| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myong Gyong Lee, Andrew Phimister, Dexter Morin, Alan Buckpitt, Charles Ploppe. In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15833892. |
this study concludes that 1) the incidence of acute nasal injury from systemic and inhaled na correlates with the rates of regional microsomal na metabolism and that 2) the nasal airflow pattern determines the pattern of olfactory mucosal injury from inhaled na. |
2005-08-26 |
2023-08-12 |
human |
| Brian H Mathison, S Randall Frame, Matthew S Bogdanff. DNA methylation, cell proliferation, and histopathology in rats following repeated inhalation exposure to dimethyl sulfate. Inhalation toxicology. vol 16. issue 9. 2005-08-12. PMID:16036751. |
dna methylation was greatest in dna isolated from nasal respiratory mucosa, less in olfactory, and little was found in lung. |
2005-08-12 |
2023-08-12 |
rat |
| Ulrika Westin, Elena Piras, Björn Jansson, Ulrika Bergström, Maria Dahlin, Eva Brittebo, Erik Björ. Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 24. issue 5. 2005-07-22. PMID:15784346. |
transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. |
2005-07-22 |
2023-08-12 |
mouse |
| Ulrika Westin, Elena Piras, Björn Jansson, Ulrika Bergström, Maria Dahlin, Eva Brittebo, Erik Björ. Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 24. issue 5. 2005-07-22. PMID:15784346. |
the aim of this study was to investigate whether morphine can be transferred along the olfactory pathway to the cns, thereby circumventing the blood-brain barrier, after nasal administration to rodents. |
2005-07-22 |
2023-08-12 |
mouse |
| Ulrika Westin, Elena Piras, Björn Jansson, Ulrika Bergström, Maria Dahlin, Eva Brittebo, Erik Björ. Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 24. issue 5. 2005-07-22. PMID:15784346. |
overall, the levels of morphine in the right olfactory bulbs (robs) significantly exceeded those in the left olfactory bulbs (lobs) and brain tissue samples 15, 60 and 240 min after right-sided nasal administration. |
2005-07-22 |
2023-08-12 |
mouse |
| Ulrika Westin, Elena Piras, Björn Jansson, Ulrika Bergström, Maria Dahlin, Eva Brittebo, Erik Björ. Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 24. issue 5. 2005-07-22. PMID:15784346. |
all the techniques used in this study demonstrate that morphine was transferred along the olfactory pathway to the cns after nasal administration to rodents. |
2005-07-22 |
2023-08-12 |
mouse |
| Karunya K Kandimalla, Maureen D Donova. Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. Journal of pharmaceutical sciences. vol 94. issue 3. 2005-07-21. PMID:15666293. |
the permeation of chlorpheniramine and chlorcyclizine in vitro across the bovine olfactory mucosa was studied to investigate the biological and physicochemical characteristics that contribute to the limited cns disposition of these compounds following nasal administration. |
2005-07-21 |
2023-08-12 |
cattle |
| Alan Mackay-Si. Olfactory ensheathing cells and spinal cord repair. The Keio journal of medicine. vol 54. issue 1. 2005-05-18. PMID:15832075. |
our experiments demonstrated that nasal olfactory ensheathing cells led to functional improvement after complete spinal cord transaction in rat. |
2005-05-18 |
2023-08-12 |
human |
| Alan Mackay-Si. Olfactory ensheathing cells and spinal cord repair. The Keio journal of medicine. vol 54. issue 1. 2005-05-18. PMID:15832075. |
after devising methods to grow human olfactory ensheathing cells from nasal biopsy we recently initiated a phase i clinical trial of transplantation into the human paraplegic spinal cord. |
2005-05-18 |
2023-08-12 |
human |
| M Knecht, T Humme. Recording of the human electro-olfactogram. Physiology & behavior. vol 83. issue 1. 2005-04-19. PMID:15501486. |
in conclusion, in combination with nasal endoscopy and air-dilution olfactometry, the eog is a unique part of a large array of techniques used to provide a complete picture of the processing of olfactory information in humans. |
2005-04-19 |
2023-08-12 |
human |
| Jun Gu, Huadong Cui, Melissa Behr, Li Zhang, Qing-Yu Zhang, Weizhu Yang, Jack A Hinson, Xinxin Din. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Molecular pharmacology. vol 67. issue 3. 2005-04-12. PMID:15550675. |
however, when circulating acetaminophen levels were made equivalent in the two strains, the severity of extrahepatic acetaminophen toxicity was decreased in the null relative to that in the wild-type mice in the lung, kidney, and lateral nasal glands, although not in the nasal olfactory and respiratory mucosa. |
