| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Arregui, E K Perry, M Rossor, B E Tomlinso. Angiotensin converting enzyme in Alzheimer's disease increased activity in caudate nucleus and cortical areas. Journal of neurochemistry. vol 38. issue 5. 1982-05-27. PMID:6278093. |
enzyme activity was found to be elevated by 44% and 41% in the medial hippocampus and parahippocampal gyrus, respectively, and by 27% and 29% in the frontal cortex (area 10 of brodman) and caudate nucleus, respectively, in alzheimer's disease patients. |
1982-05-27 |
2023-08-12 |
Not clear |
| D Dahl, D J Selkoe, R T Pero, A Bignam. Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 2. issue 1. 1982-03-22. PMID:7033478. |
using anti-chicken brain neurofilament antisera, alzheimer's neurofibrillary tangles from two patients with senile dementia were stained by immunofluorescence and by the peroxidase-antiperoxidase procedure in cryostat sections of hippocampus and frontal cortex. |
1982-03-22 |
2023-08-12 |
cattle |
| S H Appe. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Annals of neurology. vol 10. issue 6. 1982-03-13. PMID:6173010. |
in alzheimer disease, the abnormalities would lie in failure of the hippocampus and cortical cells to supply the relevant cholinergic neurotrophic hormone with resulting impairment of medial septal and nucleus basalis neurons. |
1982-03-13 |
2023-08-12 |
Not clear |
| M A Bell, M J Bal. Morphometric comparison of hippocampal microvasculature in ageing and demented people: diameters and densities. Acta neuropathologica. vol 53. issue 4. 1981-06-13. PMID:7223373. |
the diameters and densities of capillaries and arterioles in the hippocampal cortex of normal subjects and patients with alzheimer's dementia were measured in thick celloidin sections stained for alkaline phosphatase. |
1981-06-13 |
2023-08-12 |
human |
| M A Bell, M J Bal. Morphometric comparison of hippocampal microvasculature in ageing and demented people: diameters and densities. Acta neuropathologica. vol 53. issue 4. 1981-06-13. PMID:7223373. |
regional changes may, however, be important: those hippocampal zones showing the greatest severity of or increment in nerve cell lesions do correspond to those having the highest levels of or increase in capillary density and the greatest decrease in diameter, suggesting a direct association between neuronal susceptibility to alzheimer changes and degree of regional blood supply. |
1981-06-13 |
2023-08-12 |
human |
| A J Cross, T J Crow, E K Perry, R H Perry, G Blessed, B E Tomlinso. Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease. British medical journal (Clinical research ed.). vol 282. issue 6258. 1981-04-21. PMID:6779929. |
enzyme activity was decreased in the frontal and temporal cortices and hippocampus in patients with alzheimer's disease, but was within the normal range in patients with depression, multiinfarct dementia, and terminal coma.the decrease in enzyme activity in alzheimer's disease may reflect an abnormality of cortical noradrenergic fibres in some patients with the disease. |
1981-04-21 |
2023-08-12 |
Not clear |
| I Tarbit, E K Perry, R H Perry, G Blessed, B E Tomlinso. Hippocampal free amino acids in Alzheimer's disease. Journal of neurochemistry. vol 35. issue 5. 1981-03-24. PMID:7452316. |
hippocampal free amino acids in alzheimer's disease. |
1981-03-24 |
2023-08-12 |
Not clear |
| I Tarbit, E K Perry, R H Perry, G Blessed, B E Tomlinso. Hippocampal free amino acids in Alzheimer's disease. Journal of neurochemistry. vol 35. issue 5. 1981-03-24. PMID:7452316. |
the free amino acid content of the hippocampus, obtained at postmortem, has been analysed in cases of alzheimer's disease and compared with normal cases. |
1981-03-24 |
2023-08-12 |
Not clear |
| M J Ball, K Nuttal. Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia. Annals of neurology. vol 7. issue 5. 1980-09-28. PMID:6446875. |
by contrast, the number of alzheimer neurofibrillary tangles and loss of pyramidal neurons from the hippocampus exceeded levels found in considerably older subjects and fell into the same range of severity as was noted in 8 patients with alzheimer dementia. |
1980-09-28 |
2023-08-12 |
human |
| D P Perl, A R Brod. Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science (New York, N.Y.). vol 208. issue 4441. 1980-06-25. PMID:7367858. |
