| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schön, Tobias M Boeckers, Jakob Matschke, Christian Mawrin, Albert C Ludolph, Kelly Del Tredici, Francesco Roselli, Heiko Braa. Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. Acta neuropathologica communications. vol 11. issue 1. 2023-07-25. PMID:37491361. |
patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. |
2023-07-25 |
2023-08-14 |
human |
| Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen, Xiangru Wan. Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes. Journal of neuroinflammation. vol 20. issue 1. 2023-07-22. PMID:37481642. |
neuroinflammation has been implicated in the initiation and progression of several central nervous system (cns) disorders, including alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, ischemic stroke, traumatic brain injury, spinal cord injury, viral encephalitis, and bacterial encephalitis. |
2023-07-22 |
2023-08-14 |
Not clear |
| Robert B Kargb. Microbiome-Gut-Brain Axis Modulation: New Approaches in Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis. ACS medicinal chemistry letters. vol 14. issue 7. 2023-07-19. PMID:37465304. |
mitochondrial dysfunction plays a critical role in the disease's progression, while amyotrophic lateral sclerosis (als), or lou gehrig's disease, is a fatal progressive neurodegenerative disease characterized by significant motor neuron loss in the primary motor cortex, brainstem, and spinal cord. |
2023-07-19 |
2023-08-14 |
Not clear |
| Lorella Giovannelli, Elia Bari, Claudio Jommi, Fulvio Tartara, Daniele Armocida, Diego Garbossa, Fabio Cofano, Maria Luisa Torre, Lorena Segal. Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access. Bioactive materials. vol 29. 2023-07-17. PMID:37456581. |
this paper provides an overview of the most recent research on the safety and efficacy of msc-derived secretome and extracellular vesicles (evs) in clinical (if available) and preclinical models of alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, huntington's disease, acute ischemic stroke, and spinal cord injury. |
2023-07-17 |
2023-08-14 |
Not clear |
| Mohamed Mounir El Mendili, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, Aude-Marie Grappero. Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis. Neuroradiology. 2023-07-17. PMID:37458788. |
association between brain and upper cervical spinal cord atrophy assessed by mri and disease aggressiveness in amyotrophic lateral sclerosis. |
2023-07-17 |
2023-08-14 |
Not clear |
| Mohamed Mounir El Mendili, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, Aude-Marie Grappero. Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis. Neuroradiology. 2023-07-17. PMID:37458788. |
to study the relative contributions of brain and upper cervical spinal cord compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (als). |
2023-07-17 |
2023-08-14 |
Not clear |
| Kurosh Zamiri, Santosh Kesari, Ketema Paul, Sung Hee Hwang, Bruce Hammock, Karolina Elżbieta Kaczor-Urbanowicz, Andrzej Urbanowicz, Lucy Gao, Julian Whitelegge, Milan Fial. Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 8. 2023-07-12. PMID:37436778. |
in sporadic amyotrophic lateral sclerosis (sals), il-17a- and granzyme-positive cytotoxic t lymphocytes (ctl), il-17a-positive mast cells, and inflammatory macrophages invade the brain and spinal cord. |
2023-07-12 |
2023-08-14 |
Not clear |
| Karen Lync. Pathogenesis and presentation of ALS: examining reasons for delayed diagnosis and identifying opportunities for improvement. The American journal of managed care. vol 29. issue 7 Suppl. 2023-07-11. PMID:37433091. |
amyotrophic lateral sclerosis (als), or lou gehrig disease, is a progressive, always-fatal neuromuscular disease characterized by motor neuron degeneration in the brain and spinal cord. |
2023-07-11 |
2023-08-14 |
Not clear |
| M Kathryn Brewer, Pascual Torres, Victòria Ayala, Manuel Portero-Otin, Reinald Pamplona, Pol Andrés-Benito, Isidro Ferrer, Joan J Guinovart, Jordi Dura. Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis. Journal of neurochemistry. 2023-07-04. PMID:37401737. |
amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord. |
2023-07-04 |
2023-08-14 |
mouse |
| Rebecca Stevenson, Evgeniia Samokhina, Armaan Mangat, Ilaria Rossetti, Sushmitha S Purushotham, Chandra S Malladi, John W Morley, Yossi Buskil. Astrocytic K Glia. 2023-07-03. PMID:37395323. |
astrocytic k amyotrophic lateral sclerosis (als) is a neurodegenerative disorder in which patients lose motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal cord. |
2023-07-03 |
2023-08-14 |
Not clear |
| Quyen Thi Nguyen, Liem Nguyen Thanh, Van T Hoang, Trang T K Phan, Michael Heke, Duc M Hoan. Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns. Cellular and molecular neurobiology. 2023-06-25. PMID:37356043. |
