| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Feng, Ran Yang, Yuexin Tian, Xinyan Miao, Huifang Guo, Fan Gao, Lin Yang, Song Zhao, Wei Zhang, Jinxi Liu, Hongbo Li, Yu Tian, Lu Zhao, Shuo Wang, Wei Liu, Kexin Wang, Yuzhe Li, Ziwei Wang, Qingjuan Liu, Chunlin Wang, Shuxia Li. HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31667864. |
hmgb1 protein promotes glomerular mesangial matrix deposition via tlr2 in lupus nephritis. |
2021-03-09 |
2023-08-13 |
mouse |
| Xiaojuan Feng, Ran Yang, Yuexin Tian, Xinyan Miao, Huifang Guo, Fan Gao, Lin Yang, Song Zhao, Wei Zhang, Jinxi Liu, Hongbo Li, Yu Tian, Lu Zhao, Shuo Wang, Wei Liu, Kexin Wang, Yuzhe Li, Ziwei Wang, Qingjuan Liu, Chunlin Wang, Shuxia Li. HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31667864. |
however, whether or not hmgb1 participates in the pathogenesis of glomerular mesangial matrix deposition in ln remains unknown. |
2021-03-09 |
2023-08-13 |
mouse |
| Xiaojuan Feng, Ran Yang, Yuexin Tian, Xinyan Miao, Huifang Guo, Fan Gao, Lin Yang, Song Zhao, Wei Zhang, Jinxi Liu, Hongbo Li, Yu Tian, Lu Zhao, Shuo Wang, Wei Liu, Kexin Wang, Yuzhe Li, Ziwei Wang, Qingjuan Liu, Chunlin Wang, Shuxia Li. HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31667864. |
these results indicate that tlr2 regulates glomerular mesangial matrix deposition in ln through the activation of the myd88/nf-κb pathway by binding to hmgb1. |
2021-03-09 |
2023-08-13 |
mouse |
| Jie Li, Xueyu Zhang, Tao Wang, Jinghong Li, Qi Su, Cheng Zhong, Zhongshu Chen, Ying Lian. The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition. Life sciences. vol 269. 2021-02-26. PMID:33482190. |
mir155hg overexpression enhanced tgfβ1-induced increases in hmgb1 protein expression and p65 phosphorylation, nhlf proliferation, and extracellular matrix (ecm) deposition. |
2021-02-26 |
2023-08-13 |
human |
| Xiaojun Zhong, Congkai Zhang, Yunlian Diao, Shu Liao, Qingyuan Ling, Zhuoxian Zhang, Jiuhong Zhong, Ping Lon. The LncRNA H19/microRNA-29b-3p/HMGB1 signaling axis contributes to the regulation of lung cancer cell growth. FEBS open bio. 2021-02-02. PMID:33527767. |
the expression of lncrna h19, mir-29b-3p, hmgb1, toll-like receptor 4 (tlr4), and matrix metallopeptidase 9 (mmp-9) was measured by fluorescence quantitative pcr or western blotting. |
2021-02-02 |
2023-08-13 |
Not clear |
| Moeed Akbar, Derek S Gilchrist, Susan M Kitson, Briana Nelis, Lindsay A N Crowe, Emma Garcia-Melchor, James H Reilly, Shauna C Kerr, George A C Murrell, Iain B McInnes, Neal L Milla. Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis. RMD open. vol 3. issue 2. 2021-01-09. PMID:28879051. |
to seek evidence of the danger molecule, high-mobility group protein b1 (hmgb1) expression in human tendinopathy and thereafter, to explore mechanisms where hmgb1 may regulate inflammatory mediators and matrix regulation in human tendinopathy. |
2021-01-09 |
2023-08-13 |
human |
| Tuo Tang, Shengnan Wang, Tianyu Cai, Zhenyu Cheng, Yu Meng, Shimei Qi, Yao Zhang, Zhilin Q. High mobility group box 1 regulates gastric cancer cell proliferation and migration via RAGE-mTOR/ERK feedback loop. Journal of Cancer. vol 12. issue 2. 2021-01-05. PMID:33391448. |
investigation of the underlying molecular mechanisms revealed that hmgb1 enhanced cyclins expression, induced epithelial-to-mesenchymal transition and matrix metalloproteinase (mmps) expression and promoted rage expression as well as rage-mediated activation of akt/mtor/p70s6k and erk/p90rsk/creb signalling pathways. |
2021-01-05 |
2023-08-13 |
human |
| Zhiyong Shu, Xiaogang Miao, Tainhua Tang, Peng Zhan, Langqing Zeng, Yuwen Jian. The GSK‑3β/β‑catenin signaling pathway is involved in HMGB1‑induced chondrocyte apoptosis and cartilage matrix degradation. International journal of molecular medicine. vol 45. issue 3. 2020-11-30. PMID:31922219. |
