| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Langman. Microglia activation in retinal degeneration. Journal of leukocyte biology. vol 81. issue 6. 2007-09-17. PMID:17405851. |
microglia cells are phagocytic sentinels in the cns and in the retina required for neuronal homeostasis and innate immune defense. |
2007-09-17 |
2023-08-12 |
Not clear |
| Thomas Langman. Microglia activation in retinal degeneration. Journal of leukocyte biology. vol 81. issue 6. 2007-09-17. PMID:17405851. |
endogenous triggers alert microglia cells rapidly in the degenerating retina, leading to local proliferation, migration, enhanced phagocytosis, and secretion of cytokines, chemokines, and neurotoxins. |
2007-09-17 |
2023-08-12 |
Not clear |
| Thomas Langman. Microglia activation in retinal degeneration. Journal of leukocyte biology. vol 81. issue 6. 2007-09-17. PMID:17405851. |
this review summarizes the developmental and immune surveillance functions of microglia in the healthy retina and discusses early signaling events and transcriptional networks of microglia activation in retinal degeneration. |
2007-09-17 |
2023-08-12 |
Not clear |
| D M Inman, P J Horne. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia. vol 55. issue 9. 2007-07-25. PMID:17457855. |
astrocyte and müller glia populations within dba/2 retina upregulated glial fibrillary acidic protein mrna and protein compared with c57bl/6; microglial cell number increased twofold from 4 to 10 months. |
2007-07-25 |
2023-08-12 |
mouse |
| Ai Ling Wang, Albert C H Yu, Qi Hua He, Xiu'An Zhu, Mark O M Ts. AGEs mediated expression and secretion of TNF alpha in rat retinal microglia. Experimental eye research. vol 84. issue 5. 2007-07-11. PMID:17359975. |
diabetic retinopathy induces an inflammatory response in the retina characterized by an increase in inflammatory cytokines and the activation of microglia. |
2007-07-11 |
2023-08-12 |
rat |
| Ai Ling Wang, Albert C H Yu, Qi Hua He, Xiu'An Zhu, Mark O M Ts. AGEs mediated expression and secretion of TNF alpha in rat retinal microglia. Experimental eye research. vol 84. issue 5. 2007-07-11. PMID:17359975. |
the degree of microglia activation may influence the extent of retina injury following retinal metabolic stress. |
2007-07-11 |
2023-08-12 |
rat |
| Paloma Sobrado-Calvo, Manuel Vidal-Sanz, María P Villegas-Pére. Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor. The Journal of comparative neurology. vol 501. issue 6. 2007-04-26. PMID:17311318. |
left on section induces microglial activation in the ipsilateral and contralateral retina as manifested by stronger staining intensity in both retinas and increased microglial cell densities in the nfl, ipl, and gcl of the ipsilateral retina. |
2007-04-26 |
2023-08-12 |
rat |
| Paloma Sobrado-Calvo, Manuel Vidal-Sanz, María P Villegas-Pére. Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor. The Journal of comparative neurology. vol 501. issue 6. 2007-04-26. PMID:17311318. |
left on section followed by left eye puncture or intravitreal injection increases microglial cell density in both retinas and induces changes in the microglial cells of the ipsilateral retina that vary depending on the substance injected: bdnf injections delay microglial activation, possibly through retinal ganglion cell neuroprotection, whereas nt3 partially inhibits microglial activation in the nfl; mif injections have no clear effects on microglial activation. |
2007-04-26 |
2023-08-12 |
rat |
| Matthew R Ritter, Eyal Banin, Stacey K Moreno, Edith Aguilar, Michael I Dorrell, Martin Friedlande. Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17111048. |
using a model of oxygen-induced retinopathy, we demonstrate that a population of adult bm-derived myeloid progenitor cells migrated to avascular regions of the retina, differentiated into microglia, and facilitated normalization of the vasculature. |
2007-01-22 |
2023-08-12 |
Not clear |
| Minoru Tomita, Taisuke Mori, Kazuichi Maruyama, Tasneem Zahir, Matthew Ward, Akihiro Umezawa, Michael J Youn. A comparison of neural differentiation and retinal transplantation with bone marrow-derived cells and retinal progenitor cells. Stem cells (Dayton, Ohio). vol 24. issue 10. 2006-12-27. PMID:17008430. |
a majority of bone marrow derived-macrophages differentiated into cells that resembled microglia, rather than neural cells, in the explanted retina. |
