| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard E Kast, Marc-Eric Halatsc. Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma. Archives of medical research. vol 43. issue 3. 2012-12-19. PMID:22564423. |
in this short note we describe how previous research has demonstrated that the common angiotensin-converting enzyme (ace) inhibitor captopril used to treat hypertension and for renal protection inhibits 72-kda matrix metalloproteinase-2 and 92-kda matrix metalloproteinase-9, which a separate body of research shows are used by glioblastoma cells to grow and invade. |
2012-12-19 |
2023-08-12 |
Not clear |
| Alsayed Ahmed Alnahal, Usama Ahmed Khalil, Magada Alsayed Diab, Ali Fahmy Zanat. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. vol 23. issue 5. 2012-12-04. PMID:22982912. |
in conclusion, a higher level of ace mrna gene expression in patients suffering from gn may suggest a role of the ras in the process of gn, perhaps contributing to glomerular hypertrophy and matrix overproduction. |
2012-12-04 |
2023-08-12 |
human |
| Atiye Seda Yar, Sevda Menevse, Irem Dogan, Ebru Alp, Volkan Ergin, Ahmet Cumaoglu, Aysel Aricioglu, Abdullah Ekmekci, Adnan Menevs. Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. Journal of medicinal food. vol 15. issue 4. 2012-07-16. PMID:22191573. |
changes in vascular endothelial growth factor (vegf), angiotensin-converting enzyme (ace), matrix metalloproteinase (mmp)-9, and endothelial nitric oxide synthase (enos) mrna expression profiles and oxidative stress in the eye tissue microenviroment may have important roles in ocular neovascularization and permeability in proliferative diabetic retinopathy. |
2012-07-16 |
2023-08-12 |
rat |
| Josephine A Grace, Chandana B Herath, Kai Yan Mak, Louise M Burrell, Peter W Angu. Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options. Clinical science (London, England : 1979). vol 123. issue 4. 2012-06-19. PMID:22548407. |
liver injury stimulates the hepatic expression of components of the ras, such as ace (angiotensin-converting enzyme) and the at(1) receptor [angii (angiotensin ii) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. |
2012-06-19 |
2023-08-12 |
Not clear |
| Giovanna Muscogiuri, Gian Pio Sorice, Devjit Tripathy, Alberto O Chavez, Alberto Davalli, Richard A Lange, Franco Foll. Medical therapy of aortic aneurysms: a pathophysiology-based approach. Current vascular pharmacology. vol 9. issue 5. 2011-12-19. PMID:21143163. |
they work by improving matrix repair, decreasing the proteolytic pattern and inhibition of angiotensin-converting enzyme (ace) as well as preventing angiotensin ii-induced angiotensin type-1 receptor (at1r) activation. |
2011-12-19 |
2023-08-12 |
Not clear |
| Kenneth L Pinkston, Peng Gao, Daniel Diaz-Garcia, Jouko Sillanpää, Sreedhar R Nallapareddy, Barbara E Murray, Barrett R Harve. The Fsr quorum-sensing system of Enterococcus faecalis modulates surface display of the collagen-binding MSCRAMM Ace through regulation of gelE. Journal of bacteriology. vol 193. issue 17. 2011-10-06. PMID:21705589. |
ace, a known virulence factor and the first identified microbial surface component recognizing adhesive matrix molecule (mscramm) of enterococcus faecalisis associated with host cell adherence and endocarditis. |
2011-10-06 |
2023-08-12 |
Not clear |
| Sreedhar R Nallapareddy, Jouko Sillanpää, Jennifer Mitchell, Kavindra V Singh, Shahreen A Chowdhury, George M Weinstock, Paul M Sullam, Barbara E Murra. Conservation of Ebp-type pilus genes among Enterococci and demonstration of their role in adherence of Enterococcus faecalis to human platelets. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21502588. |
further studies identified that ebp pili, but not the microbial surface components recognizing adhesive matrix molecules (mscramms) ace and fss2, mediate adherence of e. faecalis to platelets. |
2011-09-02 |
2023-08-12 |
human |
