| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell. vol 20. issue 10. 2021-11-09. PMID:34547169. |
concomitantly, the diminished pfc neuronal excitability and glutamatergic synaptic transmission in p301s tau mice are also normalized by unc0642 treatment. |
2021-11-09 |
2023-08-13 |
mouse |
| Cora E Smiley, Heyam K Saleh, Katherine E Nimchuk, Constanza Garcia-Keller, Justin T Gas. Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. Behavioural brain research. vol 415. 2021-11-04. PMID:34389427. |
in summary, these studies support the hypothesis that adolescent exposure to thc and ethanol leads to alterations in fear stimuli processing through glutamatergic reliant modifications in pfc signaling. |
2021-11-04 |
2023-08-13 |
Not clear |
| Max E Joffe, Danny G Winder, P Jeffrey Con. Increased Synaptic Strength and mGlu Alcoholism, clinical and experimental research. vol 45. issue 3. 2021-11-02. PMID:33434325. |
at least 80% of the neurons in pfc are glutamatergic pyramidal cells. |
2021-11-02 |
2023-08-13 |
Not clear |
| Maryam Mahmoodkhani, Maedeh Ghasemi, Leila Derafshpour, Mohammad Amini, Nasrin Mehranfar. Long-Term Decreases in the Expression of Calcineurin and GABAA Receptors Induced by Early Maternal Separation Are Associated with Increased Anxiety-Like Behavior in Adult Male Rats. Developmental neuroscience. vol 42. issue 2-4. 2021-10-26. PMID:33341802. |
here, we investigated the effect of early life stress, such as repeated maternal separation (ms; 3 h per day from postnatal day [p] 2 to 11), on changes in the expression of calcineurin as well as the ionotropic glutamatergic and gabaergic receptors including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), n-methyl-d-aspartate (nmda) and gabaa receptors in the hippocampus and prefrontal cortex (pfc) of adolescent (p35) and adult (p62) male wistar rats and their correlations with anxiety-like behavior in adulthood. |
2021-10-26 |
2023-08-13 |
rat |
| Julio César Morales-Medina, Patricia Aguilar-Alonso, Alessandro Di Cerbo, Tommaso Iannitti, Gonzalo Flore. New insights on nitric oxide: Focus on animal models of schizophrenia. Behavioural brain research. vol 409. 2021-10-18. PMID:33865887. |
in regards to glutamatergic models of schizophrenia, phencyclidine (pcp) administration increases no levels in the prefrontal cortex (pfc) and ventral hippocampus. |
2021-10-18 |
2023-08-13 |
mouse |
| Yan-Yan Guo, Ying Zhou, Yu-Jiao Li, An Liu, Jiao Yue, Qing-Qing Liu, Le Yang, Yu-Mei Wu, Shui-Bing Liu, Kun Zhang, Ming-Gao Zha. Scutellarin ameliorates the stress-induced anxiety-like behaviors in mice by regulating neurotransmitters. Phytotherapy research : PTR. vol 35. issue 7. 2021-09-27. PMID:33856723. |
scu treatment suppressed action potential firing frequency, restored excessive presynaptic quantal release, and down-regulated glutamatergic receptor expression levels in the prefrontal cortex (pfc) of stressed mice. |
2021-09-27 |
2023-08-13 |
mouse |
| Dong-Dong Shi, Ying-Dan Zhang, Yan-Yan Ren, Shi-Yu Peng, Ti-Fei Yuan, Zhen Wan. Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats. Molecular psychiatry. 2021-09-25. PMID:34561611. |
we demonstrate that structural and functional impairments occur in glutamatergic synapses in pyramidal neurons of the medial prefrontal cortex (mpfc) in rats with unpredictable ms but not in rats with predictable ms. then, we used differentially expressed gene (deg) analysis of rna sequencing data from the adult male pfc to identify a hub gene that is responsible for stress resilience. |
2021-09-25 |
2023-08-13 |
rat |
| Junlong Li, Suixin Deng, Quansheng He, Wei Ke, Yousheng Sh. Asynchronous Glutamate Release at Autapses Regulates Spike Reliability and Precision in Mouse Neocortical Pyramidal Cells. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-09-16. PMID:33279969. |
thus, glutamatergic autapses should be essential elements in pfc and contribute to cortical information processing. |
2021-09-16 |
2023-08-13 |
mouse |
| Samuel Kohtala, Tomi Rantamäk. Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia. Basic & clinical pharmacology & toxicology. vol 129. issue 2. 2021-08-12. PMID:33973360. |
increased glutamatergic neurotransmission and synaptic plasticity in the prefrontal cortex have been associated with the rapid antidepressant effects of ketamine. |
2021-08-12 |
2023-08-13 |
Not clear |
| Lilla Ravasz, Katalin Adrienna Kékesi, Dániel Mittli, Mihail Ivilinov Todorov, Zsolt Borhegyi, Mária Ercsey-Ravasz, Botond Tyukodi, Jinhui Wang, Tamás Bártfai, James Eberwine, Gábor Juhás. Cell Surface Protein mRNAs Show Differential Transcription in Pyramidal and Fast-Spiking Cells as Revealed by Single-Cell Sequencing. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 2. 2021-08-11. PMID:32710103. |
in the pfc, the two major classes of neurons are the glutamatergic pyramidal (pyr) cells and the gabaergic interneurons such as fast-spiking (fs) cells. |
2021-08-11 |
2023-08-13 |
mouse |
