| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amulya Nidhi Shrivastava, Antoine Triller, Werner Sieghart, Isabella Sarto-Jackso. Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21343285. |
γ-aminobutyric acid type a receptors (gaba(a)rs) in the spinal cord are evolving as an important target for drug development against pain. |
2011-06-28 |
2023-08-12 |
human |
| Amulya Nidhi Shrivastava, Antoine Triller, Werner Sieghart, Isabella Sarto-Jackso. Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21343285. |
purinergic p2x(2) receptors (p2x(2)rs) are also expressed in spinal cord neurons and are known to cross-talk with gaba(a)rs. |
2011-06-28 |
2023-08-12 |
human |
| Amulya Nidhi Shrivastava, Antoine Triller, Werner Sieghart, Isabella Sarto-Jackso. Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21343285. |
here, we investigated a possible "dynamic" interaction between gaba(a)rs and p2x(2)rs using co-immunoprecipitation and fluorescence resonance energy transfer (fret) studies in human embryonic kidney (hek) 293 cells along with co-localization and single particle tracking studies in spinal cord neurons. |
2011-06-28 |
2023-08-12 |
human |
| Antoine G Godin, Santiago Costantino, Louis-Etienne Lorenzo, Jody L Swift, Mikhail Sergeev, Alfredo Ribeiro-da-Silva, Yves De Koninck, Paul W Wisema. Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 17. 2011-06-24. PMID:21482753. |
analysis of computer-based simulations and immunocytochemically stained gaba(b) receptors in spinal cord samples shows that the approach yields accurate measurements over a broader range of densities than established procedures. |
2011-06-24 |
2023-08-12 |
Not clear |
| Jean-Charles Viemari, Rémi Bos, Pascale Boulenguez, Cécile Brocard, Frédéric Brocard, Hélène Bras, Patrice Coulon, Sylvie Liabeuf, Edouard Pearlstein, Karina Sadlaoud, Aurélie Stil, Sabrina Tazerart, Laurent Vina. Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks. Progress in brain research. vol 188. 2011-06-23. PMID:21333799. |
a high [cl(-)](i) leads to a depolarizing (excitatory) action of gaba and glycine, as observed in mature dorsal root ganglion neurons and in motoneurons both early during development and in several pathological conditions, such as following spinal cord injury. |
2011-06-23 |
2023-08-12 |
Not clear |
| Dusan Usvald, Peter Vodicka, Jana Hlucilova, Radek Prochazka, Jan Motlik, Karolina Kuchorova, Karl Johe, Silvia Marsala, Miriam Scadeng, Osamu Kakinohana, Roman Navarro, Marian Santa, Michael P Hefferan, Tony L Yaksh, Martin Marsal. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell transplantation. vol 19. issue 9. 2011-05-20. PMID:20412634. |
lumbar transverse spinal cord sections were then cut and stained with a combination of human-specific (hnuma, hmoc, hnse, hsyn) or nonspecific (dcx, map2, gaba, chat) antibodies. |
2011-05-20 |
2023-08-12 |
human |
| Hyun Joo Lee, Jung Hoon Choi, Ji Hyeon Ahn, Choong Hyun Lee, Ki-Yeon Yoo, In Koo Hwang, Jin Sang Kim, Choonghyo Kim, Yun Lyul Lee, Hyung-Cheul Shin, Moo-Ho Wo. Comparison of GAD65 and 67 immunoreactivity in the lumbar spinal cord between young adult and aged dogs. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21193958. |
we investigated distribution and age-related changes in two isoforms of gaba synthesizing enzymes, glutamic acid decarboxylase (gad) 65 and 67, in the lumbar levels (l(5)-l(6)) of the dog spinal cord. |
2011-05-19 |
2023-08-12 |
dog |
| C Morgado, P Pereira-Terra, C D Cruz, I Tavare. Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord. Diabetes, obesity & metabolism. vol 13. issue 2. 2011-05-16. PMID:21199267. |
neuronal hyperactivity at the spinal cord during mechanical hyperalgesia induced by diabetes may result from a decrease in the local expression of the potassium chloride co-transporter 2 (kcc2), which shifts the action of the neurotransmitter γ-amminobutiric acid (gaba) from inhibitory to excitatory. |
2011-05-16 |
2023-08-12 |
rat |
| Graham A R Johnston, Mary Chebib, Jane R Hanrahan, Kenneth N Mewet. Neurochemicals for the investigation of GABA(C) receptors. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:20963487. |
there is evidence for functional gaba(c) receptors in many tissues such as retina, hippocampus, spinal cord, superior colliculus, pituitary and the gut. |
2011-04-28 |
2023-08-12 |
Not clear |
| Guohua Zhang, Wenling Chen, Juan Carlos G Marvizó. Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptors. The European journal of neuroscience. vol 32. issue 6. 2011-03-14. PMID:20726886. |
src family kinases mediate the inhibition of substance p release in the rat spinal cord by μ-opioid receptors and gaba(b) receptors, but not α2 adrenergic receptors. |
