| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging. vol 11. issue 18. 2020-09-08. PMID:31548435. |
furthermore, there was a decrease in the level of inactivated phosphorylated gsk-3β at ser9, an increase in the level of activated phosphorylated gsk-3β at thr216 and an obvious decrease in the level of activated phosphorylated erk1/2, but no alterations in camkii and pp2a in hippocampus of sps rats. |
2020-09-08 |
2023-08-13 |
rat |
| Fenghong Zhao, Zijiang Wang, Yingjun Liao, Gaoyang Wang, Yaping Ji. Alterations of NMDA and AMPA receptors and their signaling apparatus in the hippocampus of mouse offspring induced by developmental arsenite exposure. The Journal of toxicological sciences. vol 44. issue 11. 2020-03-30. PMID:31708534. |
the effect of arsenite in the expressions of different components of nmdar (nr1, nr2a, nr2b) and ampar (glur1, glur2, glur3), including calcium/calmodulin-dependent protein kinase ii (camkii) and phosphorylated-camkii (p-camkii), at pnd 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice. |
2020-03-30 |
2023-08-13 |
mouse |
| Qian Su, Huiping Zhang, Shaokang Dang, Dan Yao, Shuya Shao, Zhongliang Zhu, Hui L. Hippocampal Protein Kinase C Gamma Signaling Mediates the Impairment of Spatial Learning and Memory in Prenatally Stressed Offspring Rats. Neuroscience. vol 414. 2020-03-13. PMID:31283971. |
the present study proposes to determine whether hippocampal pkcγ is involved in the detrimental effects of ps on spatial learning and memory in offspring, and to further explore the effects of ps-induced pkcγ-dependent growth-associated protein 43 (gap-43) and neurogranin (ng) phosphorylation alteration on calcium/calmodulin-dependent protein kinase ii (camkii) activation. |
2020-03-13 |
2023-08-13 |
rat |
| Qian Su, Huiping Zhang, Shaokang Dang, Dan Yao, Shuya Shao, Zhongliang Zhu, Hui L. Hippocampal Protein Kinase C Gamma Signaling Mediates the Impairment of Spatial Learning and Memory in Prenatally Stressed Offspring Rats. Neuroscience. vol 414. 2020-03-13. PMID:31283971. |
the expression of phosphorylated gap-43 (p-gap-43) and phosphorylated ng (p-ng), as well as phosphorylated camkii (p-camkii), was significantly reduced in the hippocampus of ps females. |
2020-03-13 |
2023-08-13 |
rat |
| Qian Su, Huiping Zhang, Shaokang Dang, Dan Yao, Shuya Shao, Zhongliang Zhu, Hui L. Hippocampal Protein Kinase C Gamma Signaling Mediates the Impairment of Spatial Learning and Memory in Prenatally Stressed Offspring Rats. Neuroscience. vol 414. 2020-03-13. PMID:31283971. |
furthermore, enhancing pkcγ reversed ps-induced membrane and cytosolic pkcγ reduction, and restored levels of gap-43 and ng phosphorylation, and camkii activation in the hippocampus. |
2020-03-13 |
2023-08-13 |
rat |
| Qian Su, Huiping Zhang, Shaokang Dang, Dan Yao, Shuya Shao, Zhongliang Zhu, Hui L. Hippocampal Protein Kinase C Gamma Signaling Mediates the Impairment of Spatial Learning and Memory in Prenatally Stressed Offspring Rats. Neuroscience. vol 414. 2020-03-13. PMID:31283971. |
in conclusion, ps possibly decreases hippocampal pkcγ activity, resulting in a reduction of p-gap-43 and p-ng, which underlies insufficient camkii activation, thereby impairing spatial learning and memory. |
2020-03-13 |
2023-08-13 |
rat |
| Yasushi Yabuki, Lei Wu, Kohji Fukunag. Cognitive enhancer ST101 improves schizophrenia-like behaviors in neonatal ventral hippocampus-lesioned rats in association with improved CaMKII/PKC pathway. Journal of pharmacological sciences. vol 140. issue 3. 2020-02-13. PMID:31474557. |
