| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jari Willing, Christine K Wagne. Progesterone Receptor Expression in the Developing Mesocortical Dopamine Pathway: Importance for Complex Cognitive Behavior in Adulthood. Neuroendocrinology. vol 103. issue 3-4. 2017-05-15. PMID:26065828. |
numerous psychiatric and behavioral disorders such as autism, attention deficit disorder and schizophrenia may involve disruptions in the development of the mesocortical dopamine pathway, consisting of dopaminergic projections from the midbrain ventral tegmental area (vta) to the medial prefrontal cortex (mpfc). |
2017-05-15 |
2023-08-13 |
Not clear |
| Duncan A A MacLaren, David I G Wilson, Philip Win. Selective lesions of the cholinergic neurons within the posterior pedunculopontine do not alter operant learning or nicotine sensitization. Brain structure & function. vol 221. issue 3. 2016-12-19. PMID:25586659. |
these effects have been attributed to disrupted input to midbrain dopamine systems, particularly the ventral tegmental area. |
2016-12-19 |
2023-08-13 |
rat |
| Y-Z Guan, J-H Y. Glycine blocks long-term potentiation of GABAergic synapses in the ventral tegmental area. Neuroscience. vol 318. 2016-12-13. PMID:26806277. |
in the current study, we examined the effect of glycine on the electrophysiological activities of putative dopamine vta neurons in midbrain slices from ethanol-naïve rats. |
2016-12-13 |
2023-08-13 |
rat |
| Fumio Yamashita, Makoto Sasaki, Kentaro Fukumoto, Kotaro Otsuka, Ikuko Uwano, Hiroyuki Kameda, Jin Endoh, Akio Saka. Detection of changes in the ventral tegmental area of patients with schizophrenia using neuromelanin-sensitive MRI. Neuroreport. vol 27. issue 5. 2016-12-13. PMID:26901057. |
the ventral tegmental area (vta), one of the neuromelanin-containing dopaminergic nuclei in the midbrain, is closely related to the pathogenesis of schizophrenia, but its imaging findings remain unclear. |
2016-12-13 |
2023-08-13 |
human |
| Emilie Werlen, Matthew W Jone. Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions. Progress in brain research. vol 219. 2016-10-31. PMID:26072240. |
here, we review the current state of the circuitry and physiology underlying dopamine's actions, suggesting that--alongside local effects within hippocampus and prefrontal cortex--dopamine released from the midbrain ventral tegmental area is well positioned to dynamically tune interactions between limbic-cortical circuits through modulation of rhythmic network activity. |
2016-10-31 |
2023-08-13 |
Not clear |
| Tim D Auman. Environment- and activity-dependent dopamine neurotransmitter plasticity in the adult substantia nigra. Journal of chemical neuroanatomy. vol 73. 2016-09-06. PMID:26718607. |
although further research is required to establish snc (and vta) da neurotransmitter plasticity, and to determine whether it alters brain function and behavior, it is an exciting prospect because: (1) it may play important roles in movement, motor learning, reward, motivation, memory and cognition; and (2) imbalances in midbrain da cause symptoms associated with several prominent brain and behavioral disorders such as schizophrenia, addiction, obsessive-compulsive disorder, depression, parkinson's disease and attention-deficit and hyperactivity disorder. |
2016-09-06 |
2023-08-13 |
mouse |
| Jingzhong Zhang, Sebastian Götz, Daniela M Vogt Weisenhorn, Antonio Simeone, Wolfgang Wurst, Nilima Prakas. A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiology of disease. vol 82. 2016-08-19. PMID:26049140. |
the protracted and age-dependent degeneration of dopamine (da)-producing neurons of the substantia nigra pars compacta (snc) and ventral tegmental area (vta) in the mammalian midbrain is a hallmark of human parkinson's disease (pd) and of certain genetic mouse models of pd, such as mice heterozygous for the homeodomain transcription factor engrailed 1 (en1(+/-) mice). |
2016-08-19 |
2023-08-13 |
mouse |
| Sarah X Luo, Eric J Huan. Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. The American journal of pathology. vol 186. issue 3. 2016-08-09. PMID:26724386. |
midbrain dopaminergic (da) neurons in the substantia nigra pars compacta and ventral tegmental area regulate extrapyramidal movement and important cognitive functions, including motivation, reward associations, and habit learning. |
2016-08-09 |
2023-08-13 |
Not clear |
| Abigail G Schindler, Marta E Soden, Larry S Zweifel, Jeremy J Clar. Reversal of Alcohol-Induced Dysregulation in Dopamine Network Dynamics May Rescue Maladaptive Decision-making. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 13. 2016-08-08. PMID:27030756. |
indeed, we find that increased phasic dopamine signaling after adolescent alcohol use is attributable to a midbrain circuit, including the input from the pedunculopontine tegmentum to the vta. |
2016-08-08 |
2023-08-13 |
rat |
| Alessio Masi, Roberto Narducci, Francesco Resta, Carmen Carbone, Kazuto Kobayashi, Guido Mannaion. Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons. The European journal of neuroscience. vol 42. issue 9. 2016-07-27. PMID:26354486. |
