| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keisuke Migita, Masahiko Tomiyama, Junko Yamada, Masashi Fukuzawa, Takashi Kanematsu, Masato Hirata, Shinya Uen. Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice. Molecular pain. vol 7. 2012-05-11. PMID:22008183. |
phospholipase c-related inactive protein (prip) plays important roles in trafficking to the plasma membrane of gaba(a) receptor, which is involved in the dominant inhibitory neurotransmission in the spinal cord and plays an important role in nociceptive transmission. |
2012-05-11 |
2023-08-12 |
mouse |
| Keisuke Migita, Masahiko Tomiyama, Junko Yamada, Masashi Fukuzawa, Takashi Kanematsu, Masato Hirata, Shinya Uen. Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice. Molecular pain. vol 7. 2012-05-11. PMID:22008183. |
in situ hybridization studies of gaba(a) receptors revealed significantly decreased expression of γ2 subunit mrna in the dorsal and ventral horns of the spinal cord in prip-1 (-/-) mice, but no difference in α1 subunit mrna expression. |
2012-05-11 |
2023-08-12 |
mouse |
| Keisuke Migita, Masahiko Tomiyama, Junko Yamada, Masashi Fukuzawa, Takashi Kanematsu, Masato Hirata, Shinya Uen. Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice. Molecular pain. vol 7. 2012-05-11. PMID:22008183. |
these results suggest that prip-1 (-/-) mice exhibit the changes of the function and subunits expression of gaba(a) receptor in the spinal cord, which may be responsible for abnormal pain sensation in these mice. |
2012-05-11 |
2023-08-12 |
mouse |
| Makiko Hardy Yamada, Koichi Nishikawa, Kazuhiro Kubo, Yuchio Yanagawa, Shigeru Sait. Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT). Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22275517. |
however, high-performance liquid chromatography revealed that glutamate, gaba, and glycine contents in the whole brain and spinal cord were normal in vgat(+/-) mice. |
2012-05-07 |
2023-08-12 |
mouse |
| Cecilia Reali, Anabel Fernández, Milka Radmilovich, Omar Trujillo-Cenóz, Raúl E Russ. GABAergic signalling in a neurogenic niche of the turtle spinal cord. The Journal of physiology. vol 589. issue Pt 23. 2012-04-18. PMID:21911613. |
in the brain, gaba plays a major role in this kind of regulation but little is known about gabaergic signalling in neurogenic niches of the postnatal spinal cord. |
2012-04-18 |
2023-08-12 |
Not clear |
| Cecilia Reali, Anabel Fernández, Milka Radmilovich, Omar Trujillo-Cenóz, Raúl E Russ. GABAergic signalling in a neurogenic niche of the turtle spinal cord. The Journal of physiology. vol 589. issue Pt 23. 2012-04-18. PMID:21911613. |
here we explored the action of gaba around the cc of the turtle spinal cord by combining patch-clamp recordings of cc-contacting cells, immunohistochemistry for key components of gabaergic signalling and ca(2+) imaging. |
2012-04-18 |
2023-08-12 |
Not clear |
| Gordon Munro, Helle K Erichsen, Mark G Rae, Naheed R Mirz. A question of balance--positive versus negative allosteric modulation of GABA(A) receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21439986. |
after injury gaba(a) receptor positive allosteric modulators (pams) mediate robust analgesia in animals via putative restoration of post-synaptic gaba(a)-α2 and -α3 receptor function within the spinal cord. |
2012-04-17 |
2023-08-12 |
rat |
| Koichi Nishikawa, Kazuhiro Kubo, Hideaki Obata, Yuchio Yanagawa, Shigeru Sait. The influence of manipulations to alter ambient GABA concentrations on the hypnotic and immobilizing actions produced by sevoflurane, propofol, and midazolam. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21497611. |
hplc revealed that gaba levels in gad65-/- mice were reduced in the brain (76.7% of wt) and spinal cord (68.5% of wt). |
2012-04-17 |
2023-08-12 |
mouse |
| Il Ok Lee, Jin Kook Son, Eui-Sung Lim, Yeon-Soo Ki. Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice. Journal of Korean medical science. vol 26. issue 10. 2012-02-15. PMID:22022192. |
glycine and γ-aminobutyric acid (gaba) are localized and released by the same interneurons in the spinal cord. |
2012-02-15 |
2023-08-12 |
mouse |
| K Yang, H M. Blockade of GABA(B) receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse. Neuroscience. vol 193. 2012-01-18. PMID:21807068. |
in this study, whole-cell recording techniques were employed to study the effect of endogenous gaba on gaba(b) receptors in substantia gelatinosa (sg) neurons in adult rat spinal cord slices. |
2012-01-18 |