| Sreedhar R Nallapareddy, Kavindra V Singh, Jouko Sillanpää, Meng Zhao, Barbara E Murra. Relative contributions of Ebp Pili and the collagen adhesin ace to host extracellular matrix protein adherence and experimental urinary tract infection by Enterococcus faecalis OG1RF. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21505082. |
relative contributions of ebp pili and the collagen adhesin ace to host extracellular matrix protein adherence and experimental urinary tract infection by enterococcus faecalis og1rf. |
2011-09-02 |
2023-08-12 |
Not clear |
| Sreedhar R Nallapareddy, Kavindra V Singh, Jouko Sillanpää, Meng Zhao, Barbara E Murra. Relative contributions of Ebp Pili and the collagen adhesin ace to host extracellular matrix protein adherence and experimental urinary tract infection by Enterococcus faecalis OG1RF. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21505082. |
we have also shown that growth of e. faecalis in brain heart infusion (bhi) serum enhances ebp pilus and ace production and increases adherence to several host extracellular matrix proteins. |
2011-09-02 |
2023-08-12 |
Not clear |
| Wei Chen, Mao-Hua Yu, Yi-Ming Li, Wen-Jie Chen, Yian-Ping Xi. Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters. Acta diabetologica. vol 47 Suppl 1. 2011-04-15. PMID:19350199. |
in this study, we investigated the effects of aps treatment on cardiac function, myocardial collagen expression, cardiac ultrastructure, cardiac matrix metalloproteinase (mmp) activity, levels of plasma glycosylated serum protein (gsp), and myocardial enzymes, and the expression of ang ii, chymase, and angiotensin-converting enzyme (ace) in the diabetic hamster myocardium. |
2011-04-15 |
2023-08-12 |
Not clear |
| Li Zhou, Hong Xue, Ping Yuan, Jun Ni, Chen Yu, Yu Huang, Li-Min L. Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells. Clinical and experimental pharmacology & physiology. vol 37. issue 9. 2011-02-04. PMID:20590668. |
levels of emt makers, namely e-cadherin and vimentin, were estimated using fluorescence immunocytochemistry, mrna levels of angiotensinogen (agt), angiotensin-converting enzyme (ace) and at1 receptors were determined by real-time polymerase chain reaction, protein levels of e-cadherin, vimentin, fibronectin, matrix metallopeptidase (mmp)-9 and phosphorylated extracellular signal-regulated kinase (erk) 1/2 were analysed by western blotting and the concentrations of angiotensin (ang) ii and transforming growth factor (tgf)-beta1 in the culture medium were determined by enzyme immunoassay and elisa. |
2011-02-04 |
2023-08-12 |
rat |
| Sakiko Miyazaki, Takatoshi Kasai, Katsumi Miyauchi, Tadashi Miyazaki, Yoshinori Akimoto, Atsutoshi Takagi, Kouichiro Aihara, Masaki Kawamura, Satoru Suwa, Satoshi Kojima, Masataka Sumiyoshi, Hiroyuki Daid. Changes of matrix metalloproteinase-9 level is associated with left ventricular remodeling following acute myocardial infarction among patients treated with trandolapril, valsartan or both. Circulation journal : official journal of the Japanese Circulation Society. vol 74. issue 6. 2010-09-07. PMID:20378999. |
inhibition of the renin-angiotensin system (ras) with angiotensin-converting enzyme (ace) inhibitors and angiotensin ii receptor blockers (arbs) can suppress left ventricular (lv) remodeling after acute myocardial infarction (ami), possibly through the modifications of matrix metalloproteinase (mmp)-9. |
2010-09-07 |
2023-08-12 |
Not clear |
| Wei Chen, Yi-Ming Li, Mao-Hua Y. Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. Journal of diabetes and its complications. vol 24. issue 3. 2010-07-16. PMID:19230716. |
after aps/ns administration at a dose of 1 g/kg per day for 10 weeks, hemodynamic parameters, levels of insulin (ins), c-peptide (c-p), glycosylated serum protein (gsp), lipoproteins, myocardial enzymes, and ang ii (plasma and myocardial) were tested; myocardial collagen (type i and iii), myocardial ultrastructure, and activities of matrix metalloproteinase (mmps) were measured; activities and expression of cardiac chymase and ace were detected by using quantitative real-time rt-pcr and ria; protein expression of cardiac phosphoric extracellular signal-regulated kinase 1/2 (p-erk1/2) was measured by western blot. |