we previously reported that cognitive impairments in neonatal ventral hippocampus (nvh)-lesioned rats show resistance to atypical antipsychotics risperidone and are associated with reduced calcium/calmodulin-dependent protein kinase ii (camkii) and protein kinase c (pkc) signaling in memory-related regions. |
2020-02-13 |
2023-08-13 |
rat |
| Yasushi Yabuki, Lei Wu, Kohji Fukunag. Cognitive enhancer ST101 improves schizophrenia-like behaviors in neonatal ventral hippocampus-lesioned rats in association with improved CaMKII/PKC pathway. Journal of pharmacological sciences. vol 140. issue 3. 2020-02-13. PMID:31474557. |
the cognitive enhancer st101 (spiro[imi-dazo[1,2-a]pyridine-3,2-indan]-2(3h)-one) stimulates camkii activity in the hippocampus and medial prefrontal cortex (mpfc). |
2020-02-13 |
2023-08-13 |
rat |
| Wenchi Zhang, Yang-An Chuang, Youn Na, Zengyou Ye, Liuqing Yang, Raozhou Lin, Jiechao Zhou, Jing Wu, Jessica Qiu, Alena Savonenko, Daniel J Leahy, Richard Huganir, David J Linden, Paul F Worle. Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation. Molecular cell. vol 75. issue 1. 2020-01-13. PMID:31151856. |
mutant arc that cannot be phosphorylated by camkii enhances metabotropic receptor-dependent depression in the hippocampus but does not alter baseline synaptic transmission or long-term potentiation. |
2020-01-13 |
2023-08-13 |
Not clear |
| Nan-Nan Lu, Chao Tan, Ning-He Sun, Ling-Xiao Shao, Xiu-Xiu Liu, Yin-Ping Gao, Rong-Rong Tao, Quan Jiang, Cheng-Kun Wang, Ji-Yun Huang, Kui Zhao, Guang-Fa Wang, Zhi-Rong Liu, Kohji Fukunaga, Ying-Mei Lu, Feng Ha. Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 7. 2019-10-07. PMID:28591834. |
gab1 overexpression, on the other hand, improved cognitive function and restored hippocampal camkii autorphosphorylation in ad mice. |
2019-10-07 |
2023-08-13 |
mouse |
| Sanghyun Ye, Ji-Il Kim, Jooyoung Kim, Bong-Kiun Kaan. Overexpression of activated CaMKII in the CA1 hippocampus impairs context discrimination, but not contextual conditioning. Molecular brain. vol 12. issue 1. 2019-07-31. PMID:30953515. |
overexpression of activated camkii in the ca1 hippocampus impairs context discrimination, but not contextual conditioning. |
2019-07-31 |
2023-08-13 |
mouse |
| Y Li, L Li, W Pa. Repetitive transcranial magnetic stimulation (rTMS) modulates hippocampal structural synaptic plasticity in rats. Physiological research. vol 68. issue 1. 2019-06-24. PMID:30433805. |
previous studies reported that low-frequency rtms (hippocampus, synaptic protein markers and ca(2+)/calmodulin-dependent protein ii (camkii). |
2019-06-24 |
2023-08-13 |
human |
| Hong Liu, Jie Yang, Kai Wang, Tengfei Niu, Dongya Huan. Moderate- and Low-Dose of Atorvastatin Alleviate Cognition Impairment Induced by High-Fat Diet via Sirt1 Activation. Neurochemical research. vol 44. issue 5. 2019-06-11. PMID:30820818. |
the level of cognition development was examined by morris water maze (mwm) approach and novel object recognition test (nort); besides, the expression of creb1, gap-43, bdnf, camkii, and erks of frontal cortex and hippocampus was determined by reverse transcription polymerase chain reaction (rt-pcr). |
2019-06-11 |
2023-08-13 |
mouse |
| Sebahattin Karabulut, Keziban Korkmaz Bayramov, Ruslan Bayramov, Fadime Ozdemir, Tugba Topaloglu, Ergul Ergen, Kamile Yazgan, Ahmet Sevki Taskiran, Asuman Golgel. Effects of post-learning REM sleep deprivation on hippocampal plasticity-related genes and microRNA in mice. Behavioural brain research. vol 361. 2019-06-04. PMID:30594545. |
