| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamie L Hanson, Alexia V Williams, Debra A Bangasser, Catherine J Peñ. Impact of Early Life Stress on Reward Circuit Function and Regulation. Frontiers in psychiatry. vol 12. 2021-11-10. PMID:34744836. |
a major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (nac) and ventral tegmental area (vta). |
2021-11-10 |
2023-08-13 |
human |
| Kara M Wendel, Annabel K Short, Brenda P Noarbe, Elizabeth Haddad, Anton M Palma, Michael A Yassa, Tallie Z Baram, Andre Obenau. Early life adversity in male mice sculpts reward circuits. Neurobiology of stress. vol 15. 2021-11-10. PMID:34746338. |
in this study, we focused on the projections from the dorsal raphe (dr) to the ventral tegmental area (vta) and on to the nucleus accumbens (nacc), an important pathway within the reward circuit. |
2021-11-10 |
2023-08-13 |
mouse |
| Maria Vrettou, Liying Yan, Kent W Nilsson, Åsa Wallén-Mackenzie, Ingrid Nylander, Erika Comasc. DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34321562. |
the present study aimed to investigate whether dna methylation of the vesicular glutamate transporters (vglut)1-3 is related to previously observed vglut1-3 transcriptional differences in the ventral tegmental area (vta), nucleus accumbens (acb), dorsal striatum (dstr) and medial prefrontal cortex (mpfc) of adult rats exposed to els, modelled by maternal separation, and voluntary ethanol consumption. |
2021-11-08 |
2023-08-13 |
rat |
| Ming-Shuo Shao, Xiao Yang, Chen-Chun Zhang, Chang-You Jiang, Ying Mao, Wen-Dong Xu, Lan Ma, Fei-Fei Wan. O-GlcNAcylation in Ventral Tegmental Area Dopaminergic Neurons Regulates Motor Learning and the Response to Natural Reward. Neuroscience bulletin. 2021-11-06. PMID:34741260. |
here, we found that injection of thiamet g, an o-glcnacase (oga) inhibitor, in the vta and nucleus accumbens (nac) of mice, facilitated neuronal o-glcnacylation and decreased the operant response to sucrose as well as the latency to fall in rotarod test. |
2021-11-06 |
2023-08-13 |
mouse |
| Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Taku Nagai, Kiyofumi Yamada, Hiroshi Arim. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice. Scientific reports. vol 11. issue 1. 2021-11-05. PMID:34145364. |
the reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (vta) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. |
2021-11-05 |
2023-08-13 |
mouse |
| Richard Quansah Amissah, Diellor Basha, Olga Bukhtiyarova, Elena Timofeeva, Igor Timofee. Neuronal activities during palatable food consumption in the reward system of binge-like eating female rats. Physiology & behavior. vol 242. 2021-11-03. PMID:34563545. |
in humans, bed is associated with desensitization of the reward system, specifically, the medial prefrontal cortex (mpfc), nucleus accumbens (acb), and ventral tegmental area (vta). |
2021-11-03 |
2023-08-13 |
rat |
| Nanette Y Schneider, Sylvie Chaudy, Alberto L Epstein, Cécile Viollet, Alexandre Benani, Luc Pénicaud, Xavier Grosmaître, Frédérique Datiche, Jean Gascue. Centrifugal projections to the main olfactory bulb revealed by transsynaptic retrograde tracing in mice. The Journal of comparative neurology. vol 528. issue 11. 2021-11-02. PMID:31872441. |
other indirect projections have been evidenced in areas of the reward circuit such as vta and accumbens nucleus. |
2021-11-02 |
2023-08-13 |
mouse |
| b' F Quessy, T Bittar, L J Blanchette, M L\\xc3\\xa9vesque, B Labont\\xc3\\xa. Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways. Scientific reports. vol 11. issue 1. 2021-10-29. PMID:34040100.' |
density of the mesolimbic and mesocortical projections was assessed via immuno-histochemistry combined with sholl analysis along with the staining of activity-dependent markers perk and c-fos in the ventral tegmental area (vta), nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2021-10-29 |
2023-08-13 |
mouse |
| Steven R Laviolett. Molecular and neuronal mechanisms underlying the effects of adolescent nicotine exposure on anxiety and mood disorders. Neuropharmacology. vol 184. 2021-10-22. PMID:33245960. |
nicotine can potently regulate the transmission of various neurochemicals, including dopamine (da), γ-amino-butyric acid (gaba) and glutamate, within various mesocorticolimbic structures, such as the ventral tegmental area (vta), nucleus accumbens (nac) and prefrontal cortex (pfc), all of which show pathologies in these disorders. |
2021-10-22 |
2023-08-13 |
Not clear |
| Nayna Sanathara, Lamees Alhassen, Ilias Marmouzi, Mohammad Khoudari, Joseph Phan, Wedad Alhassen, Olivier Civelli, Amal Alachka. Oxytocin-MCH circuit regulates monosynaptic inputs to MCH neurons and modulates social recognition memory. Neuropharmacology. vol 184. 2021-10-22. PMID:33290754. |
deletion of oxtr from mch neurons induced a significant decrease in the primary inputs received by mch neurons from the paraventricular nucleus and the lateral hypothalamus, and from the nucleus accumbens and ventral tegmental area. |