2011-03-14 |
2023-08-12 |
rat |
| S C Lagraize, W Guo, K Yang, F Wei, K Ren, R Dubne. Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888891. |
following a low dose of sp infused into the rvm, intrathecal muscimol (gaba(a) agonist) increased sp-induced thermal hyperalgesia, phosphorylated nkcc1 protein expression, and nmda nr1 subunit phosphorylation in the spinal cord. |
2011-03-10 |
2023-08-12 |
Not clear |
| Norma A Velázquez-Ulloa, Nicholas C Spitzer, Davide Dulci. Contexts for dopamine specification by calcium spike activity in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209192. |
focusing on the ventral suprachiasmatic nucleus and the spinal cord to gain insight into these differences, we identify distinct subpopulations of neurons that express characteristic combinations of gaba and neuropeptide y as cotransmitters and lim1,2 and nurr1 transcription factors. |
2011-02-04 |
2023-08-12 |
xenopus_laevis |
| Norma A Velázquez-Ulloa, Nicholas C Spitzer, Davide Dulci. Contexts for dopamine specification by calcium spike activity in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209192. |
the results are consistent with the hypothesis that spontaneously active neurons expressing gaba are most susceptible to activity-dependent expression of dopamine in both the spinal cord and brain. |
2011-02-04 |
2023-08-12 |
xenopus_laevis |
| Sae Uchida, Fusako Kagitani, Harumi Hott. Neural mechanisms of reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthetized rats. Autonomic neuroscience : basic & clinical. vol 157. issue 1-2. 2011-02-02. PMID:20460195. |
high spinal cord transection or infusion of the gaba(a) receptors antagonist, bicuculline, into the cisterna magna is effective in disrupting the reflex bradycardia. |
2011-02-02 |
2023-08-12 |
rat |
| D V Amakhin, N P Veselki. Characteristics and interaction of GABAergic and glycinergic processes in frog spinal cord neurons. Neuroscience and behavioral physiology. vol 40. issue 5. 2011-01-28. PMID:20464506. |
whole-cell patch clamp recordings from isolated spinal cord neurons from the frog rana temporaria were made to study the interaction of processes induced by application of gaba and glycine. |
2011-01-28 |
2023-08-12 |
Not clear |
| A Tobias Latal, Thomas Kremer, Jesús Gomeza, Volker Eulenburg, Swen Hülsman. Development of synaptic inhibition in glycine transporter 2 deficient mice. Molecular and cellular neurosciences. vol 44. issue 4. 2010-11-10. PMID:20447457. |
no increase of gaba immunoreactivity was observed in the spinal cord and brainstem of glyt2(-/-) mice at any stage of postnatal development. |
2010-11-10 |
2023-08-12 |
mouse |
| Naheed R Mirza, Gordon Munr. The role of GABA(A) receptor subtypes as analgesic targets. Drug news & perspectives. vol 23. issue 6. 2010-11-09. PMID:20697602. |
specifically, based on research in animal models of inflammatory/neuropathic pain, we suggest that subtype-selective positive modulators of gaba(a) alpha(2/3) receptors might reverse a loss of postsynaptic gaba(a) receptor-mediated inhibitory function in spinal cord, leading to analgesia. |
2010-11-09 |
2023-08-12 |
mouse |
| Wendy Bautista, Justo Aguilar, José Emanuel Loeza-Alcocer, Rodolfo Delgado-Lezam. Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord. The Journal of physiology. vol 588. issue Pt 14. 2010-11-02. PMID:20519320. |
there is growing evidence that activation of high affinity extrasynaptic gaba(a) receptors in the brain, cerebellum and spinal cord substantia gelatinosa results in a tonic inhibition controlling postsynaptic excitability. |
2010-11-02 |
2023-08-12 |
Not clear |
| Wendy Bautista, Justo Aguilar, José Emanuel Loeza-Alcocer, Rodolfo Delgado-Lezam. Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord. The Journal of physiology. vol 588. issue Pt 14. 2010-11-02. PMID:20519320. |
the aim of the present study was to determine if gaba(a) receptors mediating tonic inhibition participate in the modulation of monosynaptic reflex (msr) in the vertebrate spinal cord. |
2010-11-02 |
2023-08-12 |
Not clear |
| Wendy Bautista, Justo Aguilar, José Emanuel Loeza-Alcocer, Rodolfo Delgado-Lezam. Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord. The Journal of physiology. vol 588. issue Pt 14. 2010-11-02. PMID:20519320. |
this long duration inhibition is similar to the one seen in mammalian spinal cord and it is dependent on gaba(a) as it was completely blocked by 20 microm picrotoxin (ptx) or bicuculline (bic) or 1 microm gabazine, simultaneously depressing the dorsal root potential (drp) without msr facilitation. |
2010-11-02 |
2023-08-12 |
Not clear |