| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Viereckel, Sylvie Dumas, Casey J A Smith-Anttila, Bianca Vlcek, Zisis Bimpisidis, Malin C Lagerström, Åsa Konradsson-Geuken, Åsa Wallén-Mackenzi. Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease. Scientific reports. vol 6. 2018-04-16. PMID:27762319. |
this study thus unravels markers for distinct subpopulations of neurons within the mouse and human midbrain, defines unique anatomical subregions within the vta and exposes an entirely new glutamatergic pathway. |
2018-04-16 |
2023-08-13 |
mouse |
| YongXin Hao, Aref Shabanpoor, Gerlinde A Met. Stress and corticosterone alter synaptic plasticity in a rat model of Parkinson's disease. Neuroscience letters. vol 651. 2018-03-26. PMID:28473257. |
along with impaired motor performance, stress and clamped cort partially preserved th expression in both substantia nigra (sn) and ventral tegmental area (vta), but differentially modulated the expression of syn, calcyon, and gr mrna in midbrain and cortical areas. |
2018-03-26 |
2023-08-13 |
rat |
| Elizabeth M Avegno, Michael C Salling, Anders Borgkvist, Ana Mrejeru, Alexander C Whitebirch, Elyssa B Margolis, David Sulzer, Neil L Harriso. Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27475082. |
we examined neuronal firing rates in slices of mouse midbrain following adolescent binge-like alcohol drinking and find that prior alcohol experience greatly enhanced the sensitivity to excitation by ethanol itself (10-50 mm) in a subset of ventral midbrain da neurons located in the medial vta. |
2018-02-22 |
2023-08-13 |
mouse |
| L Yetnikoff, H N Lavezzi, R A Reichard, D S Zah. An update on the connections of the ventral mesencephalic dopaminergic complex. Neuroscience. vol 282. 2018-01-26. PMID:24735820. |
this review covers the intrinsic organization and afferent and efferent connections of the midbrain dopaminergic complex, comprising the substantia nigra, ventral tegmental area and retrorubral field, which house, respectively, the a9, a10 and a8 groups of nigrostriatal, mesolimbic and mesocortical dopaminergic neurons. |
2018-01-26 |
2023-08-13 |
human |
| S K Tahajjul Taufique, Vinod Kuma. Differential activation and tyrosine hydroxylase distribution in the hippocampal, pallial and midbrain brain regions in response to cognitive performance in Indian house crows exposed to abrupt light environment. Behavioural brain research. vol 314. 2018-01-18. PMID:27478138. |
further, under ll, th- immunoreactive neurons were reduced in number in midbrain dopamine synthesis sites, the venteral tegmental area (vta) and substantia nigra (sn), with a negative correlation of co-localized zenk/th- immunoreactive cells on errors during the association tasks. |
2018-01-18 |
2023-08-13 |
Not clear |
| Zong-Bo Wei, Ye-Feng Yuan, Florence Jaouen, Mei-Sheng Ma, Chan-Juan Hao, Zhe Zhang, Quan Chen, Zengqiang Yuan, Li Yu, Corinne Beurrier, Wei L. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. vol 12. issue 7. 2018-01-16. PMID:27171858. |
we here report that an endoplasmic reticulum (er)-associated transmembrane protein slc35d3 is selectively expressed in subsets of midbrain da neurons in about 10% th (tyrosine hydroxylase)-positive neurons in the substantia nigra pars compacta (snc) and in about 22% th-positive neurons in the ventral tegmental area (vta). |
2018-01-16 |
2023-08-13 |
mouse |
| Juliann D Jaumotte, Stephanie L Wyrostek, Michael J Zigmon. Protection of cultured dopamine neurons from MPP(+) requires a combination of neurotrophic factors. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27098376. |
we therefore examined the effect of such combinations after acute exposure to the toxin 1-methyl-4-phenylpyridinium (mpp(+) ) using dissociated postnatal rat midbrain cultures isolated from sn and ventral tegmental area (vta). |
2017-12-22 |
2023-08-13 |
rat |
| Jiangping Chan, Xin Guan, Yiling Ni, Lilu Luo, Liqiang Yang, Pengyue Zhang, Jichuan Zhang, Yanmei Che. Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats. Behavioural brain research. vol 321. 2017-11-29. PMID:28025067. |
lhb is reciprocally connected with midbrain monoaminergic brain areas such as the ventral tegmental area (vta). |
2017-11-29 |
2023-08-13 |
rat |
| Jason B Cook, Linzy M Hendrickson, Grant M Garwood, Kelsey M Toungate, Christina V Nania, Hitoshi Morikaw. Junk food diet-induced obesity increases D2 receptor autoinhibition in the ventral tegmental area and reduces ethanol drinking. PloS one. vol 12. issue 8. 2017-10-13. PMID:28859110. |
in midbrain slices, we showed that cafeteria diet feeding enhances da d2 receptor (d2r) autoinhibition in vta da neurons. |
2017-10-13 |
2023-08-13 |
rat |
| Natalia Omelchenko, Priya Roy, Judith Joyce Balcita-Pedicino, Samuel Poloyac, Susan R Sesac. Impact of prenatal nicotine on the structure of midbrain dopamine regions in the rat. Brain structure & function. vol 221. issue 4. 2017-10-03. PMID:25716298. |
midbrain sections stained for nissl or by immunoperoxidase for tyrosine hydroxylase and analyzed using unbiased stereology revealed no changes in volume or cell number in the substantia nigra compacta or ventral tegmental area as a result of nic exposure. |
2017-10-03 |
2023-08-13 |
human |
