| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Merlin Monzel, Jana Karneboge, Martin Reute. The role of dopamine in visual imagery-An experimental pharmacological study. Journal of neuroscience research. 2023-10-18. PMID:37849328. |
additional exploratory analyses will use genetic data to investigate possible effects of variations on dopaminergic gene loci (e.g., dat1) on dopamine levels and strength of mental imagery. |
2023-10-18 |
2023-11-08 |
human |
| Iman Touati, Mohnad Abdalla, Yassir Boulaamane, Nawal Al-Hoshani, Abdulaziz Alouffi, Mohammed Reda Britel, Amal Maurad. Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors. Journal of biomolecular structure & dynamics. 2023-10-18. PMID:37850444. |
pd is the second most ubiquitous neurological disorder after alzheimer's disease, characterized by the depletion of dopamine in the central nervous system due to the impairment of dopaminergic neurons, leading to involuntary movements or dyskinesia. |
2023-10-18 |
2023-11-08 |
Not clear |
| Sairam Ramesh, Arosh S Perera Molligoda Arachchig. Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the literature. AIMS neuroscience. vol 10. issue 3. 2023-10-16. PMID:37841347. |
in individuals with parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. |
2023-10-16 |
2023-11-08 |
Not clear |
| Sheila A Villa-Cedillo, Daniel Matta-Yee-Chig, Adolfo Soto-Domínguez, Humberto Rodríguez-Rocha, Aracely García-García, Carlos R Montes-de-Oca-Saucedo, María de Jesús Loera-Arias, Jesús Valdés, Odila Saucedo-Cárdena. CDNF overexpression prevents motor-cognitive dysfunction by intrastriatal CPP-based delivery system in a Parkinson's disease animal model. Neuropeptides. vol 102. 2023-10-14. PMID:37837805. |
neurotrophic factors, such as cerebral dopamine neurotrophic factor (cdnf), have shown a neuroprotective effect on dopaminergic neurons. |
2023-10-14 |
2023-11-08 |
mouse |
| Mohana Devi Subramaniam, P Aishwarya Janaki, B Abishek Kumar, Janani Gopalarethinam, Aswathy P Nair, I Mahalaxmi, Balachandar Vellingir. Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis. Cellular and molecular neurobiology. 2023-10-13. PMID:37831228. |
parkinson's disease (pd) is caused due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) which leads to the depletion of dopamine in the body. |
2023-10-13 |
2023-10-15 |
Not clear |
| Hao Liu, Haibin Dong, Chunxiao Wang, Wenjuan Jia, Guangqiang Wang, Hua Wang, Lin Zhong, Lei Gon. Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells. DNA and cell biology. 2023-10-10. PMID:37815547. |
cerebral dopamine neurotrophic factor (cdnf) is a unique neurotrophic factor (ntf) that has shown significant neuroprotective and neurorestorative functions on midbrain dopaminergic neurons. |
2023-10-10 |
2023-10-15 |
human |
| Xuanxiang Jin, Xiaoli Si, Xiaoguang Lei, Huifang Liu, Anwen Shao, Lingfei L. Disruption of Dopamine Homeostasis Associated with Alteration of Proteins in Synaptic Vesicles: A Putative Central Mechanism of Parkinson's Disease Pathogenesis. Aging and disease. 2023-10-10. PMID:37815908. |
vestigial dopaminergic cells in pd have selectivity for a sub-class of hypersensitive neurons with the nigrostriatal dopamine (da) tract. |
2023-10-10 |
2023-10-15 |
Not clear |
| Xiu-Ying He, Ru-Rong Wang, Ting-Hua Wan. The role of immune cells in the course of Parkinson's disease. Ibrain. vol 7. issue 2. 2023-10-03. PMID:37786903. |
the pathological manifestations mainly consist of α-synuclein accumulation, degeneration and death of dopaminergic neurons, and insufficient dopamine secretion. |
2023-10-03 |
2023-10-07 |
Not clear |
| G Cappelletti, E V Carsana, G Lunghi, S Breviario, C Vanetti, A B Di Fonzo, E Frattini, M Magni, S Zecchini, M Clerici, M Aureli, C Fenizi. SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons. Experimental and molecular pathology. 2023-09-29. PMID:37775022. |
sars-cov-2 hampers dopamine production in ipsc-derived dopaminergic neurons. |
2023-09-29 |
2023-10-07 |
human |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
the increase in presynaptic striatal dopamine is the main dopaminergic abnormality in schizophrenia (scz). |
2023-09-28 |
2023-10-07 |
mouse |
| Paola Briñez-Gallego, Dennis Guilherme da Costa Silva, Ana Paula Horn, Mariana Appel Hor. Effects of curcumin to counteract levodopa-induced toxicity in zebrafish. Journal of toxicology and environmental health. Part A. 2023-09-28. PMID:37767720. |
