| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Sands, D S Dickerson, S J Morris, B M Chronwal. Dopamine D2 receptor stimulation alters G-protein expression in rat pituitary intermediate lobe melanotropes. Endocrine. vol 6. issue 3. 1997-12-08. PMID:9368690. |
stimulation of dopamine d2 receptors inhibits melanotrope pro-opiomelanocortin (pomc) biosynthesis and alpha-melanocyte-stimulating hormone (msh) secretion. |
1997-12-08 |
2023-08-12 |
rat |
| D J Autelitano, M van den Buus. Concomitant up-regulation of proopiomelanocortin and dopamine D2-receptor gene expression in the pituitary intermediate lobe of the spontaneously hypertensive rat. Journal of neuroendocrinology. vol 9. issue 4. 1997-07-07. PMID:9147288. |
solution hybridization/nuclease protection analysis showed that adult shr express pomc mrna in the nil at approximately 2-4 times the level seen in normotensive wky controls, associated with a concomitant 2-fold increase in dopamine d2-receptor (d2-r) mrna expression. |
1997-07-07 |
2023-08-12 |
rat |
| D J Autelitano, M van den Buus. Concomitant up-regulation of proopiomelanocortin and dopamine D2-receptor gene expression in the pituitary intermediate lobe of the spontaneously hypertensive rat. Journal of neuroendocrinology. vol 9. issue 4. 1997-07-07. PMID:9147288. |
the current data demonstrate changes in expression of both pomc and d2-r mrna in the shr nil which may be a consequence of altered dopaminergic input and/or alterations in d2-r regulation in this tissue, possibly enabling other factors in addition to dopamine to maintain the nil of the shr in a relatively hyperactive state. |
1997-07-07 |
2023-08-12 |
rat |
| A Kjae. Neurohypophysial peptides. Histaminergic regulation and function in adenohypophysial secretion. Danish medical bulletin. vol 43. issue 5. 1997-04-02. PMID:8960813. |
in addition to the major hypothalamic factors regulating pomc and prl secretion, corticotropin-releasing hormone and dopamine, the neurohypophysial peptides arginine-vasopressin (avp) and oxytocin (ot) may serve such a regulatory role in adenohypophysial hormone secretion. |
1997-04-02 |
2023-08-12 |
Not clear |
| F A Caputo, S F Ali, G L Wolff, A C Scalle. Neonatal MSG reduces hypothalamic DA, beta-endorphin, and delays weight gain in genetically obese (A viable yellow/alpha) mice. Pharmacology, biochemistry, and behavior. vol 53. issue 2. 1997-01-16. PMID:8808153. |
food intake was decreased (p < 0.05) in both phenotypes treated with msg, as was hypothalamic content of dopamine (p < 0.05) and of the pomc peptide, beta-endorphin (p < 0.001). |
1997-01-16 |
2023-08-12 |
mouse |
| C H Dotman, P M Cruijsen, B G Jenks, E W Roubo. Differential action of secreto-inhibitors on proopiomelanocortin biosynthesis in the intermediate pituitary of Xenopus laevis. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895316. |
to study the role of these secreto-inhibitors in the regulation of pomc biosynthesis, the rate of incorporation of radioactive amino acids into pomc protein was determined after in vitro treatment of the neurointermediate pituitary with npy, apomorphine (dopamine d2 receptor agonist), isoguvacine (gabaa receptor agonist) and baclofen (gabab receptor agonist). |
1996-12-17 |
2023-08-12 |
human |
| C H Dotman, P M Cruijsen, B G Jenks, E W Roubo. Differential action of secreto-inhibitors on proopiomelanocortin biosynthesis in the intermediate pituitary of Xenopus laevis. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895316. |
the observations indicate differential actions of the secreto-inhibitors npy, apomorphine, and gaba agonists on pomc biosynthesis in the xenopus intermediate pituitary, suggesting a major role for dopamine and npy, whereas gaba, acting via two receptor types, does not seem to have a major function in long term control of pomc biosynthesis. |
1996-12-17 |
2023-08-12 |
human |
| S G Matthews, M Fraser, J R Challi. Dopaminergic regulation of pituitary function in the late-gestation fetal sheep. The Journal of endocrinology. vol 150. issue 2. 1996-12-02. PMID:8869585. |
however, pomc in the intermediate lobe (il) and prl in the al are known to be primarily regulated by dopamine, via the d2 receptor, in adult sheep. |
1996-12-02 |
2023-08-12 |
Not clear |
| C Matera, S L Wardla. Aromatization is not required for androgen induced changes in proopiomelanocortin gene expression in the hypothalamus. Brain research. Molecular brain research. vol 27. issue 2. 1995-04-25. PMID:7898311. |
we have also examined the effect of the dopamine agonist, pergolide, on pomc in the dht and estradiol treated animals in light of previous studies in female rats. |
1995-04-25 |
2023-08-12 |
rat |
| F René, C Hindelang, M E Stoeckel, J M Féli. Ontogeny of glucocorticoid and D2 receptors in the rat pituitary: an in situ hybridization study. Molecular and cellular endocrinology. vol 105. issue 1. 1995-02-16. PMID:7821719. |
these data indicate a possible early regulation of pomc gene expression by glucocorticoid in corticotrophic cells of the al and by dopamine in the melanotrophic cells of the il. |