| Lilla Ravasz, Katalin Adrienna Kékesi, Dániel Mittli, Mihail Ivilinov Todorov, Zsolt Borhegyi, Mária Ercsey-Ravasz, Botond Tyukodi, Jinhui Wang, Tamás Bártfai, James Eberwine, Gábor Juhás. Cell Surface Protein mRNAs Show Differential Transcription in Pyramidal and Fast-Spiking Cells as Revealed by Single-Cell Sequencing. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 2. 2021-08-11. PMID:32710103. |
despite extensive electrophysiological, morphological, and pharmacological studies of the pfc, the therapeutically utilized drug targets are restricted to dopaminergic, glutamatergic, and gabaergic receptors. |
2021-08-11 |
2023-08-13 |
mouse |
| Zi-Jun Wang, Ben Rein, Ping Zhong, Jamal Williams, Qing Cao, Fengwei Yang, Freddy Zhang, Kaijie Ma, Zhen Ya. Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 9. 2021-08-04. PMID:34007043. |
kmt5b deficiency also produces deficits in pfc glutamatergic synaptic transmission, which is accompanied by the reduced synaptic expression of glutamate receptor subunits and associated proteins. |
2021-08-04 |
2023-08-13 |
mouse |
| Benjamin L Thompson, Marlene Oscar-Berman, Gary B Kapla. Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33152423. |
additionally, glutamatergic neurons from the prefrontal cortex, the basolateral amygdala, the hippocampus, and the thalamus project to these same msns, providing an enriched target for synaptic plasticity. |
2021-06-21 |
2023-08-13 |
Not clear |
| Sara M Green, Sanya Nathani, Joseph Zimmerman, David Fireman, Nikhil M Ur. Retrograde Labeling Illuminates Distinct Topographical Organization of D1 and D2 Receptor-Positive Pyramidal Neurons in the Prefrontal Cortex of Mice. eNeuro. vol 7. issue 5. 2021-06-18. PMID:33037031. |
glutamatergic pyramidal neurons in the prefrontal cortex (pfc) are topographically organized in different subregions such as the prelimbic, infralimbic (il), and orbitofrontal and project to topographically-organized subcortical target regions. |
2021-06-18 |
2023-08-13 |
mouse |
| Sara M Green, Sanya Nathani, Joseph Zimmerman, David Fireman, Nikhil M Ur. Retrograde Labeling Illuminates Distinct Topographical Organization of D1 and D2 Receptor-Positive Pyramidal Neurons in the Prefrontal Cortex of Mice. eNeuro. vol 7. issue 5. 2021-06-18. PMID:33037031. |
dopamine d1 and d2 receptors are expressed on glutamatergic pyramidal neurons in the pfc. |
2021-06-18 |
2023-08-13 |
mouse |
| Eman M Khedr, Yasser Elserogy, Mohamed Fawzy, Mostafa Elnoaman, Amr M Gala. Global cortical hypoexcitability of the dominant hemisphere in major depressive disorder: A transcranial magnetic stimulation study. Neurophysiologie clinique = Clinical neurophysiology. vol 50. issue 3. 2021-05-26. PMID:32169427. |
accumulating evidence suggests that major depressive disorders (mdd) are associated with an imbalance of excitation-inhibition within the prefrontal cortex (pfc), generated by a deficit of inhibitory synaptic transmission onto glutamatergic principal neurons. |
2021-05-26 |
2023-08-13 |
Not clear |
| Judith Tirado-Muñoz, Ana Belen Lopez-Rodriguez, Francina Fonseca, Magi Farré, Marta Torrens, Maria-Paz Vivero. Effects of cannabis exposure in the prenatal and adolescent periods: Preclinical and clinical studies in both sexes. Frontiers in neuroendocrinology. vol 57. 2021-05-24. PMID:32339546. |
in general, animal studies support behavioural alterations reported in humans and have revealed diverse sex differences and potential underlying mechanisms (altered mesolimbic dopaminergic and hippocampal glutamatergic systems and interference with prefrontal cortex maturation). |
2021-05-24 |
2023-08-13 |
human |
| Charalampos Brakatselos, Foteini Delis, Michail-Zois Asprogerakas, Panagiotis Lekkas, Ioulia Tseti, Petros S Tzimas, Eleftherios A Petrakis, Maria Halabalaki, Leandros A Skaltsounis, Katerina Antonio. Cannabidiol Modulates the Motor Profile and NMDA Receptor-related Alterations Induced by Ketamine. Neuroscience. vol 454. 2021-05-14. PMID:32950556. |
therefore, the aim of the present study is to evaluate the role of cbd on ket-induced motor response and relevant glutamatergic signaling in the prefrontal cortex, the nucleus accumbens, the dorsal and ventral hippocampus. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mingyue Zhang, Hannah Weiland, Michael Schöfbänker, Weiqi Zhan. Estrogen Receptors Alpha and Beta Mediate Synaptic Transmission in the PFC and Hippocampus of Mice. International journal of molecular sciences. vol 22. issue 3. 2021-04-09. PMID:33540803. |
whole-cell recordings of spontaneous excitatory postsynaptic currents (sepsc) in the pfc showed that e2 acts as a neuromodulator in glutamatergic transmission in the pfc in both sexes, but often in a cell-specific manner. |
2021-04-09 |
2023-08-13 |
mouse |
| Gilli Moshitzky, Shai Shoham, Nimrod Madrer, Amir Mouhammed Husain, David S Greenberg, Raz Yirmiya, Yoram Ben-Shaul, Hermona Sore. Cholinergic Stress Signals Accompany MicroRNA-Associated Stereotypic Behavior and Glutamatergic Neuromodulation in the Prefrontal Cortex. Biomolecules. vol 10. issue 6. 2021-04-08. PMID:32503154. |
cholinergic stress signals accompany microrna-associated stereotypic behavior and glutamatergic neuromodulation in the prefrontal cortex. |
2021-04-08 |
2023-08-13 |
mouse |