| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hilary A Marusak, Joshua R B Hatfield, Moriah E Thomason, Christine A Rabina. Reduced Ventral Tegmental Area-Hippocampal Connectivity in Children and Adolescents Exposed to Early Threat. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2019-11-20. PMID:28740870. |
here, we evaluate the impact of early threat exposure (violence, abuse) on functional connectivity of putative dopaminergic midbrain regions, the ventral tegmental area (vta) and substantia nigra (sn), giving rise to mesocorticolimbic and nigrostriatal pathways, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Martin Ulrich, Philipp Stauß, Georg Grö. Glucose Modulates Human Ventral Tegmental Activity in Response to Sexual Stimuli. The journal of sexual medicine. vol 15. issue 1. 2019-09-30. PMID:29289371. |
attribution of salience to sexual stimuli is mediated by the dopaminergic midbrain, including the ventral tegmental area (vta). |
2019-09-30 |
2023-08-13 |
human |
| Alberto Cordella, Paraskevi Krashia, Annalisa Nobili, Annabella Pignataro, Livia La Barbera, Maria Teresa Viscomi, Alessandro Valzania, Flavio Keller, Martine Ammassari-Teule, Nicola Biagio Mercuri, Nicola Berretta, Marcello D'Ameli. Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of disease. vol 116. 2019-09-06. PMID:29778899. |
in particular, the dopaminergic innervation from the vta to the hippocampus is critical for hippocampal-related memory function and alterations in the midbrain dopaminergic system are frequently reported in alzheimer's disease (ad), contributing to age-related decline in memory and non-cognitive functions. |
2019-09-06 |
2023-08-13 |
mouse |
| Rachel J Smith, Peter J Vento, Ying S Chao, Cameron H Good, Thomas C Jho. Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice. Brain structure & function. vol 224. issue 1. 2019-05-28. PMID:30302539. |
the rostromedial tegmental nucleus (rmtg), also known as the tail of the ventral tegmental area (tvta), is a gabaergic structure identified in 2009 that receives strong inputs from the lateral habenula and other sources, sends dense inhibitory projections to midbrain dopamine (da) neurons, and plays increasingly recognized roles in aversive learning, addiction, and other motivated behaviors. |
2019-05-28 |
2023-08-13 |
mouse |
| Martin Tik, Ronald Sladky, Caroline Di Bernardi Luft, David Willinger, André Hoffmann, Michael J Banissy, Joydeep Bhattacharya, Christian Windischberge. Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!-moment. Human brain mapping. vol 39. issue 8. 2019-05-21. PMID:29665228. |
besides the finding on cortical involvement of the left anterior middle temporal gyrus (amtg), here we showed for the first time robust subcortical activity changes related to insightful problem solving in the bilateral thalamus, hippocampus, and the dopaminergic midbrain comprising ventral tegmental area (vta), nucleus accumbens (nacc), and caudate nucleus. |
2019-05-21 |
2023-08-13 |
human |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
whole-transcriptome analysis (rna-seq) has been used to analyze changes in the expression of dopaminergic genes that encode proteins involved in the synthesis, inactivation, and neurotransmission of dopamine in the striatum, ventral tegmental area, raphe nuclei of the midbrain, hypothalamus, and hippocampus of male mice subjected to chronic social defeat. |
2019-04-11 |
2023-08-13 |
mouse |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
the expression of th, ddc, and slc6a3 (dat1) was upregulated, while that of ppp1r1b and sncg was downregulated in the ventral tegmental area; the expression of th, ddc, drd2, and sncg was downregulated in the raphe nuclei of midbrain; the expression of th, aldh2, and ppp1r1b was upregulated, while that of Маоа was downregulated in the hypothalamus; drd1 and snca expression was downregulated and that of sncb was upregulated in the striatum, and sncb expression was upregulated in the hippocampus. |
2019-04-11 |
2023-08-13 |
mouse |
| Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Dou Yin, Chen-Yao Wang, Yu-Dong Yan, Dian-Ru Wang, Xiang-Shan Yuan, Chen-Bo Ye, Wei Guo, Wei-Min Qu, Yoan Cherasse, Michael Lazarus, Yu-Qiang Ding, Zhi-Li Huan. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS biology. vol 16. issue 4. 2019-03-27. PMID:29652889. |
the rostromedial tegmental nucleus (rmtg), also called the gabaergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. |
2019-03-27 |
2023-08-13 |
rat |
| María Paula Cornejo, Franco Barrile, Pablo Nicolás De Francesco, Enrique Leo Portiansky, Mirta Reynaldo, Mario Perell. Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei. Neuroscience. vol 392. 2019-03-06. PMID:30268780. |
the vta is a complex midbrain structure mainly comprised of dopamine (da) and gamma-aminobutiric acid (gaba) neurons that are distributed in several vta sub-nuclei. |
2019-03-06 |
2023-08-13 |
mouse |
