| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oluwaseun O Ojo, Min Hyung Ryu, Aruni Jha, Helmut Unruh, Andrew J Halayk. High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 11. 2016-05-09. PMID:26432865. |
as epithelial cell responses are fundamental drivers of asthma, including abnormal repair-restitution linked to changes in extracellular matrix (ecm) synthesis, we tested the hypothesis that hmgb1 promotes bronchial epithelial cell wound repair via tlr4 and/or rage signaling that regulates ecm (fibronectin and the γ2-chain of laminin-5) and integrin protein abundance. |
2016-05-09 |
2023-08-13 |
human |
| Dan Li, Chunyan Lei, Shuting Zhang, Shihong Zhang, Ming Liu, Bo W. Blockade of high mobility group box-1 signaling via the receptor for advanced glycation end-products ameliorates inflammatory damage after acute intracerebral hemorrhage. Neuroscience letters. vol 609. 2016-04-12. PMID:26483322. |
treating animals with the hmgb1 antagonist ep or rage antagonist fps-zm1 significantly reduced inflammatory cell infiltration and expression of il-1β, matrix metalloproteinase-9 in the perihematoma after ich. |
2016-04-12 |
2023-08-13 |
rat |
| He Wu, Tao Wu, Wei Hua, Xianghui Dong, Yufeng Gao, Xiaochun Zhao, Wenwu Chen, Wangsen Cao, Qingwu Yang, Jiping Qi, Jin Zhou, Jian Wan. PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25623334. |
these results indicate that misoprostol protects brain against ich injury through mechanisms that may involve the hmgb1, src kinase, and matrix metalloproteinase-2/9 pathways. |
2015-11-24 |
2023-08-13 |
mouse |
| Chen-Chen Lee, Chien-Neng Wang, Yueh-Lun Lee, Yi-Ru Tsai, Jau-Jin Li. High mobility group box 1 induced human lung myofibroblasts differentiation and enhanced migration by activation of MMP-9. PloS one. vol 10. issue 2. 2015-11-11. PMID:25692286. |
however, we found that treatment with 10 and 100 ng/ml of hmgb1 induced the differentiation of lung fibroblasts into myofibroblasts and myofibroblasts showed higher migration ability through activation of matrix metalloproteinase (mmp)-9 activation. |
2015-11-11 |
2023-08-13 |
human |
| Wen Li, Qiaoyi Xu, Yuxiao Deng, Zhongwei Yang, Shunpeng Xing, Xianyuan Zhao, Ping Zhu, Xiangrui Wang, Zhengyu He, Yuan Ga. High-mobility group box 1 accelerates lipopolysaccharide-induced lung fibroblast proliferation in vitro: involvement of the NF-κB signaling pathway. Laboratory investigation; a journal of technical methods and pathology. vol 95. issue 6. 2015-08-25. PMID:25867768. |
secretion of matrix metalloproteinase (mmp)-2 and mmp-9, and tissue inhibitor of metalloproteinase 2 (timp-2) was significantly upregulated after treatment with lps, hmgb1, or their combination. |
2015-08-25 |
2023-08-13 |
Not clear |
| Paulo Emílio C Leite, Katia G Lima-Araújo, Guilherme R França, Jussara Lagrota-Candido, Wilson C Santos, Thereza Quirico-Santo. Implant of polymer containing pentacyclic triterpenes from Eugenia punicifolia inhibits inflammation and activates skeletal muscle remodeling. Archivum immunologiae et therapiae experimentalis. vol 62. issue 6. 2015-07-24. PMID:24830560. |
c2c12 cells were seeded on eight-well plates and [(3)h]-thymidine incorporation, tunel assays, mitochondria viability, zymography for matrix metalloproteases (mmps), western blot analysis for mapkinase signaling pathway, nfκb activation and hmgb1 production subsequently determined under basal conditions and after ep-cm treatment. |
2015-07-24 |
2023-08-13 |
mouse |
| Iversen Ann-Charlott. Inflammatory mechanisms in preeclampsia. Pregnancy hypertension. vol 3. issue 2. 2015-06-25. PMID:26105840. |
prrs activate inflammatory responses by recognising endogenous damage-associated molecular patterns (damps) released from injured tissues and stressed or dying cells; including degraded extracellular matrix components, heat-shock proteins, hmgb1 proteins, nucleic acids and crystalline structures such as cholesterol crystals. |
2015-06-25 |
2023-08-13 |
Not clear |
| Fei Wu, Zuo-Hui Zhao, Sen-Tai Ding, Hai-Hu Wu, Jia-Ju L. High mobility group box 1 protein is methylated and transported to cytoplasm in clear cell renal cell carcinoma. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 10. 2015-01-21. PMID:24289579. |
however, hmgb1 can also localize in the cytoplasm and be released into extracellular matrix, where it plays critical roles in carcinogenesis and inflammation. |
2015-01-21 |
2023-08-12 |
Not clear |
| Yuping Yin, Wei Li, Meizhou Deng, Peng Zhang, Qian Shen, Guobing Wang, Kaixiong Ta. Extracellular high mobility group box chromosomal protein 1 promotes drug resistance by increasing the expression of P‑glycoprotein expression in gastric adenocarcinoma cells. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24549588. |
it has previously been reported that high mobility group box chromosomal protein 1 (hmgb1) is overexpressed in the majority of gastric adenocarcinoma cell types, and that hmgb1 can be released into the extracellular matrix from stressed or necrotic cancer cells. |
