| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
extensive research has been conducted on dopaminergic neurons, receptors, and dopamine levels as critical factors in cognition and memory in ad. |
2023-12-01 |
2023-12-10 |
Not clear |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
recently, a previously overlooked element of the dopaminergic system, the dopamine transporter, has shown significant promise as a more effective target for enhancing cognition while addressing dopaminergic system dysfunction in ad. |
2023-12-01 |
2023-12-10 |
Not clear |
| Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, Akihiro Mouri, Norio Ozaki, Toshitaka Nabeshima, Kuniaki Sait. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2023-12-01. PMID:38037233. |
both chemogenetic activation of dopaminergic neurons and treatment with methylphenidate, a dopamine reuptake inhibitor, ameliorated the asd-like behavior of ido2 ko mice. |
2023-12-01 |
2023-12-10 |
mouse |
| Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John T Williams, Malcolm G Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia J Weber, Lei Wang, Bozhi Li, Yu Wei, Guochuan Li, Huan Wang, Yu Zheng, Yulin Zhao, Marina E Wolf, Yingjie Zhu, Mitsuko Watabe-Uchida, Yulong L. Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. Nature methods. 2023-11-30. PMID:38036855. |
dopamine (da) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections. |
2023-11-30 |
2023-12-10 |
Not clear |
| Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenk. Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001881. |
the observed region-specific changes in the tissue levels of serotonin and in the expression of dopamine and serotonergic metabolism enzymes in rats with an excess of dopamine can indicate important consequences for the pharmacotherapy of drugs that modulate the dopaminergic system. |
2023-11-25 |
2023-11-28 |
rat |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
however, it is not clear whether mobilization of 2-ag specifically from midbrain dopamine neurons is necessary for dopaminergic responses to external stimuli predicting forthcoming reward. |
2023-11-24 |
2023-11-28 |
mouse |
| Laura Dazzi, Fabrizio Sanna, Giuseppe Talani, Valentina Bassareo, Francesca Biggio, Paolo Follesa, Maria Giuseppina Pisu, Patrizia Porcu, Roberta Puliga, Marina Quartu, Mariangela Serra, Maria Pina Serra, Enrico Sann, Elio Acqua. Binge-like administration of alcohol mixed to energy drinks to male adolescent rats severely impacts on mesocortical dopaminergic function in adulthood: A behavioral, neurochemical and electrophysiological study. Neuropharmacology. 2023-11-12. PMID:37952712. |
we did so by measuring: i) physiological sensorimotor gating; ii) voluntary alcohol consumption and dopamine transmission before, during, and after presentation of alcohol; iii) electrophysiological activity of vta dopaminergic neurons and their sensitivity to a challenge with alcohol. |
2023-11-12 |
2023-11-20 |
rat |
| Kyoungjune Pak, Lauri Nummenma. Brain dopamine receptor system is not altered in obesity: Bayesian and frequentist meta-analyses. Human brain mapping. 2023-11-11. PMID:37950852. |
feeding induces dopamine release in the striatum, and a dysfunction of the dopaminergic reward system can lead to overeating, and obesity. |
2023-11-11 |
2023-11-20 |
human |
| Patricia Alejandra Brand-Rubalcava, Aldo Rafael Tejeda-Martínez, Orfil González-Reynoso, Angelica Yanet Nápoles-Medina, Verónica Chaparro-Huerta, Mario Eduardo Flores-Sot. β-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome. Parkinsonism & related disorders. vol 117. 2023-11-04. PMID:37924806. |
parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta (snpc), resulting in diminished dopamine levels in the striatum (str) and chronic neuroinflammation. |
2023-11-04 |
2023-11-08 |
Not clear |
| Rafael Rivas-Santisteban, Alberto Rico, Ana Muñoz, Ana I Rodriguez, Irene Reyes-Resina, Gemma Navarro, José Luis Labandeira-García, José Luis Lanciego, Rafael Franc. Boolean analysis shows a high proportion of dopamine D Neurobiology of disease. 2023-11-02. PMID:37918757. |