hmgb1 also induced cartilage matrix degradation, as shown by alcian blue staining. |
2020-11-30 |
2023-08-13 |
Not clear |
| Zhiyong Shu, Xiaogang Miao, Tainhua Tang, Peng Zhan, Langqing Zeng, Yuwen Jian. The GSK‑3β/β‑catenin signaling pathway is involved in HMGB1‑induced chondrocyte apoptosis and cartilage matrix degradation. International journal of molecular medicine. vol 45. issue 3. 2020-11-30. PMID:31922219. |
moreover, hmgb1 markedly upregulated the expression levels of matrix metallopeptidases (mmps) and a disintegrin and metalloproteinase with thrombospondin motifs (adamts), while genetic silencing of hmgb1 significantly suppressed their expressions. |
2020-11-30 |
2023-08-13 |
Not clear |
| Weitian Li, Qiyu Tang, Na Dai, Weikuan Feng, Changqing Xie, Guofu Cheng, Xiaoli Liu, Wanpo Zhang, Xueying Hu, Changqin G. Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida. Scientific reports. vol 10. issue 1. 2020-11-24. PMID:32286320. |
the inflammatory factors hmgb1 and il-6, intercellular matrix mmp, the cell apoptosis-associated caspase-3 and necrotic apoptosis signal molecules ripk1 and ripk3 were widely expressed in the lungs of group q and were significantly different compared with those of 1g1 group and uninfected group (p < 0.05). |
2020-11-24 |
2023-08-13 |
chicken |
| M I Airapetov, S O Eresko, A A Lebedev, E R Bychkov, P D Shabano. [Involvement of TOLL-like receptors in the neuroimmunology of alcoholism]. Biomeditsinskaia khimiia. vol 66. issue 3. 2020-10-30. PMID:32588826. |
ethanol consumption leads to activation of neuroimmune signaling in the central nervous system through many types of toll-like receptors (tlrs), as well as the release of their endogenous agonists (hmgb1 protein, s100 protein, heat shock proteins, extracellular matrix breakdown proteins). |
2020-10-30 |
2023-08-13 |
Not clear |
| Biao Fu, Xia Lu, Er-Yang Zhao, Ji-Xin Wang, Si-Min Pen. HMGB1-induced autophagy promotes extracellular matrix degradation leading to intervertebral disc degeneration. International journal of clinical and experimental pathology. vol 13. issue 9. 2020-10-13. PMID:33042328. |
the hmgb1 expression and the effect of hmgb1 on npcs and extracellular matrix and autophagy were all evaluated. |
2020-10-13 |
2023-08-13 |
Not clear |
| Claudia Cristina Biguetti, Franco Cavalla, Elcia Varize Silveira, André Petenuci Tabanez, Carolina Favaro Francisconi, Rumio Taga, Ana Paula Campanelli, Ana Paula Favaro Trombone, Danieli C Rodrigues, Gustavo Pompermaier Garle. HGMB1 and RAGE as Essential Components of Ti Osseointegration Process in Mice. Frontiers in immunology. vol 10. 2020-09-21. PMID:31024546. |
the inhibition of hmgb1 or rage impaired the osseointegration, affecting the dynamics of mineralized and organic bone matrix, and resulting in a foreign body reaction, with persistence of macrophages, necrotic bone, and foreign body giant cells until later time points. |
2020-09-21 |
2023-08-13 |
mouse |
| Claudia Cristina Biguetti, Franco Cavalla, Elcia Varize Silveira, André Petenuci Tabanez, Carolina Favaro Francisconi, Rumio Taga, Ana Paula Campanelli, Ana Paula Favaro Trombone, Danieli C Rodrigues, Gustavo Pompermaier Garle. HGMB1 and RAGE as Essential Components of Ti Osseointegration Process in Mice. Frontiers in immunology. vol 10. 2020-09-21. PMID:31024546. |
in conclusion, hmgb1 and rage have a marked role in the osseointegration, evidenced by their influence on host inflammatory immune response, which includes macrophages migration and m1/m2 response, msc markers expression, which collectively modulate bone matrix deposition and osseointegration outcome. |