in this review, we discuss known and unknown aspects of bmmncs, including the cell harvesting, administration route and dose; mechanisms of action; and their applications in neurological diseases, including stroke, cerebral palsy, spinal cord injury, traumatic brain injury, amyotrophic lateral sclerosis, autism spectrum disorder, and epilepsy. |
2023-06-25 |
2023-08-14 |
Not clear |
| Brian M Balog, Anisha Sonti, Richard E Zigmon. Neutrophil Biology in Injuries and Diseases of the Central and Peripheral Nervous Systems. Progress in neurobiology. 2023-06-24. PMID:37355220. |
we then turn to a review of what is known about the role of neutrophils in cns and pns diseases and injury, including stroke, alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, spinal cord and traumatic brain injuries, cns and pns axon regeneration, and neuropathic pain. |
2023-06-24 |
2023-08-14 |
Not clear |
| Nomakhosazana R Monnakgotla, Amokelani C Mahungu, Jeannine M Heckmann, Gerrit Botha, Nicola J Mulder, Gang Wu, Evadnie Rampersaud, Jason Myers, Marka Van Blitterswijk, Rosa Rademakers, J Paul Taylor, Joanne Wuu, Michael Benatar, Melissa Ne. Analysis of Structural Variants Previously Associated With ALS in Europeans Highlights Genomic Architectural Differences in Africans. Neurology. Genetics. vol 9. issue 4. 2023-06-22. PMID:37346932. |
amyotrophic lateral sclerosis (als) is a degenerative condition of the brain and spinal cord in which protein-coding variants in known als disease genes explain a minority of sporadic cases. |
2023-06-22 |
2023-08-14 |
Not clear |
| Amanda J Guise, Santosh A Misal, Richard Carson, Hannah Boekweg, Daisha Van Der Watt, Thy Truong, Yiran Liang, Jen-Hwa Chu, Nora C Welsh, Jake Gagnon, Samuel H Payne, Edward D Plowey, Ryan T Kell. TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333094. |
unbiased proteomics has been employed to interrogate central nervous system (cns) tissues (brain, spinal cord) and fluid matrices (csf, plasma) from amyotrophic lateral sclerosis (als) patients; yet, a limitation of conventional bulk tissue studies is that motor neuron (mn) proteome signals may be confounded by admixed non-mn proteins. |
2023-06-19 |
2023-08-14 |
human |
| Pramod Kumar Pisharady, Lynn E Eberly, Isaac M Adanyeguh, Georgios Manousakis, Gaurav Guliani, David Walk, Christophe Lengle. Multimodal MRI improves diagnostic accuracy and sensitivity to longitudinal change in amyotrophic lateral sclerosis. Communications medicine. vol 3. issue 1. 2023-06-16. PMID:37328685. |
in this work, we aim to demonstrate increased sensitivity to disease progression as well as improved diagnostic accuracy in amyotrophic lateral sclerosis (als) with multimodal mri of the brain and cervical spinal cord. |
2023-06-16 |
2023-08-14 |
Not clear |
| Michael N Maxwell, Anthony L Marullo, Aoife D Slyne, Eric F Lucking, Ken D O'Hallora. Ventilatory Effects of Acute Intermittent Hypoxia in Conscious Dystrophic Mice. Advances in experimental medicine and biology. vol 1427. 2023-06-15. PMID:37322338. |
interest has grown in developing aih interventions to treat ventilatory insufficiency, with promising results in spinal cord injury and amyotrophic lateral sclerosis. |
2023-06-15 |
2023-08-14 |
mouse |
| Erica Tavazzi, Enrico Longato, Martina Vettoretti, Helena Aidos, Isotta Trescato, Chiara Roversi, Andreia S Martins, Eduardo N Castanho, Ruben Branco, Diogo F Soares, Alessandro Guazzo, Giovanni Birolo, Daniele Pala, Pietro Bosoni, Adriano Chiò, Umberto Manera, Mamede de Carvalho, Bruno Miranda, Marta Gromicho, Inês Alves, Riccardo Bellazzi, Arianna Dagliati, Piero Fariselli, Sara C Madeira, Barbara Di Camill. Artificial intelligence and statistical methods for stratification and prediction of progression in amyotrophic lateral sclerosis: A systematic review. Artificial intelligence in medicine. vol 142. 2023-06-14. PMID:37316101. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disorder characterised by the progressive loss of motor neurons in the brain and spinal cord. |
2023-06-14 |
2023-08-14 |
Not clear |
| Satoshi Yamashita, Nozomu Tawara, Kentaro Hara, Mitsuharu Ued. Gender differences in clinical features at the initial examination of late-onset amyotrophic lateral sclerosis. Journal of the neurological sciences. vol 451. 2023-06-09. PMID:37295193. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease that mainly affects motor neurons in the brain and spinal cord. |
2023-06-09 |
2023-08-14 |
Not clear |
| Noelle C Punessen, Claudia Pena, Alexandra Sandberg, Lilia A Koza, Daniel A Linsema. A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons. Molecular and cellular neurosciences. 2023-06-01. PMID:37263460. |
neurodegenerative diseases such as amyotrophic lateral sclerosis, alzheimer's and parkinson's disease are caused by a progressive and aberrant destruction of neurons in the brain and spinal cord. |
2023-06-01 |
2023-08-14 |
rat |
| Hui Wang, LiPing Guan, Min Den. Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy. Frontiers in neuroscience. vol 17. 2023-05-30. PMID:37250416. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord. |
2023-05-30 |
2023-08-14 |
Not clear |