boolean analysis shows a high proportion of dopamine d the antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine d |
2023-11-02 |
2023-11-08 |
Not clear |
| Antonino Natalello, Stefania Brocca, Erika Ponzini, Carlo Santambrogio, Rita Grandor. Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919088. |
dopaminergic neurons are constantly threatened by the thin boundaries between functional α-synuclein (as) structural disorder and pathogenic aggregation, and between dopamine (da) neurotransmitter activity and accumulation of cytotoxic by-products. |
2023-11-02 |
2023-11-08 |
Not clear |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
we found that cell type-specific deletion of plcγ1 does not adversely affect the development and cellular morphology of midbrain dopamine neurons but does facilitate dopamine release from dopaminergic axon terminals in the striatum. |
2023-11-01 |
2023-11-08 |
mouse |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
the enhancement of dopamine release was accompanied by increased colocalization of vesicular monoamine transporter 2 (vmat2) at dopaminergic axon terminals. |
2023-11-01 |
2023-11-08 |
mouse |
| Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteba. The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891948. |
the production of ras peptides and the expression of several ras enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| David A Vogelsang, Daniella J Furman, Derek E Nee, Ioannis Pappas, Robert L White, Andrew S Kayser, Mark D'Esposit. Dopamine Modulates Effective Connectivity in Frontal Cortex. Journal of cognitive neuroscience. 2023-10-30. PMID:37902578. |
using a randomized, double-blind, within-subject design, we analyzed resting-state fmri data of 66 healthy young participants who were scanned once each after administration of bromocriptine (a dopamine agonist with preferential affinity for d2 receptor), tolcapone (an inhibitor of catechol-o-methyltransferase), and placebo, to determine whether dopaminergic stimulation modulated effective functional connectivity between hierarchically organized frontal regions in the left hemisphere. |
2023-10-30 |
2023-11-08 |
human |
| Priya Rathor, Ratnasekhar C. Metabolic Basis of Circadian Dysfunction in Parkinson's Disease. Biology. vol 12. issue 10. 2023-10-27. PMID:37887004. |
impaired α-synuclein secretion and dopamine release may cause mitochondrial dysfunction and perturb energy metabolism, subsequently altering the activity and survival of dopaminergic neurons, thus perpetuating the neurodegenerative process in pd. |
2023-10-27 |
2023-11-08 |
human |
| M López-Aguirre, M Matarazzo, J Blesa, M H G Monje, R Rodríguez-Rojas, A Sánchez-Ferro, J A Obeso, J A Pineda-Pard. Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson's disease patients. NPJ Parkinson's disease. vol 9. issue 1. 2023-10-20. PMID:37852988. |
loss of dopaminergic neurons in the substantia nigra pars compacta (snc) and a profound reduction of striatal dopamine are two hallmarks of parkinson's disease (pd). |
2023-10-20 |
2023-11-08 |
human |
| Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin S. COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain. Journal of the American Chemical Society. 2023-10-20. PMID:37859408. |
parkinson's disease (pd) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (da) in the striatum; thus, da can act as a marker for pd diagnosis and therapeutic evaluation. |
2023-10-20 |
2023-11-08 |
mouse |
| Jeonghyun Park, Eunsoo Moon, Hyun Ju Lim, Kyungwon Kim, Yoo Rha Hong, Jung Hyun Le. Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 21. issue 4. 2023-10-20. PMID:37859441. |
: as dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. |
2023-10-20 |
2023-11-08 |
mouse |
| Elena Contaldi, Silvia Gallo, Lucia Corrado, Sandra D'Alfonso, Luca Magistrell. Parkinsonism in SCA19/22: Dopamine Transporter Imaging in an Italian Family Harboring a Novel Mutation. Cerebellum (London, England). 2023-10-19. PMID:37857779. |
patients underwent dopamine transporter single-photon emission computed tomography to assess dopaminergic degeneration. |
2023-10-19 |
2023-11-08 |
Not clear |