| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bhranti S Shah, Kevin G Burt, Timothy Jacobsen, Tiago D Fernandes, Didier Olivier Alipui, Kathryn T Weber, Mitchell Levine, Sangeeta S Chavan, Huan Yang, Kevin J Tracey, Nadeen O Chahin. High mobility group box-1 induces pro-inflammatory signaling in human nucleus pulposus cells via toll-like receptor 4-dependent pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 1. 2019-11-04. PMID:30273982. |
lastly, effects of hmgb1 on matrix deposition was evaluated in a 3d culture system of human np cells. |
2019-11-04 |
2023-08-13 |
human |
| Qin Xu, Xia Liu, Liyan Mei, Quan Wen, Jing Chen, Jifei Miao, Hang Lei, Huina Huang, Dongfeng Chen, Shaohui Du, Aijun Liu, Saixia Zhang, Jianhong Zhou, Rudong Deng, Yiwei Li, Chun Li, Hui L. Paeonol Reduces the Nucleocytoplasmic Transportation of HMGB1 by Upregulating HDAC3 in LPS-Induced RAW264.7 Cells. Inflammation. vol 41. issue 4. 2019-04-29. PMID:29736733. |
hyperacetylation of hmgb1, regulated by histone acetyltransferases (hats) and histone deacetylases (hdacs), changes its subcellular localization and secretion to the extracellular matrix. |
2019-04-29 |
2023-08-13 |
Not clear |
| Yiqing Tong, Xin Ku, Chunrong Wu, Jianjun Liu, Chunhui Yang, Wenzhi Tang, Wei Yan, Jianguo Tan. Data-independent acquisition-based quantitative proteomic analysis reveals differences in host immune response of peripheral blood mononuclear cells to sepsis. Scandinavian journal of immunology. vol 89. issue 4. 2019-04-08. PMID:30667541. |
among them, five proteins (high-mobility group box1 [hmgb1], matrix metalloproteinase 8 [mmp8], neutrophil gelatinase-associated lipocalin [ngal], lactotransferrin [ltf] and grancalcin [gca]) were identified by elisa as closely related to the development of sepsis. |
2019-04-08 |
2023-08-13 |
Not clear |
| Jinpan Liu, Ronghui Li, Tongjun Liu, Xiaohui Rausch-Fan, Mingguo Wan. High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease. Scientific reports. vol 7. issue 1. 2019-02-27. PMID:28765610. |
high mobility group box 1 (hmgb1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. |
2019-02-27 |
2023-08-13 |
Not clear |
| Jing Wang, Yuqi Gao, Xinyi Liu, Jiajie W. [Over-expression and suppression of HMGB1 affect proliferation and invasion of endometrial carcinoma and underlying mechanisms]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 7. 2019-02-07. PMID:28844999. |
western blot and reverse transcription-pcr (rt-pcr) were used to detect the expression of nf-κb, vegf, and matrix metalloproteinase 2 (mmp2) in the cells.
results: over-expression of hmgb1 promoted the proliferation, invasion, and migration of hec-1a cell, and up-regulated nf-κb, vegf, and mmp2 expressions, while suppression of hmgb1 inhibited the proliferation, invasion, and migration of hec-1a cells and down-regulated nf-κb, vegf, and mmp2 expressions.