| Simon McArthur, Ilse S Pienaar, Sindhu M Siddiqi, Glenda E Gillie. Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Brain structure & function. vol 221. issue 5. 2017-09-20. PMID:25944572. |
the mammalian midbrain dopaminergic systems arising in the substantia nigra pars compacta (snc) and ventral tegmental area (vta) are critical for coping behaviours and are implicated in neuropsychiatric disorders where early life challenges comprise significant risk factors. |
2017-09-20 |
2023-08-13 |
mouse |
| Michael E Authement, Ludovic D Langlois, Haifa Kassis, Shawn Gouty, Matthieu Dacher, Ryan D Shepard, Brian M Cox, Fereshteh S Nugen. Morphine-induced synaptic plasticity in the VTA is reversed by HDAC inhibition. Journal of neurophysiology. vol 116. issue 3. 2017-09-08. PMID:27306674. |
using a combination of immunohistochemistry, western blot, and whole cell patch-clamp recording in rat midbrain slices, we show that morphine increased hdac2 activity in vta da neurons and reduced histone h3 acetylation at lysine 9 (ac-h3k9) in the vta 24 h after the injection. |
2017-09-08 |
2023-08-13 |
rat |
| Shabana Khan, Simon R W Stott, Audrey Chabrat, Anna M Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque, Siew-Lan An. Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 9. 2017-08-18. PMID:28130357. |
in this paper, we report the identification and characterization of a novel subset of midbrain dopaminergic neurons located in the ventral tegmental area that expresses the basic helix-loop-helix transcription factor, neurogenic differentiation factor-6 (neurod6). |
2017-08-18 |
2023-08-13 |
Not clear |
| N N Kudryavtseva, D A Smagin, I L Kovalenko, A G Galyamina, G B Vishnivetskaya, V N Babenko, Yu L Orlo. [Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data]. Molekuliarnaia biologiia. vol 51. issue 2. 2017-08-14. PMID:28537235. |
using the data of whole transcriptome analysis (rna-seq), the changes in the expression of serotonergic genes involved in the synthesis, inactivation, and reception of serotonin, as well as of the creb1 (transcription factor) gene and the bdnf (brain-derived neurotrophic factor) gene were detected in the striatum (str), ventral tegmental area (vta), midbrain raphe nuclei (mrn), hypothalamus (hyp), and hippocampus (hip) of defeated and aggressive male mice. |
2017-08-14 |
2023-08-13 |
mouse |
| Vaishnav Krishnan, David C Stoppel, Yi Nong, Mark A Johnson, Monica J S Nadler, Ekim Ozkaynak, Brian L Teng, Ikue Nagakura, Fahim Mohammad, Michael A Silva, Sally Peterson, Tristan J Cruz, Ekkehard M Kasper, Ramy Arnaout, Matthew P Anderso. Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Nature. vol 543. issue 7646. 2017-08-04. PMID:28297715. |
this ube3a-seizure synergy maps to glutamate neurons of the midbrain ventral tegmental area (vta), where cbln1 deletions impair sociability and weaken glutamatergic transmission. |
2017-08-04 |
2023-08-13 |
mouse |
| Ji Hoon Yoo, Vivien Zell, Johnathan Wu, Cindy Punta, Nivedita Ramajayam, Xinyi Shen, Lauren Faget, Varoth Lilascharoen, Byung Kook Lim, Thomas S Hnask. Activation of Pedunculopontine Glutamate Neurons Is Reinforcing. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053028. |
dopamine transmission from midbrain ventral tegmental area (vta) neurons underlies behavioral processes related to motivation and drug addiction. |
2017-07-24 |
2023-08-13 |
mouse |
| Katsuo Kimura, Ken-Ichi Inoue, Yoshiyuki Kuroiwa, Fumiaki Tanaka, Masahiko Takad. Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861638. |
it was found that the occurrence of α-syn-positive neurons proceeded topologically based on the midbrain dopamine pathways arising from the substantia nigra and the ventral tegmental area where they were primarily observed. |
2017-06-26 |
2023-08-13 |
human |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
here we used rat foetal midbrain progenitors at two developmental stages corresponding to a peak in either a9 or a10 neurogenesis and examined their commitment to respective dopaminergic phenotypes by grafting cells into different forebrain regions that contain targets of either nigral a9 dopamine innervation (dorsal striatum), ventral tegmental area a10 dopamine innervation (nucleus accumbens and prefrontal cortex), or only sparse dopamine but rich noradrenaline innervation (hippocampus). |
2017-05-16 |
2023-08-13 |
rat |
| Jari Willing, Christine K Wagne. Progesterone Receptor Expression in the Developing Mesocortical Dopamine Pathway: Importance for Complex Cognitive Behavior in Adulthood. Neuroendocrinology. vol 103. issue 3-4. 2017-05-15. PMID:26065828. |
numerous psychiatric and behavioral disorders such as autism, attention deficit disorder and schizophrenia may involve disruptions in the development of the mesocortical dopamine pathway, consisting of dopaminergic projections from the midbrain ventral tegmental area (vta) to the medial prefrontal cortex (mpfc). |
2017-05-15 |
2023-08-13 |
Not clear |
| Duncan A A MacLaren, David I G Wilson, Philip Win. Selective lesions of the cholinergic neurons within the posterior pedunculopontine do not alter operant learning or nicotine sensitization. Brain structure & function. vol 221. issue 3. 2016-12-19. PMID:25586659. |
these effects have been attributed to disrupted input to midbrain dopamine systems, particularly the ventral tegmental area. |
2016-12-19 |
2023-08-13 |
rat |