2021-10-22 |
2023-08-13 |
mouse |
| John A Dani, Daniel Jenson, John I Broussard, Mariella De Bias. Neurophysiology of Nicotine Addiction. Journal of addiction research & therapy. vol S1. issue 1. 2021-10-21. PMID:22454789. |
mesocorticolimbic circuitry that includes the dopaminergic pathway originating in the ventral tegmental area and projecting to the nucleus accumbens is recognized as vital for reinforcing behaviors during the initiation of nicotine addiction. |
2021-10-21 |
2023-08-12 |
Not clear |
| Max E Joffe, Carrie A Grueter, Brad A Gruete. Biological substrates of addiction. Wiley interdisciplinary reviews. Cognitive science. vol 5. issue 2. 2021-10-21. PMID:24999377. |
drug abuse is well known to recruit components of the mesolimbic dopamine system, including the nucleus accumbens and ventral tegmental area. |
2021-10-21 |
2023-08-13 |
Not clear |
| Olga Skiteva, Ning Yao, Karima Chergu. Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34650029. |
ketamine induces opposite changes in ampa receptor calcium permeability in the ventral tegmental area and nucleus accumbens. |
2021-10-21 |
2023-08-13 |
mouse |
| Olga Skiteva, Ning Yao, Karima Chergu. Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34650029. |
the mechanisms might involve the induction of metaplasticity in brain regions associated with reward-related behaviors, mood, and hedonic drive, particularly the ventral tegmental area (vta) and the nucleus accumbens (nac). |
2021-10-21 |
2023-08-13 |
mouse |
| Catherine S Thomas, Aida Mohammadkhani, Madiha Rana, Min Qiao, Corey Baimel, Stephanie L Borglan. Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-10-19. PMID:34663867. |
we found that optical stimulation of lh orexin/dynorphin inputs in the vta potentiates mesolimbic dopamine neurotransmission in the nucleus accumbens (nac) core, produces real time and conditioned place preference, and increases the food cue-directed orientation in a pavlovian conditioning procedure. |
2021-10-19 |
2023-08-13 |
Not clear |
| L M Molina-Martínez, J Juáre. Deficit of β-endorphin neurons in the hypothalamus and high expression of MOR in mesolimbic structures are related to high alcohol consumption in outbred rats. Alcohol (Fayetteville, N.Y.). vol 95. 2021-10-15. PMID:34022405. |
we analyzed the number of β-endorphin-positive neurons in the arcuate nucleus (arn) and the expression of μ-opioid receptors (mor) in regions of the reward system, such as the nucleus accumbens (nac), amygdala (amy), and ventral tegmental area (vta) in outbred rats with low (lc) or high (hc) voluntary alcohol consumption. |
2021-10-15 |
2023-08-13 |
rat |
| Anne T Park, Ursula A Tooley, Julia A Leonard, Austin L Boroshok, Cassidy L McDermott, M Dylan Tisdall, Allyson P Macke. Early childhood stress is associated with blunted development of ventral tegmental area functional connectivity. Developmental cognitive neuroscience. vol 47. 2021-10-13. PMID:33395612. |
work in animals has shown that early life stress has a profound impact on the ventral tegmental area (vta), which provides dopamine to regions including nucleus accumbens (nacc), anterior hippocampus, and medial prefrontal cortex (mpfc), with cascading effects over the course of development. |
2021-10-13 |
2023-08-13 |
Not clear |
| Ream Al-Hasani, Raajaram Gowrishankar, Gavin P Schmitz, Christian E Pedersen, David J Marcus, Sofia E Shirley, Taylor E Hobbs, Abigail J Elerding, Sophie J Renaud, Miao Jing, Yulong Li, Veronica A Alvarez, Julia C Lemos, Michael R Brucha. Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Nature neuroscience. vol 24. issue 10. 2021-10-08. PMID:34385700. |
the long-range gabaergic input from the ventral tegmental area (vta) to the nucleus accumbens (nac) is relatively understudied, and therefore its role in reward processing has remained unknown. |
2021-10-08 |
2023-08-13 |
mouse |
| Yongxiang Li, Lvshuang Chen, Weijie Zhao, Lijuan Sun, Ruixue Zhang, Shuqing Zhu, Kailai Xie, Xiajie Feng, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Lina Wang, Qingyan Jian. Food reward depends on TLR4 activation in dopaminergic neurons. Pharmacological research. vol 169. 2021-10-04. PMID:33971268. |
conditional deletion of tlr4 also decreased the activity of da neurons while suppressing the expression of tyrosine hydroxylase (th) in the vta, which regulates the concentration of da in the nucleus accumbens (nac) to affect food reward. |
2021-10-04 |
2023-08-13 |
mouse |
| Jonna M Leyrer-Jackson, Lauren E Hood, M Foster Oliv. Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala. Neuropharmacology. vol 195. 2021-09-29. PMID:34153315. |
pro-opiomelanocortin (pomc) producing neurons located within the arcuate nucleus (arcn) of the hypothalamus make up one circuit of the endogenous opioid system, and heavily projects to reward-related brain areas such as the amygdala, nucleus accumbens (nac) and ventral tegmental area (vta). |
2021-09-29 |
2023-08-13 |
Not clear |