| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Narmadhaa Sivagurunathan, Mohamudha Parveen Rahamathulla, Hussein Al-Dossary, Latchoumycandane Calivaratha. Emerging Role of Long Noncoding RNAs in Regulating Inflammasome-Mediated Neurodegeneration in Parkinson's Disease. Molecular neurobiology. 2023-12-17. PMID:38105409. |
the underlying pathophysiology involves the progressive loss of dopaminergic neurons within the substantia nigra pars compacta, leading to dopamine depletion in the basal ganglia circuitry. |
2023-12-17 |
2023-12-21 |
Not clear |
| Moriah E Weese-Myers, Ashley E Ros. Subsecond Codetection of Dopamine and Estradiol at a Modified Sharkfin Waveform. Analytical chemistry. 2023-12-16. PMID:38103188. |
in particular, it is a well-known dopamine (da) regulator and is responsible for modulating the expression of dopaminergic receptors and transporters. |
2023-12-16 |
2023-12-19 |
Not clear |
| Rana Alnasser Alsukhni, Ekawat Vichayanrat, Shiwen Koay, Laura May Davis, Gordon Ingle, Patricia McNamara, Jalesh N Panicker, Kailash P Bhatia, Christopher Mathias, Jamshed Bomanji, Valeria Iodic. Abnormal dopamine transporter imaging in pure autonomic failure: a potential biomarker of central nervous system involvement. European journal of neurology. 2023-12-12. PMID:38085264. |
a possibility is to evaluate the nigrostriatal dopaminergic degeneration by imaging of dopamine transporter with datscan brain imaging. |
2023-12-12 |
2023-12-17 |
Not clear |
| Osama A Mohammed, Mohammed S Elballal, Ahmed A El-Husseiny, Emad Gamil Khidr, Manar Mohammed El Tabaa, Ola Elazazy, Mai A Abd-Elmawla, Ahmed E Elesawy, Henwa M Ibrahim, Ahmed I Abulsoud, Walaa A El-Dakroury, Sherif S Abdel Mageed, Mahmoud A Elrebehy, Yousra Nomier, Mustafa Ahmed Abdel-Reheim, Hussein M El-Husseiny, Abdulla M A Mahmoud, Sameh Saber, Ahmed S Doghis. Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease. Pathology, research and practice. vol 253. 2023-12-11. PMID:38081104. |
the occurrence of striatal dopamine insufficiency can be attributed to a notable decline in dopaminergic neurons inside the substantia nigra pars compacta. |
2023-12-11 |
2023-12-17 |
Not clear |
| Osama A Mohammed, Mohammed S Elballal, Ahmed A El-Husseiny, Emad Gamil Khidr, Manar Mohammed El Tabaa, Ola Elazazy, Mai A Abd-Elmawla, Ahmed E Elesawy, Henwa M Ibrahim, Ahmed I Abulsoud, Walaa A El-Dakroury, Sherif S Abdel Mageed, Mahmoud A Elrebehy, Yousra Nomier, Mustafa Ahmed Abdel-Reheim, Hussein M El-Husseiny, Abdulla M A Mahmoud, Sameh Saber, Ahmed S Doghis. Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease. Pathology, research and practice. vol 253. 2023-12-11. PMID:38081104. |
while current therapy approaches for pd aim to preserve dopaminergic neurons or replenish dopamine levels in the brain, it is important to acknowledge that achieving complete remission of the condition remains elusive. |
2023-12-11 |
2023-12-17 |
Not clear |
| Laura Kubens, Ann-Kathrin Weishaupt, Vivien Michaelis, Isabelle Rohn, Fabian Mohr, Julia Bornhors. Exposure to the environmentally relevant fungicide Maneb: Studying toxicity in the soil nematode Caenorhabditis elegans. Environment international. vol 183. 2023-12-10. PMID:38071851. |
nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (gaba) was observed as well as morphological changes in the dopaminergic neurons upon maneb exposure, which underlines the assumption of the neurotoxic potential of maneb. |
2023-12-10 |
2023-12-17 |
caenorhabditis_elegans |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
ventral midbrain (vm) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of parkinson's disease (pd). |
2023-12-10 |
2023-12-17 |
human |
| Adolfo López-Ornelas, Itzel Escobedo-Avila, Gabriel Ramírez-García, Rolando Lara-Rodarte, César Meléndez-Ramírez, Beetsi Urrieta-Chávez, Tonatiuh Barrios-García, Verónica A Cáceres-Chávez, Xóchitl Flores-Ponce, Francia Carmona, Carlos Alberto Reynoso, Carlos Aguilar, Nora E Kerik, Luisa Rocha, Leticia Verdugo-Díaz, Víctor Treviño, José Bargas, Verónica Ramos-Mejía, Juan Fernández-Ruiz, Aurelio Campos-Romo, Iván Velasc. Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys. Cells. vol 12. issue 23. 2023-12-09. PMID:38067166. |
dans from hescs expressed dopaminergic markers, generated action potentials, and released dopamine (da) in vitro. |
2023-12-09 |
2023-12-17 |
human |
| Ichiro Kawahata, Kohji Fukunag. Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease-Potential Biomarkers and Therapeutic Targets. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069360. |
in particular, fabp3, abundant in nigrostriatal dopaminergic neurons, is responsible for α-synuclein propagation into neurons and intracellular accumulation, affecting the loss of mesencephalic tyrosine hydroxylase protein, a rate-limiting enzyme of dopamine biosynthesis. |
2023-12-09 |
2023-12-17 |
Not clear |
