| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eva de Lago, Miguel Moreno-Martet, Ana Cabranes, José A Ramos, Javier Fernández-Rui. Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB1 receptor-mediated anti-inflammatory effects. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22342378. |
levels of glutamate and gaba in the spinal cord and also in the brainstem of eae mice were similar to control animals, and, accordingly, they were not altered by the treatment with win55,212-2. |
2012-12-20 |
2023-08-12 |
mouse |
| A Mickle, P Kannampalli, M Bruckert, A Miranda, B Banerjee, J N Sengupt. Pronociceptive effect of 5-HT(1A) receptor agonist on visceral pain involves spinal N-methyl-D-aspartate (NMDA) receptor. Neuroscience. vol 219. 2012-11-20. PMID:22626644. |
these results indicate that the 5-ht(1a) receptor agonist dpat produces pronociceptive effects, primarily via the activation of presynaptic 5-ht(1a) receptors in gabaergic neuron to restrict gaba release and thereby disinhibits the excitatory glutamatergic neurons in the spinal cord. |
2012-11-20 |
2023-08-12 |
rat |
| Kwan Yeop Lee, Michael S Gol. Inflammatory mediators potentiate high affinity GABA(A) currents in rat dorsal root ganglion neurons. Neuroscience letters. vol 518. issue 2. 2012-10-04. PMID:22580064. |
because inflammatory mediators (im), such as prostaglandin e(2) are also released in the spinal cord following tissue injury, as well as evidence that e(cl) is already depolarized in primary afferents, an alternative hypothesis is that an im-induced increase in gaba(a) receptor mediated current (i(gaba)) could underlie the injury-induced increase in drr. |
2012-10-04 |
2023-08-12 |
rat |
| N Lagos, F Valdés, F Orreg. A search for endogenous modulators of the GABA receptor in different regions of the rat CNS. Neurochemistry international. vol 5. issue 3. 2012-10-02. PMID:20487956. |
the possible existence of endogenous substances other than ?-aminobutyric acid (gaba), that can also bind to rat brain gaba receptors, has been investigated in synaptic membranes derived from whole rat brain, or from cerebral cortex; as well as in isolated synaptic vesicles obtained from cerebral cortex, striatum, hypothalamus, cerebellum and spinal cord and in the superfusion fluid of electrically stimulated brain cortex slices, where a gaba-like substance is released by a calcium-dependent process. |
2012-10-02 |
2023-08-12 |
rat |
| G S Bhumbra, N J Moore, M Moroni, M Beat. Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice. Frontiers in cellular neuroscience. vol 6. 2012-10-02. PMID:22461768. |
the fast inhibitory neurotransmitters glycine and gaba are co-localized in synaptic terminals of inhibitory interneurons in the spinal cord and co-released onto lumbar motoneurons in neonatal rats. |
2012-10-02 |
2023-08-12 |
mouse |
| Mehdi Hossaini, Jacqueline A C Goos, Somesh K Kohli, Jan C Holsteg. Distribution of glycine/GABA neurons in the ventromedial medulla with descending spinal projections and evidence for an ascending glycine/GABA projection. PloS one. vol 7. issue 4. 2012-09-10. PMID:22558137. |
in this study, we have identified the distribution of glycine and gaba containing neurons in the vm with projections to the cervical spinal cord, the lumbar dorsal horn, and the lumbar ventral horn. |
2012-09-10 |
2023-08-12 |
Not clear |
| Mehdi Hossaini, Jacqueline A C Goos, Somesh K Kohli, Jan C Holsteg. Distribution of glycine/GABA neurons in the ventromedial medulla with descending spinal projections and evidence for an ascending glycine/GABA projection. PloS one. vol 7. issue 4. 2012-09-10. PMID:22558137. |
the present study has now firmly established that gaba and glycine are present in many vm neurons that project to the spinal cord. |
2012-09-10 |
2023-08-12 |
Not clear |
| Yong-Hui Gao, Shu-Ping Chen, Jun-Ying Wang, Li-Na Qiao, Yan-Jing Han, Dan Lin, Chang-Fu Ji, Qiu-Ling Xu, Jun-Ling Li. [Effects of electroacupuncture of "Futu" (LI 18), etc. on pain behavior and expression of GABA receptor subunit genes in cervical spinal cord in rats with thyroid regional pain]. Zhen ci yan jiu = Acupuncture research. vol 37. issue 2. 2012-08-28. PMID:22764592. |
on pain behavior and expression of gaba receptor subunit genes in cervical spinal cord in rats with thyroid regional pain]. |
2012-08-28 |
2023-08-12 |
rat |
| Yong-Hui Gao, Shu-Ping Chen, Jun-Ying Wang, Li-Na Qiao, Yan-Jing Han, Dan Lin, Chang-Fu Ji, Qiu-Ling Xu, Jun-Ling Li. [Effects of electroacupuncture of "Futu" (LI 18), etc. on pain behavior and expression of GABA receptor subunit genes in cervical spinal cord in rats with thyroid regional pain]. Zhen ci yan jiu = Acupuncture research. vol 37. issue 2. 2012-08-28. PMID:22764592. |
to observe the effect of electroacupuncture (ea) at different acupoints on the expression of gamma aminobutyric (gaba) receptor (r) subunit genes in the cervical spinal cord in rats with thyroid regional inflammatory pain so as to analyze its analgesic mechanism for thyroid surgery. |
2012-08-28 |
2023-08-12 |
rat |
| Sarah Nickolls, Hannah Mace, Rebecca Fish, Michelle Edye, Rachel Gurrell, Magnus Ivarsson, Tom Pitcher, Sachi Tanimoto-Mori, Denise Richardson, Catherine Sweatman, Janet Nicholson, Cameron Ward, John Jinks, Christine Bell, Kimberly Young, Huw Rees, Andrew Moss, Ross Kinloch, Gordon McMurra. A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain. Advances in pharmacological sciences. vol 2011. 2012-08-23. PMID:22162674. |
