| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Reis, G Gilad, V M Pickel, T H Jo. Reversible changes in the activities and amounts of tyrosine hydroxylase in dopamine neurons of the substantia nigra in response to axonal injury as studied by immunochemical and immunocytochemical methods. Brain research. vol 144. issue 2. 1978-06-12. PMID:25123. |
reversible changes in the activities and amounts of tyrosine hydroxylase in dopamine neurons of the substantia nigra in response to axonal injury as studied by immunochemical and immunocytochemical methods. |
1978-06-12 |
2023-08-11 |
Not clear |
| R B Rastogi, R L Singha. Evidence for the role of adrenocortical hormones in the regulation of noradrenaline and dopamine metabolism in certain brain areas. British journal of pharmacology. vol 62. issue 1. 1978-03-29. PMID:23193. |
corticosterone treatment for 7 days beginning from the 8th day of adrenalectomy virtually restored the concentrations of noradrenaline and dopamine as well as the activities of striatal tyrosine hydroxylase and cerebrocortical monoamine oxidase to the values seen for sham-operated controls. |
1978-03-29 |
2023-08-11 |
rat |
| M M Ames, P Lerner, W Lovenber. Tyrosine hydroxylase. Activation by protein phosphorylation and end product inhibition. The Journal of biological chemistry. vol 253. issue 1. 1978-02-23. PMID:22545. |
at physiological concentrations of dopamine, the increase in ki by phosphorylation would effectively release tyrosine hydroxylase from end product feedback inhibition. |
1978-02-23 |
2023-08-11 |
rat |
| B Ablad, O Almgren, A Carlsson, M Henning, J Jonasson, B Ljun. Reduced adrenal amine synthesis in spontaneously hypertensive rats after long-term treatment with propranolol. British journal of pharmacology. vol 61. issue 2. 1978-01-27. PMID:922261. |
adrenal dopamine content and tyrosine hydroxylase activity were reduced to 76% and 71% of the control values, respectively. |
1978-01-27 |
2023-08-11 |
rat |
| U Otten, M Schwab, C Gagnon, H Thoene. Selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats. Brain research. vol 133. issue 2. 1977-11-25. PMID:20194. |
selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats. |
1977-11-25 |
2023-08-11 |
rat |
| R N Rosenthal, T A Slotki. Development of nicotinic responses in the rat adrenal medulla and long-term effects of neonatal nicotine administration. British journal of pharmacology. vol 60. issue 1. 1977-09-22. PMID:18246. |
after the short-term catecholamine depletion caused by nicotine, there were persistent elevations of catecholamines and tyrosine hydroxylase until 23 days of age; however, dopamine beta-hydroxylase remained elevated into young adulthood. |
1977-09-22 |
2023-08-11 |
rat |
| J H Khalsa, W M Davi. Motility response to morphine and amphetamine during chronic inhibition of tyrosine hydroxylase or dopamine beta-hydroxylase. The Journal of pharmacology and experimental therapeutics. vol 202. issue 1. 1977-08-25. PMID:17725. |
motility response to morphine and amphetamine during chronic inhibition of tyrosine hydroxylase or dopamine beta-hydroxylase. |
1977-08-25 |
2023-08-11 |
Not clear |
| A E Raine, I W Chub. Long term beta-adrenergic blockade reduces tyrosine hydroxylase and dopamine beta-hydroxylase activities in sympathetic ganglia. Nature. vol 267. issue 5608. 1977-07-23. PMID:17075. |
long term beta-adrenergic blockade reduces tyrosine hydroxylase and dopamine beta-hydroxylase activities in sympathetic ganglia. |
1977-07-23 |
2023-08-11 |
Not clear |
| N Halász, A Ljungdahl, T Hökfelt, O Johansson, M Goldstein, D Park, P Biberfel. Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons. Brain research. vol 126. issue 3. 1977-07-18. PMID:16685. |
in the principal bulb the first two enzymes, tyrosine hydroxylase (th) and dopa decarboxylase (ddc), but not dopamine-beta-hydroxylase (dbh), were present in a proportion of periglomerular cell bodies and dendrites indicating that these neurons synthesize dopamine (da). |
1977-07-18 |
2023-08-11 |
rat |
| R Schwarcz, J T Coyl. Striatal lesions with kainic acid: neurochemical characteristics. Brain research. vol 127. issue 2. 1977-07-18. PMID:16686. |
in contrast, the striatal content of dopamine and the synaptosomal uptake of dopamine were unchanged, and the activity of tyrosine hydroxylase was significantly increased. |
1977-07-18 |
2023-08-11 |
rat |
| R B Rastoge, R L Singha. Lithium: modification of behavioral activity and brain biogenic amines in developing hyperthyroid rats. The Journal of pharmacology and experimental therapeutics. vol 201. issue 1. 1977-05-27. PMID:850149. |
