| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H Sohn, Seok Jong Chun. Patterns of striatal dopamine depletion and motor deficits in de novo Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-12-03. PMID:36462096. |
after quantifying dat availability in each striatal sub-region, principal component (pc) analysis was conducted to yield pcs representing the spatial patterns of striatal dopamine depletion. |
2022-12-03 |
2023-08-14 |
human |
| Samantha Ayoub, Johnny A Kenton, Morgane Milienne-Petiot, Debbie S Deben, Cristian Achim, Mark A Geyer, William Perry, Igor E Grant, Jared W Young, Arpi Minassia. iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression. Pharmacology, biochemistry, and behavior. 2022-12-03. PMID:36462584. |
the hiv regulatory protein, tat, has been implicated in the neurobehavioral impacts of hiv and is purported to inhibit dopamine transporter (dat) function in a way similar to methamphetamine. |
2022-12-03 |
2023-08-14 |
mouse |
| Seong Ho Jeong, Namki Hong, Hye Sun Lee, Sookyeong Han, Young-Gun Lee, Yoonju Lee, Yumie Rhee, Young H Sohn, Phil Hyu Le. Low skull bone density is associated with poor motor prognosis in women with Parkinson's disease. Frontiers in aging neuroscience. vol 14. 2022-12-02. PMID:36457758. |
we analyzed the data of 260 drug-naïve female pd patients aged ≥50 years old who were followed-up for ≥3 years after their first visit to the clinic with baseline dopamine transporter (dat) imaging. |
2022-12-02 |
2023-08-14 |
Not clear |
| Rui-Fang Wang, Yan-Peng Li, Han-Yue Zhang, Sha-Sha Xu, Zhuo Wang, Xing-Min Han, Bao-Ping Li. Sleep benefit in patients with Parkinson's disease is associated with the dopamine transporter expression in putamen. Brain research. 2022-12-02. PMID:36460060. |
this study aimed to evaluate whether the sb phenomenon in pd patients is associated with dopamine transporter (dat) expression levels in the striatum. |
2022-12-02 |
2023-08-14 |
Not clear |
| Sarah E Davis, Mark J Ferris, Subramaniam Ananthan, Corinne E Augelli-Szafran, Jun Zh. The Journal of pharmacology and experimental therapeutics. 2022-12-01. PMID:36456195. |
development of neurocognitive disorder in hiv infected patients has been linked to dysregulation of dopamine by hiv-1 transactivator of transcription (tat) protein, a negative allosteric modulator of dopamine transporter (dat). |
2022-12-01 |
2023-08-14 |
Not clear |
| Skye Hsin-Hsien Yeh, Chuang-Hsin Chiu, Hung-Wen Kao, Ching-Po Lin, Yu-Hus Lai, Wen-Sheng Huan. Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-24. PMID:36421475. |
we examined the relationship between dopamine transporter (dat) loss using kit-based tc-99m-trodat-1 (dat single-photon emission-computed tomography (spect) radioligand) and globus pallidus necrosis on mri, dat availability before and after hyperbaric oxygen therapy (hbot), and feasibility of tc-99m-trodat-1 as an index for parkinsonian syndrome in co poisoning. |
2022-11-24 |
2023-08-14 |
Not clear |
| Andrés Angel Calderon-Garcia, Maria Perez-Fernandez, Daniel Curto-Aguilera, Ivan Rodriguez-Martin, Mercedes Sánchez-Barba, Veronica Gonzalez-Nune. Exposure to Morphine and Cocaine Modify the Transcriptomic Landscape in Zebrafish Embryos. Neuroscience. 2022-11-21. PMID:36404518. |
cocaine is a potent inhibitor of dopamine, serotonin, and noradrenaline reuptake, as it blocks dat, the dopamine transporter, causing an increase in the local concentration of these neurotransmitters in the synaptic cleft. |
2022-11-21 |
2023-08-14 |
zebrafish |
| Mehmet Evren Öztürk, Anıl Yirün, Selinay Başak Erdemli-Köse, Aylin Balcı-Özyurt, Deniz Arca Çakır, Didem Oral, Pınar Erkekoğl. Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell line. Human & experimental toxicology. vol 41. 2022-11-21. PMID:36411272. |
nuclear factor erythroid 2-associated factor 2 (nrf2), norepinephrine (ne), dopamine transporter (dat) and dopamine beta β-hydroxylase (dbh) levels were measured by sandwich elisa kits while 8-hydroxy deoxyguanosine (8-ohdg) and dopamine levels were determined by competitive elisa kits. |
2022-11-21 |
2023-08-14 |
Not clear |
| Susanna Jakobson Mo, Jan Axelsson, Lars Stiernman, Katrine Riklun. Validation of dynamic [ EJNMMI research. vol 12. issue 1. 2022-11-17. PMID:36394638. |
validation of dynamic [ dopamine transporter (dat) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with lewy bodies but cannot differentiate between these syndromes, and an extra brain imaging examination of the regional cerebral blood flow (rcbf) or glucose metabolism is often needed for differential diagnosis. |
2022-11-17 |
2023-08-14 |
Not clear |
| Thomas R Barber, Kinan Muhammed, Daniel Drew, Kevin M Bradley, Daniel R McGowan, Johannes C Klein, Sanjay G Manohar, Michele T M Hu, Masud Husai. Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder. Brain : a journal of neurology. 2022-11-17. PMID:36395092. |
