| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uri Nimrod Ramírez-Jarquín, Ricardo Tapi. Excitatory and Inhibitory Neuronal Circuits in the Spinal Cord and Their Role in the Control of Motor Neuron Function and Degeneration. ACS chemical neuroscience. vol 9. issue 2. 2018-08-17. PMID:29350907. |
a pharmacological experimental approach by administering in the spinal cord agonists and antagonists of glutamate, gaba, glycine, and acetylcholine receptors to alter their synaptic action has also produced important results, linking the deficits in the synaptic function with the resulting motor alterations. |
2018-08-17 |
2023-08-13 |
mouse |
| Yoshihisa Nakahata, Kei Eto, Hideji Murakoshi, Miho Watanabe, Toshihiko Kuriu, Hiromi Hirata, Andrew J Moorhouse, Hitoshi Ishibashi, Junichi Nabekur. Activation-Dependent Rapid Postsynaptic Clustering of Glycine Receptors in Mature Spinal Cord Neurons. eNeuro. vol 4. issue 1. 2018-07-31. PMID:28197549. |
in the spinal cord and brainstem, presynaptically released inhibitory neurotransmitter dominantly switches from gaba to glycine during normal development |
2018-07-31 |
2023-08-13 |
Not clear |
| Yu-Mao Jiang, Dan-Dan Sun, Zhi-Guo Wang, Tao Li, Xiao-Liang Zhao, Yue Jiao, Yang Liu, Yu-Juan Li, Jing-Feng Ouyang, Dan-Qiao Wan. [Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959846. |
the levels of glutamate (glu), gamma aminobutyric acid (gaba), glycine (gly), and taurine (tau) in the l3-l5 spinal cord were measured by the high performance liquid chromatography-fluorescence detector (hplc-fld); aimplex detection technology with multiple factors was used to detect the levels of regulated on activation in normal t-cell expressed and secreted (rantes), monocyte chemoattractant protein (mcp-3) in the l3-l5 spinal cord. |
2018-06-21 |
2023-08-13 |
mouse |
| Yu-Mao Jiang, Dan-Dan Sun, Zhi-Guo Wang, Tao Li, Xiao-Liang Zhao, Yue Jiao, Yang Liu, Yu-Juan Li, Jing-Feng Ouyang, Dan-Qiao Wan. [Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959846. |
then we observed the influence of gabaa receptor antagonist (bicuculline) on analgesic effect of cq prescription.the results indicated that cq prescription could remarkably increase mwt of model mice(p<0.01, p<0.05), decrease the level of glu(p<0.01, p<0.05), improve the levels of gaba, gly, tau(p<0.01, p<0.05), lower the ratio of glu/gaba(p<0.01, p<0.05), and reduce the levels of rantes, mcp-3(p<0.05) in the l3-l5 spinal cord, and gabaa receptor antagonist significantly blocked the analgesic effect of cq prescription at two time points(p<0.05).this study showed that cq prescription had significant analgesic effect on ciimip model mice, and its mechanism was associated with regulating the balance between excitability amino acid(eaa) and inhibitory amino acid (iaa) transmitters in central nervous system, partially activating gabaa receptor, and reducing the release of rantes and mcp-3 in the spinal cord. |
2018-06-21 |
2023-08-13 |
mouse |
| A Iura, A Takahashi, S Hakata, T Mashimo, Y Fujin. Reductions in tonic GABAergic current in substantia gelatinosa neurons and GABA European journal of pain (London, England). vol 20. issue 10. 2018-01-24. PMID:27221080. |
reductions in tonic gabaergic current in substantia gelatinosa neurons and gaba decreased gamma-aminobutyric acid (gaba)-ergic phasic inhibitory transmission in the spinal cord is thought to be responsible for the development of neuropathic pain. |
2018-01-24 |
2023-08-13 |
mouse |
| Karin R Aubre. Presynaptic control of inhibitory neurotransmitter content in VIAAT containing synaptic vesicles. Neurochemistry international. vol 98. 2018-01-08. PMID:27296116. |
