| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ceren Ergorul, Arjun Ray, Wei Huang, Dan Yi Wang, Yixin Ben, Ippolita Cantuti-Castelvetri, Cynthia L Grosskreut. Hypoxia inducible factor-1α (HIF-1α) and some HIF-1 target genes are elevated in experimental glaucoma. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20237864. |
these data support the hypothesis that hif-1alpha becomes transcriptionally active in astrocytes and müller cells but not microglia or neurons in glaucoma, arguing against a global hypoxia stimulus to the retina. |
2011-04-04 |
2023-08-12 |
rat |
| A D Dic. Influence of microglia on retinal progenitor cell turnover and cell replacement. Eye (London, England). vol 23. issue 10. 2011-03-25. PMID:19098699. |
microglia within the retina are continually replaced from the bone marrow and are the resident myeloid-derived cells within the retina. |
2011-03-25 |
2023-08-12 |
human |
| Marcus Karlstetter, Stefanie Ebert, Thomas Langman. Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology. vol 215. issue 9-10. 2011-03-11. PMID:20573418. |
microglia in the healthy and degenerating retina: insights from novel mouse models. |
2011-03-11 |
2023-08-12 |
mouse |
| Ahmed S Ibrahim, Mamdouh M El-Shishtawy, Alejandro Peña, Gregory I Lio. Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation. Molecular vision. vol 16. 2011-02-08. PMID:21042558. |
the aims of this study are to evaluate the efficacy of genistein for alleviation of diabetes-induced retinal inflammation and also to gain insight into the molecular mechanisms involved therein by analyzing the effect of genistein on concomitant microglia activation in the diabetic retina and in isolated cells. |
2011-02-08 |
2023-08-12 |
Not clear |
| Sachiko Saino-Saito, Reza Mohammad Nourani, Hiroo Iwasa, Hisatake Kondo, Yuji Owad. Discrete localization of various fatty-acid-binding proteins in various cell populations of mouse retina. Cell and tissue research. vol 338. issue 2. 2010-07-30. PMID:19763623. |
the discrete localization of b-, h-, e-, and a-fabp species in various cell populations of the retina has been clarified: b-fabp is mainly localized in the cone photoreceptor cells, h-fabp in some populations of amacrine/bipolar/horizontal interneurons, and e-fabp in ganglion cells, with a-fabp-like immunoreactivity being located in resident microglia of normal retinae. |
2010-07-30 |
2023-08-12 |
mouse |
| Andy J Fischer, Melissa A Scott, Christopher Zelinka, Patrick Sherwoo. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Müller glia. Glia. vol 58. issue 6. 2010-05-20. PMID:19941335. |
with microglia and nirg cells stimulated by igf1 there were elevated levels of cell death and numerous focal detachments across the retina in response to excitotoxic damage. |
2010-05-20 |
2023-08-12 |
Not clear |
| John V Forrester, Heping Xu, Lucia Kuffová, Andrew D Dick, Paul G McMenami. Dendritic cell physiology and function in the eye. Immunological reviews. vol 234. issue 1. 2010-05-20. PMID:20193026. |
most of the macrophage and dendritic cell (dc) populations in the eye are restricted to the supporting connective tissues, including the cornea, while the neural tissue (the retina) contains almost no dcs, occasional macrophages (perivascularly distributed), and a specialized myeloid cell type, the microglial cell. |
2010-05-20 |
2023-08-12 |
Not clear |
| Wenxin Ma, Lian Zhao, Aurora M Fontainhas, Robert N Fariss, Wai T Won. Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PloS one. vol 4. issue 11. 2010-04-26. PMID:19936204. |
microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to amd. |
2010-04-26 |
2023-08-12 |
mouse |
| Wenxin Ma, Lian Zhao, Aurora M Fontainhas, Robert N Fariss, Wai T Won. Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PloS one. vol 4. issue 11. 2010-04-26. PMID:19936204. |
also, retinal microglia, the resident immune cells of the retina, have been observed to translocate from their normal position in the inner retina to accumulate in the subretinal space close to the rpe layer in amd eyes and in animal models of amd. |
2010-04-26 |
2023-08-12 |
mouse |
| Wenbing Huang, Coral G Chamberlain, Richard Y Sarafian, Tailoi Chan-Lin. MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron glia biology. vol 4. issue 4. 2010-03-29. PMID:19575844. |
mhc class ii expression by beta2 integrin (cd18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. |
2010-03-29 |
2023-08-12 |
rabbit |
| Wenbing Huang, Coral G Chamberlain, Richard Y Sarafian, Tailoi Chan-Lin. MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron glia biology. vol 4. issue 4. 2010-03-29. PMID:19575844. |
