| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sriparna Ghosal, Brendan Hare, Ronald S Duma. Prefrontal Cortex GABAergic Deficits and Circuit Dysfunction in the Pathophysiology and Treatment of Chronic Stress and Depression. Current opinion in behavioral sciences. vol 14. 2020-10-01. PMID:27812532. |
notably, exposure to repeated uncontrollable stress causes persistent changes in the synaptic integrity and function of the principal glutamatergic excitatory neurons in the pfc, characterized by neuronal atrophy and loss of synaptic connections. |
2020-10-01 |
2023-08-13 |
human |
| Lamine Bouamrane, Andrew F Scheyer, Olivier Lassalle, Jillian Iafrati, Aurore Thomazeau, Pascale Chavi. Reelin-Haploinsufficiency Disrupts the Developmental Trajectory of the E/I Balance in the Prefrontal Cortex. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28127276. |
we have recently shown that reelin plays a key role in the maturation of glutamatergic functions in the postnatal pfc, but no data are available regarding the gabaergic circuits. |
2020-10-01 |
2023-08-13 |
mouse |
| Manoela V Fogaça, Ronald S Duma. Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30914923. |
however, accumulating evidence suggests that mdd and chronic stress are associated with an imbalance of excitation-inhibition (e:i) within the pfc, generated by a deficit of inhibitory synaptic transmission onto principal glutamatergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ji Hyeong Baek, Arul Vignesh, Hyeonwi Son, Dong Hoon Lee, Gu Seob Roh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Hyun Joon Ki. Glutamine Supplementation Ameliorates Chronic Stress-induced Reductions in Glutamate and Glutamine Transporters in the Mouse Prefrontal Cortex. Experimental neurobiology. vol 28. issue 2. 2020-10-01. PMID:31138994. |
chronic immobilization stress (cis) induces low levels of glutamate (glu) and glutamine (gln) and hypoactive glutamatergic signaling in the mouse prefrontal cortex (pfc), which is closely related to the glu-gln cycle. |
2020-10-01 |
2023-08-13 |
mouse |
| Luye Qin, Kaijie Ma, Zhen Ya. Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation. iScience. vol 17. 2020-10-01. PMID:31247448. |
here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (pfc) of shank3-deficient mice with the hm3d (gq) dreadd restored social preference behaviors and elevated glutamatergic synaptic function in pfc. |
2020-10-01 |
2023-08-13 |
mouse |
| Luye Qin, Kaijie Ma, Zhen Ya. Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation. iScience. vol 17. 2020-10-01. PMID:31247448. |
blocking sgk function in shank3-deficient mice prevented gq dreadd from rescuing social and synaptic deficits, whereas blocking sgk function in wild-type mice led to the attenuation of pfc glutamatergic signaling and the induction of autism-like social deficits. |
2020-10-01 |
2023-08-13 |
mouse |
| Taira Mayanagi, Kenji Sobu. Social Stress-Induced Postsynaptic Hyporesponsiveness in Glutamatergic Synapses Is Mediated by PSD-Zip70-Rap2 Pathway and Relates to Anxiety-Like Behaviors. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31969804. |
psd-zip70 knockout (psd-zip70ko) mice exhibit defective glutamatergic synaptic transmission in the prefrontal cortex (pfc) with aberrant rap2 activation. |
2020-09-30 |
2023-08-13 |
mouse |
| Ashleigh L Osborne, Nadia Solowij, Ilijana Babic, Jeremy S Lum, Kelly A Newell, Xu-Feng Huang, Katrina Weston-Gree. Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-26. PMID:31202911. |
this study investigated the effects of chronic cbd treatment on markers of glutamatergic, gabaergic and endocannabinoid signalling in brain regions implicated in social behaviour and cognitive function, including the prefrontal cortex (pfc) and hippocampus (hpc). |
2020-08-26 |
2023-08-13 |
rat |
| Ashleigh L Osborne, Nadia Solowij, Ilijana Babic, Jeremy S Lum, Xu-Feng Huang, Kelly A Newell, Katrina Weston-Gree. Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31326506. |
after 3 weeks of cbd treatment, the prefrontal cortex (pfc) and hippocampus (hpc) were collected to assess effects on endocannabinoid, glutamatergic and gamma-aminobutyric acid (gaba) signalling markers. |
2020-08-14 |
2023-08-13 |
rat |
| Ashleigh L Osborne, Nadia Solowij, Ilijana Babic, Jeremy S Lum, Xu-Feng Huang, Kelly A Newell, Katrina Weston-Gree. Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31326506. |