2006-12-27 |
2023-08-12 |
mouse |
| Daniella Checchin, Florian Sennlaub, Etienne Levavasseur, Martin Leduc, Sylvain Chemto. Potential role of microglia in retinal blood vessel formation. Investigative ophthalmology & visual science. vol 47. issue 8. 2006-08-31. PMID:16877434. |
the role of microglia, present in the retina early in development before vascularization, remains ill defined. |
2006-08-31 |
2023-08-12 |
Not clear |
| Michael H Davies, Joshua P Eubanks, Michael R Power. Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. Molecular vision. vol 12. 2006-06-16. PMID:16710171. |
microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. |
2006-06-16 |
2023-08-12 |
mouse |
| Ana M Sánchez-López, Miguel A Cuadros, Ruth Calvente, Mohamed Tassi, José L Marín-Teva, Julio Navascué. Activation of immature microglia in response to stab wound in embryonic quail retina. The Journal of comparative neurology. vol 492. issue 1. 2006-01-23. PMID:16175556. |
activation of immature microglia in response to stab wound in embryonic quail retina. |
2006-01-23 |
2023-08-12 |
Not clear |
| Ana M Sánchez-López, Miguel A Cuadros, Ruth Calvente, Mohamed Tassi, José L Marín-Teva, Julio Navascué. Activation of immature microglia in response to stab wound in embryonic quail retina. The Journal of comparative neurology. vol 492. issue 1. 2006-01-23. PMID:16175556. |
transitional forms between normal ameboid and activated-like microglial cells were seen at the wound edge, supporting the view that ameboid microglia become activated when they contact the wound during the normal course of their migration in the retina. |
2006-01-23 |
2023-08-12 |
Not clear |
| T A Albini, R C Wang, B Reiser, E Zamir, G S Wu, N A Ra. Microglial stability and repopulation in the retina. The British journal of ophthalmology. vol 89. issue 7. 2005-09-26. PMID:15965175. |
the present study sought to determine repopulation of retinal microglia in uniflammed retina by bone marrow derived monocytes in bone marrow chimeric rats. |
2005-09-26 |
2023-08-12 |
rat |
| Alejandro Caicedo, Diego G Espinosa-Heidmann, Yolanda Piña, Eleut P Hernandez, Scott W Cousin. Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. Experimental eye research. vol 81. issue 1. 2005-09-20. PMID:15978253. |
we have combined laser-induced cnv in mice and bone marrow transplantation with gfp-labeled bone marrow to determine the relative role of recruited blood-derived macrophages versus resident microglia in the retina associated with cnv. |
2005-09-20 |
2023-08-12 |
mouse |
| Ai Ling Wang, Albert C H Yu, Lok Ting Lau, Chong Lee, Le Meng Wu, Xiu'An Zhu, Mark O M Ts. Minocycline inhibits LPS-induced retinal microglia activation. Neurochemistry international. vol 47. issue 1-2. 2005-09-01. PMID:15904993. |
retinal neurodegenerative disease involves an inflammatory response in the retina characterized by an increase in inflammatory cytokines and activation of microglia. |
2005-09-01 |
2023-08-12 |
Not clear |
| V T Pham, L Wen, P McCluskey, M C Madigan, P L Penfol. Human retinal microglia express candidate receptors for HIV-1 infection. The British journal of ophthalmology. vol 89. issue 6. 2005-07-07. PMID:15923514. |
microglia are the primary antigen presenting cells in the central nervous system and the retina, and can harbour viral antigens that may damage neural tissue via the release of neurotoxins. |
2005-07-07 |
2023-08-12 |
human |
| J Kyle Krady, Anirban Basu, Colleen M Allen, Yuping Xu, Kathryn F LaNoue, Thomas W Gardner, Steven W Leviso. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes. vol 54. issue 5. 2005-07-05. PMID:15855346. |
furthermore, mrnas for interleukin-1beta and tumor necrosis factor-alpha, proinflammatory mediators known to be released from microglia, are also increased in the retina early in the course of diabetes. |
2005-07-05 |
2023-08-12 |
Not clear |
| J Kyle Krady, Anirban Basu, Colleen M Allen, Yuping Xu, Kathryn F LaNoue, Thomas W Gardner, Steven W Leviso. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes. vol 54. issue 5. 2005-07-05. PMID:15855346. |
minocycline represses diabetes-induced inflammatory cytokine production, reduces the release of cytotoxins from activated microglia, and significantly reduces measurable caspase-3 activity within the retina. |
2005-07-05 |
2023-08-12 |
Not clear |