gaba(a) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. |
2012-08-23 |
2023-08-12 |
Not clear |
| Mary J Eaton, Yerko Berrocal, Stacey Q Wolf. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines. Pain research and treatment. vol 2012. 2012-08-23. PMID:22619713. |
cell lines derived from the human neuronal nt2 cell line parentage, the hnt2.17 and hnt2.19 lines, which synthesize and release the neurotransmitters gamma-aminobutyric acid (gaba) and serotonin (5ht), respectively, have been used to evaluate the potential of cell-based release of antinociceptive agents near the lumbar dorsal (horn) spinal sensory cell centers to relieve neuropathic pain after pns (partial nerve and diabetes-related injury) and cns (spinal cord injury) damage in rat models. |
2012-08-23 |
2023-08-12 |
human |
| Alexis Laux, François Delalande, Jinane Mouheiche, Denise Stuber, Alain Van Dorsselaer, Enrica Bianchi, Erwan Bezard, Pierrick Poisbeau, Yannick Goumo. Localization of endogenous morphine-like compounds in the mouse spinal cord. The Journal of comparative neurology. vol 520. issue 7. 2012-08-17. PMID:22102217. |
by using different microscopy approaches, we found the presence of morphine, codeine, or morphine glucuronides in γ-aminobutyric acid (gaba)-ergic neurons and astrocytes of the spinal cord. |
2012-08-17 |
2023-08-12 |
mouse |
| N I Kalinina, G G Kurchavyĭ, N P Veselki. [Inhibitory regulation of glutamate receptors in the frog motoneuron]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 5. 2012-08-14. PMID:22838192. |
the interaction of exogenously applied excitatory (glutamate and their agonists nmda, ampa, kainate) and inhibitory (glycine and gaba) amino acid effects was studied intracellularly in the motoneurones of the isolated frog spinal cord. |
2012-08-14 |
2023-08-12 |
Not clear |
| Ellen D Stück, Randolph N Christensen, J Russell Huie, C Amy Tovar, Brandon A Miller, Yvette S Nout, Jacqueline C Bresnahan, Michael S Beattie, Adam R Ferguso. Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo. Neural plasticity. vol 2012. 2012-08-02. PMID:22530155. |
tumor necrosis factor alpha mediates gaba(a) receptor trafficking to the plasma membrane of spinal cord neurons in vivo. |
2012-08-02 |
2023-08-12 |
human |
| Masaru Yoshizumi, Renee A Parker, James C Eisenach, Ken-ichiro Hayashid. Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology. vol 116. issue 6. 2012-07-18. PMID:22487864. |
based on previous electrophysiologic studies, the authors tested whether gabapentin reduced γ-amino butyric acid (gaba) release in the locus coeruleus (lc), a major site of descending inhibition, rather than in the spinal cord. |
2012-07-18 |
2023-08-12 |
rat |
| S M Valle-Maroto, B Fernández-López, V Villar-Cerviño, A Barreiro-Iglesias, R Anadón, M Celina Rodici. Inhibitory descending rhombencephalic projections in larval sea lamprey. Neuroscience. vol 194. 2012-06-25. PMID:21856380. |
neurobiotin was applied in the rostral spinal cord at the level of the third gill, and inhibitory populations were identified by the use of cocktails of antibodies raised against glycine and gaba. |
2012-06-25 |
2023-08-12 |
Not clear |
| S P Janssen, S Gerard, M E Raijmakers, M Truin, M Van Kleef, E A Jooste. Decreased intracellular GABA levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of KCC2 and GABA(A) receptor-mediated inhibition. Neurochemistry international. vol 60. issue 1. 2012-06-20. PMID:22107704. |
decreased intracellular gaba levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of kcc2 and gaba(a) receptor-mediated inhibition. |
2012-06-20 |
2023-08-12 |
rat |
| S P Janssen, S Gerard, M E Raijmakers, M Truin, M Van Kleef, E A Jooste. Decreased intracellular GABA levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of KCC2 and GABA(A) receptor-mediated inhibition. Neurochemistry international. vol 60. issue 1. 2012-06-20. PMID:22107704. |
elevated spinal extracellular γ-aminobutyric acid (gaba) levels have been described during spinal cord stimulation (scs)-induced analgesia in experimental chronic peripheral neuropathy. |
2012-06-20 |
2023-08-12 |
rat |
| Robert I Westphalen, No-Bong Kwak, Keir Daniels, Hugh C Hemming. Regional differences in the effects of isoflurane on neurotransmitter release. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21651920. |
isoflurane completely inhibited total 4ap-evoked glutamate release (ic(50) = 0.42 ± 0.03 mm) more potently than gaba release (ic(50) = 0.56 ± 0.02 mm) from cerebral cortex (1.3-fold greater potency), hippocampus and striatum, but inhibited glutamate and gaba release from spinal cord terminals equipotently. |
2012-05-25 |
2023-08-12 |
rat |
| Robert I Westphalen, No-Bong Kwak, Keir Daniels, Hugh C Hemming. Regional differences in the effects of isoflurane on neurotransmitter release. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21651920. |
the magnitude of inhibition of na(+) channel-mediated 4ap-evoked release by a single clinical concentration of isoflurane (0.35 mm) varied by region and transmitter: inhibition of glutamate release from spinal cord was greater than from the three brain regions and greater than gaba release for each cns region. |
2012-05-25 |
2023-08-12 |
rat |