the higher brain uses only gaba, but in the spinal cord and brain stem both gaba and glycine act as inhibitory signals. |
2018-01-08 |
2023-08-13 |
Not clear |
| Max Larsso. Pax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn. Neuroscience letters. vol 638. 2017-11-17. PMID:27939388. |
pax2 continues to be expressed in the adult murine spinal cord and has been used as a presumed marker of gabaergic neurons in the superficial dorsal horn of the adult mouse, although a strict association between adult pax2 expression and presence of gaba throughout the dorsal horn has not been firmly established. |
2017-11-17 |
2023-08-13 |
mouse |
| Max Larsso. Pax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn. Neuroscience letters. vol 638. 2017-11-17. PMID:27939388. |
here, immunofluorescent labeling of pax2 and gaba in the lumbar spinal cord of adult rats was used to investigate this issue. |
2017-11-17 |
2023-08-13 |
mouse |
| Masanobu Sunagawa, Chigusa Shimizu-Okabe, Jeongtae Kim, Shiori Kobayashi, Yoshinori Kosaka, Yuchio Yanagawa, Masayuki Matsushita, Akihito Okabe, Chitoshi Takayam. Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord. Neuroscience. vol 343. 2017-11-17. PMID:28039040. |
in the spinal cord, glycine and γ-amino butyric acid (gaba) are inhibitory neurotransmitters. |
2017-11-17 |
2023-08-13 |
mouse |
| Cristina Romei, Tiziana Bonifacino, Marco Milanese, Cesare Usai, Luca Raiter. Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain research bulletin. vol 127. 2017-11-13. PMID:27565422. |
we could observe that functional transporters for glycine and glutamate are coexpressed on nerve terminals in the cerebellum; transporters for dopamine and gaba coexist on striatal terminals; transporters for glycine and gaba, previously found to coexist as cotransmission markers on nerve terminals of spinal cord and cerebellum, are not coexpressed in neocortex and hippocampus, where cotransmission has not been proposed to occur; transporters for gaba, glycine and glutamate are colocalized on nerve terminals of the spinal cord. |
2017-11-13 |
2023-08-13 |
Not clear |
| Qiang Cheng, Guo-Jing Sun, Shui-Bing Liu, Qi Yang, Xiao-Ming Li, Xu-Bo Li, Gang Liu, Jian-Ning Zhao, Ming-Gao Zha. A novel translocator protein 18 kDa ligand, ZBD-2, exerts neuroprotective effects against acute spinal cord injury. Clinical and experimental pharmacology & physiology. vol 43. issue 10. 2017-09-12. PMID:27292096. |
high-dose zbd-2 alleviated the oxidative stress induced by sci and regulated the imbalance between nr2b-containing nmda and gaba receptors by increasing the levels of gad67 in the spinal cord of sci mice. |
2017-09-12 |
2023-08-13 |
mouse |
| Uri Nimrod Ramírez-Jarquín, Ricardo Tapi. Chronic GABAergic blockade in the spinal cord in vivo induces motor alterations and neurodegeneration. Neuropharmacology. vol 117. 2017-08-29. PMID:28161374. |
in this work we studied the effects of gabaergic and glycinergic blockade, by means of microdialysis perfusion (acute administration) and osmotic minipumps infusion (chronic administration) of gaba and glycine receptors antagonists directly in the lumbar spinal cord. |
2017-08-29 |
2023-08-13 |
Not clear |
| Tommaso Bonfiglio, Guendalina Olivero, Elisa Merega, Silvia Di Prisco, Cristina Padolecchia, Massimo Grilli, Marco Milanese, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Giambattista Bonanno, Mario Marchi, Anna Pittalug. Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis. PloS one. vol 12. issue 1. 2017-08-10. PMID:28125677. |