2014-10-21 |
2023-08-12 |
human |
| Ping Cheng, Weiqi Dai, Fan Wang, Jie Lu, Miao Shen, Kan Chen, Jingjing Li, Yan Zhang, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Yuanyuan Zheng, Chuan-Yong Guo, Ling X. Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways. Biochemical and biophysical research communications. vol 443. issue 4. 2014-04-14. PMID:24361892. |
moreover, ep decreased the expression of hmgb1, rage, p-akt and matrix metallopeptidase-9 (mmp9) and increased the bax/bcl-2 ratio. |
2014-04-14 |
2023-08-12 |
Not clear |
| Ya-Dong Dong, Long Cui, Cheng-Hong Peng, Dong-Feng Cheng, Bao-San Han, Fang Huan. Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23042506. |
the expression of hmgb1, phosphorylated akt (p-akt), ki-67 and matrix metallopeptidase-2 (mmp-2) was detected by real-pcr and western blot assays. |
2014-01-09 |
2023-08-12 |
human |
| Xiabing Tang, Xiaohui Shen, Xiaoyun Qian, Xia Ga. [Expressions of HMGB1, MMP-2 and MMP-9 and prognostic alue in human laryngeal carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 27. issue 4. 2013-12-23. PMID:23631130. |
to investigate the expressions of high mobility group box b1 protein (hmgb1), matrix metalloproteinases-2(mmp-2) and matrix metalloproteinases-9 (mmp-9) in human laryngeal carcinoma and study their relationships with clinicopathological characteristics and prognosis. |
2013-12-23 |
2023-08-12 |
human |
| Yiyu He, Xiaoya Zhou, Xiaoxin Zheng, Xuejun Jian. Exogenous high-mobility group box 1 protein prevents postinfarction adverse myocardial remodeling through TGF-β/Smad signaling pathway. Journal of cellular biochemistry. vol 114. issue 7. 2013-10-29. PMID:23355476. |
the expressions of collagen i, collagen iii, and tissue inhibitor of metalloproteinase 2 (timp2) were also decreased, while the matrix metalloproteinases 2 (mmp2) and mmp9 expressions were upregulated by hmgb1 injection (p < 0.05) compared with control group. |
2013-10-29 |
2023-08-12 |
rat |
| J R van Beijnum, P Nowak-Sliwinska, E van den Boezem, P Hautvast, W A Buurman, A W Griffioe. Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1. Oncogene. vol 32. issue 3. 2013-03-11. PMID:22391561. |
importantly, we show that hmgb1 triggers and helps to sustain this proangiogenic gene expression program in ecs, additionally characterized by increased activity of matrix metalloproteinases, integrins and nuclear factor-κb. |
2013-03-11 |
2023-08-12 |
chicken |
| Chuan-tao Tu, Qun-yan Yao, Bei-li Xu, Ji-yao Wang, Chao-hui Zhou, Shun-cai Zhan. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 9. 2013-01-15. PMID:22683883. |
moreover, curcumin significantly inhibited extracellular matrix deposition, reduced the number of activated stellate cells, and decreased the levels of hmgb1, tlr4 and tlr2 expression in the rat model of fibrogenesis. |
2013-01-15 |
2023-08-12 |
rat |
| Xiao-Rong Hu, Xiao-Hong Wang, Hua-Fen Liu, Wen-Jie Zhou, Hong Jian. High mobility group box 1 protein: possible pathogenic link to atrial fibrillation. Chinese medical journal. vol 125. issue 13. 2012-12-28. PMID:22882860. |
fourth, hmgb1 can promote matrix metalloproteinase-9 upregulation and activation. |
2012-12-28 |
2023-08-12 |
Not clear |
| Chunhong Wang, Guangru Fei, Zhongmin Liu, Qinchuan Li, Zengguang Xu, Tao Re. HMGB1 was a pivotal synergistic effecor for CpG oligonucleotide to enhance the progression of human lung cancer cells. Cancer biology & therapy. vol 13. issue 9. 2012-11-26. PMID:22617774. |
we observed a myd88-dependent upregulation of matrix metalloproteinase (mmp) 2, mmp9 and cyclin-dependent kinase (cdk) 2 in 95d cells in response to hmgb1. |
2012-11-26 |
2023-08-12 |
human |
| Jing Zhang, Jin-Shui Zhu, Zhou Zhou, Wei-Xiong Chen, Ni-Wei Che. Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo. Oncology reports. vol 27. issue 5. 2012-07-23. PMID:22246223. |
ep decreased the expression of hmgb1, rage, akt, p-akt, ki-67 and matrix metallopeptidase-9 (mmp‑9), and increased the expression of p53. |
2012-07-23 |
2023-08-12 |
human |
| Roberta Vitali, Laura Stronati, Anna Negroni, Giovanni Di Nardo, Maria Pierdomenico, Emanuela del Giudice, Paolo Rossi, Salvatore Cucchiar. Fecal HMGB1 is a novel marker of intestinal mucosal inflammation in pediatric inflammatory bowel disease. The American journal of gastroenterology. vol 106. issue 11. 2012-01-03. PMID:21788990. |
in inflammatory conditions, hmgb1 is actively secreted from immune cells in the extracellular matrix, where it behaves as a proinflammatory cytokine. |
2012-01-03 |
2023-08-12 |
Not clear |
| Stefania Mardente, Alessandra Zicari, Fabrizio Consorti, Emanuela Mari, Maura Di Vito, Martina Leopizzi, Carlo Della Rocca, Alfredo Antonac. Cross-talk between NO and HMGB1 in lymphocytic thyroiditis and papillary thyroid cancer. Oncology reports. vol 24. issue 6. 2011-02-24. PMID:21042739. |
no and hmgb1 are known to attract macrophages that would promote angiogenesis, matrix remodelling and suppression of an efficient immune response. |
2011-02-24 |
2023-08-12 |
Not clear |