| Andrew S Clark, Javier Huayta, Katherine S Morton, Joel N Meyer, Adriana San-Migue. Morphological Hallmarks of Dopaminergic Neurodegeneration are Associated With Altered Neuron Function in Caenorhabditis elegans. Neurotoxicology. 2023-12-09. PMID:38070655. |
we adapted an established dopaminergic neuronal function assay by measuring paralysis in the presence of exogenous dopamine, which revealed clear differences between cat-2 dopamine deficient mutants, wildtype worms, and dat-1 dopamine abundant mutants. |
2023-12-09 |
2023-12-17 |
caenorhabditis_elegans |
| Andrew S Clark, Javier Huayta, Katherine S Morton, Joel N Meyer, Adriana San-Migue. Morphological Hallmarks of Dopaminergic Neurodegeneration are Associated With Altered Neuron Function in Caenorhabditis elegans. Neurotoxicology. 2023-12-09. PMID:38070655. |
we show that nematodes with dopaminergic dendrite degeneration markers, such as blebbing or breakage, paralyze at higher rates in a dopamine solution, providing evidence that dopaminergic neurodegeneration morphologies are correlated with functional neuronal outputs. |
2023-12-09 |
2023-12-17 |
caenorhabditis_elegans |
| Antía González-Vila, María Luengo-Mateos, María Silveira-Loureiro, Pablo Garrido-Gil, Nataliia Ohinska, Marco González-Domínguez, Jose Luis Labandeira-García, Cristina García-Cáceres, Miguel López, Olga Barca-May. Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner. Nature communications. vol 14. issue 1. 2023-12-09. PMID:38071352. |
remarkably, the mutants exhibit altered dopamine metabolism, and the pharmacological modulation of dopaminergic signaling partially restores distinct circadian traits in both male and female mutant mice. |
2023-12-09 |
2023-12-17 |
mouse |
| Nidhi Sachan, Saripella Srikrishna, Devendra Kumar Patel, Mahendra Pratap Sing. Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations. Molecular neurobiology. 2023-12-08. PMID:38064103. |
deferoxamine attenuated cypermethrin-induced iron accumulation and number of iron-positive cells and ameliorated the demise of dopaminergic cells and dopamine content. |
2023-12-08 |
2023-12-17 |
Not clear |
| Pinar Eser, Ersoy Kocabicak, Ahmet Bekar, Yasin Teme. The interplay between neuroinflammatory pathways and Parkinson's disease. Experimental neurology. vol 372. 2023-12-08. PMID:38061555. |
parkinson's disease, a progressive neurodegenerative disorder predominantly affecting elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway, culminating in neuronal loss within the substantia nigra pars compacta (snpc) and dopamine depletion. |
2023-12-08 |
2023-12-17 |
Not clear |
| Vesna Sočan, Klemen Dolinar, Mojca Krža. Transporters involved in adult rat cortical astrocyte dopamine uptake: Kinetics, expression and pharmacological modulation. The European journal of neuroscience. 2023-12-06. PMID:38054361. |
in addition, we were interested in the expression of mrna of dopamine transporters as well as dopamine receptors d1 and d2 and in the effect of dopaminergic drugs on the expression of these transporters and receptors. |
2023-12-06 |
2023-12-10 |
rat |
| Jong Mi Park, Masoud Rahmati, Sang Chul Lee, Jae Il Shin, Yong Wook Ki. Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis. Neural regeneration research. vol 19. issue 7. 2023-12-05. PMID:38051903. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, and although restoring striatal dopamine levels may improve symptoms, no treatment can cure or reverse the disease itself. |
2023-12-05 |
2023-12-10 |
Not clear |
| Reka Csehi, Viktor Molnar, Mariann Fedor, Vivien Zsumbera, Agnes Palasti, Karoly Acsai, Zoltan Grosz, Gyorgy Nemeth, Maria Judit Molna. The improvement of motor symptoms in Huntington's disease during cariprazine treatment. Orphanet journal of rare diseases. vol 18. issue 1. 2023-12-02. PMID:38041194. |
their emergence is related to alterations in striatal dopaminergic neurotransmission: dopamine levels increase in the early stages of the disease, while more advanced stages are characterised by reduced dopamine levels. |
2023-12-02 |
2023-12-10 |
Not clear |
| Rong-Xin Song, Hui-Tao Miao, Shi-Yan Jia, Wen-Guang Li, Ji-Zhen Liu, Wei Zhang, Bao-Rui Xing, Jian-Yong Zhao, Li-Min Zhang, Xiao-Ming L. Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction. Molecular neurobiology. 2023-12-02. PMID:38041715. |
the hsr caused excessive dopaminergic signaling and cognitive dysfunction in the mpfc, a condition that might be ameliorated using a dopamine d1 receptor inhibitor. |
2023-12-02 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
in conclusion, this study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects. |
2023-12-01 |
2023-12-10 |
mouse |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
extensive research has been conducted on dopaminergic neurons, receptors, and dopamine levels as critical factors in cognition and memory in ad. |
2023-12-01 |
2023-12-10 |
Not clear |