| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiro Niwa, Yuka Yamamot. Stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome P450 2D6. Drug metabolism and bioanalysis letters. 2023-09-15. PMID:37711131. |
stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome p450 2d6. |
2023-09-15 |
2023-10-07 |
Not clear |
| Bruno Vincent, Mayuri Shukl. The common denominators of Parkinson's disease pathogenesis and methamphetamine abuse. Current neuropharmacology. 2023-09-11. PMID:37691228. |
methamphetamine-induced neurodegeneration involves altered dopamine homeostasis that promotes the aggregation of α-synuclein protofibrils in the dopaminergic neurons and drives these neurons to make them more vulnerable to degeneration as recognized in parkinson's disease. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
one of the hallmarks of parkinson's disease (pd) is the progressive loss of dopaminergic neurons and associated dopamine depletion. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
several mechanisms, previously considered in isolation, have been proposed to contribute to the pathophysiology of dopaminergic degeneration: dopamine oxidation-mediated neurotoxicity, high dopamine transporter (dat) expression density per neuron, and autophagy-lysosome pathway (alp) dysfunction. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
in pd, alp dysfunction could increase dat density per neuron, and enhance dopamine reuptake, oxidation, and neurotoxicity, potentially contributing to the progressive loss of dopaminergic neurons. |
2023-09-11 |
2023-10-07 |
Not clear |
| Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvell. Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37685899. |
the dopamine transporter (dat) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic space into the dopaminergic neurons. |
2023-09-09 |
2023-10-07 |
Not clear |
| Liaqat Hussain, Ina Masood, Matloob Ahmad, Muhammad Yasir Ali, Uzma Saleem, Musaddique Hussain, Syed Haroon Khalid, Zunera Chauhdar. Pharmacological and toxicological evaluation of methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxoide against haloperidol induced Parkinson like symptoms in animal model: In-vitro and in-vivo studies. Toxicology and applied pharmacology. 2023-09-08. PMID:37683697. |
in parkinson's disease (pd), degradation of dopaminergic neurons in substantia nigra causes striatal deficiency of dopamine, which results in tremors, bradykinesia with instability in posture, rigidity and shuffled gait. |
2023-09-08 |
2023-10-07 |
mouse |
| Jan Booij, Sem P Tellier, John Seibyl, Chris Vrien. Dopamine Transporter Availability in Early Parkinson's Disease is Dependent on Sunlight Exposure. Movement disorders : official journal of the Movement Disorder Society. 2023-09-06. PMID:37670567. |
preliminary studies suggested seasonality of dopaminergic functioning, but it is unknown whether dopamine transporter (dat) expression in humans is also dependent on the seasons. |
2023-09-06 |
2023-10-07 |
Not clear |
| Natalia F Sardi, Ana C Pescador, Evellyn M Azevedo, José A Pochapski, Caroline Kukolj, Katherinne M Spercoski, Anderson J M Andrade, Claudio da Cunha, Luana Fische. Sleep and pain: a role for the anterior cingulate cortex, nucleus accumbens and dopamine in the increased pain sensitivity following sleep restriction. The journal of pain. 2023-09-06. PMID:37673193. |
data on indirect dopaminergic parameters, dat glycosylation and darpp-32 phosphorylation, as well as dopamine, serotonin and norepinephrine levels, suggest that dopaminergic function decreases in the nucleus accumbens and anterior cingulate cortex after sleep restriction. |
2023-09-06 |
2023-10-07 |
rat |
| Luiz Henrique Dias de Oliveira, Jorddy Neves Cruz, Cleydson Breno Rodrigues Dos Santos, Eduardo Borges de Mel. Multivariate QSAR, similarity search and ADMET studies based in a set of methylamine derivatives described as dopamine transporter inhibitors. Molecular diversity. 2023-09-05. PMID:37670118. |
the dopamine transporter (dat), responsible for the regulation of dopaminergic neurotransmission, is implicated in the etiology of several neuropsychiatric disorders which, in turn, have contributed to high rates of disability and numerous deaths in recent years, significantly impacting the global health system. |
2023-09-05 |
2023-10-07 |
Not clear |