glutamate exocytosis was shown to be impaired in cortical and spinal cord terminals isolated from eae mice at 21 ± 1 d.p.i., while gaba alteration emerged only at the spinal cord level. |
2017-08-10 |
2023-08-13 |
mouse |
| Hyeong Cheol Moon, Youn Joo Lee, Chul Bum Cho, Young Seok Par. Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model. Neuroscience letters. vol 632. 2017-08-08. PMID:27561604. |
suppression of the gamma-aminobutyric acid (gaba)ergic activity of the zona incerta (zi) reportedly plays a role in neuropathic pain after spinal cord injury (sci). |
2017-08-08 |
2023-08-13 |
rat |
| Jittima Gotts, Lucy Atkinson, Yuchio Yanagawa, Jim Deuchars, Susan A Deuchar. Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: A focus on lamina X. Brain research. vol 1646. 2017-07-20. PMID:27378584. |
to determine the co-localisation of the enzymes responsible for the production of gaba and acetylcholine (which play major roles in the spinal cord) in lamina x of the adult and juvenile mouse, we used a transgenic mouse expressing green fluorescent protein (gfp) in glutamate decarboxylase 67 (gad67) neurons, combined with choline acetyltransferase (chat) immunohistochemistry. |
2017-07-20 |
2023-08-13 |
mouse |
| Yukihide Koyama, Tomio Andoh, Yoshinori Kamiya, Tomoyuki Miyazaki, Koichi Maruyama, Takayuki Kariya, Takahisa Got. Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats. PloS one. vol 11. issue 10. 2017-06-14. PMID:27783647. |
gamma-aminobutyric acid (gaba) has been shown to induce excitation on immature neurons due to increased expression of na+-k+-2cl- co-transporter isoform 1 (nkcc1), and the transition of gabaergic signaling from excitatory to inhibitory occurs before birth in the rat spinal cord and spreads rostrally according to the developmental changes in cation-chloride co-transporter expression. |
2017-06-14 |
2023-08-13 |
rat |
| Yung-Jen Huang, Kuan H Lee, Lauren Murphy, Sandra M Garraway, James W Gra. Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization. Experimental neurology. vol 285. issue Pt A. 2017-05-08. PMID:27639636. |
acute spinal cord injury (sci) transforms how gaba affects nociceptive sensitization. |
2017-05-08 |
2023-08-13 |
rat |
| Yung-Jen Huang, Kuan H Lee, Lauren Murphy, Sandra M Garraway, James W Gra. Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization. Experimental neurology. vol 285. issue Pt A. 2017-05-08. PMID:27639636. |
the current study provides evidence that spinal cord injury (sci) transforms how gaba affects nociceptive transmission within the spinal cord, recapitulating an earlier developmental state wherein gaba has an excitatory effect. |
2017-05-08 |
2023-08-13 |
rat |
| Katherine A Mifflin, Curtis Benson, Kevin C Thorburn, Glen B Baker, Bradley J Ker. Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice. The journal of pain. vol 17. issue 4. 2016-12-27. PMID:26748043. |
changes in serotonin (5-hydroxytryptamine; 5-ht), noradrenaline (na), and γ-aminobutyric acid (gaba) levels in the spinal cord are known to occur in response to nociceptive stimuli, yet little research has examined possible underlying sex differences in these changes and how they might affect nociception. |
2016-12-27 |
2023-08-13 |
mouse |
| Carlos Gonzalez-Islas, Miguel Angel Garcia-Bereguiain, Brendan O'Flaherty, Peter Wenne. Tonic nicotinic transmission enhances spinal GABAergic presynaptic release and the frequency of spontaneous network activity. Developmental neurobiology. vol 76. issue 3. 2016-10-21. PMID:26061781. |
rather, we found that nachr activation tonically enhanced evoked and spontaneous presynaptic release of gaba in the embryonic spinal cord. |
2016-10-21 |
2023-08-13 |
Not clear |