lithium treatment in normal rats increased the activity of striatal tyrosine hydroxylase, but produced no significant effect on the endogenous levels of norepinephrine and dopamine in several discrete brain regions examined. |
1977-05-27 |
2023-08-11 |
rat |
| R B Rastoge, R L Singha. Lithium: modification of behavioral activity and brain biogenic amines in developing hyperthyroid rats. The Journal of pharmacology and experimental therapeutics. vol 201. issue 1. 1977-05-27. PMID:850149. |
in contrast to the effects seen in normal rats, admininstration of lithium in l-triiodothyronine-treated animals significantly decreased tyrosine hydroxylase as well as dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid, suggesting that this antimanic drug reduced the synthesis and turnover of dopamine. |
1977-05-27 |
2023-08-11 |
rat |
| T Nagatsu, T Kato, Y Numata, K Ikuta, M San. Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain. Clinica chimica acta; international journal of clinical chemistry. vol 75. issue 2. 1977-05-20. PMID:14798. |
the activities of tyrosine hydroxylase (th), dopa decarboxylase (ddc), dopamine beta-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt), and monoamine oxidase (mao) with serotonin and phenylethylamine as substrates were measured in catecholaminergic regions of human brain from 10 controls and 3 patients with parkinsonism. |
1977-05-20 |
2023-08-11 |
human |
| R Schwarcz, J T Coyl. Kainic acid: neurotoxic effects after intraocular injection. Investigative ophthalmology & visual science. vol 16. issue 2. 1977-03-31. PMID:832974. |
the dopaminergic neurons, as assessed by activity of tyrosine hydroxylase and concentration of endogenous dopamine, are reduced only 50% by the kainic acid treatment. |
1977-03-31 |
2023-08-11 |
Not clear |
| J R Walters, R H Rot. Dopaminergic neurons: an in vivo system for measuring drug interactions with presynaptic receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 296. issue 1. 1977-03-21. PMID:13315. |
it was found that administration of the dopamine agonists, apomorphine or et-495 [1-(2-pyrimidyl)-piperonyl-piperazine], modified the apparent activity of striatal tyrosine hydroxylase when impulse flow was blocked in dopamine neurons. |
1977-03-21 |
2023-08-11 |
rat |
| A Löfströ. Catecholamine turnover alterations in discrete areas of the median eminence of the 4- and 5-day cyclic rat. Brain research. vol 120. issue 1. 1977-03-15. PMID:12857. |
using quantitative microfluorimetry in combination with tyrosine hydroxylase inhibition (h44/68) the concentration and turnover of noradrenaline (na) and dopamine (da) was studied in the subependymal layer (sel) and the medial (mpz) and lateral palisade zone (lpz) of the rat median eminence during the 4- and 5- day vaginal estrous cycle. |
1977-03-15 |
2023-08-11 |
rat |
| D S Robinson, T L Sourkes, A Nies, L S Harris, S Spector, D L Bartlett, I S Kay. Monoamine metabolism in human brain. Archives of general psychiatry. vol 34. issue 1. 1977-03-15. PMID:13761. |
norepinephrine (ne), dopamine (da), tyrosine hydroxylase (th), catechol-o-methyltransferase (comt) and monoamine oxidase (mao) levels were measured in human brain tissue obtained at autopsy from a series of 39 patients dying of various medical and accidental causes. |
1977-03-15 |
2023-08-11 |
human |
| L C Murrin, R H Rot. Dopaminergic neurons: reversal of effects elicited by gamma-butyrolactone by stimulation of the nigro-neostriatal pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 295. issue 1. 1977-02-16. PMID:12482. |
in vivo studies demonstrate that administration of gamma-butyrolactone, a precursor of gamma-hydroxybutyric acid causes a rapid increase in endogenous levels of striatal dopamine and an increase in tyrosine hydroxylase activity measured by following the short term accumulation of dihydroxyphenylalanine. |
1977-02-16 |
2023-08-11 |
Not clear |
| L C Murrin, R H Rot. Dopaminergic neurons: reversal of effects elicited by gamma-butyrolactone by stimulation of the nigro-neostriatal pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 295. issue 1. 1977-02-16. PMID:12482. |
these results are also consistent with the hypothesis that gbl activates tyrosine hydroxylase and increases endogenous dopamine levels primarily by blocking impulse flow in central dopaminergic neurons. |
1977-02-16 |
2023-08-11 |
Not clear |
| P L McGeer, E G McGeer, J S Suzuk. Aging and extrapyramidal function. Archives of neurology. vol 34. issue 1. 1977-02-16. PMID:12731. |
the most severe loss found was that in striatal tyrosine hydroxylase activity, the rate-controlling enzyme in the synthesis of dopamine. |
1977-02-16 |
2023-08-11 |
human |