2005-04-12 |
2023-08-12 |
mouse |
| J P H Burbac. [The 2004 Nobel Prize for Physiology or Medicine for research into smell receptors and the organization of the olfactory system]. Nederlands tijdschrift voor geneeskunde. vol 148. issue 52. 2005-04-08. PMID:15646858. |
odourants in inhaled air are specifically recognized and bound by the smell receptors on the olfactory neurones in the nasal epithelium. |
2005-04-08 |
2023-08-12 |
rat |
| Karin Schwarzenbacher, Jörg Fleischer, Heinz Breer, Sidonie Conzelman. Expression of olfactory receptors in the cribriform mesenchyme during prenatal development. Gene expression patterns : GEP. vol 4. issue 5. 2005-03-31. PMID:15261832. |
olfactory receptors (ors) are expressed in sensory neurons of the nasal epithelium, where they are supposed to be involved in the recognition of suitable odorous compounds and in the guidance of outgrowing axons towards the appropriate glomeruli in the olfactory bulb. |
2005-03-31 |
2023-08-12 |
Not clear |
| Karin Schwarzenbacher, Jörg Fleischer, Heinz Breer, Sidonie Conzelman. Expression of olfactory receptors in the cribriform mesenchyme during prenatal development. Gene expression patterns : GEP. vol 4. issue 5. 2005-03-31. PMID:15261832. |
molecular phenotyping demonstrated that the receptor expressing cells in the cribriform mesenchyme co-express key elements, including galpha(olf), aciii and omp, characteristic for olfactory neurons in the nasal epithelium. |
2005-03-31 |
2023-08-12 |
Not clear |
| Timothy D Smith, Kunwar P Bhatnagar, Praphul Tuladhar, Annie M Burrow. Distribution of olfactory epithelium in the primate nasal cavity: are microsmia and macrosmia valid morphological concepts? The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. vol 281. issue 1. 2005-03-31. PMID:15472902. |
we examined the distribution of olfactory neuroepithelium (oe) across the anteroposterior length of the nasal fossa (from the first completely enclosed cross-section of the nasal fossa to the choanae) in the microsmatic marmoset (callithrix jacchus) compared to four species of nocturnal strepsirrhines (otolemur crassicaudatus, o. garnetti, microcebus murinus, and cheirogaleus medius). |
2005-03-31 |
2023-08-12 |
marmoset |
| H Oya Alpar, S Somavarapu, K N Atuah, V W Bramwel. Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery. Advanced drug delivery reviews. vol 57. issue 3. 2005-03-31. PMID:15560949. |
additional concerns addressed here include the potential of uptake of vaccine formulations by the primary olfactory nerves in the nasal cavity, effective delivery to the lung, strategies to maximise the immunopotentiation of candidate vaccine formulations, as well as the evaluation of animal models and interpretation of engendered immune responses in terms of antigen-specific antibody production. |
2005-03-31 |
2023-08-12 |
mouse |
| Daniel B Kurtz, Kai Zhao, David E Hornung, Peter Schere. Experimental and numerical determination of odorant solubility in nasal and olfactory mucosa. Chemical senses. vol 29. issue 9. 2005-03-16. PMID:15574812. |
experimental and numerical determination of odorant solubility in nasal and olfactory mucosa. |
2005-03-16 |
2023-08-12 |
human |
| Daniel B Kurtz, Kai Zhao, David E Hornung, Peter Schere. Experimental and numerical determination of odorant solubility in nasal and olfactory mucosa. Chemical senses. vol 29. issue 9. 2005-03-16. PMID:15574812. |
odorant deposition in the nasal and olfactory mucosas is dependent on a number of factors including local air/odorant flow distribution patterns, odorant mucosal solubility and odorant diffusive transport in the mucosa. |
2005-03-16 |
2023-08-12 |
human |
| M Schwen. [Multiple Chemical Sensitivity (MCS) -- scientific and health policy aspects]. Laryngo- rhino- otologie. vol 83. issue 11. 2005-03-10. PMID:15538670. |
the ent doctor should look at the nasal airflow resistance, nasal mucosa and olfactory system. |
2005-03-10 |
2023-08-12 |
Not clear |
| Mary Beth Genter, Kathleen H Goss, Joanna Grode. Strain-specific of alachlor on murine olfactory mucosal responses. Toxicologic pathology. vol 32. issue 6. 2005-03-10. PMID:15580706. |
alachlor-treated a/j mice developed pronounced intracellular accumulation of amorphous eosinophilic material in the olfactory mucosa, foci of respiratory-like metaplasia,and hyperplasia of nasal mucus glands. |
2005-03-10 |
2023-08-12 |
mouse |