the aim of this study was to investigate the developmental expression of major histocompatibility complex class ii (mhcii) by microglia and macrophages and their relationship to blood vessels in the retina, a representative tissue of the central nervous system. |
2010-03-29 |
2023-08-12 |
rabbit |
| Wenbing Huang, Coral G Chamberlain, Richard Y Sarafian, Tailoi Chan-Lin. MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron glia biology. vol 4. issue 4. 2010-03-29. PMID:19575844. |
cd18+ cells consistently exhibited characteristics of macrophages or microglia in the vascularized and non-vascularized regions of the retina, respectively. |
2010-03-29 |
2023-08-12 |
rabbit |
| Wenbing Huang, Coral G Chamberlain, Richard Y Sarafian, Tailoi Chan-Lin. MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron glia biology. vol 4. issue 4. 2010-03-29. PMID:19575844. |
mhcii expression by ramified microglia, first detected on postnatal day 30, was lower in the peripheral retina and intermediate in the avascular region of the myelinated streak. |
2010-03-29 |
2023-08-12 |
rabbit |
| Xu Wang, Michele L Archibald, Kelly Stevens, William H Baldridge, Balwantray C Chauha. Cyan fluorescent protein (CFP) expressing cells in the retina of Thy1-CFP transgenic mice before and after optic nerve injury. Neuroscience letters. vol 468. issue 2. 2010-03-04. PMID:19879331. |
cells with spindle shape, immunohistochemically identified as microglia, were seen in the retina with cfp expression at both 7 and 21 days after optic nerve transection. |
2010-03-04 |
2023-08-12 |
mouse |
| Gauri P Misra, Ravi S J Singh, Tomas S Aleman, Samuel G Jacobson, Thomas W Gardner, Tao L Low. Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina. Biomaterials. vol 30. issue 33. 2010-02-18. PMID:19709741. |
the hydrogels can be implanted under the conjunctiva without causing adverse effects to the retina based on hematoxylin and eosin stain, immunostaining for microglial cell activation, and electroretinography. |
2010-02-18 |
2023-08-12 |
Not clear |
| Luísa Mendes-Jorge, David Ramos, Mariana Luppo, Cristina Llombart, Graça Alexandre-Pires, Victor Nacher, Verónica Melgarejo, Miguel Correia, Marc Navarro, Ana Carretero, Sabrina Tafuro, Alfonso Rodriguez-Baeza, José António Esperança-Pina, Fàtima Bosch, Jesús Rubert. Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier. Investigative ophthalmology & visual science. vol 50. issue 12. 2009-12-23. PMID:19608545. |
the retina contains two distinct populations of monocyte-derived cells: perivascular macrophages, and microglia. |
2009-12-23 |
2023-08-12 |
mouse |
| Tat Fong Ng, Bruce Turpie, Sharmila Masl. Thrombospondin-1-mediated regulation of microglia activation after retinal injury. Investigative ophthalmology & visual science. vol 50. issue 11. 2009-12-04. PMID:19494207. |
microglia, the local antigen-presenting cells in the retina, undergo rapid activation in response to injury and have the ability to produce both proinflammatory and regenerative neurotrophic factors. |
2009-12-04 |
2023-08-12 |
Not clear |
| Athanasios Dagkalis, Carol Wallace, Benjamin Hing, Janet Liversidge, Isabel J Cran. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Immunology. vol 128. issue 1. 2009-11-04. PMID:19689733. |
resident microglia within the retina were activated equally as eau developed in mice with or without cx3cr1, as determined by changes in morphology, suggesting that the microglial cell response did not account for the differences. |
2009-11-04 |
2023-08-12 |
mouse |
| Lian Zhao, Wenxin Ma, Robert N Fariss, Wai T Won. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Experimental eye research. vol 88. issue 6. 2009-10-08. PMID:19176215. |
our results show that: (1) cx3cr1 signaling is not required for normal vascular, microglial, and neuronal development in the retina in the first postnatal week, (2) the processes of retinal vascular repair and neovascularization following ischemia occur similarly with and without cx3cr1 signaling, (3) microglia redistribution in the retina and their association with vascular elements occurring concurrently is independent of cx3cr1, and (4) cx3cr1 does not influence the extent of neuronal cell loss in the retina following ischemia. |
2009-10-08 |
2023-08-12 |
mouse |
| Thomas Langmann, Stefanie Ebert, Yana Walczak, Karin Weigelt, Markus U Ehrengruber, Thorsten Stiewe, Bernhard H F Webe. Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo. Neuromolecular medicine. vol 11. issue 2. 2009-10-05. PMID:19365618. |
we have previously identified activation of microglia and induction of the early growth response gene 1 (egr1) in the retina of retinoschisin-deficient (rs1h(-/y)) mice. |
2009-10-05 |
2023-08-12 |
mouse |