| Ping Dai, Jin Sun, Zhongkai Yu, Tongyue Zhang, Zixin Wen, Tianzi Jian, Lanlan Guo, Aerbusili Genjiafu, Baotian Kan, Binbin Zhang, Xiangdong Jia. Case report: Reversible splenial lesion syndrome caused by diquat poisoning. Frontiers in neurology. vol 14. 2023-09-04. PMID:37662033. |
at the same time, dq can also affect the activity of dopaminergic nerve cells through oxidative stress, causing degeneration and reducing dopamine uptake. |
2023-09-04 |
2023-09-07 |
Not clear |
| Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Jinxia Wan, Ruyi Cai, John T Williams, Tongrui Qian, Malcolm G Campbell, Xiaolei Miao, Bozhi Li, Yu Wei, Guochuan Li, Huan Wang, Yu Zheng, Mitsuko Watabe-Uchida, Yulong L. Improved dual-color GRAB sensors for monitoring dopaminergic activity bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662187. |
improved dual-color grab sensors for monitoring dopaminergic activity dopamine (da) plays multiple roles in a wide range of physiological and pathological processes via a vast network of dopaminergic projections. |
2023-09-04 |
2023-09-07 |
Not clear |
| Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Che. Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway. Neurobiology of stress. vol 26. 2023-09-04. PMID:37664874. |
concurrent with behavioral amelioration, the csds dbs-on group exhibited enhanced fc in the dopaminergic pathway with increased expression of bdnf- and neun-positive cells increased dopamine d1 receptor, dopamine d2 receptors, and th in the medial prefrontal cortex, nac, ventral hippocampus, ventral tegmental area, and amygdala. |
2023-09-04 |
2023-09-07 |
mouse |
| Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peter. Dopamine regulates decision thresholds in human reinforcement learning in males. Nature communications. vol 14. issue 1. 2023-09-04. PMID:37666865. |
here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection via a combined pharmacological neuroimaging approach in male human volunteers (n = 31, within-subjects; placebo, 150 mg of the dopamine precursor l-dopa, 2 mg of the d2 receptor antagonist haloperidol). |
2023-09-04 |
2023-09-07 |
human |
| Jarkko Johansson, Nina Karalija, Alireza Salam. Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum. Aging brain. vol 4. 2023-08-30. PMID:37645244. |
extant research suggest aging-related losses of different dopaminergic markers, including presynaptic dopamine transporters as well as post-synaptic da receptors. |
2023-08-30 |
2023-09-07 |
human |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Hidekazu Sotoyam. Putative neural mechanisms underlying release-mode-specific abnormalities in dopamine neural activity in a schizophrenia-like model: The distinct roles of glutamate and serotonin in the impaired regulation of dopamine neurons. The European journal of neuroscience. 2023-08-23. PMID:37611917. |
dopaminergic neuronal activity in the resting state related to tonic release was increased by disinhibition of the dopamine neurons due to the impairment of 5ht2 (5ht2a) receptor-regulated gabaergic inputs. |
2023-08-23 |
2023-09-07 |
Not clear |
| Amin Hassanshahi, Mahyar Janahmadi, Moazamehosadat Razavinasab, Hoda Ranjbar, Narges Hosseinmardi, Gila Behzadi, Kristi A Kohlmeier, Mehran Ilaghi, Mohammad Shaban. Preventive putative effect of agmatine on cognitive and molecular outcomes in ventral tegmental area of male offspring following physical and psychological prenatal stress. Developmental psychobiology. vol 65. issue 6. 2023-08-22. PMID:37607891. |
ps is known to result in heightened dopamine release in the ventral tegmental area (vta), in part through the effects of corticotropin-releasing hormone, which directly excites dopaminergic cells. |
2023-08-22 |
2023-09-07 |
mouse |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
motor deficits observed in parkinson's disease (pd) are caused by the loss of dopaminergic neurons and the subsequent dopamine depletion in different brain areas. |
2023-08-20 |
2023-09-07 |
mouse |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
the most common therapy to treat motor symptoms for patients with this disorder is the systemic intake of l-dopa that increases dopamine levels in all the brain, making it difficult to discern the main locus of dopaminergic action in the alleviation of motor control. |
2023-08-20 |
2023-09-07 |
mouse |