| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanna Molas, Rubing Zhao-Shea, Timothy G Freels, Andrew R Tappe. Viral tracing confirms paranigral ventral tegmental area dopaminergic inputs to the interpeduncular nucleus where dopamine release encodes motivated exploration. eNeuro. 2023-01-04. PMID:36599671. |
to verify the existence of this circuit, we combined presynaptic targeted and retrograde viral tracing in the dopamine transporter (dat)-cre mouse line. |
2023-01-04 |
2023-08-14 |
mouse |
| Jacqueline Saenz, Oscar Yao, Elnaz Khezerlou, Meha Aggarwal, Xiaofeng Zhou, David J Barker, Emanuel DiCicco-Bloom, Ping-Yue Pa. Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter. iScience. vol 26. issue 1. 2023-01-03. PMID:36594015. |
cocaine acts by inhibiting plasma membrane dopamine transporter (dat) function and altering its surface expression. |
2023-01-03 |
2023-08-14 |
mouse |
| Leonardo Alexandre-Santos, Ana Carolina Trevisan, Felipe Arriva Pitella, Vitor Tumas, Jose Henrique Silvah, Mery Kato, Eder Rezende de Moraes, Lauro Wichert-An. Assessment of different regions of interest-based methods for [99mTc]Tc DAT-SPECT quantification using an anthropomorphic striatal phantom. EJNMMI physics. vol 9. issue 1. 2022-12-28. PMID:36577862. |
molecular imaging of the dopamine transporters (dat) provides valuable information about neurodegenerative diseases, such as parkinson's. |
2022-12-28 |
2023-08-14 |
Not clear |
| Tahereh Ghaedian, Ali Razmkon, Leila Kalhor, Vahid Reza Ostovan, Omid Yousefi, Raziyeh Rezaei, Mohammad Reza Hossein-Tehrani, Abbas Rakhsh. Correlation of response to subthalamic deep brain stimulation in Parkinson's disease patients with striatal dopamine transporter density on 99mtc-TRODAT-1 SPECT. Neurological research. 2022-12-27. PMID:36573915. |
since the loss of dopaminergic neurons in the substantia nigra is the main pathophysiology of pd, we aimed to evaluate the association of response to dbs with preoperative dopamine transporter density (dat) and its postoperative changes in pd patients who underwent the bilateral implantation of the electrodes in the subthalamic nucleus (stn). |
2022-12-27 |
2023-08-14 |
Not clear |
| Shiyu Wang, Anna I Neel, Kristen L Adams, Haiguo Sun, Sara R Jones, Allyn C Howlett, Rong Che. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters. Neuropharmacology. 2022-12-25. PMID:36567004. |
the function of dopamine transporters (dat) is regulated by membrane cholesterol content. |
2022-12-25 |
2023-08-14 |
Not clear |
| Shiyu Wang, Anna I Neel, Kristen L Adams, Haiguo Sun, Sara R Jones, Allyn C Howlett, Rong Che. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters. Neuropharmacology. 2022-12-25. PMID:36567004. |
a direct, acute removal of membrane cholesterol by methyl-β-cyclodextrin (mβcd) has been shown to reduce dopamine (da) uptake and release mediated by dat. |
2022-12-25 |
2023-08-14 |
Not clear |
| Sarah Thomas Broome, Alessandro Castorin. Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551930. |
molecular analyses showed reductions of both th and dat expression in the midbrain, striatum and spinal cord, accompanied by altered expression of dopamine receptors and brain-derived neurotrophic factor (bdnf). |
2022-12-23 |
2023-08-14 |
mouse |
| Gordana Nedic Erjavec, Mirko Grubor, Maja Zivkovic, Nada Bozina, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dubravka Svob Stra. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551993. |
since dopamine availability might influence the aip risk, the dopamine transporter (dat) and serotonin receptors (5-htrs), which modulate the dopamine release, may be also involved in the aip development. |
2022-12-23 |
2023-08-14 |
Not clear |
| Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huan. Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552604. |
we revealed that the 8-week supplementation of a low dose (lmp) and a high dose of the mp extract (hmp) improved motor function, as observed in decreased contralateral rotation, improved time spent on rod, and higher dopamine binding transporter (dat) in the substantia nigra pars compacta (snc). |
2022-12-23 |
2023-08-14 |
rat |
| Adele Stewart, Gwynne L Davis, Lorena B Areal, Maximilian J Rabil, Vuong Tran, Felix P Mayer, Randy D Blakel. Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes. Cells. vol 11. issue 24. 2022-12-23. PMID:36552823. |