conclusion: hmgb1 plays an important role in proliferation, invasion, and migration of hec-1a cell via nf-κb/vegf/mmp2 pathway. |
2019-02-07 |
2023-08-13 |
Not clear |
| Shafqat Rasul Chaudhry, Ahmad Hafez, Behnam Rezai Jahromi, Thomas Mehari Kinfe, Alf Lamprecht, Mika Niemelä, Sajjad Muhamma. Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH). International journal of molecular sciences. vol 19. issue 7. 2018-11-06. PMID:30011792. |
here, we have reviewed the most important damps molecules including high mobility group box-1 (hmgb1), s100b, hemoglobin and its derivatives, extracellular matrix components, il-1α, il-33, and mitochondrial dna in the context of asah and their role in post-asah complications and clinical outcome after asah. |
2018-11-06 |
2023-08-13 |
Not clear |
| Xiaojin Wu, Weitao Wang, Yuanyuan Chen, Xiangqun Liu, Jindong Wang, Xiaobin Qin, Dawei Yuan, Tao Yu, Guangxia Chen, Yanyan Mi, Jie Mou, Jinpeng Cui, Ankang Hu, Yunxiang E, Dongsheng Pe. High Mobility Group Box Protein 1 Serves as a Potential Prognostic Marker of Lung Cancer and Promotes Its Invasion and Metastasis by Matrix Metalloproteinase-2 in a Nuclear Factor- BioMed research international. vol 2018. 2018-10-01. PMID:29850505. |
high mobility group box protein 1 serves as a potential prognostic marker of lung cancer and promotes its invasion and metastasis by matrix metalloproteinase-2 in a nuclear factor- several studies have reported a significant role of high mobility group box protein 1 (hmgb1) in lung cancer. |
2018-10-01 |
2023-08-13 |
Not clear |
| Xiaojin Wu, Weitao Wang, Yuanyuan Chen, Xiangqun Liu, Jindong Wang, Xiaobin Qin, Dawei Yuan, Tao Yu, Guangxia Chen, Yanyan Mi, Jie Mou, Jinpeng Cui, Ankang Hu, Yunxiang E, Dongsheng Pe. High Mobility Group Box Protein 1 Serves as a Potential Prognostic Marker of Lung Cancer and Promotes Its Invasion and Metastasis by Matrix Metalloproteinase-2 in a Nuclear Factor- BioMed research international. vol 2018. 2018-10-01. PMID:29850505. |
the matrix metalloproteinase-2 (mmp-2) expression and activity were upregulated after treatment with hmgb1, while the upregulated expression of mmp-2 stimulated by hmgb1 in lung cancer cells was significantly reduced with the blockage of si-p65. |
2018-10-01 |
2023-08-13 |
Not clear |
| Seidu A Richard, Marian Sackey, Zhaoliang Su, Huaxi X. Pivotal neuroinflammatory and therapeutic role of high mobility group box 1 in ischemic stroke. Bioscience reports. vol 37. issue 6. 2018-07-26. PMID:29054968. |
hmgb1 may signal via its putative receptors, such as receptor for advanced glycation end products (rage), toll-like receptors (tlrs) as well as matrix metalloproteinase (mmp) enzymes during is. |
2018-07-26 |
2023-08-13 |
Not clear |
| Fang Fang, Dianming Jian. IL-1β/HMGB1 signalling promotes the inflammatory cytokines release via TLR signalling in human intervertebral disc cells. Bioscience reports. vol 36. issue 5. 2017-11-29. PMID:27512095. |
and the expression of matrix metalloproteinases (mmps) such as mmp-1, -3 and -9 was also additively up-regulated by il-1β and hmgb1. |
2017-11-29 |
2023-08-13 |
human |
| Ana S Falcão, Luís A R Carvalho, Gonçalo Lidónio, Ana R Vaz, Susana D Lucas, Rui Moreira, Dora Brite. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS chemical neuroscience. vol 8. issue 1. 2017-10-30. PMID:27797173. |
vs also suppressed aβ-induced expression of inflammatory mediators in microglia, such as matrix metalloproteinase (mmp)-2 and mmp-9, as well as high-mobility group box protein-1 (hmgb1), nod-like receptor protein 3 (nlrp3)-inflammasome, and interleukin (il)-1β. |
2017-10-30 |
2023-08-13 |
mouse |
| J Yuan, Y Y Liu, X J Ma, J B L. [Effect of high fat on fibrosis in rat hepatic stellate cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 24. issue 3. 2017-09-26. PMID:27095762. |