cbd attenuated poly i:c-induced deficits in recognition memory, social interaction and glutamatergic n-methyl-d-aspartate receptor (nmdar) binding in the pfc of poly i:c offspring. |
2020-08-14 |
2023-08-13 |
rat |
| Bart de Laat, Akila Weerasekera, Gil Leurquin-Sterk, Willy Gsell, Guy Bormans, Uwe Himmelreich, Cindy Casteels, Koen Van Laer. Effects of alcohol exposure on the glutamatergic system: a combined longitudinal Addiction biology. vol 24. issue 4. 2020-08-10. PMID:29790622. |
effects of alcohol exposure on the glutamatergic system: a combined longitudinal in a longitudinal rat model of alcohol consumption, we showed that exposure to alcohol decreased the concentration of glutamate in the prefrontal cortex, whereas a normalization occurred during abstinence. |
2020-08-10 |
2023-08-13 |
rat |
| Chloe E Page, Laurence Coutellie. Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition. Neuroscience and biobehavioral reviews. vol 105. 2020-06-29. PMID:31377218. |
chronic stress-induced emotional disorders like anxiety and depression involve imbalances between the excitatory glutamatergic system and the inhibitory gabaergic system in the prefrontal cortex (pfc). |
2020-06-29 |
2023-08-13 |
Not clear |
| Allyson P Mallya, Hui-Dong Wang, Han Noo Ri Lee, Ariel Y Deutc. Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-05-22. PMID:29668872. |
in the contralateral pfc we evaluated if mg engulfed presynaptic (glutamatergic) and postsynaptic (dendritic spines) elements. |
2020-05-22 |
2023-08-13 |
rat |
| Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécame. Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-05-22. PMID:29917056. |
among the 5-ht receptors abundantly expressed in pfc, 5-ht2a receptors located in dendrites of layer v pyramidal neurons control neuronal excitability and mediate the psychotropic effects of psychedelic hallucinogens, but their impact on glutamatergic transmission and synaptic plasticity remains poorly characterized. |
2020-05-22 |
2023-08-13 |
mouse |
| Samuel J Millard, Jeremy S Lum, Francesca Fernandez, Katrina Weston-Green, Kelly A Newel. Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression. Journal of psychopharmacology (Oxford, England). vol 33. issue 2. 2020-05-22. PMID:30698051. |
perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: a comparison between sprague-dawley rats and the wistar-kyoto rat model of depression. |
2020-05-22 |
2023-08-13 |
rat |
| Ana Lúcia Bertarello Zeni, Anderson Camargo, Ana Paula Dalmagr. Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. Pharmacology, biochemistry, and behavior. vol 179. 2020-04-20. PMID:30786251. |
in addition, both lut and fluoxetine presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity. |
2020-04-20 |
2023-08-13 |
mouse |
| Max E Joffe, Chiaki I Santiago, Julie L Engers, Craig W Lindsley, P Jeffrey Con. Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function. Molecular psychiatry. vol 24. issue 6. 2020-03-02. PMID:29269844. |
stress can precipitate or worsen symptoms of many psychiatric disorders by dysregulating glutamatergic function within the prefrontal cortex (pfc). |
2020-03-02 |
2023-08-13 |
Not clear |
| Gyorgy Lur, Mona Fariborzi, Michael J Higle. Ketamine disrupts neuromodulatory control of glutamatergic synaptic transmission. PloS one. vol 14. issue 3. 2019-12-23. PMID:30865708. |
sub-anesthetic doses produce rapid and sustained changes in depressive behavior, both in patients and rodent models, associated with reorganization of glutamatergic synapses in the prefrontal cortex (pfc). |
2019-12-23 |
2023-08-13 |
mouse |
| Gyorgy Lur, Mona Fariborzi, Michael J Higle. Ketamine disrupts neuromodulatory control of glutamatergic synaptic transmission. PloS one. vol 14. issue 3. 2019-12-23. PMID:30865708. |
here, we combine electrophysiology with 2-photon imaging and glutamate uncaging in acute slices of mouse pfc to further examine how ketamine alters glutamatergic synaptic transmission. |
2019-12-23 |
2023-08-13 |
mouse |
| Hanna J Szkudlarek, Sagar J Desai, Justine Renard, Brian Pereira, Christopher Norris, Christina E L Jobson, Nagalingam Rajakumar, Brian L Allman, Steven R Laviolett. Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-11-25. PMID:30538288. |
in contrast, intra-pfc cbd reversed the cognitive impairments induced by acute glutamatergic antagonism within the pfc, and blocked the anxiogenic properties of thc, suggesting that the therapeutic properties of cbd within the pfc may be present only during pathologically aberrant states within the pfc. |
2019-11-25 |
2023-08-13 |
rat |