identified across multiple psychiatric disorders, the dopamine (da) transporter (dat) ala559val substitution triggers non-vesicular, anomalous da efflux (ade), perturbing da neurotransmission and behavior. |
2022-12-23 |
2023-08-14 |
mouse |
| Garima Singh, Namrata Mittra, Chetna Sing. Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation. Molecular and cellular biochemistry. 2022-12-23. PMID:36562918. |
conversely, zn elevated the expression of dopamine transporter (dat) and mitochondrial bcl-2-associated x (bax) protein along with mitochondrial cytochrome c release. |
2022-12-23 |
2023-08-14 |
Not clear |
| Gustavo Henrique Marques Sousa, Renan Augusto Gomes, Eliseu Ortega de Oliveira, Gustavo Henrique Goulart Trossin. Machine learning methods applied for the prediction of biological activities of triple reuptake inhibitors. Journal of biomolecular structure & dynamics. 2022-12-22. PMID:36546689. |
thus, major efforts have been made to develop drugs that inhibit serotonin (sert), norepinephrine (net) and dopamine (dat) transporters and increase the availability of these monoamines. |
2022-12-22 |
2023-08-14 |
Not clear |
| David Matuskey, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Kristen Torres, Mark Dias, Gustavo A Angarita, Yiyun Huang, Susan E Shoaf, Richard E Carson, Shailly Mehrotr. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults. Journal of psychopharmacology (Oxford, England). 2022-12-14. PMID:36515395. |
centanafadine is an inhibitor of reuptake transporters for norepinephrine (net), dopamine (dat) and serotonin (sert). |
2022-12-14 |
2023-08-14 |
Not clear |
| Jason Langley, Kristy S Hwang, Xiaoping P Hu, Daniel E Huddlesto. Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit. Frontiers in neuroscience. vol 16. 2022-12-12. PMID:36507343. |
striatal dopamine transporter (dat) imaging using |
2022-12-12 |
2023-08-14 |
Not clear |
| Omeed Rahimi, Jianjing Cao, Jenny Lam, Steven R Childers, Rana Rais, Linda J Porrino, Amy Newman, Michael A Nade. The Journal of pharmacology and experimental therapeutics. 2022-12-12. PMID:36507847. |
furthermore, the range of dopamine transporter (dat) compounds provides an opportunity to develop pharmacotherapeutics without abuse liability. |
2022-12-12 |
2023-08-14 |
rat |
| Chen Dongfang, Mao Xianzhi, Lou Cen, Huang Zhongk. Use of Hellenic journal of nuclear medicine. 2022-12-12. PMID:36507880. |
use of this study aimed to explore the availability of striatal dopamine transporter (dat) after deep brain stimulation (dbs) by single photon emission computed tomography (spect) using technetium-99m-labeled tropane derivative ( |
2022-12-12 |
2023-08-14 |
Not clear |
| Ciara Frances Pugh, Brian Thomas DeVree, Solveig Gaarde Schmidt, Claus Juul Lolan. Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Cells. vol 11. issue 23. 2022-12-11. PMID:36497070. |
pharmacological characterization of purified full-length dopamine transporter from the dopamine transporter (dat) is a member of the neurotransmitter:sodium symporter (nss) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission. |
2022-12-11 |
2023-08-14 |
Not clear |
| Marta Pardo, Michele Martin, Raul R Gainetdinov, Deborah C Mash, Sari Izenwasse. Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499749. |
the dopamine transporter (dat) plays a major role in mediating cocaine's reward effect. |
2022-12-11 |
2023-08-14 |
rat |
| Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H Sohn, Seok Jong Chun. Patterns of striatal dopamine depletion and motor deficits in de novo Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-12-03. PMID:36462096. |
we enrolled 404 drug-naïve patients with early stage pd who underwent dopamine transporter (dat) imaging. |
2022-12-03 |
2023-08-14 |
human |
| Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H Sohn, Seok Jong Chun. Patterns of striatal dopamine depletion and motor deficits in de novo Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-12-03. PMID:36462096. |
after quantifying dat availability in each striatal sub-region, principal component (pc) analysis was conducted to yield pcs representing the spatial patterns of striatal dopamine depletion. |
2022-12-03 |
2023-08-14 |
human |