2010-07-16 |
2023-08-12 |
Not clear |
| Rekha Singh, Divaker Choubey, Jianming Chen, David J Leehe. Inhibition of intracellular angiotensin II formation blocks high glucose effect on mesangial matrix. Regulatory peptides. vol 158. issue 1-3. 2010-01-25. PMID:19712706. |
these data suggest that intracellular ang ii may play an important role in the mediation of the high glucose effect on matrix and that ace inhibitors may not be effective in blocking intracellular ang ii formation in mesangial cells. |
2010-01-25 |
2023-08-12 |
human |
| Antoni P A Hendrickx, Rob J L Willems, Marc J M Bonten, Willem van Schai. LPxTG surface proteins of enterococci. Trends in microbiology. vol 17. issue 9. 2009-11-03. PMID:19726195. |
here we review current knowledge of enterococcal lpxtg surface proteins, including aggregation substance, enterococcal surface protein, three collagen-binding microbial surface components that recognize adhesive matrix molecules (ace, acm, scm) and pili (ebp, pila and pilb), their interactions with host molecules and their role in pathogenicity and biofilm development. |
2009-11-03 |
2023-08-12 |
Not clear |
| Ven-Shing Wang, Ming-Yen L. Application of solid-phase microextraction and gas chromatography-mass spectrometry for measuring chemicals in saliva of synthetic leather workers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 877. issue 1-2. 2009-03-13. PMID:19036646. |
the aim of this study is to establish an analytical method, headspace solid-phase microextraction (hs-spme) followed by gas chromatography-mass spectrometry (gc-ms), by which the saliva matrix can be monitored for multiple compounds with various polarities, such as methyl ethyl ketone (mek), isopropyl alcohol (ipa), and n,n-dimethyl formamide (dmf) (common solvents used in synthetic leather manufacture), as well as acetone (ace) and n-methyl formamide (nmf) (metabolites of ipa and dmf, respectively). |
2009-03-13 |
2023-08-12 |
human |
| Muneyoshi Okada, Ryuta Kikuzuki, Toshiyuki Harada, Yasutomo Hori, Hideyuki Yamawaki, Yukio Har. Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats. Journal of pharmacological sciences. vol 108. issue 4. 2009-02-19. PMID:19057128. |
little is known about the influence of angiotensin converting enzyme (ace) inhibitors on matrix metalloproteinase (mmp) in right ventricular remodeling. |
2009-02-19 |
2023-08-12 |
rat |
| Hongtao Li, Robert J Hardy, Xiaochen G. Effect of drug solubility on polymer hydration and drug dissolution from polyethylene oxide (PEO) matrix tablets. AAPS PharmSciTech. vol 9. issue 2. 2008-09-12. PMID:18431663. |
different peo matrix tablets were prepared using acetaminophen (ace) and ibuprofen (ibu) as study compounds and polyox wsr301 (peo) as primary hydrophilic matrix polymer. |
2008-09-12 |
2023-08-12 |
Not clear |
| Daisuke Yamamoto, Shinji Takai, Mizuo Miyazak. Inhibitory profiles of captopril on matrix metalloproteinase-9 activity. European journal of pharmacology. vol 588. issue 2-3. 2008-09-02. PMID:18501888. |
to investigate the inhibitory profiles of angiotensin-converting enzyme (ace) inhibitors on matrix metalloproteinase-9 (mmp-9) activity, the inhibitory activity and molecular interaction of captopril on human mmp-9 were studied. |
2008-09-02 |
2023-08-12 |
human |
| Xiao-Gang Guo, Hiroyasu Uzui, Toshihiro Mizuguchi, Takanori Ueda, Jun-zhu Chen, Jong-Dae Le. Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1beta via NO-dependent pathway. International journal of cardiology. vol 126. issue 3. 2008-07-29. PMID:18192036. |
angiotensin-converting enzyme (ace) inhibitors are widely used in treatment of heart failure, but little is known regarding whether ace inhibitors regulate the activity of matrix metalloproteinases (mmps) and the tissue inhibitor of mmps (timps) in cardiac cells. |
2008-07-29 |
2023-08-12 |
human |