| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Brownstein, M Palkovits, M L Tappaz, J M Saavedra, J S Kize. Effect of surgical isolation of the hypothalamus on its neurotransmitter content. Brain research. vol 117. issue 2. 1977-01-28. PMID:11035. |
the concentrations of norepinephrine, dopamine-beta-hydroxylase, dopamine, tyrosine hydroxylase, phenylethanolamine-n-methyltransferase, serotonin, tryptophan hydroxylase, histamine, glutamic acid decarboxylase, and choline acetyltransferase were determined in selected hypothalamic nuclei and in the median eminence after deafferentation of the medial basal hypothalamus. |
1977-01-28 |
2023-08-11 |
Not clear |
| M J Brownstein, M Palkovits, M L Tappaz, J M Saavedra, J S Kize. Effect of surgical isolation of the hypothalamus on its neurotransmitter content. Brain research. vol 117. issue 2. 1977-01-28. PMID:11035. |
norepinephrine and dopamine-beta-hydroxylase fell markedly while dopamine and tyrosine hydroxylase did not. |
1977-01-28 |
2023-08-11 |
Not clear |
| E H LaBrosse, E Comoy, C Bohuon, J M Zucker, O Schweisgut. Catecholamine metabolism in neuroblastoma. Journal of the National Cancer Institute. vol 57. issue 3. 1976-12-30. PMID:10450. |
review of the results of tracer studies aimed at elucidating the in vivo metabolic origins of the urinary metabolites suggested that a) in neuroblastoma, the catecholamines were largely inactivated by intracellular metabolism in the tumor cells; b) there was excess production and excretion of the norepinephrine precursors, dopa and dopamine; and c) in the tumors of most neuroblastoma patients, the initial enzyme in catecholamine synthesis, tyrosine hydroxylase, had an activity comparable with that in normal adrenal glands. |
1976-12-30 |
2023-08-11 |
Not clear |
| P A Shor. On the role of storage granules in the functional utilization of newly synthesized dopamine. Journal of neural transmission. vol 39. issue 1-2. 1976-12-30. PMID:1049242. |
it was found that the injection of a small dose of l-dopa did not reverse the catalepsy produced by the short-acting dopamine depleter, ro 4-1284, either when the depleter was given alone or was given after tyrosine hydroxylase blockade by alpha-methyltyrosine, provided that the l-dopa was given at a time when ro 4-1284 was present. |
1976-12-30 |
2023-08-11 |
Not clear |
| A Carlsson, W Kehr, M Lindqvis. The role of intraneuronal amine levels in the feedback control of dopamine, noradrenaline and 5-hydroxytryptamine synthesis in rat brain. Journal of neural transmission. vol 39. issue 1-2. 1976-12-30. PMID:1086343. |
the influence of varying levels of dopamine and noradrenaline on the synthesis of these amines could still be demonstrated after blockade of dopamine receptos and of alpha-adrenergic (noradrenaline) receptors by haloperidol, suggesting that the mechanism involved in this feedback control is mediated via end-product inhibition of tyrosine hydroxylase. |
1976-12-30 |
2023-08-11 |
rat |
| J F Tallman, J M Saavedra, J Axelro. Biosynthesis and metabolism of endogenous tyramine and its normal presence in sympathetic nerves. The Journal of pharmacology and experimental therapeutics. vol 199. issue 1. 1976-12-23. PMID:10424. |
the levels of tyramine in brain were increased to a similar extent by injecting animals with a monoamine oxidase inhibitor, pargyline, and a dopamine beta-hydroxylase inhibitor, fla-63; in contrast, pretreatment of animals with alpha-methyl-para-tyrosine, a tyrosine hydroxylase inhibitor, did not lead to an increase in tyramine levels in brain. |
1976-12-23 |
2023-08-11 |
rat |
| R B Rastogi, R L Singha. Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain. The Journal of pharmacology and experimental therapeutics. vol 198. issue 3. 1976-12-23. PMID:978462. |
exposure of developing rats to thyroid hormone significantly increased the endogenous concentration of striatal tyrosine and the activity of tyrosine hydroxylase as well as the levels of dopamine in several brain regions. |
1976-12-23 |
2023-08-11 |
rat |
| U Otten, H Thoene. Mechanisms of tyrosine hydroxylase and dopamine beta-hydroxylase induction in organ cultures of rat sympathetic ganglia by potassium depolarization and cholinomimetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 292. issue 2. 1976-09-25. PMID:7752. |
mechanisms of tyrosine hydroxylase and dopamine beta-hydroxylase induction in organ cultures of rat sympathetic ganglia by potassium depolarization and cholinomimetics. |
1976-09-25 |
2023-08-11 |
rat |
| U Otten, H Thoene. Mechanisms of tyrosine hydroxylase and dopamine beta-hydroxylase induction in organ cultures of rat sympathetic ganglia by potassium depolarization and cholinomimetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 292. issue 2. 1976-09-25. PMID:7752. |
