| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huanfeng Hao, Li Song, Luoying Zhan. Wolfram syndrome 1 regulates sleep in dopamine receptor neurons by modulating calcium homeostasis. PLoS genetics. vol 19. issue 7. 2023-07-03. PMID:37399203. |
consistently, the influence of wfs1 on sleep is blocked or partially rescued by inhibiting or knocking down the rate-limiting enzyme of dopamine synthesis, suggesting that wfs1 modulates sleep via dopaminergic signaling. |
2023-07-03 |
2023-08-14 |
drosophila_melanogaster |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease. European journal of pharmacology. 2023-06-29. PMID:37385578. |
in the current study, administration of 100 mg/kg lap in rotenone-treated rats for 21 days ameliorates motor impairment, debilitated histopathological alterations, and revived dopaminergic neurons by increasing tyrosine hydroxylase (th) expression in sn, along with increased dopamine level. |
2023-06-29 |
2023-08-14 |
rat |
| Julieta Griselda Mendoza-Torreblanca, Noemi Cárdenas-Rodríguez, Jazmín Carro-Rodríguez, Itzel Jatziri Contreras-García, David Garciadiego-Cázares, Daniel Ortega-Cuellar, Valentín Martínez-López, Alfonso Alfaro-Rodríguez, Alberto Nayib Evia-Ramírez, Iván Ignacio-Mejía, Marco Antonio Vargas-Hernández, Cindy Bandal. Antiangiogenic Effect of Dopamine and Dopaminergic Agonists as an Adjuvant Therapeutic Option in the Treatment of Cancer, Endometriosis, and Osteoarthritis. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373348. |
antiangiogenic effect of dopamine and dopaminergic agonists as an adjuvant therapeutic option in the treatment of cancer, endometriosis, and osteoarthritis. |
2023-06-28 |
2023-08-14 |
Not clear |
| Iveta Vojtechova, Klara Tuckova, Radomir Juza, Ales Stuchlik, Eduard Kelemen, Jan Korabecny, Ondrej Soukup, Tomas Petrase. Dopaminergic and glutamatergic models of psychosis show differential sensitivity to aripiprazole and a novel experimental compound modulating D Progress in neuro-psychopharmacology & biological psychiatry. 2023-06-28. PMID:37379895. |
dopaminergic and glutamatergic models of psychosis show differential sensitivity to aripiprazole and a novel experimental compound modulating d dopamine type 2 receptors (d |
2023-06-28 |
2023-08-14 |
Not clear |
| Raymond Brewer, Kenneth Blum, Abdalla Bowirrat, Edward J Modestino, David Baron, Rajendra D Badgaiyan, Mark Moran, Brent Boyett, Mark S Gol. Transmodulation of Dopaminergic Signaling to Mitigate Hypodopminergia and Pharmaceutical Opioid-Induced Hyperalgesia. Current psychopharmacology. vol 9. issue 3. 2023-06-27. PMID:37361136. |
neuroscientists and psychiatrists working in the areas of "pain and addiction" are asked in this perspective article to reconsider the current use of dopaminergic blockade (like chronic opioid agonist therapy), and instead to consider induction of dopamine homeostasis by putative pro-dopamine regulation. |
2023-06-27 |
2023-08-14 |
Not clear |
| Willian Goulart Salgueiro, Marcell Valandro Soares, Cassiano Fiad Martins, Fávero Reisdorfer Paula, Rafaela Maria Rios-Anjos, Thiago Carrazoni, Marcelo A Mori, Roman-Ulrich Müller, Michael Aschner, Cháriston André Dal Belo, Daiana Silva Ávil. Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model. Chemico-biological interactions. 2023-06-22. PMID:37348670. |
this led to suggestive evidence on how quercetin may act as a dopaminergic modulator by interacting with c. elegans' dopamine transporter and alter the nematode's exploratory behavior. |
2023-06-22 |
2023-08-14 |
caenorhabditis_elegans |
| Emile F van Vliet, Maarten J Knol, Raymond M Schiffelers, Massimiliano Caiazzo, Marcel H A M Fen. Levodopa-loaded nanoparticles for the treatment of Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society. 2023-06-21. PMID:37343725. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) resulting in dopamine (da) deficiency, which manifests itself in motor symptoms including tremors, rigidity and bradykinesia. |
2023-06-21 |
2023-08-14 |
Not clear |
| Ilene Trinh, Angeni Muralidhar, Justin Yang, Nicolás Phielip. Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease. Movement disorders clinical practice. vol 10. issue 6. 2023-06-19. PMID:37332639. |
dopamine transporter single-photon emission computed tomography (dat-spect) can be used to assess dopaminergic denervation by detecting loss of striatal dopamine transporters (dat). |
2023-06-19 |
2023-08-14 |
Not clear |
| Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel, Lee Wei Li. Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms. Cells. vol 12. issue 11. 2023-06-11. PMID:37296570. |
given that dopaminergic neurotransmission has been found to be disrupted in depression, we investigated the dopamine(da)-dependent mechanism of the antidepressant-like effects of hfs of the prelimbic cortex (hfs prl). |
2023-06-11 |
2023-08-14 |
rat |
| Tarique Bagalkot, Alexander Sorki. Endocytic down-regulation of the striatal dopamine transporter by amphetamine in sensitized mice in sex-dependent manner. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293021. |
acute amph is proposed to cause transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. |
2023-06-09 |
2023-08-14 |
mouse |
