-Soo Kim, Ji-Eun Kim, Sung-Eun Kwak, Dae-Won Kim, Soo-Young Choi, Oh-Shin Kwon, Tae-Chon Kan. Seizure activity selectively reduces 5-HT1A receptor immunoreactivity in CA1 interneurons in the hippocampus of seizure-prone gerbils. Brain research. vol 1154. 2007-10-12. PMID:17493597. |
5-ht immunoreactivity in the dorsal raphe nucleus and the median raphe nucleus was also similarly detected in both animal groups. |
2007-10-12 |
2023-08-12 |
Not clear |
| S E Gartside, A J Cole, A P Williams, R McQuade, S J Judg. AMPA and NMDA receptor regulation of firing activity in 5-HT neurons of the dorsal and median raphe nuclei. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17509083. |
here, we used extracellular single unit recording in midbrain slices to examine glutamate receptor mediated effects on 5-ht neuronal activity in the dorsal raphe nucleus (drn) and the median raphe nucleus (mrn). |
2007-08-17 |
2023-08-12 |
Not clear |
| Daniel Badauê-Passos, Andrea Godino, Alan Kim Johnson, Laura Vivas, José Antunes-Rodrigue. Dorsal raphe nuclei integrate allostatic information evoked by depletion-induced sodium ingestion. Experimental neurology. vol 206. issue 1. 2007-08-17. PMID:17544397. |
serotonin (5-ht) and the dorsal raphe nuclei (drn) have been implicated in the inhibitory control of salt intake (i.e., sodium appetite). |
2007-08-17 |
2023-08-12 |
rat |
| Zhiyuan Ma, Elliot Pearson, Rui Ta. CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats. Neuroscience letters. vol 417. issue 3. 2007-07-25. PMID:17346884. |
cart peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats. |
2007-07-25 |
2023-08-12 |
rat |
| Zhiyuan Ma, Elliot Pearson, Rui Ta. CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats. Neuroscience letters. vol 417. issue 3. 2007-07-25. PMID:17346884. |
the aim of the present studies was to investigate the effect of cart peptides on extracellular 5-ht in the dorsal raphe nucleus (drn) and nucleus accumbens (nacc) using a microdialysis approach in freely behaving rats. |
2007-07-25 |
2023-08-12 |
rat |
| Ieda F Oliveira-Silva, Lucas Pinto, Silvia R C Pereira, Vany P Ferraz, Alfredo J A Barbosa, Vivian A A Coelho, Felipe F A S Gualberto, Valeria F Souza, Rosiane R M Faleiro, Glaura C Franco, Angela M Ribeir. Age-related deficit in behavioural extinction is counteracted by long-term ethanol consumption: correlation between 5-HIAA/5HT ratio in dorsal raphe nucleus and cognitive parameters. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17481744. |
we investigated age-related changes in learning and memory performance and behavioural extinction in the water maze; and in endogenous levels of serotonin (5-ht) and 5-hydroxyindole acetic acid (5-hiaa) in the neocortex, hippocampus, thalamus and dorsal raphe nucleus of wistar rats. |
2007-07-24 |
2023-08-12 |
human |
| L Arborelius, M B Eklun. Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats. Neuroscience. vol 145. issue 2. 2007-06-26. PMID:17222517. |
in the lms females tissue levels of both 5-ht and 5-hydroxyindole acetic acid (5-hiaa) were significantly increased in the dorsal raphe nucleus, and 5-hiaa and homovanillic acid levels were also elevated in the nucleus accumbens as compared with afr and bms rats. |
2007-06-26 |
2023-08-12 |
rat |
| B E H Sumner, K E Grant, R Rosie, Ch Hegele-Hartung, K-H Fritzemeier, G Fin. Raloxifene blocks estradiol induction of the serotonin transporter and 5-hydroxytryptamine2A receptor in female rat brain. Neuroscience letters. vol 417. issue 1. 2007-06-22. PMID:17398000. |
specifically, estradiol-17beta in its acute positive feedback mode for gonadotropin release in the female rat induces expression of the genes for the 5-hydroxytryptamine(2a) receptor (5-ht(2a)r) and the serotonin transporter (sert) in the dorsal raphe nucleus (drn). |
2007-06-22 |
2023-08-12 |
human |
| Xiaoying Lu, Lisa Sharkey, Tamas Bartfa. The brain galanin receptors: targets for novel antidepressant drugs. CNS & neurological disorders drug targets. vol 6. issue 3. 2007-06-20. PMID:17511615. |
it is thus little surprising when the neuropeptide, galanin, is discovered to coexist with norepinephrine (ne) in locus coeruleus (lc) neurons and with serotonin (5-ht) in the dorsal raphe nucleus (drn) neurons, a link between galanin mediated signaling and mood regulation is sought. |
2007-06-20 |
2023-08-12 |
human |
| Marilyn J Duncan, Kathleen M Frankli. Expression of 5-HT7 receptor mRNA in the hamster brain: effect of aging and association with calbindin-D28K expression. Brain research. vol 1143. 2007-06-13. PMID:17300762. |
previously, we showed that aging induces a decrease in the hamster dorsal raphe (drn) in both 5-ht(7) receptor binding and circadian phase resetting responses to 8-oh-dpat microinjection. |
2007-06-13 |
2023-08-12 |
Not clear |
| Gabriella Gobbi, Tommaso Cassano, Fatiha Radja, Maria Grazia Morgese, Vincenzo Cuomo, Luca Santarelli, René Hen, Pierre Blie. Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 5. 2007-05-22. PMID:16950604. |
dorsal raphe 5-ht and locus coeruleus ne neurons were recorded in vivo in mice lacking nk1 receptors in wildtype mice pretreated with the nk1 antagonist rp67580 and its inactive enantiomer rp 68651. |
2007-05-22 |
2023-08-12 |
mouse |
| Barbara Langen, Chris Rundfeld. ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study. Pharmacology, biochemistry, and behavior. vol 86. issue 1. 2007-05-22. PMID:17257662. |
the increase of 5-ht in the striatum was reversed by systemic and by local administration of the benzodiazepine antagonist flumazenil in the dorsal raphe nucleus by a microdialysis probe, suggesting that the increase in 5-ht was mediated by the activity of elb139 at the benzodiazepine binding site. |
2007-05-22 |
2023-08-12 |
rat |
| Tian-Hua Ren, Justin Wu, David Yew, Eric Ziea, Lixing Lao, Wai-Keung Leung, Brian Berman, Pin-Jin Hu, Joseph J Y Sun. Effects of neonatal maternal separation on neurochemical and sensory response to colonic distension in a rat model of irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 3. 2007-04-24. PMID:17110521. |
tissues from dorsal raphe nucleus in midbrain, lumbar-sacral cord, and distal colon were harvested for semiquantitative analysis of c-fos and 5-ht. |
2007-04-24 |
2023-08-12 |
rat |