2020-09-21 |
2023-08-13 |
mouse |
| Li Wenzhao, Ni Jiangdong, Song Deye, Ding Muliang, Wang Junjie, Huang Xianzhe, Yan Mingming, Huang Ju. Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice. Cell cycle (Georgetown, Tex.). vol 18. issue 18. 2020-09-01. PMID:31313630. |
in the current study, we used quantitative real-time pcr(q-pcr) to detect them rna levels of collagen type ii alpha 1(col2a1), aggrecan, mmp3(matrix metallopeptidase 3), mmp13, adamts4 and adamts5; enzyme-linked immunosorbent assay(elisa) was used to detect the content of il-1β and calpain protein; cell apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling(tunel) assay and flow cytometryanalysis; western blot and immunofluorescence assays were applied to assess the expression of hmgb1; lastly autophagic activity was mainly verified by monodansylcadaverine (mdc) staining. |
2020-09-01 |
2023-08-13 |
mouse |
| Guangyi Zhao, Jianying Zhang, Daibang Nie, Yiqin Zhou, Feng Li, Kentaro Onishi, Timothy Billiar, James H-C Wan. HMGB1 mediates the development of tendinopathy due to mechanical overloading. PloS one. vol 14. issue 9. 2020-03-12. PMID:31560698. |
here we report that high mobility group box1 (hmgb1) is released to the tendon extracellular matrix and initiates an inflammatory cascade in response to mechanical overloading in a mouse model. |
2020-03-12 |
2023-08-13 |
mouse |
| Guangyi Zhao, Jianying Zhang, Daibang Nie, Yiqin Zhou, Feng Li, Kentaro Onishi, Timothy Billiar, James H-C Wan. HMGB1 mediates the development of tendinopathy due to mechanical overloading. PloS one. vol 14. issue 9. 2020-03-12. PMID:31560698. |
additionally, mechanical overloading of tendon cells in vitro induces hmgb1 release to the extracellular milieu, thereby eliciting inflammatory and catabolic responses as marked by increased production of prostaglandin e2 (pge2) and matrix metalloproteinase-3 (mmp-3) in tendon cells. |
2020-03-12 |
2023-08-13 |
mouse |
| Radislav Nako. New markers in ulcerative colitis. Clinica chimica acta; international journal of clinical chemistry. vol 497. 2020-02-11. PMID:31361991. |
in the current review based on a literature search using pubmed, we reviewed eight new potential markers in uc studied mainly in the last five years: trefoil factor 3 (tff3), leucine-rich Α-2 glycoprotein (lrg), high mobility group box 1 protein (hmgb1), soluble st2 (sst2), b cell-activating factor (baff), annexin a1 (anxa1), matrix metalloproteinases (mmp), and neutrophil gelatinase-associated lipocalin (ngal). |
2020-02-11 |
2023-08-13 |
Not clear |
| Richard L Jayaraj, Sheikh Azimullah, Rami Beiram, Fakhreya Y Jalal, Gary A Rosenber. Neuroinflammation: friend and foe for ischemic stroke. Journal of neuroinflammation. vol 16. issue 1. 2020-01-13. PMID:31291966. |
here, we also focus on time-dependent entry of immune cells to the ischemic area and the impact of other pathological mediators, including oxidative stress, excitotoxicity, matrix metalloproteinases (mmps), high-mobility group box 1 (hmgb1), arachidonic acid metabolites, mitogen-activated protein kinase (mapk), and post-translational modifications that could potentially perpetuate ischemic brain damage after the acute injury. |
2020-01-13 |
2023-08-13 |
Not clear |
| Si-Yi Wang, Jie-Yao Li, Ji-Hao Xu, Zhong-Sheng Xia, Di Cheng, Wa Zhong, Yu Lai, Tao Yu, Qi-Kui Che. Butyrate suppresses abnormal proliferation in colonic epithelial cells under diabetic state by targeting HMGB1. Journal of pharmacological sciences. vol 139. issue 4. 2020-01-02. PMID:30871870. |
under a high glucose state, increased expression of hmgb1 was accompanied with a release from cell nuclei into the cytoplasm and extracellular matrix. |
2020-01-02 |
2023-08-13 |
mouse |