to investigate the effect of high fat on the expression of high-mobility group box 1 (hmgb1),α-smooth muscle actin (α-sma), and matrix metalloproteinase-2 (mmp-2) in rat hepatic stellate cells (hsc-t6 cells). |
2017-09-26 |
2023-08-13 |
rat |
| Qiang Chen, Jun-Jie Bei, Chuan Liu, Shi-Bin Feng, Wei-Bo Zhao, Zhou Zhou, Zheng-Ping Yu, Xiao-Jun Du, Hou-Yuan H. HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization. PloS one. vol 11. issue 5. 2017-07-18. PMID:27243975. |
hmgb1 induces secretion of matrix vesicles by macrophages to enhance ectopic mineralization. |
2017-07-18 |
2023-08-13 |
mouse |
| Sam Man Lee, Mark Hutchinson, David A Sain. The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and experimental pharmacology & physiology. vol 43. issue 9. 2017-06-27. PMID:27249055. |
examples include heat shock proteins, high mobility group box one (hmgb1) and extracellular matrix proteins, all of which are involved in iri. |
2017-06-27 |
2023-08-13 |
Not clear |
| Meriam Nefla, Dirk Holzinger, Francis Berenbaum, Claire Jacque. The danger from within: alarmins in arthritis. Nature reviews. Rheumatology. vol 12. issue 11. 2017-06-22. PMID:27733758. |
in oa, high mobility group protein b1 (hmgb1) and s100 proteins, along with many other alarmins, are abundantly secreted by joint cells, promoting cartilage matrix catabolism, osteophyte formation, angiogenesis and hypertrophic differentiation. |
2017-06-22 |
2023-08-13 |
Not clear |
| Yahui Fu, Jinlai Lei, Yan Zhuang, Kun Zhang, Daigang L. Overexpression of HMGB1 A-box reduced IL-1β-induced MMP expression and the production of inflammatory mediators in human chondrocytes. Experimental cell research. vol 349. issue 1. 2017-05-15. PMID:27771306. |
the aim of this study was to investigate the effects and mechanism of high mobility group box 1 (hmgb1) inhibitors hmgb1 a-box on the expression of matrix metalloproteinase (mmp) and the production of inflammatory mediators in human osteoarthritis chondrocytes after activation by il-1β. |
2017-05-15 |
2023-08-13 |
human |
| b' Agnieszka Irena Mazur-Bialy, Ewa Poche\\xc4\\x8. Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development. Molecules (Basel, Switzerland). vol 21. issue 12. 2017-04-28. PMID:27983705.' |
the apoptosis of adipocytes and macrophages as well as tumor necrosis factor-alpha (tnf-α), interleukin 6 (il-6), interleukin 1beta (il-1β), monocyte chemotactic protein 1 (mcp-1), high-mobility group box 1 (hmgb1), transforming growth factor-beta 1 (tgfβ), interleukin 10 (il-10), inducible nitric oxide synthase (inos), nitric oxide (no), matrix metalloproteinase 9 (mmp-9), tissue inhibitor of metalloproteinases-1 (timp-1) expression and release, macrophage migration and adipokines (adiponectin and leptin) were determined. |
2017-04-28 |
2023-08-13 |
Not clear |
| Shibo Ying, Zhaoqiang Jiang, Xianglei He, Min Yu, Riping Chen, Junqiang Chen, Guoqing Ru, Yuan Chen, Wanyuan Chen, Lijin Zhu, Tao Li, Yixiao Zhang, Xinnian Guo, Xianhong Yin, Xing Zhang, Jianlin Lo. Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases. Disease markers. vol 2017. 2017-04-20. PMID:28348451. |
in addition, serum matrix metalloproteinases 2 and 9 are not correlated with hmgb1 in ards. |
2017-04-20 |
2023-08-13 |
human |
| Yuan-Bo Li, Peng Xu, Ke Xu, Yong-Song Cai, Meng-Yao Sun, Le Yang, Jian Sun, She-Min L. Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression. Molecular and cellular biochemistry. vol 420. issue 1-2. 2017-02-06. PMID:27522665. |
furthermore, the effects of hmgb1 on matrix metalloproteinase (mmp)-2 and mmp-13 were measured using western blot analysis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Wei Lv, Na Chen, Yanliang Lin, Hongyan Ma, Yongwei Ruan, Zhiwei Li, Xungeng Li, Xiaohua Pan, Xingsong Tia. Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis. Cancer letters. vol 375. issue 2. 2016-08-24. PMID:26952810. |
caveolin-1 phosphorylation contributed to hmgb1 secretion from the cytoplasm to the extracellular matrix. |
2016-08-24 |
2023-08-13 |
Not clear |