| Marc Fakhour. The tail of the ventral tegmental area in behavioral processes and in the effect of psychostimulants and drugs of abuse. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29421265. |
the tail of the ventral tegmental area (tvta) is a recently identified structure that exerts a major inhibitory drive onto midbrain dopamine (da) neurons. |
2019-02-14 |
2023-08-13 |
mouse |
| Ray Luo, Akira Uematsu, Adam Weitemier, Luca Aquili, Jenny Koivumaa, Thomas J McHugh, Joshua P Johanse. A dopaminergic switch for fear to safety transitions. Nature communications. vol 9. issue 1. 2019-01-11. PMID:29950562. |
the midbrain ventral tegmental area (vta) dopamine system has been implicated in reward and more broadly in signaling when a better-than-expected outcome has occurred. |
2019-01-11 |
2023-08-13 |
Not clear |
| Jeongah Kim, Sangwon Jang, Mijung Choi, Sooyoung Chung, Youngshik Choe, Han Kyoung Choe, Gi Hoon Son, Kunsoo Rhee, Kyungjin Ki. Abrogation of the Circadian Nuclear Receptor REV-ERBα Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration. Molecules and cells. vol 41. issue 8. 2018-12-17. PMID:30078232. |
rev-erbα deficiency significantly exacerbated 6-ohda-induced motor deficits as well as daergic neuronal loss in the vertebral midbrain including the sn and the ventral tegmental area. |
2018-12-17 |
2023-08-13 |
mouse |
| Xinglong Gu, Wei L. Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience letters. vol 668. 2018-11-09. PMID:29355693. |
here we report that in both cortical pyramidal neurons and midbrain dopamine neurons in ventral tegmental area (vta), genetic deletion of the glun1 subunit, which is required for assembly of functional nmdars, leads to a strong reduction of gabaergic synaptic transmission. |
2018-11-09 |
2023-08-13 |
Not clear |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
the present study used resting-state fmri and seed-based functional connectivity of putative dopaminergic midbrain regions (i.e., substantia nigra (sn) and ventral tegmental area (vta)) to investigate the circuit-related abnormalities in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Bo Fu, Xie-Chuan Weng, Jing Wang, Tao Huang, Bin Wang, Shi-de Lin, Shao-Jun Li. [The impact of electrophysiology of central dopaminergic neurons and the depression-state induced by chronic neuropathic pain]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 32. issue 5. 2018-10-18. PMID:29931842. |
to explore the underlying electrophysiological mechanism of depression induced by chronic pain in dopaminergic neurons in midbrain ventral tegmental area (vta) of rats. |
2018-10-18 |
2023-08-13 |
rat |
| Susanne Nichterwitz, Geng Chen, Julio Aguila Benitez, Marlene Yilmaz, Helena Storvall, Ming Cao, Rickard Sandberg, Qiaolin Deng, Eva Hedlun. Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling. Nature communications. vol 7. 2018-08-29. PMID:27387371. |
importantly, we demonstrate that lcm-seq can provide biological insight on highly similar neuronal populations, including motor neurons isolated from different levels of the mouse spinal cord, as well as human midbrain dopamine neurons of the substantia nigra compacta and the ventral tegmental area. |
2018-08-29 |
2023-08-13 |
mouse |
| J M Wenzel, J F Chee. Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 1. 2018-07-26. PMID:28653666. |
indeed, ecb signaling in the ventral tegmental area stimulates activation of midbrain da cells and promotes da release in terminal regions such as the nucleus accumbens (nac). |
2018-07-26 |
2023-08-13 |
human |
| Xiaojie Liu, Peng Zhong, Casey Vickstrom, Yan Li, Qing-Song Li. PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28497801. |
repeated cocaine exposure in vivo caused a decrease in inhibitory postsynaptic currents (ipscs) and an increase in the ampar/nmdar ratio in ventral tegmental area (vta) dopamine neurons in midbrain slices ex vivo. |
2018-04-24 |
2023-08-13 |
mouse |
| Thomas Viereckel, Sylvie Dumas, Casey J A Smith-Anttila, Bianca Vlcek, Zisis Bimpisidis, Malin C Lagerström, Åsa Konradsson-Geuken, Åsa Wallén-Mackenzi. Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease. Scientific reports. vol 6. 2018-04-16. PMID:27762319. |
the ventral tegmental area (vta) and substantia nigra pars compacta (snc) of the midbrain are associated with parkinson's disease (pd), schizophrenia, mood disorders and addiction. |
2018-04-16 |
2023-08-13 |
mouse |
| Thomas Viereckel, Sylvie Dumas, Casey J A Smith-Anttila, Bianca Vlcek, Zisis Bimpisidis, Malin C Lagerström, Åsa Konradsson-Geuken, Åsa Wallén-Mackenzi. Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease. Scientific reports. vol 6. 2018-04-16. PMID:27762319. |
here, several unique gene expression patterns were identified in the mouse midbrain of which neurod6 and grp were expressed within different dopaminergic subpopulations of the vta, and trpv1 within a small heterogeneous population. |
2018-04-16 |
2023-08-13 |
mouse |