| Jihong Wang, Zheng Li, Ye Tu, Feng Ga. The Dopaminergic System In The Ventral Tegmental Area Contributes To Morphine Analgesia And Tolerance. Neuroscience. 2023-06-07. PMID:37286162. |
existing studies show that dopamine receptors and μ-opioid receptors participate in morphine tolerance through the altered activities of dopaminergic and/or non-dopaminergic neurons in the vta. |
2023-06-07 |
2023-08-14 |
Not clear |
| Chen-Meng Qiao, Wei Quan, Yu Zhou, Gu-Yu Niu, Hui Hong, Jian Wu, Li-Ping Zhao, Ting Li, Chun Cui, Wei-Jiang Zhao, Yan-Qin She. Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice. Molecular neurobiology. 2023-06-02. PMID:37266763. |
and strikingly, high serum tmao significantly promoted the metabolism of striatal dopamine (da) of pd model mice, although it had no significant effect on the number of dopaminergic neurons or the content of da. |
2023-06-02 |
2023-08-14 |
mouse |
| Chuanqi Chu, Tiantian Li, Leilei Yu, Yiwen Li, Miaoyu Li, Min Guo, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Che. A Low-Protein, High-Carbohydrate Diet Exerts a Neuroprotective Effect on Mice with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson's Disease by Regulating the Microbiota-Metabolite-Brain Axis and Fibroblast Growth Factor 21. Journal of agricultural and food chemistry. 2023-06-02. PMID:37267589. |
here, we found that an lphc diet ameliorated 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (mptp)-induced motor deficits, decreased dopaminergic neuronal death, and increased the levels of striatal dopamine, serotonin, and their metabolites in pd mice. |
2023-06-02 |
2023-08-14 |
mouse |
| Anthony L Gaeta, Karolina Willicott, Corey W Willicott, Luke E McKay, Candice M Keogh, Tyler J Altman, Logan C Kimble, Abigail L Yarbrough, Kim A Caldwell, Guy A Caldwel. Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a iScience. vol 26. issue 6. 2023-06-01. PMID:37260751. |
mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a failure of inherently protective cellular processes and misfolded protein-associated stress contribute to the progressive loss of dopamine (da) neurons characteristic of parkinson's disease (pd). |
2023-06-01 |
2023-08-14 |
Not clear |
| Mydirah Littlepage-Saunders, Michael J Hochstein, Doris S Chang, Kari A Johnso. G protein-coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects. British journal of pharmacology. 2023-05-31. PMID:37258878. |
g protein-coupled receptors (gpcrs) that bind a variety of neuromodulators including dopamine, endocannabinoids, acetylcholine, and endogenous opioid peptides regulate dopamine release by acting on several components of dopaminergic circuitry. |
2023-05-31 |
2023-08-14 |
Not clear |
| Carmen Costas-Ferreira, Rafael Durán, Lilian Ferreira Far. Neurotoxic effects of exposure to glyphosate in rat striatum: Effects and mechanisms of action on dopaminergic neurotransmission. Pesticide biochemistry and physiology. vol 193. 2023-05-29. PMID:37248010. |
so, two possible hypotheses could explain this additive effect: both glyphosate and nomifensine act through different mechanisms at the dopaminergic terminals to increase dopamine levels; or both nomifensine and glyphosate act on dat, with glyphosate simultaneously inhibiting reuptake and stimulating dopamine release by reversing the dat function. |
2023-05-29 |
2023-08-14 |
rat |
| Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wan. Spatial Distribution of Neurons Expressing Single, Double, and Triple Molecular Characteristics of Glutamatergic, Dopaminergic, or GABAergic Neurons in the Mouse Ventral Tegmental Area. Journal of molecular neuroscience : MN. 2023-05-27. PMID:37243808. |
the vta contains three main neuronal populations, namely, dopamine (da), γ-aminobutyric acid (gaba), and glutamate neurons, but some neurons exhibit combinatorial molecular characteristics of dopaminergic, gabaergic, or glutamatergic neurons. |
2023-05-27 |
2023-08-14 |
mouse |
| Makito Hirano, Makoto Samukawa, Chiharu Isono, Yoshitaka Naga. The effects of safinamide on dysphagia in Parkinson's disease. PloS one. vol 18. issue 5. 2023-05-25. PMID:37228084. |
the transdermal dopamine agonist rotigotine alleviates dysphagia in patients with pd and is more effective than oral levodopa, suggesting the importance of continuous dopaminergic stimulation (cds) in swallowing. |
2023-05-25 |
2023-08-14 |
Not clear |
| Le-le Liu, Yu Han, Zi-Jia Zhang, Yi-Qi Wang, Yu-Wei Hu, Elena Kaznacheyeva, Jian-Qing Ding, Dong-Kai Guo, Guang-Hui Wang, Bin Li, Hai-Gang Re. Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation. Acta pharmacologica Sinica. 2023-05-24. PMID:37225849. |
parkinson's disease (pd) is a common neurodegenerative motor disorder characterized by a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal dopamine (da) levels. |
2023-05-24 |
2023-08-14 |
mouse |
| Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
mechanistically, bh4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ros, maintains neuronal excitability and promotes mitochondrial atp production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical pd animal models, human dopaminergic midbrain-like organoids and primary cells from pd-affected individuals. |
2023-05-23 |
2023-08-14 |
mouse |