the elemental content of neurons of the hippocampus was studied by a combination of scanning electron microscopy and x-ray spectrometry in autopsy-derived brain tissue from three cases of senile dementia (alzheimer type) and three nondemented elderly controls. |
1980-06-25 |
2023-08-12 |
Not clear |
| R H Perry, G Blessed, E K Perry, B E Tomlinso. Histochemical observations on cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients. Age and ageing. vol 9. issue 1. 1980-05-30. PMID:7370097. |
the extent and distribution of acetylcholinesterase staining in the hippocampus has been compared in normal elderly cases and patients with alzheimer's disease. |
1980-05-30 |
2023-08-12 |
Not clear |
| R H Perry, G Blessed, E K Perry, B E Tomlinso. Histochemical observations on cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients. Age and ageing. vol 9. issue 1. 1980-05-30. PMID:7370097. |
the positive staining of processes in senile plaques suggests that they are, at least partly, derived from cholinergic, axonal fibres and the decrease in acetylcholinesterase staining of nerve processes may indicate a diminution in cholinergic, afferent input fibres to the hippocampus in alzheimer's disease. |
1980-05-30 |
2023-08-12 |
Not clear |
| I Grundke-Iqbal, A B Johnson, R D Terry, H M Wisniewski, K Iqba. Alzheimer neurofibrillary tangles: antiserum and immunohistological staining. Annals of neurology. vol 6. issue 6. 1980-04-26. PMID:394670. |
the reactivity of the anti-paired helical filament protein serum with neurofibrillary tangles was studied by immunofluorescence on cryostat sections of hippocampus from alzheimer autopsy tissue and by the peroxidase-antiperoxidase technique on paraffin sections of an alzheimer brain biopsy. |
1980-04-26 |
2023-08-11 |
human |
| H Okazaki, T J Reagan, R J Campbel. Clinicopathologic studies of primary cerebral amyloid angiopathy. Mayo Clinic proceedings. vol 54. issue 1. 1979-03-29. PMID:759733. |
alzheimer's neurofibrillary tangles were absent or were limited to the hippocampal region in all but two cases. |
1979-03-29 |
2023-08-11 |
Not clear |
| E K Perry, R H Perry, G Blessed, B E Tomlinso. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathology and applied neurobiology. vol 4. issue 4. 1978-12-29. PMID:703927. |
acetylcholinesterase was significantly reduced and butyrylcholinesterase significantly increased, compared with the normal, in the hippocampus and temporal cortex of the alzheimer cases. |
1978-12-29 |
2023-08-11 |
Not clear |
| C M Smith, M Swas. Possible biochemical basis of memory disorder in Alzheimer disease. Annals of neurology. vol 3. issue 6. 1978-09-25. PMID:209723. |
the most common presenting symptom of alzheimer disease is loss of short-term memory, and histologically the hippocampus is characteristically affected. |
1978-09-25 |
2023-08-11 |
human |
| M J Bal. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study. Acta neuropathologica. vol 42. issue 2. 1978-07-26. PMID:654888. |
topographic analysis was performed of the distribution of alzheimer's neurofibrillary tangles and the granulovacuolar degeneration of simchowicz in the hippocampal cortex of patients with alzheimer's dementia and mentally normal aged controls. |
1978-07-26 |
2023-08-11 |
Not clear |
| P H Gibson, B E Tomlinso. Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease. Journal of the neurological sciences. vol 33. issue 1-2. 1977-11-25. PMID:903782. |
numbers of hirano bodies in the hippocampus of normal and demented people with alzheimer's disease. |
1977-11-25 |
2023-08-11 |
human |
| P H Gibson, B E Tomlinso. Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease. Journal of the neurological sciences. vol 33. issue 1-2. 1977-11-25. PMID:903782. |
hirano bodies were counted in the pyramidal layer of the hippocampus in the brains of 34 demented patients with alzheimer's disease or senile dementia of the alzheimer type and 24 non-demented subjects of 60 years and over who had been psychometrically assessed. |
1977-11-25 |
2023-08-11 |
human |
| M J Bal. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta neuropathologica. vol 37. issue 2. 1977-05-25. PMID:848276. |
the number of pyramidal neurones in the hippocampal cortex was determined in serially sectioned mesial temporal lobe from brains of 18 mentally normal people, as well as those of 8 demented patients with pathologically confirmed alzheimer's disease. |
1977-05-25 |
2023-08-11 |
Not clear |