here, we present an electrophysiological investigation of the functional role of ih in the integration of synaptic inputs in identified snc and vta da neurons, comparatively, in acute midbrain slices from th-gfp mice. |
2016-07-27 |
2023-08-13 |
mouse |
| Judith Mylius, Max F K Happel, Alexander G Gorkin, Ying Huang, Henning Scheich, Michael Brosc. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain structure & function. vol 220. issue 6. 2016-07-25. PMID:25084746. |
motivated by the increasing evidence that auditory cortex is under control of dopaminergic cell structures of the ventral midbrain, we studied how the ventral tegmental area and substantia nigra affect neuronal activity in auditory cortex. |
2016-07-25 |
2023-08-13 |
monkey |
| Mayur S Parmar, Juliann D Jaumotte, Michael J Zigmond, Jane E Cavanaug. ERK1, 2, and 5 expression and activation in dopaminergic brain regions during postnatal development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 46. 2016-06-20. PMID:26363522. |
in the striatum (str) and ventral mesencephalon regions of the substantia nigra (sn) and ventral tegmental area (vta), erk5 expression and activation were high during early postnatal days and declined with aging. |
2016-06-20 |
2023-08-13 |
Not clear |
| J N Berry, S E Engle, J M McIntosh, R M Drena. α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity. Neuroscience. vol 304. 2016-05-24. PMID:26210579. |
by coupling local infusion of drugs and brain slice patch-clamp electrophysiology, we show that activating α6(∗) nachrs in midbrain da areas is sufficient to enhance glutamatergic transmission in ventral tegmental area (vta) da neurons. |
2016-05-24 |
2023-08-13 |
mouse |
| Xue-Feng Wang, Jing-Jing Liu, Julia Xia, Ji Liu, Vincent Mirabella, Zhiping P Pan. Endogenous Glucagon-like Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive onto Mesolimbic Dopamine Neurons. Cell reports. vol 12. issue 5. 2016-05-09. PMID:26212334. |
using chemogenetic tools, we discovered that central glp-1 acts on the midbrain ventral tegmental area (vta) and suppresses high-fat food intake. |
2016-05-09 |
2023-08-13 |
Not clear |
| Elyssa B Margolis, Jennifer M Mitchell, Gregory O Hjelmstad, Howard L Field. A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons. The Journal of physiology. vol 589. issue 17. 2016-04-22. PMID:21690191. |
here we report that following stress, activating δ opioid receptors (dors) on midbrain ventral tegmental area (vta) neurons causes a novel synaptic effect: the augmentation of gaba(a) receptor (gaba(a)r)-mediated inhibitory postsynaptic currents. |
2016-04-22 |
2023-08-12 |
Not clear |
| Mengia-Seraina Rioult-Pedotti, Ana Pekanovic, Clement Osei Atiemo, John Marshall, Andreas Rüdiger Luf. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. PloS one. vol 10. issue 5. 2016-04-04. PMID:25938462. |
dopaminergic neurons in the ventral tegmental area, the major midbrain nucleus projecting to the motor cortex, play a key role in motor skill learning and motor cortex synaptic plasticity. |
2016-04-04 |
2023-08-13 |
rat |
| Maria Vadalà, Annamaria Vallelunga, Lucia Palmieri, Beniamino Palmieri, Julio Cesar Morales-Medina, Tommaso Iannitt. Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson's disease. Behavioral and brain functions : BBF. vol 11. 2016-03-30. PMID:26347217. |
parkinson's disease is a neurodegenerative pathology caused by abnormal degeneration of dopaminergic neurons in the ventral tegmental area and substantia nigra pars compacta in the midbrain resulting in damage to the basal ganglia. |
2016-03-30 |
2023-08-13 |
Not clear |
| Idaira Oliva, Matthew J Wana. Ventral Tegmental Area Afferents and Drug-Dependent Behaviors. Frontiers in psychiatry. vol 7. 2016-03-25. PMID:27014097. |
preclinical studies demonstrate that the acquisition and expression of many drug-dependent behaviors involves the ventral tegmental area (vta), a midbrain structure comprised of dopamine, gaba, and glutamate neurons. |
2016-03-25 |
2023-08-13 |
Not clear |
| Emmanouil Metzakopian, Kamal Bouhali, Matías Alvarez-Saavedra, Jeffrey A Whitsett, David J Picketts, Siew-Lan An. Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25804738. |
midbrain dopamine neuronal progenitors develop into heterogeneous subgroups of neurons, such as substantia nigra pars compacta, ventral tegmental area and retrorubal field, that regulate motor control, motivated and addictive behaviours. |
2016-02-13 |
2023-08-13 |
mouse |
| Wolfgang M Pauli, Tobias Larsen, Sven Collette, Julian M Tyszka, Ben Seymour, John P O'Dohert. Distinct Contributions of Ventromedial and Dorsolateral Subregions of the Human Substantia Nigra to Appetitive and Aversive Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 42. 2016-01-25. PMID:26490862. |
the role of neurons in the substantia nigra (sn) and ventral tegmental area (vta) of the midbrain in contributing to the elicitation of reward prediction errors during appetitive learning has been well established. |
2016-01-25 |
2023-08-13 |
human |