however, although dopamine transporter (dat) spect has been used to demonstrate the presence of nigro-striatal deficit in irbd, quantifiable correlates of this are currently lacking. |
2022-11-17 |
2023-08-14 |
Not clear |
| Hyeon Jin Lee, Kyonghwan Choe, Jun Sung Park, Amjad Khan, Min Woo Kim, Tae Ju Park, Myeong Ok Ki. O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson's Disease Mouse Models. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-11. PMID:36358479. |
in addition, administration of cps1p restored dopamine-related proteins such as tyrosine hydroxylase (th), vesicular monoamine transporter 2 (vmat2), and dopamine transporter (dat). |
2022-11-11 |
2023-08-14 |
mouse |
| Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. |
the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), α-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). |
2022-11-07 |
2023-08-14 |
rat |
| Jing Deng, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Gender differences in cocaine-induced hyperactivity and dopamine transporter trafficking to the plasma membrane. Addiction biology. vol 27. issue 6. 2022-10-27. PMID:36301205. |
as well known, cocaine induces stimulant effects and dopamine transporter (dat) trafficking to the plasma membrane of dopaminergic neurons. |
2022-10-27 |
2023-08-14 |
rat |
| Elon Wallert, Erwann Letort, Friso van der Zant, Ania Winogrodzka, Henk Berendse, Martijn Beudel, Rob de Bie, Jan Booij, Pieter Raijmakers, Elsmarieke van de Giesse. Comparison of [ EJNMMI research. vol 12. issue 1. 2022-10-23. PMID:36273088. |
comparison of [ two commonly used imaging techniques to aid in the diagnosis of neurodegenerative parkinsonian syndromes are dopamine transporter (dat) imaging with [ |
2022-10-23 |
2023-08-14 |
Not clear |
| Tanya Simuni, Kalpana Merchant, Michael C Brumm, Hyunkeun Cho, Chelsea Caspell-Garcia, Christopher S Coffey, Lana M Chahine, Roy N Alcalay, Kelly Nudelman, Tatiana Foroud, Brit Mollenhauer, Andrew Siderowf, Caroline Tanner, Hirotaka Iwaki, Todd Sherer, Kenneth Mare. Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort. NPJ Parkinson's disease. vol 8. issue 1. 2022-10-22. PMID:36273008. |
all participants were assessed annually with comprehensive motor and non-motor scales, dopamine transporter (dat) imaging, and biofluid biomarkers. |
2022-10-22 |
2023-08-14 |
human |
| Tsung-Hua Lu, Shih-Hsien Lin, Huai-Hsuan Tseng, Yen Kuang Yang, Nan Tsing Chiu, Po See Che. Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [ Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 20. issue 4. 2022-10-20. PMID:36263651. |
whether the striatal dopamine transporter (dat) availability is related to sleep quality among patients with bd is unclear. |
2022-10-20 |
2023-08-14 |
Not clear |
| Limin Yin, Yu Zhou, Hong Liu, Yang L. LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer disease. Autophagy. 2022-10-10. PMID:36215390. |
in our recent study, we have identified a group of lysosome-enhancing compounds (lyecs), which significantly promote the activation of tfeb (transcription factor eb) and lysosome biogenesis via inhibiting dopamine transporters (dat). |
2022-10-10 |
2023-08-14 |
mouse |
| Pavan A Vaswani, James F Morley, Danna Jennings, Andrew Siderowf, Kenneth Mare. Serial olfactory testing for the diagnosis of prodromal Parkinson's disease in the PARS study. Parkinsonism & related disorders. vol 104. 2022-10-04. PMID:36194902. |
the parkinson associated risk syndrome (pars) study was designed to evaluate whether screening with olfactory testing and dopamine transporter (dat) imaging could identify participants at risk for developing parkinson's disease (pd). |
2022-10-04 |
2023-08-14 |
human |
| Hirotaka Sekiguchi, Geoff Pavey, Brian Dea. Altered levels of dopamine transporter in the frontal pole and the striatum in mood disorders: A postmortem study. Journal of affective disorders. 2022-09-26. PMID:36162690. |
the dopamine transporter (dat) plays a critical role in regulating dopamine concentration at the synaptic cleft and therefore could have an important role in the molecular pathology of mdd and bd. |
2022-09-26 |
2023-08-14 |
Not clear |
| Pawel Grochecki, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Predrag Kalaba, Vladimir Dragacevic, Patrycja Kotlinska, Malgorzata Filip, Gert Lubec, Jolanta H Kotlinsk. Novel Dopamine Transporter Inhibitor, CE-123, Ameliorates Spatial Memory Deficits Induced by Maternal Separation in Adolescent Rats: Impact of Sex. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142621. |
to test the hypothesis that dopamine signaling is a major factor in this, an atypical new dopamine transporter (dat) inhibitor, ce-123, was assessed for its potential to counteract the ms-induced spatial learning and memory deficit in male and female rats. |
2022-09-23 |
2023-08-14 |
rat |