| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T A Roepke, J Qiu, M A Bosch, O K Rønnekleiv, M J Kell. Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus. Journal of neuroendocrinology. vol 21. issue 4. 2009-08-10. PMID:19187465. |
we have found that e(2) can rapidly reduce the potency of the gaba(b) receptor agonist baclofen and mu-opioid receptor agonist damgo to activate g-protein-coupled, inwardly rectifying k(+) (girk) channels in hypothalamic neurones, thereby increasing the excitability (firing activity) of pro-opiomelanocortin (pomc) and dopamine neurones. |
2009-08-10 |
2023-08-12 |
mouse |
| Tullio Florio, Federica Barbieri, Renato Spaziante, Gianluigi Zona, Leo J Hofland, Peter M van Koetsveld, Richard A Feelders, Günter K Stalla, Marily Theodoropoulou, Michael D Culler, Jesse Dong, John E Taylor, Jacques-Pierre Moreau, Alexandru Saveanu, Ginette Gunz, Henry Dufour, Philippe Jaque. Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. Endocrine-related cancer. vol 15. issue 2. 2008-09-11. PMID:18509006. |
cells were characterized for gh, pomc, sstr1-sstr5, total dopamine d2 receptor (d2r) (in all cases), and d2 receptor long and short isoforms (in 15 out of 38 cases) mrna expression and for alpha-subunit, lh, and fsh release. |
2008-09-11 |
2023-08-12 |
human |
| Anna Malyala, Martin J Kelly, Oline K Rønneklei. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. Steroids. vol 70. issue 5-7. 2005-09-20. PMID:15862823. |
hypothalamic target neurons of estrogen include neurosecretory neurons such as gonadotropin-releasing hormone (gnrh) and dopamine neurons, and local circuitry neurons such as proopiomelanocortin (pomc) and gamma-aminobutyric acid (gaba) neurons. |
2005-09-20 |
2023-08-12 |
Not clear |
| Anna Malyala, Martin J Kelly, Oline K Rønneklei. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. Steroids. vol 70. issue 5-7. 2005-09-20. PMID:15862823. |
e2 rapidly uncouples mu-opioid and gaba(b) receptors from g protein-gated inwardly rectifying k+ (girk) channels in pomc and dopamine neurons as manifested by a reduction in the potency of mu-opioid and gaba(b) receptor agonists to activate these channels. |
2005-09-20 |
2023-08-12 |
Not clear |
| Martin J Kelly, Jian Qiu, Oline K Rønneklei. Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Annals of the New York Academy of Sciences. vol 1007. 2004-03-25. PMID:14993035. |
neurosecretory neurons, such as gonadotropin-releasing hormone (gnrh) and dopamine neurons, and local circuitry neurons, such as pro-opiomelanocortin (pomc) and gamma-aminobutyric acid (gaba) neurons, are among those involved. |
2004-03-25 |
2023-08-12 |
Not clear |
| Martin J Kelly, Jian Qiu, Oline K Rønneklei. Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Annals of the New York Academy of Sciences. vol 1007. 2004-03-25. PMID:14993035. |
e(2) rapidly uncouples micro -opioid and gaba(b) receptors from g-protein-gated inwardly rectifying k(+) (girk) channels in pomc and dopamine neurons as manifested by a reduction in the potency of micro -opioid and gaba(b) receptor agonists to activate these channels. |
2004-03-25 |
2023-08-12 |
Not clear |
| Martin J Kelly, Jian Qiu, Oline K Rønneklei. Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Annals of the New York Academy of Sciences. vol 1007. 2004-03-25. PMID:14993035. |
these findings indicate that e(2) can modulate k(+) channels in hypothalamic (pomc, dopamine, gaba, gnrh) neurons that are involved in regulating numerous homeostatic functions through multiple intracellular signaling pathways. |
2004-03-25 |
2023-08-12 |
Not clear |
| Jian Qiu, Martha A Bosch, Sandra C Tobias, David K Grandy, Thomas S Scanlan, Oline K Ronnekleiv, Martin J Kell. Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 29. 2003-10-30. PMID:14573532. |
we discovered that e2 can alter mu-opioid and gaba neurotransmission rapidly through nontranscriptional events in hypothalamic gaba, proopiomelanocortin (pomc), and dopamine neurons. |
2003-10-30 |
2023-08-12 |
Not clear |
| Jian Qiu, Martha A Bosch, Sandra C Tobias, David K Grandy, Thomas S Scanlan, Oline K Ronnekleiv, Martin J Kell. Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 29. 2003-10-30. PMID:14573532. |
moreover, using single-cell reverse transcription-pcr, we identified the critical transcripts, pkcdelta and its downstream target adenylyl cyclase vii, for rapid, novel signaling of e2 in gaba, pomc, and dopamine neurons. |
2003-10-30 |
2023-08-12 |
Not clear |
| Martin J Kelly, Jian Qiu, Edward J Wagner, Oline K Rønneklei. Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system (CNS). The Journal of steroid biochemistry and molecular biology. vol 83. issue 1-5. 2003-05-23. PMID:12650715. |
some of the neurons include neurosecretory neurons such as gonadotropin-releasing hormone (gnrh) and dopamine neurons, and local circuitry neurons such as proopiomelanocortin (pomc) and gamma-aminobutyric acid (gaba) neurons. |