2023-08-12 |
rat |
| Luis Quintero, Ricardo Cardenas, Heberto Suarez-Roc. Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. Pain. vol 152. issue 8. 2011-11-23. PMID:21636214. |
stress-induced hyperalgesia is associated with a reduced and delayed gaba inhibitory control that enhances post-synaptic nmda receptor activation in the spinal cord. |
2011-11-23 |
2023-08-12 |
rat |
| Luis Quintero, Ricardo Cardenas, Heberto Suarez-Roc. Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. Pain. vol 152. issue 8. 2011-11-23. PMID:21636214. |
pain behavior, spinal nociceptive neuronal activation and gaba and glutamate release were respectively evaluated by the formalin test, the expression of c-fos and in vivo microdialysis of superficial laminae of the lumbar spinal cord, 48 hours after the last conditioning session. |
2011-11-23 |
2023-08-12 |
rat |
| Jing Huang, Jing Chen, Wen Wang, Ya Yun Wang, Wei Wang, Yan Yan Wei, Ri Yi Shi, Takeshi Kaneko, Yun Qing Li, Sheng Xi W. Expression pattern of enkephalinergic neurons in the developing spinal cord revealed by preproenkephalin-green fluorescent protein transgenic mouse and its colocalization with GABA immunoreactivity. Cells, tissues, organs. vol 193. issue 6. 2011-11-15. PMID:21124002. |
expression pattern of enkephalinergic neurons in the developing spinal cord revealed by preproenkephalin-green fluorescent protein transgenic mouse and its colocalization with gaba immunoreactivity. |
2011-11-15 |
2023-08-12 |
mouse |
| Alberto Castro, Justo Aguilar, Ricardo González-Ramírez, Emanuel Loeza-Alcocer, Martha Canto-Bustos, Ricardo Felix, Rodolfo Delgado-Lezam. Tonic inhibition in spinal ventral horn interneurons mediated by α5 subunit-containing GABA(A) receptors. Biochemical and biophysical research communications. vol 412. issue 1. 2011-10-14. PMID:21798246. |
in the present report, using slices of the adult turtle spinal cord as a model system we have recorded a tonic inhibitory current in ventral horn interneurons (vhis) and determined the functional contribution of the α(5) subunit-containing gaba(a) receptors to this current. |
2011-10-14 |
2023-08-12 |
Not clear |
| Young S Gwak, Claire E Hulsebosc. GABA and central neuropathic pain following spinal cord injury. Neuropharmacology. vol 60. issue 5. 2011-10-03. PMID:21216257. |
gaba and central neuropathic pain following spinal cord injury. |
2011-10-03 |
2023-08-12 |
Not clear |
| Young S Gwak, Claire E Hulsebosc. GABA and central neuropathic pain following spinal cord injury. Neuropharmacology. vol 60. issue 5. 2011-10-03. PMID:21216257. |
however, hyperexcitable neurons and glial activation after spinal cord injury disrupts the balance of chloride ions, glutamate and gaba distribution in the spinal dorsal horn and results in chronic neuropathic pain. |
2011-10-03 |
2023-08-12 |
Not clear |
| June Yowtak, Kwan Yeop Lee, Hee Young Kim, Jigong Wang, Hee Kee Kim, Kyungsoon Chung, Jin Mo Chun. Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. Pain. vol 152. issue 4. 2011-07-26. PMID:21296500. |
our results indicate that the increased ros in spinal cord may induce pain by reducing gaba inhibitory influence on sg neurons that are involved in pain transmission. |
2011-07-26 |
2023-08-12 |
mouse |
| Emilie Muller, Hervé Le-Corronc, Pascal Legendr. Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor? Frontiers in molecular neuroscience. vol 1. 2011-07-14. PMID:18946536. |
glycine and gaba mediate inhibitory neurotransmission in the spinal cord and central nervous system. |
2011-07-14 |
2023-08-12 |
Not clear |
| Eui Sung Lim, Il Ok Le. Effect of intrathecal glycine and related amino acids on the allodynia and hyperalgesic action of strychnine or bicuculline in mice. Korean journal of anesthesiology. vol 58. issue 1. 2011-07-14. PMID:20498816. |
the intrathecal (it) administration of glycine or gaba(a) receptor antagonist result in a touch evoked allodynia through disinhibition in the spinal cord. |
2011-07-14 |
2023-08-12 |
mouse |
| Lihua Wang, Gareth Bruce, Emma Spary, Jim Deuchars, Susan A Deuchar. GABA(B) Mediated Regulation of Sympathetic Preganglionic Neurons: Pre- and Postsynaptic Sites of Action. Frontiers in neurology. vol 1. 2011-07-14. PMID:21206526. |
at the level of the spinal cord, the sympathetic preganglionic neurons (spns) can be modulated by activation of presynaptic gaba(b) heteroreceptors on glutamatergic terminals and by postsynaptic gaba(b) receptors. |
2011-07-14 |
2023-08-12 |
Not clear |