it was the aim of the present study to elucidate the mechanisms involved in specific tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) induction by potassium depolarization and cholinomimetics in rat superior cervical ganglia kept in organ culture. |
1976-09-25 |
2023-08-11 |
rat |
| J Bartolomé, T A Slotki. Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. Psychopharmacology communications. vol 1. issue 5. 1976-09-01. PMID:7001. |
prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. |
1976-09-01 |
2023-08-11 |
rat |
| J Bartolomé, T A Slotki. Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. Psychopharmacology communications. vol 1. issue 5. 1976-09-01. PMID:7001. |
although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. |
1976-09-01 |
2023-08-11 |
rat |
| H C Stanton, R L Muelle. Sympathoadrenal Neurochemistry and early weaning of swine. American journal of veterinary research. vol 37. issue 7. 1976-09-01. PMID:7171. |
adrenal gland weights and tyrosine hydroxylase (ec 1.14.3a), dopamine beta-hydroxylase (ec 1.14.2.1), phenethanolamine-n-methyl transferase (ec 2.1.1), and monoamine oxidase (ec 1.4.3.4) activities were increased after weaning. |
1976-09-01 |
2023-08-11 |
Not clear |
| F J Kogan, W K Nichols, J W Gib. Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. European journal of pharmacology. vol 36. issue 2. 1976-08-23. PMID:6286. |
influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. |
1976-08-23 |
2023-08-11 |
rat |
| U Otten, H Thoene. Selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase in sympathetic ganglia in organ culture: role of glucocorticoids as modulators. Molecular pharmacology. vol 12. issue 3. 1976-08-23. PMID:6895. |
selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase in sympathetic ganglia in organ culture: role of glucocorticoids as modulators. |
1976-08-23 |
2023-08-11 |
Not clear |
| I B Black, C K Petit. Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension. Science (New York, N.Y.). vol 192. issue 4242. 1976-08-02. PMID:5774. |
discrete brain areas and sympathetic ganglia obtained at autopsy from patients with idiopathic orthostatic hypotension were assayed for tyrosine hydroxylase and dopamine beta-hydroxylase. |
1976-08-02 |
2023-08-11 |
Not clear |
| I B Black, C K Petit. Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension. Science (New York, N.Y.). vol 192. issue 4242. 1976-08-02. PMID:5774. |
dopamine beta-hydroxylase activity was decreased 7.5-fold in sympathetic ganglia, while tyrosine hydroxylase activity was reduced more than 50-fold in the pontine nucleus locus coeruleus. |
1976-08-02 |
2023-08-11 |
Not clear |
| J R Walters, R H Rot. Dopaminergic neurons - alteration in the sensitivity of tyrosine hydroxylase to inhibition by endovenous dopamine after cessation of impulse flow. Biochemical pharmacology. vol 25. issue 6. 1976-08-02. PMID:6034. |
dopaminergic neurons - alteration in the sensitivity of tyrosine hydroxylase to inhibition by endovenous dopamine after cessation of impulse flow. |
1976-08-02 |
2023-08-11 |
Not clear |
| J Bartolomé, F J Seidler, T R Anderson, T A Slotki. Effects of prenatal reserpine administration on development of the rat adrenal medulla and central nervous system. The Journal of pharmacology and experimental therapeutics. vol 197. issue 2. 1976-08-02. PMID:1271281. |
rats born to mothers who received reserpine on days 6, 5 and 4 or 4, 3 and 2 before delivery showed early postnatal adrenal catecholamine depletion, an effect which can be attributed to a direct action of the drug; however, at no time was induction of tyrosine hydroxylase or dopamine beta-hydroxylase observed. |
1976-08-02 |
2023-08-11 |
rat |
| J M Saavedra, J Zivi. Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in discrete areas of the rat limbic system. Brain research. vol 105. issue 3. 1976-07-06. PMID:4197. |
the ratio between tyrosine hydroxylase and dopamine-beta-hydroxylase activities showed a significant correlation when compared with the ratio of dopamine and norepinephrine concentrations for the areas studied. |
1976-07-06 |
2023-08-11 |
rat |
| R L Patrick, J D Barcha. Dopamine synthesis in rat brain striatal synaptosomes. I. Correlations between veratridine-induced synthesis stimulation and endogenous dopamine release. The Journal of pharmacology and experimental therapeutics. vol 197. issue 1. 1976-07-06. PMID:1263135. |
these results indicate that, in general, the degree of synthesis stimulation produced by depolarizing agents such as veratridine can be correlated with their stimulation of dopamine release, suggesting either 1)that transmitter release itself is a signal for synthesis stimulation, possibly by removal of feedback inhibition of tyrosine hydroxylase or 2) that depolarizing agents increase synthesis through a secondary metabolic change that is either caused by, or at least accompanied by, transmitter release. |
1976-07-06 |
2023-08-11 |
rat |