currently, treatment of pd has focused on increasing dopamine levels, using a dopamine precursor, levodopa (l-dopa) or stimulation of dopaminergic receptors. |
2023-09-28 |
2023-10-07 |
zebrafish |
| Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, Jörg B Schulz, Judith Stegmülle. Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects. Journal of neurochemistry. 2023-09-27. PMID:37753846. |
nex-cre;fbxo7fl/fl mice revealed an increase in striatal dopamine concentrations, changes in the glutamatergic, gabaergic and dopaminergic pathways, astrogliosis and microgliosis and little or no neuronal loss in the striatum. |
2023-09-27 |
2023-10-07 |
mouse |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| Jingjing Song, Yang Zhao, Xiaoqian Shan, Yongyin Luo, Nan Hao, Lan Zha. Active ingredients of Chinese medicine with immunomodulatory properties: NF-κB pathway and Parkinson's disease. Brain research. 2023-09-25. PMID:37748570. |
it has been found that an increasing number of active ingredients in chinese medicines, such as flavonoids, alkaloids, saponins, terpenoids, phenols and phenylpropanoids, have anti-inflammatory properties that can regulate neuroglia cell activation and ameliorate neuroinflammation through the nf-κb pathway, and increase dopamine release or protect dopaminergic neurons for neuroprotection to improve behavioural dysfunction in pd. |
2023-09-25 |
2023-10-07 |
Not clear |
| Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Amir Shojaei, Yaghoub Fathollahi, Nahid Roohi, Vicrotia Barkley, Javad Mirnajafi-Zade. Age-dependent effects of dopamine on working memory and synaptic plasticity in hippocampal CA3-CA1 synapses in mice. Neuroscience. 2023-09-23. PMID:37741356. |
regarding the role of the dopaminergic system's changes in old age, we examined the effect of age and applied dopamine on working memory, synaptic transmission, and long-term potentiation (ltp) induction and maintenance in young adult and mature adult mice. |
2023-09-23 |
2023-10-07 |
mouse |
| Xin Gong, Mengyi Huang, Lei Che. NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m CNS neuroscience & therapeutics. 2023-09-22. PMID:37735974. |
nrf1 mitigates motor dysfunction and dopamine neuron degeneration in mice with parkinson's disease by promoting glrx m the feature of parkinson's disease (pd) is the heavy dopaminergic neuron loss of substantia nigra pars compacta (snpc), while glutaredoxin (glrx) has been discovered to modulate the death of dopaminergic neurons. |
2023-09-22 |
2023-10-07 |
mouse |
| Victor Pando-Naude, Tomas Edward Matthews, Andreas Højlund, Sebastian Jakobsen, Karen Østergaard, Erik Johnsen, Eduardo A Garza-Villarreal, Maria A G Witek, Virginia Penhune, Peter Vuus. Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms. The European journal of neuroscience. 2023-09-19. PMID:37724707. |
dopamine in motor and limbic networks is implicated in beat-based timing and music-induced pleasure, suggesting a central role of basal ganglia (bg) dopaminergic systems in plumm. |
2023-09-19 |
2023-10-07 |
human |
| Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim, Eng King Ta. Role of dopamine in the pathophysiology of Parkinson's disease. Translational neurodegeneration. vol 12. issue 1. 2023-09-17. PMID:37718439. |
a pathological feature of parkinson's disease (pd) is the progressive loss of dopaminergic neurons and decreased dopamine (da) content in the substantia nigra pars compacta in pd brains. |
2023-09-17 |
2023-10-07 |
Not clear |
| Toshiro Niwa, Yuka Yamamot. Stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome P450 2D6. Drug metabolism and bioanalysis letters. 2023-09-15. PMID:37711131. |
stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome p450 2d6. |
2023-09-15 |
2023-10-07 |
Not clear |
| Bruno Vincent, Mayuri Shukl. The common denominators of Parkinson's disease pathogenesis and methamphetamine abuse. Current neuropharmacology. 2023-09-11. PMID:37691228. |
methamphetamine-induced neurodegeneration involves altered dopamine homeostasis that promotes the aggregation of α-synuclein protofibrils in the dopaminergic neurons and drives these neurons to make them more vulnerable to degeneration as recognized in parkinson's disease. |
2023-09-11 |
2023-10-07 |
Not clear |