further, we found that the rem sd after training significantly changes the hippocampal expression of brain-derived neurotrophic factor (bdnf) mrna; however, it causes minimal difference in the hippocampal expressions of calcium-calmodulin-dependent protein kinase ii (camkii) and camp response-element-binding (creb). |
2019-06-04 |
2023-08-13 |
mouse |
| Mitra-Sadat Sadat-Shirazi, Hamid Ahmadian-Moghadam, Solmaz Khalifeh, Setareh Nouri Zadeh-Tehrani, Maryam Farahmandfar, Mohammad-Reza Zarrindas. The role of calcium-calmodulin-dependent protein kinase II in modulation of spatial memory in morphine sensitized rats. Behavioural brain research. vol 359. 2019-04-19. PMID:30428335. |
the effect of camkii inhibitor (kn-93) on memory changes was investigated by hippocampal microinjection of kn-93 on the morphine-sensitized rats. |
2019-04-19 |
2023-08-13 |
rat |
| Guyue Zhang, Hui Fang, Yukai Li, Jing Xu, Dandan Zhang, Yanan Sun, Lei Zhou, He Zhan. Neuroprotective Effect of Astragalus Polysacharin on Streptozotocin (STZ)-Induced Diabetic Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-02-20. PMID:30610831. |
the morris water maze test (mwm) was used to assess learning and memory ability, and we measured levels of n-methyl-d-aspartate receptor (nmda), calcium/calmodulin-dependent protein kinase ii (camkii), and camp response element-binding protein (creb) in the hippocampus. |
2019-02-20 |
2023-08-13 |
rat |
| Fabio Antonio Vigil, Keiko Mizuno, Walter Lucchesi, Victoria Valls-Comamala, Karl Peter Gies. Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28642476. |
we also found that substantial overexpression of camk2n2 in dorsal hippocampus impairs ltm formation, but not ltm maintenance, suggesting that camkii activity is not required for ltm storage. |
2018-12-31 |
2023-08-13 |
mouse |
| Yang Yao, Faqi Wang, Xuening Yang, Dawei Zang, Jiajia Yang, Zhiyun Wan. Bombesin attenuated ischemia-induced spatial cognitive and synaptic plasticity impairment associated with oxidative damage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29635132. |
besides, the decreased expression of synapse plasticity-related proteins, calcium- calmodulin- dependent protein kinase ii (camkii) and synaptophysin (syp) in the hippocampus were increased with drug treatment. |
2018-10-15 |
2023-08-13 |
rat |
| Dunjia Wang, Xiaodong Wang, Xiaofang Liu, Liping Jiang, Guang Yang, Xiaoxia Shi, Cong Zhang, Fengyuan Pia. Inhibition of miR-219 Alleviates Arsenic-Induced Learning and Memory Impairments and Synaptic Damage Through Up-regulating CaMKII in the Hippocampus. Neurochemical research. vol 43. issue 4. 2018-09-24. PMID:29478199. |
inhibition of mir-219 alleviates arsenic-induced learning and memory impairments and synaptic damage through up-regulating camkii in the hippocampus. |
2018-09-24 |
2023-08-13 |
mouse |
| Dunjia Wang, Xiaodong Wang, Xiaofang Liu, Liping Jiang, Guang Yang, Xiaoxia Shi, Cong Zhang, Fengyuan Pia. Inhibition of miR-219 Alleviates Arsenic-Induced Learning and Memory Impairments and Synaptic Damage Through Up-regulating CaMKII in the Hippocampus. Neurochemical research. vol 43. issue 4. 2018-09-24. PMID:29478199. |
taken together, the results of this study indicate that inhibition of mir-219 regulates arsenic-induced damage in the structure of the hippocampus and impairment of learning and memory, possibly by targeting camkii. |
2018-09-24 |
2023-08-13 |
mouse |