2003-05-23 |
2023-08-12 |
Not clear |
| Martin J Kelly, Jian Qiu, Edward J Wagner, Oline K Rønneklei. Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system (CNS). The Journal of steroid biochemistry and molecular biology. vol 83. issue 1-5. 2003-05-23. PMID:12650715. |
estrogen rapidly uncouples mu-opioid receptors from g protein-gated inwardly-rectifying k(+) (girk) channels in pomc neurons and gaba(b) receptors from girk channels in dopamine neurons as manifested by a reduction in the potency of mu-opioid and gaba(b) receptor agonists to hyperpolarize their respective cells. |
2003-05-23 |
2023-08-12 |
Not clear |
| Martin J Kelly, Jian Qiu, Edward J Wagner, Oline K Rønneklei. Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system (CNS). The Journal of steroid biochemistry and molecular biology. vol 83. issue 1-5. 2003-05-23. PMID:12650715. |
these findings indicate a richly complex yet coordinated steroid modulation of k(+) channel activity in hypothalamic (pomc, dopamine, gaba, gnrh) neurons that are involved in regulating numerous homeostatic functions. |
2003-05-23 |
2023-08-12 |
Not clear |
| F S Shen, G Aguilera, Y P Lo. Altered biosynthesis and secretion of pro-opiomelanocortin in the intermediate and anterior pituitary of carboxypeptidase E-deficient, Cpe(fat)/ Cpe(fat)mice. Neuropeptides. vol 33. issue 4. 2000-06-01. PMID:10657504. |
this result indicates that the elevated, dopamine-insensitive pomc secretion previously observed in the intermediate pituitary of cpe(fat)/ cpe(fat)mice was constitutive, rather than due to defective dopamine receptors. |
2000-06-01 |
2023-08-12 |
mouse |
| E D Hendle. WKHA rats with genetic hyperactivity and hyperreactivity to stress: a review. Neuroscience and biobehavioral reviews. vol 24. issue 1. 2000-02-17. PMID:10654659. |
neurochemical studies have revealed changes in brain monoamine function in wkha rats, particularly in frontal cortical norepinephrine and dopamine uptake, and they show marked changes in neuroendocrine responses in the hypothalamic/pituitary/adrenal axis, as well as altered pomc peptides in the pituitary anterior and posterior lobes. |
2000-02-17 |
2023-08-12 |
rat |
| J L González de Aguilar, M M Malagón, R M Vázquez-Martínez, A J Martínez-Fuentes, M C Tonon, H Vaudry, F Gracia-Navarr. Differential effects of dopamine on two frog melanotrope cell subpopulations. Endocrinology. vol 140. issue 1. 1999-01-28. PMID:9886821. |
similarly, dopamine significantly decreased the accumulation of pomc messenger rna in ld cells, whereas it did not affect pomc gene expression in the hd melanotrope subset. |
1999-01-28 |
2023-08-12 |
Not clear |
| A Saiardi, E Borrell. Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice. Molecular endocrinology (Baltimore, Md.). vol 12. issue 8. 1998-10-29. PMID:9717839. |
dopamine negatively regulates pomc gene expression in melanotrophs of the intermediate lobe of the pituitary gland. |
1998-10-29 |
2023-08-12 |
mouse |
| A Saiardi, E Borrell. Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice. Molecular endocrinology (Baltimore, Md.). vol 12. issue 8. 1998-10-29. PMID:9717839. |
pomc is differently processed in the corticotrophs, where it is not regulated by dopamine and it is principally processed into acth. |
1998-10-29 |
2023-08-12 |
mouse |
| A Saiardi, E Borrell. Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice. Molecular endocrinology (Baltimore, Md.). vol 12. issue 8. 1998-10-29. PMID:9717839. |
indeed, we demonstrate that in addition to controlling pomc gene expression in these cells, dopamine, by modulating the expression of the convertases involved in the cleavage of the pomc prohormone, strictly regulates its processing. |
1998-10-29 |
2023-08-12 |
mouse |
| L García-García, J A Fuentes, J Manzanare. Differential 5-HT-mediated regulation of stress-induced activation of proopiomelanocortin (POMC) gene expression in the anterior and intermediate lobe of the pituitary in male rats. Brain research. vol 772. issue 1-2. 1998-02-19. PMID:9406963. |
5,7-dht neurotoxic lesion, which resulted in a marked depletion of 5-ht (below the level of sensitivity of the neurochemical assay, 6 pg/sample) but not of dopamine or norepinephrine concentrations in the periventricular nucleus of the hypothalamus, had no effect on basal pomc mrna levels in the anterior or intermediate lobe of the pituitary. |
1998-02-19 |
2023-08-12 |
rat |
| R Hnasko, S Khurana, N Shackleford, R Steinmetz, M J Low, N Ben-Jonatha. Two distinct pituitary cell lines from mouse intermediate lobe tumors: a cell that produces prolactin-regulating factor and a melanotroph [seecomments]. Endocrinology. vol 138. issue 12. 1997-12-29. PMID:9389547. |
rt-pcr revealed that mil39, but not mil5 cells, express pomc and dopamine d2 receptors, typical of a melanotroph phenotype. |
1997-12-29 |
2023-08-12 |
mouse |