1995-02-16 |
2023-08-12 |
rat |
| C Matera, S L Wardla. Dopamine and sex steroid regulation of POMC gene expression in the hypothalamus. Neuroendocrinology. vol 58. issue 5. 1994-03-30. PMID:8115018. |
dopamine and sex steroid regulation of pomc gene expression in the hypothalamus. |
1994-03-30 |
2023-08-12 |
rat |
| C Matera, S L Wardla. Dopamine and sex steroid regulation of POMC gene expression in the hypothalamus. Neuroendocrinology. vol 58. issue 5. 1994-03-30. PMID:8115018. |
in this study we have examined the effects of dopamine on pomc in the mbh and questioned whether the increase in dopamine activity which occurs in the mbh of chronically castrated rats is responsible for the stimulation of pomc seen under these conditions. |
1994-03-30 |
2023-08-12 |
rat |
| C Matera, S L Wardla. Dopamine and sex steroid regulation of POMC gene expression in the hypothalamus. Neuroendocrinology. vol 58. issue 5. 1994-03-30. PMID:8115018. |
we have therefore measured pomc gene expression and peptide content in the mbh of chronically castrated male and female rats in response to the dopamine antagonist haloperidol, and in intact or sex steroid replaced animals in response to the dopamine agonist pergolide. |
1994-03-30 |
2023-08-12 |
rat |
| R Day, M K Schäfer, M W Collard, E Weihe, H Aki. Prodynorphin gene expression in the rat intermediate pituitary lobe: gender differences and postpartum regulation. Endocrinology. vol 133. issue 6. 1994-01-06. PMID:8243288. |
intermediate lobe prodyn gene expression was not regulated by dopamine, in contrast to intermediate lobe pomc mrna levels, which were increased with haloperidol and decreased with bromocriptine treatment, as expected. |
1994-01-06 |
2023-08-12 |
rat |
| C A Zerbe, T P Clark, J L Sartin, R J Kemppaine. Domperidone treatment enhances corticotropin-releasing hormone stimulated adrenocorticotropic hormone release from the dog pituitary. Neuroendocrinology. vol 57. issue 2. 1993-07-12. PMID:8389997. |
while dopamine (da) is known to inhibit pituitary intermediate lobe proopiomelanocortin (pomc) peptide secretion and synthesis in most species, its influence on anterior-lobe (al) pomc peptide synthesis and secretion is less clear. |
1993-07-12 |
2023-08-12 |
dog |
| L C Saland, J A Carr, A Samora, D Tejed. Benzodiazepine suppression of corticotropin-releasing factor (CRF)-induced beta-endorphin release from rat neurointermediate pituitary. Peptides. vol 13. issue 5. 1993-02-09. PMID:1480515. |
dopamine and gamma-aminobutyric acid (gaba) inhibit pomc peptide release from the pituitary intermediate lobe, via interaction with d2 or gaba-a/benzodiazepine receptors. |
1993-02-09 |
2023-08-11 |
rat |
| Y Tong, G Pelletie. Role of dopamine in the regulation of proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus and pituitary gland of the female rat as studied by in situ hybridization. Brain research. Molecular brain research. vol 15. issue 1-2. 1992-12-02. PMID:1331668. |
role of dopamine in the regulation of proopiomelanocortin (pomc) mrna levels in the arcuate nucleus and pituitary gland of the female rat as studied by in situ hybridization. |
1992-12-02 |
2023-08-11 |
rat |
| Y Tong, G Pelletie. Role of dopamine in the regulation of proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus and pituitary gland of the female rat as studied by in situ hybridization. Brain research. Molecular brain research. vol 15. issue 1-2. 1992-12-02. PMID:1331668. |
the present data clearly demonstrate that pomc mrna levels are differently regulated by dopamine in the intermediate lobe of the pituitary and the arcuate nucleus and that the effects of bro and hal on arcuate pomc mrna are not mediated by the pituitary gland. |
1992-12-02 |
2023-08-11 |
rat |
| T A Ayoubi, B G Jenks, E W Roubos, G J Marten. Transcriptional and posttranscriptional regulation of the proopiomelanocortin gene in the pars intermedia of the pituitary gland of Xenopus laevis. Endocrinology. vol 130. issue 6. 1992-07-06. PMID:1597153. |
the dopamine d2-receptor agonist apomorphine decreased pomc mrna biosynthesis about 5-fold, which confirms that regulation of pomc gene expression includes a transcriptional component. |
1992-07-06 |
2023-08-11 |
xenopus_laevis |
| B Koch, B Lutz-Buche. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates cyclic AMP formation as well as peptide output of cultured pituitary melanotrophs and AtT-20 corticotrophs. Regulatory peptides. vol 38. issue 1. 1992-06-04. PMID:1315448. |
this study shows that (1) pituitary pomc cells did respond to pacap by enhancing camp accumulation and elevating hormone secretion as well; (2) the effect of pacap was additive with crf on camp production in melanotrophs, but not in corticotrophs, while there was no additivity on peptide output from both cell types; (3) activation of dopamine receptors in melanotrophs dampened both camp formation and peptide secretion. |
1992-06-04 |
2023-08-11 |
Not clear |